Abstracts tagged "Pulmonary Involvement"

Abstract Number: 944 • 2017 ACR/ARHP Annual Meeting
Long-Term Survival and Follow-up of Anti-Th/to Antibody Positive Systemic Sclerosis Patients
Devon Charlton¹, Maureen Laffoon², Thomas A. Medsger Jr.³ and Robyn T. Domsic⁴, ¹Division of Rheumatology and Clinical Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA, ²Rheumatology, University of Pittsburgh Medical Center, Pittsburgh, PA, ³Department of Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁴Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Anti-Th/To antibody is an autoantibody associated with systemic sclerosis (SSc), occurring in 5-10% of patients. To date, only relatively small case series have described…
Abstract Number: 947 • 2017 ACR/ARHP Annual Meeting
Norway As a National Reference Population for Systemic Sclerosis; Preliminary Results from a Complete, Nationwide Cohort
Anna-Maria Hoffmann-Vold¹, Håvard Fretheim¹, Anne Kristine Halse², Marit Seip³, Marianne Wallenius⁴, Helle Bitter⁵, Torhild Garen¹, Oyvind Midtvedt¹ and Øyvind Molberg¹, ¹Oslo University Hospital, Oslo, Norway, ²Haukeland University Hospital, Bergen, Norway, ³University Hospital of North Norway, Tromso, Norway, ⁴St. Olav's University Hospital, Trondheim, Norway, ⁵Hospital of Southern Norway, Kristiansand, Norway
Background/Purpose: To fully understand the impact of Systemic sclerosis (SSc) there is a need to complement existing multi-center registry data with novel, unbiased, high resolution…
Abstract Number: 1276 • 2017 ACR/ARHP Annual Meeting
Nail Fold Capillary Changes Are Associated with Pulmonary, but Not with Cardiac Involvement in Juvenile Dermatomyositis
Zoltán Barth^1,2,3, Thomas Schwartz^2,4, Berit Flatø^5,6, Akos Koller^7,8, May Brit Samersaw-Lund⁹, Ivar Sjaastad^10,11 and Helga Sanner⁶, ¹Bjorknes College, Oslo, Norway, ²Oslo University Hospital and University of Oslo, Institute for Experimental Medical Research, Oslo, Norway, ³Medical School, University of Pecs, Institute for Translational Medicine, Pecs, Hungary, ⁴Institute for Experimental Medical Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway, ⁵Institute for Clinical Medicine, University of Oslo, Oslo, Norway, Oslo, Norway, ⁶Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, ⁷University of Physical Education, Institute of Natural Sciences, Budapest, Hungary, ⁸Medical School, University of Pecs, Department of Neurosurgery, Pecs, Hungary, ⁹Oslo University Hospital, Rikshospitalet, Department of Respiratory Medicine, Oslo, Norway, ¹⁰Department of Cardiology, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ¹¹Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway, Oslo, Norway
Background/Purpose: Juvenile dermatomyositis (JDM) is a rare autoimmune disease of unknown origin, characterised primarily by cutaneous rashes and symmetrical weakness of the proximal skeletal muscles.…
Abstract Number: 1697 • 2017 ACR/ARHP Annual Meeting
Unique Characteristics of Scleroderma Among African Americans: A Population Based Study
Sarah M. Compton¹, Richard M. Silver² and Diane L. Kamen³, ¹Internal Medicine, Medical University Of South Carolina, Charleston, SC, ²Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, ³Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Systemic sclerosis (SSc) is a rare autoimmune disease categorized on the basis of skin involvement as either limited or diffuse cutaneous SSc, the latter…
Abstract Number: 105 • 2017 Pediatric Rheumatology Symposium
Isolated Pediatric Pulmonary Capillaritis: A Comprehensive Single-Center Review of Disease Course, Management, and Prognosis
William Lapin¹, Saimun Singla², Eyal Muscal³ and Manuel Silva-Carmona⁴, ¹Department of Pediatrics, Division of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, ²Department Pediatrics, Division of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, ³Immunology, Allergy and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, ⁴Department of Pediatrics, Pulmonology Section, Baylor College of Medicine, Texas Children's Hospital, Houston, TX
Background/Purpose: Pediatric diffuse alveolar hemorrhage (DAH) is a life-threatening disorder characterized by pulmonary hemorrhage and respiratory insufficiency. Histologically, DAH with capillary inflammation is known as…
Abstract Number: 1238 • 2016 ACR/ARHP Annual Meeting
Assessment of Mortality and Healthcare Costs Associated with Systemic Sclerosis with and without Lung Involvement
