ACR Meeting Abstracts

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Abstracts tagged "Pulmonary Involvement"

  • Abstract Number: 1113 • 2018 ACR/ARHP Annual Meeting

    Distinct Pathways in Anti-RNP-Associated Pulmonary Hypertension and Anti-RNP-Associated Raynaud’s Phenomenon

    Lisa Harlow1, Ying Wang2, YunJuan Zang2, Vineet Gupta3, Karen Young4, Jian Huang4, Bethly Aubourg2 and Eric Greidinger5, 1Rheumatology and Clinical Immunology, University of Miami Miller School of Medicine, Miami, FL, 2Rheumatology, University of Miami, Miami, FL, 3Rush University, Chicago, IL, 4Pediatrics, University of Miami, Miami, FL, 5Miami VA Medical Center, Miami, FL

    Background/Purpose: Anti-RNP Autoimmunity is associated with multiple manifestations of vasculopathy, including Raynaud’s Phenomenon (RP) and Pulmonary Hypertension (PH). We have previously linked anti-K10 antibodies to…
  • Abstract Number: 1123 • 2018 ACR/ARHP Annual Meeting

    Plasmacytoid Dendritic Cells in Bronchoalveolar Lavage Correlate with Pulmonary Artery Diameter and Infiltrate Perivascular Areas in the Lungs from Patients with Systemic Sclerosis Associated Pulmonary Hypertension

    Isela Valera1, Anagha Divekar2, Dinesh Khanna3, Fereidoun Abtin4, Rajan Saggar4 and Ram R. Singh4, 1Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, UCLA, Los Angeles, CA, 2Biolegend, Sa Diego, CA, 3Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, 4UCLA, Los Angeles, CA

    Background/Purpose: In patients with systemic sclerosis (SSc), plasmacytoid dendritic cells (pDCs) increase in the bronchoalveolar lavage (BAL) and lung tissues (Kafaja S, et al, JCI…
  • Abstract Number: 1702 • 2017 ACR/ARHP Annual Meeting

    Disease Progression in Systemic Sclerosis Patients with Concomittant or Isolated Interstitial Lung Disease and Pulmonary Arterial Hypertension in the Scleroderma Cohort Singapore

    Maria Noviani1, Seyed Ehsan Saffari2, Sandra Mei Yu Kua1, Grace Yin Lai Chan3, Gim Gee Teng4, Weng Giap Law5, Amelia Santosa4, Anita Yee Nah Lim4, Swee Cheng Ng1 and Andrea Hsiu Ling Low1, 1Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore, Singapore, 2Center for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore, Singapore, 3Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore, SIngapore, Singapore, 4Division of Rheumatology, University Medicine Cluster, National University Health System, Singapore, Singapore, Singapore, 5Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore, Singapore, Singapore

    Background/Purpose: Pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD) are leading causes of mortality in patients with systemic sclerosis (SSc).  We aimed to determine…
  • Abstract Number: 1769 • 2017 ACR/ARHP Annual Meeting

    Incidence, Predictors, and Outcome of Diffuse Alveolar Hemorrhage in Patients with MPO-ANCA Positive Microscopic Polyangiitis: A Multi-Center Retrospective Cohort Study

    Takashi Kida, Shunya Kaneshita, Takuya Inoue, Amane Nakabayashi, Yuji Kukida, Kazuki Fujioka, Hidetake Nagahara, Makoto Wada, Takahiro Seno, Masataka Kohno and Yutaka Kawahito, Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Background/Purpose: In patients with microscopic polyangiitis (MPA), a variety of pulmonary lesions including diffuse alveolar hemorrhage (DAH), airways disease and interstitial lung disease (ILD) have…
  • Abstract Number: 2008 • 2017 ACR/ARHP Annual Meeting

    “Intrathoracic Manifestations of Connective Tissue Diseases on High Resolution Computed Tomography”

