Abstracts tagged "radiography and rheumatoid arthritis (RA)"

Abstract Number: 559 • 2018 ACR/ARHP Annual Meeting
Radiographic Progression Based on Baseline Demographics and Disease Characteristics from Three TNF-Alpha Inhibitor Biosimilar Studies in Patients with Rheumatoid Arthritis
Josef S. Smolen¹, Young Mo Kang², Wan-Hee Yoo³, Paul Emery⁴, Michael E Weinblatt⁵, Edward C. Keystone⁶, Mark C. Genovese⁷, Gihyun Myung⁸, Evelyn Hong⁸, Inyoung Baek⁸ and Jeehoon Ghil⁸, ¹Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria, ²Kyungpook National University School of Medicine, Daegu, Korea, Republic of (South), ³Chonbuk National University School of Medicine, Jeonju, Korea, Republic of (South), ⁴University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, ⁵Brigham and Women's Hospital, Boston, MA, ⁶Mount Sinai Hospital, Toronto, ON, Canada, ⁷Stanford University Medical Center, Palo Alto, CA, ⁸Samsung Bioepis Co., Ltd., Incheon, Korea, Republic of (South)
Background/Purpose: SB4, SB2, and SB5 are biosimilars of reference etanercept, infliximab, and adalimumab, respectively. Radiographic data were assessed using the modified Total Sharp Score (mTSS)…
Abstract Number: 890 • 2018 ACR/ARHP Annual Meeting
A Phase 3, Randomized, Double-Blind Study Comparing Upadacitinib to Placebo and to Adalimumab, in Patients with Active Rheumatoid Arthritis with Inadequate Response to Methotrexate
Roy Fleischmann¹, Aileen L. Pangan², Eduardo Mysler³, Louis Bessette⁴, Charles Peterfy⁵, Patrick Durez⁶, Andrew Ostor⁷, Yihan Li², Yijie Zhou², Ahmed A. Othman², In-Ho Song⁸ and Mark C. Genovese⁹, ¹University of Texas Southwestern Medical Center at Dallas, Metroplex Clinical Research Center, Dallas, TX, ²AbbVie, Inc., North Chicago, IL, ³Organización Medica de Investigación, Buenos Aires, Argentina, ⁴Laval University, Québec, QC, Canada, ⁵Spire Sciences LLC, Boca Raton, FL, ⁶Rheumatology, Rheumatology - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, ⁷Cabrini Medical Center, Malvern, Australia, ⁸AbbVie, Inc., north chicago, IL, ⁹Stanford University Medical Center, Palo Alto, CA
Background/Purpose: To assess efficacy, including inhibition of radiographic progression, and safety with upadacitinib (UPA), a JAK1- selective inhibitor, vs placebo (PBO) and active comparator, originator…
Abstract Number: 1450 • 2018 ACR/ARHP Annual Meeting
Clinical Radiology Reports Are Unreliable for Assessment of Radiographic Structural Progression in US Veterans with Rheumatoid Arthritis Initiating Tumor Necrosis Factor Inhibitor Therapy
Kevin R. Lammert¹, Alan R. Erickson², Brian C. Sauer¹ and Grant W. Cannon¹, ¹Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, ²Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Rheumatologists rely on hand radiograph findings including bone erosions (BE) and joint space narrowing (JSN) to make treatment decisions for patients with rheumatoid arthritis…
Abstract Number: 1454 • 2018 ACR/ARHP Annual Meeting
Levels of 14-3-3eta Are an Independent Predictor of Long-Term Radiographic Erosive Progression and of Short-Term Rapid Radiographic Erosive Progression in Patients with Inflammatory Polyarthritis
Gilles Boire¹, Nathalie Carrier², Artur J deBrum Fernandes³, Patrick Liang¹, Ariel Masetto⁴, Sophie Roux⁴, Norma K Biln⁵, Yuan Gui⁵, Jane Savill⁵, Sara Michienzi⁵ and Walter P. Maksymowych⁶, ¹Rheumatology Division, Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke and Universite de Sherbrooke, Sherbrooke, QC, Canada, ²Centre intégré universitaire de santé et de services sociaux de l'Estrie -Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada, ³Medicine, Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke and Universite de Sherbrooke, Sherbrooke, QC, Canada, ⁴Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke and Universite de Sherbrooke, Sherbrooke, QC, Canada, ⁵Augurex Life Sciences Corp, Vancouver, BC, Canada, ⁶Department of Medicine, CaRE Arthritis and University of Alberta, Edmonton, Canada, Edmonton, AB, Canada
Background/Purpose: Our objective is to examine the additional contribution of 14-3-3η levels to known predictors of radiographic progression in inflammatory polyarthritis, both over several years…
Abstract Number: 1455 • 2018 ACR/ARHP Annual Meeting
Development of a Predictive Model of Radiological Damage in Patients with Rheumatoid Arthritis Based on Artificial Intelligence