Karina Raimundo¹, Amanda Farr², Ashley Cole³ and Aryeh Fischer⁴, ¹Genentech, Inc., a Member of the Roche Group, South San Francisco, CA, ²Truven Health Analytics, Cambridge, MA, ³Truven Health Analytics, Bethesda, MD, ⁴Medicine / Center for Lungs and Breathing, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Patients with systemic sclerosis (SSc) are at high risk of developing interstitial lung disease (ILD) and/or pulmonary hypertension (PH). These two lung manifestations are…
Abstract Number: 1344 • 2016 ACR/ARHP Annual Meeting
Characteristics, Treatment and Outcome of Severe Pulmonary Hemorrhage Related to Systemic Disease: French Multicentric Study
Adrien Mirouse¹, Antoine Parrot², Jacques Cadranel³, Eric Mariotte⁴, Julien Mayaux⁵, Nicolas Bréchot⁶, Mathieu Vautier⁷, Etienne de Montmollin⁸, Nicolas de Prost⁹, Patrice Cacoub¹⁰ and David Saadooun¹⁰, ¹Service de médecine interne, Hôpital Saint-Antoine, Paris, France, ²Service de pneumologie, Hôpital Tenon, 75020, France, ³Service de pneumologie, Hôpital Tenon, Paris, France, ⁴Service de réanimation médicale, Hôpital Saint-Louis, Paris, France, ⁵Service de pneumologie et réanimation médicale, Hôpital Pitié-Salpêtrière, Paris, France, ⁶Service de réanimation médicale, Hôpital Pitié-Salpêtrière, Paris, France, ⁷Service de médecine interne, CHU de Caen, Caen, France, ⁸Service de réanimation médicale, Hôpital Delafontaine, Saint-Denis, France, ⁹Service de réanimation médicale, Hôpital Henri Mondor, Créteil, France, ¹⁰Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier Pitié-Salpêtrière, Département de Médecine Interne et d’Immunologie clinique, DHU i2B, Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, Paris 6, Paris, France, Paris, France
Background/Purpose: pulmonary hemorrhage (PH) may complicate systemic disease. The main objective of this study was to describe characteristics, treatment and outcome of patients presenting severe…
Abstract Number: 1491 • 2016 ACR/ARHP Annual Meeting
M-Ficolin and MAp44 As Potential Markers of Subclinical Cardiovascular Comorbidity; Cardiac Evaluation By Coronary Computer Tomography and Myocardial Deformation of Left Ventricle in Early Rheumatoid Arthritis Patients
Ida G. Louw¹, Christian G. Ammitzböll², Brian Bridal Løgstrup³, Jesper Blegvad-Nissen⁴, Grazina Urbonaviciene⁴, Trine Bay Laurberg⁴, Mette Herly⁵, Agnete H. Nielsen⁴, Steffen Thiel⁶ and Torkell Ellingsen⁵, ¹University of Southern Denmark, Odense, DK, Odense, Denmark, ²Department of Rheumatology, Aarhus University Hospital, Aarhus, DK, Aarhus, Denmark, ³Department of Cardiology, Skejby, Aarhus University Hospital, Aarhus, DK, Aarhus, Denmark, ⁴Diagnostic Centre, University Research Clinic for Innovative Patient Pathways, Silkeborg Regional Hospital, DK, Silkeborg, Denmark, ⁵Department of Rheumatology, Odense University Hospital, Odense, DK, Odense, Denmark, ⁶Institute of Biomedicine, Aarhus University, Aarhus, DK, Aarhus, Denmark
Background/Purpose: 79 DMARD-naïve RA patients with a disease duration < 6 months were included from an inception cohort. Clinical variables, plasma- and serum-M-ficolin and MAp44…
Abstract Number: 1896 • 2016 ACR/ARHP Annual Meeting
Efficacy of Pulmonary Arterial Hypertension-Specific Drugs Combination Therapy in Survival of Patients with Pulmonary Arterial Hypertension Associated with Systemic Sclerosis and Other Connective Tissue Diseases
Sumiaki Tanaka¹, Yu Matsueda¹, Gakuro Abe², Jun Okada³ and Shunsei Hirohata¹, ¹Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, ²Kitasato University School of Medicine, Sagamihara, Japan, ³Nutritional management, Kitasato Junior Collage of health and Hygienic Sciences, Minami-Uonuma, Japan
Background/Purpose: Survival of patients with pulmonary arterial hypertension (PAH) associated with connective tissue disease (CTD), especially systemic sclerosis (SSc), is poorer than that of patients…
Abstract Number: 2158 • 2016 ACR/ARHP Annual Meeting
Serum Uric Acid Is Positively Associated with Pulmonary Function in Korean Health Screening Examinees: A Cross-Sectional Study
Joong Kyong Ahn¹, Jiwon Hwang², Jae-Uk Song³, Hyemin Jeong⁴, Ji Young Chae⁵, Hyungjin Kim⁴, Hoon-Suk Cha⁴ and Eun-Mi Koh⁴, ¹Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, ²Department of Medicine, National Police Hospital, Seoul, Korea, The Republic of, ³Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea, The Republic of, ⁴Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁵Departement of Internal Medicine, Bundang Jesaeng General Hospital, Seongnam, Korea, The Republic of