    Diego Baenas1, Maira Orozco2, María Eugenia Olmos3, Luis Lasca4, Paula Riba5, Patricio Muszinsky5, Juan Pablo Pirola6, Verónica Saurit7, Alejandro Alvarellos7, Ana C. Alvarez8, Soledad Retamozo9,10, Nadia Riscanevo7,11, Janet Flores12, Ariel Blua3, Ana María López13, Gustavo Muiño14, Santiago Orozco15 and Francisco Caeiro16, 1Rheumatology Unit, Hospital Privado Universitario de Córdoba, Postgraduate Career of Rheumatology Catholic University of Córdoba., Cordoba, Argentina, 2Radiology, Radiology Unit, Hospital Privado Universitario de Córdoba, Cordoba, Argentina, 3Pulmonary, Pulmonary Unit, Hospital Privado Universitario de Córdoba, Cordoba, Argentina, 4Radiology Unit, Oulton Institute, Cordoba, Argentina, 5Radiology, Radiology Unit, Oulton Institute, Cordoba, Argentina, 6Rheumatology, Rheumatology Unit, Hospital Privado Universitario de Córdoba., Cordoba, Argentina, 7Rheumatology, Rheumatology Unit, Hospital Privado Universitario de Córdoba, Cordoba, Argentina, 8Rheumatology, Rheumatology Unit, Hospital Privado Universitario de Córdoba, Córdoba, Argentina, 9Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Córdoba, Consejo Nacional de Investigaciones Científicas y Técnicas (INICSA-UNC-CONICET), Cordoba, Argentina, 10Hospital Privado Centro Médico de Córdoba, Cordoba, Argentina, 11Rheumatology Unit, Hospital Privado Universitario de Córdoba, Cordoba, Argentina, 12Rheumatology Unit, Rheumatology Unit, Hospital Privado Universitario de Córdoba, Cordoba, Argentina, 13Pulmonary Unit, Pulmonary Unit, Hospital Privado Universitario de Córdoba., Cordoba, Argentina, 14Radiology, Radiology Unit,Hospital Privado Universitario de Córdoba., Cordoba, Argentina, 15Radiology, Radiology Unit, Hospital Privado Universitario de Córdoba., Cordoba, Argentina, 16Rheumatology, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina

    Background/Purpose: Connective tissue diseases (CTD) can cause intrathoracic involvement, increasing patients morbidity and mortality. High-resolution computed tomography (HRCT) is a key method for evaluation of…
  • Abstract Number: 2398 • 2017 ACR/ARHP Annual Meeting

    A Population-Based Cohort Study of Chronic Obstructive Pulmonary Disease Among Patients with Rheumatoid Arthritis: Comorbidity and Mortality

    Charlotte Hyldgaard1, Elisabeth Bendstrup1, Alma Becic Pedersen2, Sinna Pilgaard Ulrichsen3, Anders Løkke1, Ole Hilberg4 and Torkell Ellingsen5,6, 1Pulmonology, Århus University Hospital, Århus, Denmark, 2Clinical Epidemiology, Århus University Hospital, Århus, Denmark, 3Clinicla Epidemiology, Århus University Hospital, Århus, Denmark, 4Internal medicine, Vejle Hospital, Vejle, Denmark, 5Diagnostic Centre, Region Hospital Silkeborg, Silkeborg, Denmark, 6Department of Rheumatology, Odense University Hospital, Odense, DK, Odense, Denmark

    Background/Purpose: Only few studies have addressed the prognostic impact of chronic obstructive pulmonary disease (COPD) among patients with rheumatoid arthritis (RA), although both diseases are…
  • Abstract Number: 2676 • 2017 ACR/ARHP Annual Meeting

    Reduction of Dlco and FVC in Patients with GERD and Systemic Sclerosis

    Rodrigo Aguila Maldonado1, Pierina Sansinanea2, Claudia Elizabeth Pena1, Ana Carolina Costi1, Ariel Vulcano2, Adriana Testi2, Mariana Pera3, Lucila García2, Valeria Arturi3, Viviana Nagua2 and Mercedes Garcia1, 1Rheumatology, HIGA General San Martin La Plata, La Plata, Argentina, 2Rheumatology, HIGA General San Martin La Plata, la plata, Argentina, 3HIGA General San Martin La Plata, la plata, Argentina

