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Abstracts tagged "Psoriatic arthritis"

  • Abstract Number: 1805 • ACR Convergence 2021

    Low Rates of Radiographic Progression with 2 Years of Guselkumab (TREMFYA®), a Selective Inhibitor of the Interleukin-23p19 Subunit: Results from a Phase 3, Randomized, Double-blind, Placebo-controlled Study of Biologic-naïve Patients with Active Psoriatic Arthritis

    Philip Mease1, Alice Gottlieb2, Iain McInnes3, Proton Rahman4, Alexa Kollmeier5, Xie Xu6, Yusang Jiang6, Shihong Sheng6, May Shawi7, Soumya Chakravarty8, Frederic Lavie9 and Désirée van der Heijde10, 1Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, WA, 2Icahn School of Medicine at Mount Sinai, New York, NY, 3University of Glasgow, School of Medicine, Glasgow, Scotland, United Kingdom, 4Department of Medicine, Eastern Health and Memorial University of Newfoundland, St John's, NL, Canada, 5Janssen Research & Development, LLC, La Jolla, CA, 6Janssen Research & Development, LLC, Spring House, PA, 7Janssen Immunology Global Commercial Strategy Organization, Toronto, ON, Canada, 8Janssen Scientific Affairs, LLC and Drexel University College of Medicine, Horsham, PA, 9Janssen Global Services, LLC, Horsham, PA, 10Department of Rheumatology, Leiden University Medical Center, Meerssen, Netherlands

    Background/Purpose: Guselkumab (GUS), an IL-23p19-subunit inhibitor, is efficacious in treating patients (pts) with psoriasis and psoriatic arthritis (PsA). In the Phase 3, double-blind, placebo (PBO)-controlled…
  • Abstract Number: 1823 • ACR Convergence 2021

    Efficacy of Upadacitinib in Patients with Active Psoriatic Arthritis and a Low or High Swollen Joint Count: A Subgroup Analysis of 2 Phase 3 Studies

    Laure Gossec1, Dafna Gladman2, Erin McDearmon-Blondell3, Philipp Sewerin4, Christopher Ritchlin5, Dai Feng6, Apinya Lertratanakul7, Roberto Ranza8, Lai-Shan Tam9, Antonio Marchesoni10, Laura Coates11 and Peter Nash12, 1Sorbonne Université; APHP, Rheumatology Department, Pitié-Salpêtrière Hospital, Paris, France, 2Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, 3AbbVie Inc., Elmhurst, IL, 4Department and Hiller Research Unit of Rheumatology, Heinrich Heine University Duesseldorf, Duesseldorf, Germany, 5Division of Allergy, Immunology, and Rheumatology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY, 6AbbVie Inc., East Brunswick, NJ, 7AbbVie Inc., North Chicago, IL, 8Hospital de Clinicas, Universidade Federal de Uberlândia, Uberlandia, MG, Brazil, 9Department of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China (People's Republic), 10Dipartimento di Reumatologia, ASST Gaetano Pini-CTO, Milano, Italy, 11Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 12Griffith University, Brisbane, Australia

    Background/Purpose: Although most patients with psoriatic arthritis (PsA) enrolled in clinical trials have polyarticular arthritis, patients in clinical practice may present with oligoarthritis. Data on…
  • Abstract Number: 1944 • ACR Convergence 2021

    Sustained Remission/Low Disease Activity Is Feasible in the Long Term in Patients with Psoriatic Arthritis Treated with IL-23/12 Inhibition with Ustekinumab (STELARA®) and Tumor Necrosis Factor Inhibitors in a Real-World, Multicenter Study

    Josef Smolen1, Paul Bergmans2, Kurt de Vlam3, Elisa Gremese4, Beatriz Joven-Ibáñez5, Tatiana Korotaeva6, Wim Noël7, Michael Nurmohamed8, Petros Sfikakis9, Stefan Siebert10, Elke Theander11 and Laure Gossec12, 1Medical University of Vienna, Vienna, Austria, 2Janssen-Cilag BV, Breda, Netherlands, 3University Hospitals Leuven, Leuven, Belgium, 4Fondazione Policlinico A Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy, 5University Hospital 12 de Octubre, Madrid, Spain, 6VA Nasonova Research Institute of Rheumatology, Moscow, Russia, 7Janssen Pharmaceutica, HEMAR Department, Beerse, Belgium, 8Reade and Amsterdam University Medical Center, location VUmc, Amsterdam, Netherlands, 9National Kapodistrian University of Athens Medical School, Athens, Greece, Athens, Greece, 10University of Glasgow, Glasgow, United Kingdom, 11Janssen Cilag, Lund, Sweden, 12Sorbonne Université and Hôpital Pitié-Salpêtrière, Paris, France

