ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016 ACR/ARHP Annual Meeting
    • 2015 ACR/ARHP Annual Meeting
    • 2014 ACR/ARHP Annual Meeting
    • 2013 ACR/ARHP Annual Meeting
    • 2012 ACR/ARHP Annual Meeting
    • 2011 ACR/ARHP Annual Meeting
    • 2010 ACR/ARHP Annual Meeting
    • 2009 ACR/ARHP Annual Meeting
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • Register
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 2387

Relation Between Disease Activity Indices and Their Individual Components and Radiographic Progression in Rheumatoid Arthritis: A Systematic Literature Review

Victoria Navarro-Compán1, Ana Maria Gherghe2, Josef Smolen3, Daniel Aletaha4, Robert B. M. Landewé5,6 and Désirée van der Heijde7, 1Leiden University Medical Center, Leiden, Netherlands, 2Internal Medicine and Rheumatology, Carol Davila University of Medicine and Pharmacy & Cantacuzino Hospital, Bucharest, Romania, 3Division of Rheumatology, Department of Internal Medicine III,, Medical University of Vienna and Hietzing Hospital, Vienna, Austria, 4Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 5Department of Rheumatology, Amsterdam Rheumatology Center, Amsterdam, Netherlands, 6Atrium Medical Center, Heerlen, Netherlands, 7Dept of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords: Disease Activity, radiography and rheumatoid arthritis (RA)

  • Tweet
  • Email
  • Print
Save to PDF
Session Information

Session Title: Rheumatoid Arthritis - Clinical Aspects (ACR): Impact of Various Interventions and Therapeutic Approaches

Session Type: Abstract Submissions (ACR)

Background/Purpose: Composite indices and single items are available to monitor disease activity in rheumatoid arthritis (RA). Their relation to radiographic progression is an important aspect to select the most appropriate as target. The objective of this study was to investigate the relationship between different disease activity indices (DAIs) and their individual components and radiographic progression in patients with RA.

Methods: A systematic literature review until July 2013 was performed by two independent reviewers using Medline and EMBASE databases. The research question was formulated according to the PICO method: Population (RA patients); Intervention (DAI including DAS, DAS28, SDAI, CDAI, RADAI and RAPID and individual items or scales including patientxs global health (GH), patientxs global disease activity, pain, evaluatorxs global disease activity (EGA), all on a VAS, CRP, ESR, SJC and TJC); Outcome (radiographic progression). Longitudinal studies with ≥ 12 months of follow up assessing the relation between DAIs and single items and radiographic progression were included. Risk of bias of the studies was evaluated according to Hayden tool (range 1-6). The results were grouped based on the means of measuring (baseline versus time-integrated) and analysis (univariable or multivariable). 

Results: Fifty five studies from 1232 citations were included. Most of the studies were prospective cohorts and had an overall quality score ≥ 4 points. Radiographic progression was mainly assessed using the modified Sharp van der Heijde or Larsen scoring methods and the period to evaluate progression ranged between 12 and 240 months. The table shows a summary of the studies included in the SLR. All published studies that assessed the relationship between any time-integrated DAI and radiographic progression reached a statistically significant association. Among the single items, only SJC and ESR were associated with radiographic progression, while no significant association was found for TJC. Data with respect to CRP is conflicting. Data on patientxs GH, pain assessment and EGA is limited and does not support a positive association with progression of joint damage.

Conclusion: Published data indicates that composite disease activity scores including swollen joints are more related to radiographic progression than their individual components. Therefore, these are the optimal tools to monitor disease activity in patients with RA. The best performing single items are SJC and ESR.

Table: Summary of studies evaluating the relationship between disease activity indices and their individual components and radiographic progression; Data show total number of studies and the percentage of studies that reached statistically significance (% sig) based on the type of measure and analysis employed.

Baseline measure

Time-integrated measure

Number of studies

Univariable studies

n, (% sig)

Multivariable studies

n, (% sig)

Univariable studies

n, (% sig)

Multivariable studies

n, (% sig)

Disease activity index

DAS

11

7 (29)

1 (100)

–

3 (100)

DAS28

18

6 (17)

2 (50)

6 (100)

4 (≥75)

SDAI

7

1  (100)

–

5 (100)

1 (100)

CDAI

5

1 (0)

–

3 (100)

1(100)

RADAI

2

2 (50)

–

–

–

RAPID

0

–

–

–

–

Item or scale

TJC

24

16 (31)

3 (33)

3 (100)

3 (0)

SJC

34

20 (44)

5 (60)

3 (100)

6 (67)

GH

2

1 (0)

1 (100)

–

–

PGA

4

2 (0)

–

2 (100)

–

VAS pain

8

4 (25)

2 (50)

1 (100)

1 (0)

EGA

7

5 (20)

–

1 (100)

1 (100)

ESR

37

14 (43)

12 (83)

6 (100)

5 (60)

CRP

36

18 (50)

8 (63)

6 (67)

4 (50)


Disclosure:

V. Navarro-Compán,
None;

A. M. Gherghe,
None;

J. Smolen,
None;

D. Aletaha,
None;

R. B. M. Landewé,
None;

D. van der Heijde,
None.

  • Tweet
  • Email
  • Print
Save to PDF

« Back to 2014 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/relation-between-disease-activity-indices-and-their-individual-components-and-radiographic-progression-in-rheumatoid-arthritis-a-systematic-literature-review/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

Annual Meeting in Atlanta, Georgia

© COPYRIGHT 2019 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.