    Background/Purpose: Esophageal involvement is common in Systemic Sclerosis (SSc). It is estimated to occur in 70-90% of patients. Esophageal motor dysfunction is characterized by hypotonia…
  • Abstract Number: 2678 • 2017 ACR/ARHP Annual Meeting

    Comparison of Scleroderma Associated Isolated Pulmonary Arterial Hypertension and Pulmonary Hypertension with Concomitant Interstitial Lung Disease

    Alexander Hannan1, Raed Dweik2, Kristin B. Highland3, Gustavo Heresi4, Adriano Tonelli5, William Messner6 and Soumya Chatterjee1,7, 1Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, 2Respiratory Institute, Cleveland Clinic, Cleveland, OH, 3Rheumatology.org, Cleveland Clinic, Cleveland, OH, 4Respiratory Institute - Pulmonary Medicine, Cleveland Clinic, Cleveland, OH, 5Pulmonary Medicine - Respiratory Institute, Cleveland Clinic, Cleveland, OH, 6Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, 7Rheumatic and Immunologic Ds, Cleveland Clinic, Cleveland, OH

    Background/Purpose: Relatively little data exist in the literature to characterize the differences between patients with scleroderma-associated isolated pulmonary arterial hypertension (SSc-PAH, WHO Group 1) and…
  • Abstract Number: 2679 • 2017 ACR/ARHP Annual Meeting

    Mortality Is Increased in Scleroderma Associated Pulmonary Arterial Hypertension Patients with Younger Age, Lower Systolic Blood Pressure, and Lower Cardiac Index, but Not in Idiopathic Pulmonary Arterial Hypertension

    Alexander Hannan1, Raed Dweik2, Kristin B. Highland3, Gustavo Heresi4, Adriano Tonelli5, William Messner6 and Soumya Chatterjee1, 1Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, 2Respiratory Institute, Cleveland Clinic, Cleveland, OH, 3Rheumatology.org, Cleveland Clinic, Cleveland, OH, 4Respiratory Institute - Pulmonary Medicine, Cleveland Clinic, Cleveland, OH, 5Pulmonary Medicine - Respiratory Institute, Cleveland Clinic, Cleveland, OH, 6Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH

    Background/Purpose: Survival in scleroderma associated pulmonary arterial hypertension (SSc-PAH) is known to be significantly worse compared to that in idiopathic pulmonary arterial hypertension (iPAH). However,…
  • Abstract Number: 2687 • 2017 ACR/ARHP Annual Meeting

    Characteristic of Pulmonary Arterial Hypertension in Patients with Anti-U1RNP Antibody-Positive-Connective Tissue Diseases Is Determined By the Underlying Disease Rather Than Autoantibody Profile

    Hidekata Yasuoka1, Hiroshi Takei1, Yuichiro Shirai2, Kunihiro Yamaoka1, Masataka Kuwana1,2 and Tsutomu Takeuchi1, 1Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 2Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan

    Background/Purpose: Patients with connective tissue diseases (CTDs) positive for anti-U1RNP antibody (U1) is characterized by overlapping feature of systemic sclerosis (SSc), systemic lupus erythematosus (SLE),…
  • Abstract Number: 2737 • 2017 ACR/ARHP Annual Meeting

    Pulmonary Manifestations of Primary Systemic Vasculitides

    Jean-Paul Makhzoum1, Raashid Luqmani2, Richard A. Watts3, Anthea Craven4, Peter A. Merkel5 and Christian Pagnoux6, 1Rheumatology, Vasculitis Clinic, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 2Botnar Research Centre, University of Oxford, Oxford, United Kingdom, 3Rheumatology Department, The Ipswich Hospital, Ipswich, Great Britain, 4Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, Oxford University Hospitals, Oxford, United Kingdom, 5Division of Rheumatology, University of Pennsylvania; Perelman School of Medicine, Philadelphia, PA, 6Rheumatology-Vasculitis clinic, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Pulmonary involvement in systemic primary vasculitides is diverse and occurs with variable incidence depending on the type of vasculitis. This study aimed to describe…
  • Abstract Number: 378 • 2017 ACR/ARHP Annual Meeting