    Background/Purpose: Among treatment options for PsA, IL-23/12 inhibition with ustekinumab (UST) was the first new biologic after TNF inhibitors (TNFi). Few data compare long-term effectiveness…
  • Abstract Number: 0099 • ACR Convergence 2021

    First Results of the BELCOMID Study: BELgian Cohort Study of COVID-19 in Immune Mediated Inflammatory Diseases (IMID)

    Kurt de Vlam1, Jeroen Geldhof2, Marie Truyens3, Joao Sabino4, Marc ferrante4, Jo Lambert3, Hilde lapeere3, Tom hillary4, an Van Laethem4, Triana Lobaton3, severine vermeire4, Barbara Neerinckx1 and Patrick Verschueren5, 1University Hospitals Leuven, Leuven, Belgium, 2University Hospital Gent, Gent, Belgium, 3university hospital gent, gent, 4university hospitals leuven, leuven, 5University Hospitals Leuven - KULeuven, Leuven, Belgium

    Background/Purpose: It has been suggested that 100% of SARS-CoV2 infections leads to development of specific IgG antibodies that remain detectable for a long period of…
  • Abstract Number: 0488 • ACR Convergence 2021

    Efficacy and Safety of Brepocitinib (Tyrosine Kinase 2/Janus Kinase 1 Inhibitor) for the Treatment of Active Psoriatic Arthritis: Results from a Phase 2b Randomized Controlled Trial

    Philip Mease1, Philip S Helliwell2, Paula Silwinska-Stanczyk3, Malgorzata Miakisz4, Andrew Ostor5, Elena Peeva6, Michael Vincent6, Vanja Sikirica7, Randall Winnette8, Ruolun Qiu6, Gang Li7, Gang Feng6, Jean Beebe6 and David Martin6, 1Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, WA, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 3REUMATIKA – Centrum Reumatologii NZOZ, Warsaw, Poland, 4Twoja Przychodnia Centrum Medyczne Nowa Sol, Nowa Sol, Poland, 5Monash University, Cabrini Hospital & Emeritus Research, Melbourne, Australia, 6Pfizer Inc, Cambridge, MA, 7Pfizer Inc, Collegeville, PA, 8Pfizer Inc, New York, NY

    Background/Purpose: Brepocitinib is a small-molecule tyrosine kinase 2/Janus kinase 1 inhibitor that has shown promising results in an oral formulation for plaque psoriasis and alopecia…
  • Abstract Number: 0838 • ACR Convergence 2021

    Predictors of Treatment for Inflammatory Arthritis with Immune Modulating Medications (IMM) in US Veterans

    Tawnie Braaten1, shaobo Pei2, Anitha Rathod2, Gopi Penmetsa3, Kevin Douglas4, Jodi Walker4, Jerry Clewell5 and Jessica Walsh6, 1Salt Lake City Veteran Affairs and University of Utah Medical Center, Salt Lake City, UT, 2University of Utah, Salt Lake City, UT, 3Salt Lake City Veteran Affairs and University of Utah Medical Centers, Salt Lake City, UT, 4AbbVie Inc., North Chicago, IL, 5Abbvie Inc, North Chicago, IL, 6Salt Lake City Veteran Affairs Medical Center (VAMC)/University of Utah Hospital, Salt Lake City, UT

    Background/Purpose: Non-treatment and treatment delays contribute to suboptimal symptom control and irreversible joint damage in patients with inflammatory arthritis (IA). This investigations objective was to…
  • Abstract Number: 1317 • ACR Convergence 2021

    Impairment of Memory in Axial Spondyloarthritis?

    Stefan Kleinert1, Florian Schuch2, Praxedis Rapp2, Monika Ronneberger2, Joerg Wendler2, Patrizia Sternad3, Florian Popp3, Peter Bartz-Bazzanella4, Cay Von der Decken5, Kirsten Karberg6, Georg Gauler7, Patrick Wurth8, Susanna Späthling-Mestekemper9, Christoph Kuhn10, Mathias Englbrecht11, Wolfgang Vorbrüggen12, Georg Adler13 and Martin Welcker14, 1Praxisgemeinschaft Rheumatologie - Nephrologie (PGRN), Erlangen, Germany, 2Praxisgemeinschaft Rheumatologie-Nephrologie, Erlangen, Germany, 3Medizinisches Versorgungszentrum für Rheumatologie Dr. M. Welcker GmbH, Planegg, Germany, 4Rhein-Maas Klinikum, Wuerselen, Germany, 5Klinik für Internistische Rheumatologie, Rhein-Maas-Klinikum, Würselen, Germany, 6Praxis für Rheumatologie und Innere Medizin, Berlin, Germany, Berlin, Germany, 7rheumapraxis, Osnabrck, Germany, 8Rheumatologische Schwerpunktpraxis, Osnabrück, Germany, 9Rheumapraxis München, München, Germany, 10Praxis für Rheumatologie, Karlsruhe, Germany, Karlsruhe, Germany, 11Freelance Healthcare Data Scientist, Eckental, Germany., Eckental, Germany, 12Verein zur Förderung der Rheumatologie e.V., Würselen, Germany, 13Institut für Studien zur Psychischen Gesundheit (ISPG), Mannheim, Germany, 14MVZ für Rheumatologie, Planegg, Germany