Jose M Lezcano¹, José Ivorra-Cortes², Alfredo Madrid³, Raquel Lopez-Mejías⁴, Javier Martin⁵, Benjamín Fernández-Gutiérrez⁶, Miguel Angel González-Gay⁷, Alejandro Balsa⁸, Isidoro Gonzalez-Alvaro⁹, Fernando Salazar¹⁰, Lydia A Alcazar¹¹ and Luis Rodriguez-Rodriguez¹¹, ¹Helix BioS CEO, Madrid, Spain, ²Rheumatology, University Hospital la Fe, Valencia, Spain, ³Rheumatology Department, and Instituto de Investigación Sanitaria (IdISSC), Hospital Clínico San Carlos, Madrid, Spain, ⁴Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, ⁵Instituto de Parasitología y Biomedicina López Neyra, Granada, Spain, ⁶Department of Rheumatology, Hospital Clinico San Carlos, Madrid, Spain, ⁷School of Medicine, University of Cantabria, Santander, Spain, Santander, Spain, ⁸Rheumatology Department, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain, ⁹Rheumatology Department, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain, ¹⁰International Centre for Numerical Methods in Engineering (CIMNE), Madrid, Spain, ¹¹Rheumatology Department and Heath Research Institute (IdISSC), Hospital Clinico San Carlos, Madrid, Spain
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with increased mortality and disability. Although different factors have been associated with prognosis, it is…
Abstract Number: 1435 • 2017 ACR/ARHP Annual Meeting
Consistent Inhibition of Joint Destruction By Denosumab in Important Subgroups of Japanese Patients with Rheumatoid Arthritis: Pooled Analysis of Phase 2 and 3 Studies
Yoshiya Tanaka¹, Tsutomu Takeuchi², Satoshi Soen³, Naoki Ishiguro⁴, Hisashi Yamanaka⁵, Toshiyuki Yoneda⁶, Sakae Tanaka⁷, Takaya Nitta⁸, Naoki Okubo⁹, Harry K. Genant¹⁰ and Désirée van der Heijde¹¹, ¹University of Occupational and Environmental Health, Kitakyushu, Japan, ²Keio University School of Medicine, Tokyo, Japan, ³Kindai University Nara Hospital, Ikoma, Japan, ⁴Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan, ⁵Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ⁶Indiana University School of Medicine, Indianapolis, IN, ⁷Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Japan, ⁸Daiichi Sankyo Co., Ltd., Tokyo, Japan, ⁹DaiichiSankyo CO., LTD., Tokyo, Japan, ¹⁰University of California, San Francisco, CA, ¹¹Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Denosumab is a fully human monoclonal antibody (IgG2 subclass) that inhibits bone resorption by blocking RANKL. Phase 2 (DRIVE) and phase 3 (DESIRABLE) studies…
Abstract Number: 2909 • 2017 ACR/ARHP Annual Meeting
Only Very High Radiographic Progression Affects HAQ-DI, Results from the Swiss Scqm Cohort
Ruediger Mueller¹, Reto Thalmann², Hendrik Schulze-Koops³, Nicole Graf⁴ and Johannes von Kempis², ¹Rheumatology, MD, St. Gallen, Switzerland, ²Rheumatology, Kantonsspital St. Gallen, St. Gallen, Switzerland, ³Division of Rheumatology and Clinical Immunology, Department of Internal Medicine IV, University of Munich, Munich, Germany, ⁴Graf Biostatistics, Winterthur, Switzerland
Background/Purpose: The aim of treatment of rheumatoid arthritis is to control disease activity and to inhibit joint damage. Progression of damage is analysed by conventional…
Abstract Number: 429 • 2017 ACR/ARHP Annual Meeting
Repair of Joint Damage Is Rare in Newly Diagnosed Rheumatoid Arthritis Patients and Appears Not to Relate to Previous Suppression of Inflammation
Joy A. van der Pol¹, Gulsah Akdemir¹, Marianne van den Broek¹, Linda Dirven¹, Pit J.S.M. Kerstens², Willem F. Lems³, Iris M. Markusse¹, Cornelia F Allaart¹ and Tom W.J. Huizinga¹, ¹Department of Rheumatology, LUMC, Leiden, Netherlands, Leiden, Netherlands, ²Department of Rheumatology, Reade, Amsterdam, Netherlands, ³Department of Rheumatology, VU Medical Center, Amsterdam, Netherlands, Amsterdam, Netherlands
Background/Purpose: Joint damage in RA is thought to be irreparable. We hypothesized that in patients in whom inflammation is persistently well suppressed, repair may be…
Abstract Number: 1352 • 2017 ACR/ARHP Annual Meeting
The Relevance of Elevated CRP As an Inclusion Criterion in Clinical Trials in Patients with Rheumatoid Arthritis
Craig Scoville¹, Jessica L. Suboticki², Sheng Zhong³ and Edward C. Keystone⁴, ¹Idaho Falls Arthritis Clinic, Idaho Falls, ID, ²AbbVie Inc., Mettawa, IL, ³AbbVie Inc., North Chicago, IL, ⁴Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Elevated C-reactive protein (CRP) is often used as an entry criterion in clinical trials (CT) with rheumatoid arthritis (RA) patients (pts), resulting in the…
Abstract Number: 506 • 2016 ACR/ARHP Annual Meeting
The Relationship Between Elevations in CRP with Physical Function and Radiographic Progression over the Long-Term in Patients with Rheumatoid Arthritis
Arthur Kavanaugh¹, Boulos Haraoui², Prashanth Sunkureddi³, Benjamin Wolfe⁴, Li Wang⁴, Jessica Suboticki⁴ and Edward Keystone⁵, ¹University of California San Diego, La Jolla, CA, ²University of Montreal, Montreal, QC, Canada, ³University of Texas Medical Branch, Galveston, TX, ⁴AbbVie Inc., North Chicago, IL, ⁵Mt. Sinai Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: For patients (pts) with rheumatoid arthritis (RA), quantification of radiographic progression, through measures such as modified total Sharp score (mTSS), is not routinely captured…
Abstract Number: 578 • 2016 ACR/ARHP Annual Meeting
Do Specific Anti-Citrullinated Antibodies Predict Different Phenotype of Rheumatoid Arthritis?