    Musculoskeletal Features in Copa Syndrome

    William B. Lapin1, Monica Marcus2, Andrea A. Ramirez3, Marietta M. de Guzman3 and Levi B. Watkin4,5, 1Department of Pediatrics, Division of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, 2Pediatric Immunology, Allergy and Rheumatology, Texas Children's Hospital, Houston, TX, 3Immunology, Allergy and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, 4Department of Pediatrics, Division of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, 5Texas Children's Hospital, Center for Human Immunobiology, Houston, TX

    Background/Purpose: COPA syndrome is a newly discovered primary immunodeficiency resulting in immune dysregulation showing autosomal dominant inheritance with incomplete penetrance. Its name is derived from…
  • Abstract Number: 2980 • 2017 ACR/ARHP Annual Meeting

    Chemokine CCL21 As a Potential Serum Biomarker for Pulmonary Arterial Hypertension in Systemic Sclerosis

    Anna-Maria Hoffmann-Vold1, Roger Hesselstrand2, Håvard Fretheim1, Thor Ueland1, Arne K Andreassen1, Oyvind Midtvedt1, Torhild Garen1, Pål Aukrust1, John A Belperio3 and Øyvind Molberg1, 1Oslo University Hospital, Oslo, Norway, 2Lund University, Lund, Sweden, 3University of California, Los Angeles, Los Angeles, CA

    Background/Purpose : Systemic sclerosis (SSc) is a major cause of pulmonary arterial hypertension (PAH). Murine models indicate key roles of chemokines CCL19/21 and their receptor…
  • Abstract Number: 730 • 2017 ACR/ARHP Annual Meeting

    The Association of Pulmonary Hypertension with Isolated Nucleolar Serum Autoantibodies in Systemic Sclerosis

    Kathleen Aren1, Mary A. Carns1, Michael Cuttica2, Julia (Jungwha) Lee3, Virginia D. Steen4 and Monique Hinchcliff5, 1Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, 2Northwestern University, Feinberg School of Medicine, Division of Pulmonary and Critical Care, Chicago, IL, 3Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 4Division of Rheumatology, Department of Medicine, MedStar Georgetown University Hospital, Washington, DC, 5Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose:  Serum antibodies are used to identify SSc patients who may be at higher risk for SSc-PH. The Pulmonary Hypertension Assessment and Recognition of Outcomes…
  • Abstract Number: 752 • 2017 ACR/ARHP Annual Meeting

    Role of the Six-Minute Walk Test in Systemic Sclerosis: Five Years Evolution

    Els Vandecasteele1, Karin Melsens2, Filip De Keyser3, Michel De Pauw4, Ellen Deschepper5, Saskia Decuman6, Yves Piette2, Kristof Thevissen7, Guy Brusselle8 and Vanessa Smith3, 1Dep of Cardiology, University Hospital Ghent, Ghent, Belgium, 2Ghent University Hospital, Department of Rheumatology, Ghent, Belgium, Ghent, Belgium, 3Ghent University, Department of Internal Medicine, Ghent, Belgium, Ghent, Belgium, 4Dep of cardiology, University Hospital Ghent, Ghent, Belgium, 5Biostatistics Unit, UGent, Ghent, Belgium, 6Department of Internal Medicine, Ghent University, Ghent, Belgium, 7University Hospital Ghent, Ghent, Belgium, 8Gent University, Gent, Belgium

    TitleRole of the Six-Minute Walk Test in Systemic Sclerosis: five years evolution. Background/Purpose: Interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH) are the leading…
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