    Background/Purpose: There is certain evidence that neuropsychiatric changes occur in systemic lupus(1) and rheumatoid arthritis (2). However, there is little knowledge about possible cognitive changes…
  • Abstract Number: 1337 • ACR Convergence 2021

    Long-Term Safety Data for IL-12/23 Inhibitor (Ustekinumab) or Tumor Necrosis Factor Inhibitor in Patients with Psoriatic Arthritis from a Real-World Study

    Stefan Siebert1, Paul Bergmans2, Kurt de Vlam3, Elisa Gremese4, Beatriz Joven-Ibáñez5, Tatiana Korotaeva6, Wim Noël7, Michael Nurmohamed8, Petros Sfikakis9, Elke Theander10, Laure Gossec11 and Josef Smolen12, 1University of Glasgow, Glasgow, United Kingdom, 2Janssen-Cilag BV, Breda, Netherlands, 3University Hospitals Leuven, Leuven, Belgium, 4Fondazione Policlinico A Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy, 5University Hospital 12 de Octubre, Madrid, Spain, 6VA Nasonova Research Institute of Rheumatology, Moscow, Russia, 7Janssen Pharmaceutica, HEMAR Department, Beerse, Belgium, 8Reade and Amsterdam University Medical Center, location VUmc, Amsterdam, Netherlands, 9National Kapodistrian University of Athens Medical School, Athens, Greece, Athens, Greece, 10Janssen Cilag, Lund, Sweden, 11Sorbonne Université; APHP, Rheumatology Department, Pitié-Salpêtrière Hospital, Paris, France, 12Medical University of Vienna, Vienna, Austria

    Background/Purpose: Psoriasis and PsA are associated with multiple comorbidities such as cardiovascular disease and metabolic syndrome. These comorbidities may render patients prone to developing adverse…
  • Abstract Number: 1354 • ACR Convergence 2021

    Differences in Real-World Patient Characteristics of 8921 Patients with Psoriasis with and Without Comorbid Psoriatic Arthritis Using the UK BADBIR Database

    William Tillett1, Alexis Ogdie2, Patricia Gorecki3 and Alun Passey4, 1Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, 2University of Pennsylvania, Philadelphia, PA, 3Janssen Medical Affairs, London, United Kingdom, 4Janssen Real World Evidence, HEMAR EMEA, High Wycombe, United Kingdom

    Background/Purpose: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis (PsO) and multiple comorbidities.1 Approximately one-third of patients with PsO develop PsA during…
  • Abstract Number: 1722 • ACR Convergence 2021

    Risk of Pre-eclampsia and Impact of Disease Activity and Anti-rheumatic Treatment in Women with Rheumatoid Arthritis, Axial Spondylarthritis, and Psoriatic Arthritis – A Collaborative Matched Cohort Study from Sweden and Denmark

    Anne Emilie Secher1, Karin Hellgren2, Bente Glintborg3, Ane Rom4, Merete Hetland5 and Fredrik Granath2, 1COPECARE, Centre for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, Frederiksberg, Denmark, 2Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, 3COPECARE, Centre for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, Glostrup, Denmark, 4The Juliane Marie Centre, Rigshospitalet, Copenhagen, Denmark, Copenhagen, Denmark, 5DANBIO and COPECARE, Centre for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark

    Background/Purpose: Pre-eclampsia is a pregnancy-related syndrome with potentially fatal outcomes. In RA, high disease activity has been associated to adverse pregnancy outcomes such as preterm…
  • Abstract Number: 1789 • ACR Convergence 2021

    Prediction of Psoriatic Arthritis in Patients with Psoriasis Using DNA Methylation Profiles

    Omar Cruz Correa1, Remy Pollock1, Rohan Machhar2 and Dafna Gladman3, 1University Health Network, Toronto, ON, Canada, 2Krembil Research Institute, University Health Network, Toronto, ON, Canada, 3Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: Psoriatic arthritis (PsA) poses an immense clinical burden with significantly increased morbidity and mortality risk compared to psoriasis alone. PsA may develop in 30%…
  • Abstract Number: 1806 • ACR Convergence 2021

    Designing a Phase 3b, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Investigate the Effect of Guselkumab (TREMFYA®/sup>) Dosing Interval in Psoriatic Arthritis Patients with Inadequate Response to Tumor Necrosis Factor Inhibition

