Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: The aim was to investigate M-ficolin and Map44, proteins from the lectin pathway, as prognostic markers of subclinical cardiovascular disease in untreated early rheumatoid arthritis (RA) patients. We evaluated the associations between M-ficolin, MAp44 and disease activity (DAS28, CRP and HAQ-score), the degree of coronary artery calcification and myocardial deformation of left ventricle in an inception cohort.
Methods: 79 DMARD-naïve RA patients with a disease duration < 6 months were included from an inception cohort. Clinical variables, plasma- and serum-M-ficolin and MAp44 levels, myocardial deformation analysis and coronary calcification were measured at baseline and after two years. M-ficolin and Map44 were measured with an in-house time-resolved flourometric immunoassay. Coronary calcification was evaluated by Agatston calcium-score using cardiac computer tomography. Left ventricle deformation imaging was determined by speckle tracking echocardiography. Level of statistical dependence and significance were determined with Spearman rank correlation test.
Results: Baseline serum M-ficolin was associated to CRP (r=0.26, p=0.02) and DAS28 (r=0.24, p=0.04). Further, baseline Map44 was associated to CRP in serum (r=0.25, p=0.03) and plasma (r=0.29, p=0.01). At the two-year follow-up patient’s global assessment, assessment of pain, fatigue and HAQ score were associated to serum MAp44 (range p=0.002; 0.04), (range r=-0.36; -0.25). We found associations between baseline fasting insulin and M-ficolin and MAp44 (range p=0.001; 0.02). No associations were found between Agatston calcium score and MAp44 or M-ficolin. Only baseline plasma MAp44 showed association to global longitudinal strain (GLS) (r=0.27, p=0.03).
Conclusion: M-ficolin and MAp44 were associated with disease activity markers and plasma insulin at baseline and at two-year follow-up. GLS and MAp44 were positively associated at baseline.
To cite this abstract in AMA style:Louw IG, Ammitzböll CG, Løgstrup BB, Blegvad-Nissen J, Urbonaviciene G, Bay Laurberg T, Herly M, Nielsen AH, Thiel S, Ellingsen T. M-Ficolin and MAp44 As Potential Markers of Subclinical Cardiovascular Comorbidity; Cardiac Evaluation By Coronary Computer Tomography and Myocardial Deformation of Left Ventricle in Early Rheumatoid Arthritis Patients [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/m-ficolin-and-map44-as-potential-markers-of-subclinical-cardiovascular-comorbidity-cardiac-evaluation-by-coronary-computer-tomography-and-myocardial-deformation-of-left-ventricle-in-early-rheumatoid/. Accessed October 27, 2020.
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