Mikael Brink¹, Monika Hansson², Linda Mathsson-Alm^3,4, Johan Rönnelid⁵, Karl Skriner⁶, Guy Serre⁷, Lars Klareskog² and Solbritt Rantapää-Dahlqvist¹, ¹Rheumatology, Umeå University, Umeå, Sweden, ²Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ³ThermoFisher Scientific, Uppsala, Sweden, Uppsala, Sweden, ⁴Thermo Fisher Scientific, Uppsala, Sweden, ⁵Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, ⁶Humboldt University of Berlin, Berlin, Germany, ⁷Unité Différenciation Épidermique et Autoimmunité Rhumatoïde, Unité Mixte de Recherche, INSERM, Toulouse, France
Background/Purpose: Antibodies against cyclic citrullinated peptides (anti-CCP) have been suggested to identify a more severe phenotype of rheumatoid arthritis. In this study we have analysed…
Abstract Number: 588 • 2016 ACR/ARHP Annual Meeting
Radiographic Progression Is Less Significant in Anti-Carbamylated Antibody-Positive Patients with Rheumatoid Arthritis (RA) Who Were Clinically Active and Under the Treatment with Biological Dmards
Kazuko Shiozawa¹, Ken Tsumiyama² and Shunichi Shiozawa², ¹The Rheumatic Diseases Center, Kohnan Kakogawa Hospital, Kakogawa, Japan, ²Department of Medicine, Rheumatic Diseases Unit, Kyushu University Beppu Hospital, Beppu, Japan
Background/Purpose: A newly discovered anti-carbamylated protein antibody (anti-CarP) is found prior to disease-onset, associates with the conversion towards arthralgia and with a more severe disease…
Abstract Number: 926 • 2016 ACR/ARHP Annual Meeting
Increased Concentration of Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) Predate Onset of Rheumatoid Arthritis
Linda Johansson¹, Lisbeth Ärlestig¹, Heidi Kokkonen² and Solbritt Rantapaa-Dahlqvist³, ¹Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden, ²Public Health and Clinical Medicine/ Rheumatology, Umeå University, Umeå, Sweden, ³Umeå University, Department of Public Health and Clinical Medicine/ Rheumatology, Umeå, Sweden
Background/Purpose: Receptor activator of nuclear factor κB ligand (RANKL) an important regulator of bone metabolism has a key role in local bone destruction and osteoporosis…
Abstract Number: 2081 • 2016 ACR/ARHP Annual Meeting
Dermal Temperature Is an Excelent Prognostic Indicator to Guide RA Therapy
JoAnn Ball¹ and Maria Greenwald², ¹rheumatology, Desert Medical Advances, Palm Deseret, CA, ²Rheumatology, Desert Medical Advances, Palm Desert, CA
Background/Purpose: Nurses and rheumatology extenders can rapidly identify rheumatoid arthritis (RA) patients who flare, with high predictive value for which individual is at high risk…
Abstract Number: 2591 • 2016 ACR/ARHP Annual Meeting
Association Between Flare and Radiographic Progression in Patients with Rheumatoid Arthritis
Josef Smolen¹, Heather Jones², Ehab Mahgoub², Ronald Pedersen³ and Lisa Marshall², ¹Division of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria, ²Inflammation Global Medical Affairs, Pfizer, Collegeville, PA, ³Department of Biostatistics, Pfizer, Collegeville, PA
Background/Purpose: Biologic therapy has improved RA management and enabled some patients to achieve remission. Many clinicians decrease the biologic dose for patients in low disease…

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