    Alexis Ogdie-Beatty1, Joseph Merola2, Philip Mease3, Christopher Ritchlin4, Jose Scher5, Daphne Chan6, Soumya Chakravarty7, Wayne Langholff8, Olivia Choi9, Yevgeniy Krol9, Katelyn Rowland9 and Alice Gottlieb10, 1University of Pennsylvania, Philadelphia, PA, 2Harvard Medical School, Brigham and Women’s Hospital, Boston, MA, 3Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, WA, 4Division of Allergy, Immunology, and Rheumatology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY, 5New York University School of Medicine, New York, NY, 6Janssen Scientific Affairs, LLC, Spring House, PA, 7Janssen Scientific Affairs, LLC and Drexel University College of Medicine, Horsham, PA, 8Janssen Research & Development, LLC, Spring House, PA, 9Janssen Scientific Affairs, LLC, Horsham, PA, 10Icahn School of Medicine at Mount Sinai, New York, NY

    Background/Purpose: Tumor necrosis factor inhibitors (TNFi) are frequently chosen as the first biologic therapy for patients (pts) with PsA, though a sizeable proportion of pts…
  • Abstract Number: 1824 • ACR Convergence 2021

    Secukinumab Treatment Provides Sustained Resolution of Enthesitis at Individual Joints Through 52 Weeks in a Phase 3b, Double-Blind, Randomized, Active-Controlled Study

    Gurjit Kaeley1, Georg Schett2, Philip Conaghan3, Dennis McGonagle4, Frank Behrens5, Philippe Goupille6, Corine Gaillez7, Bhumik Parikh8, Xiangyi Meng8 and Catherine Bakewell9, 1University of Florida, Jacksonville, FL, 2Universitätsklinikum Erlangen, Department of Internal Medicine 3 – Rheumatology and Immunology, Erlangen, Germany, Erlangen, Germany, 3Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 4University of Leeds, Leeds, United Kingdom, 5Rheumatology and Fraunhofer ITMP - Translational Medicine and Pharmacology, Goethe University, Frankfurt, Germany, 6University hospital of Tours, Rheumatology department, Tours, France, 7Novartis Pharma AG, Basel, Switzerland, 8Novartis Pharmaceuticals Corporation, East Hanover, NJ, 9Intermountain Healthcare Medical Group, Salt Lake City, UT

    Background/Purpose: Enthesitis is a key musculoskeletal manifestation of psoriatic arthritis (PsA). In the double-blind, head-to-head EXCEED study (NCT02745080), although the primary endpoint of superiority of…
  • Abstract Number: 1945 • ACR Convergence 2021

    Efficacy of Upadacitinib on Psoriatic Arthritis with Axial Involvement Defined by Investigator Assessment and PRO-Based Criteria: Results from Two Phase 3 Studies

    Xenofon Baraliakos1, Roberto Ranza2, Andrew Ostor3, Francesco Ciccia4, Laura Coates5, Simona Rednic6, Jessica Walsh7, Tianming Gao8, Apinya Lertratanakul8, In-Ho Song8, Fabiana Ganz8, Kevin Douglas8 and Atul Deodhar9, 1Rheumazentrum Ruhrgebiet Herne, Ruhr-Universität Bochum, Herne, Germany, 2Hospital de Clinicas, Universidade Federal de Uberlândia, Uberlandia, MG, Brazil, 3Monash University, Cabrini Hospital, and Emertius Research, Malvern, Australia, 4University of Campania Luigi Vanvitelli, Napoli, Italy, 5Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 6Emergency Clinical County Hospital, Rheumatology and Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania, 7Salt Lake City Veteran Affairs Medical Center (VAMC)/University of Utah Hospital, Salt Lake City, UT, 8AbbVie Inc., North Chicago, IL, 9Oregon Health & Science University, Portland, OR

    Background/Purpose: Patients with PsA and axial involvement have higher disease activity and greater reductions in quality of life;1 however, there are no accepted criteria for…
  • Abstract Number: 0135 • ACR Convergence 2021

    Comparing Rheumatoid Arthritis (RA), Psoriatic Arthritis (PA) and Systemic Lupus Erythematosus (SLE) Total Cost of Care (TCC) in Those with Optimally Managed Depression to Those with Sub-optimally Managed Depression

    Joseph Couto1, Elisea Avalos-Reyes2, Amanda McCarthy3, Olga Matlin4, Michele Hamburger5, Gerard Maher6 and Kjel Johnson1, 1CVS Health, Lincoln, RI, 2CVS Health, Irving, TX, 3CVS Health, Greensboro, GA, 4CVS Health, Northbrook, IL, 5Frances Hamburger Institute, Hauppauge, NY, 6Frances Hamburger Institute, Hauppaugue, NY

    Background/Purpose: Rheumatic diseases (RD) are characterized by systemic signs and symptoms, including articular and extra-articular manifestations. Three common forms of RDs are RA, PsA and…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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