Background/Purpose: Serum uric acid (SUA) has been shown to be a powerful endogenous antioxidant in the body. The double-edged characteristics of serum uric acid (SUA)…
Abstract Number: 2201 • 2016 ACR/ARHP Annual Meeting
Self-Reported Breathlessness on Exertion Is Associated with Poor Outcomes Among Women with Systemic Lupus Erythematosus (SLE)
Patricia P. Katz¹, Sofia Pedro², Robert S. Katz³, Frederick Wolfe⁴ and Kaleb Michaud⁵, ¹Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ²National Data Bank for Rheumatic Diseases, Wichita, KS, ³Rush University Medical Center, Chicago, IL, ⁴National Data Bank, Wichita, KS, ⁵University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Breathlessness is often considered as a predictor of functional outcomes in pulmonary disease, but has not been examined in SLE. Methods: Data were from…
Abstract Number: 2659 • 2016 ACR/ARHP Annual Meeting
Respiratory Symptoms in Patients with Primary SjöGren’s Syndrome – a Case-Control Study
Thomas Mandl¹, Peter Olsson¹, Roger Hesselstrand² and Victor Strevens Bolmgren³, ¹Dept of Rheumatology, Skane University Hospital Malmö, Lund University, Malmo, Sweden, ²Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden, ³Dept of Rheumatology, Skane University Hospital Malmo, Lund University, Malmo, Sweden
Background/Purpose: To evaluate the amount and impact of respiratory symptoms in patients with primary Sjögren’s syndrome (pSS) and to assess if such symptoms are related…
Abstract Number: 2888 • 2016 ACR/ARHP Annual Meeting
Usefulness of Bosentan in the Prevention of Pulmonary Hypertension in Patients with Systemic Sclerosis
Ivan Castellví¹, Carmen Pilar Simeón², Monica Paola Sarmiento¹, Alfredo Guillen², Cesar Diaz-Torné³, Josep Maria De Llobet Zubiaga¹, Jordi Casademont⁴ and Vicent Fonollosa², ¹Rheumatology, Hospital Universitari de la Santa Creu i Sant Pau, Barcelona, Spain, ²Internal Medicine, Hospital Universitari Vall d'Hebron, Barcelona, Spain, ³Rheumatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, ⁴Internal Medicine, Hospital Universitari de la Santa Creu i Sant Pau, Barcelona, Spain
Background/Purpose: Systemic sclerosis (SSc) is a systemic autoimmune disease in which the damage of microcirculation is critical to develop the disease. In SSc, vascular complications…
Abstract Number: 504 • 2016 ACR/ARHP Annual Meeting
Clinical Significance of Multiple Autoantibody Specificities in Rheumatoid Arthritis: The Role of Anti-Citrullinated Alpha-Enolase and Anti-Interferon Inducible Protein 16 Antibodies
Alessia Alunno¹, Onelia Bistoni¹, Federico Pratesi², Valeria Caneparo³, Fabiana Topini¹, Ilaria Puxeddu², Marco De Andrea⁴, Santo Landolfo⁴, Paola Migliorini² and Roberto Gerli¹, ¹Department of Medicine, Rheumatology Unit, University of Perugia, Perugia, Italy, ²Department of Clinical and Experimental Medicine, Clinical Immunology Unit, University of Pisa, Pisa, Italy, ³Department of Translational Medicine, Virology Unit, Novara Medical School, Novara, Italy, ⁴Department of Public Health and Pediatric Sciences, Viral Pathogenesis Unit, Turin Medical School, Torino, Italy
Background/Purpose: Anti-cyclic citrullinated peptide (anti-CCP) auto-antibodies (auto-Abs) represent the current gold standard for the diagnosis of rheumatoid arthritis (RA). However, growing evidence suggests that a…
Abstract Number: 801 • 2016 ACR/ARHP Annual Meeting
Multi-Tissue Gene Expression Pathway Analysis of Emerging Therapeutics in a TGFβ Dependent Mouse Model of Systemic Sclerosis
Emma C. Derrett-Smith^1,2, Shiwen Xu³, Rachel K. Hoyles⁴ and Christopher Denton⁵, ¹Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine, London, United Kingdom, ²Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, ³Division of Medicine, Centre for Rheumatology and Connective tissue disease, University College London, London, United Kingdom, ⁴Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom, ⁵Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom
Background/Purpose: We have previously investigated the interplay between TGFβ, BMP, VEGF and endothelin in SSc using the TβRIIΔk-fib strain, a transgenic mouse model in…

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