ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "proteomics"

  • Abstract Number: 521 • 2015 ACR/ARHP Annual Meeting

    Targeted Quantitative Analysis to Identify Citrullinated Peptides in the Synovial Fluid of Patients with Rheumatoid Arthritis

    Min Jueng Kang1, Ji Soo Kim2, Eugene C. Yi1 and Eun Young Lee2, 1Molecular Medicine and Biopharmaceutical Sciences, Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, South Korea, 2Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea

    Background/Purpose: The protein/peptide citrullination is a post-translational modification and the citrullinated peptide epitopes are recognized by anti-citrullinated protein/peptide antibody (ACPA), which is a major diagnostic…
  • Abstract Number: 2923 • 2014 ACR/ARHP Annual Meeting

    Protein Quantification Using Mass Spectrometry Methods to Predict Response to Abatacept and Methotrexate Combination Therapy in Rheumatoid Arthritis

    A Obry1,2, P Cosette2, T Lequerré1,3, Maria-Antonietta d'Agostino4, C Gaillez5, M Le Bars6 and O Vittecoq1,3, 1Inserm 905, Institute for Biomedical Research, University of Rouen, Rouen, France, 2UMR 6270 CNRS, PISSARO Proteomic Facility, IRIB, Normandy University, University of Rouen, Rouen, France, 3Department of Rheumatology, Rouen University Hospital, Rouen, France, 4AP-HP Ambroise Paré Hospital, Boulogne-Billancourt, France, 5Formerly of Bristol-Myers Squibb, Rueil-Malmaison, France, 6Bristol-Myers Squibb, Rueil-Malmaison, France

    Background/Purpose: Targeted biologic therapies with different mechanisms of action are commonly used in RA. Abatacept is a recombinant fusion protein that inhibits T-cell co-stimulatory molecules…
  • Abstract Number: 2091 • 2014 ACR/ARHP Annual Meeting

    Plasma Microparticle Protein Features Distinctively Classify Systemic Lupus Erythematosus and Systemic Sclerosis and Their Clinical Phenotype

    Ole Østergaard1, Christoffer T. Nielsen2, Line V. Iversen3, Anders A. Bengtsson4, Søren Jacobsen5 and Niels H. H. Heegaard6, 1Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institute, Copenhagen S, Denmark, 2Infectious Diseases and Rheumatology, University Hospital Rigshospitalet, Copenhagen, Denmark, 3Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark, 4Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden, 5Department of Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, 6Department of Clinical Biochemistry & Pharmacology, Odense University Hospital, Odense C, Denmark

    Background/Purpose Plasma microparticles (MPs) comprise a heterogenous population of submicron membraneous vesicles shed from the cell-surface both constitutively and as a consequence of pathological processes.…
  • Abstract Number: 1586 • 2014 ACR/ARHP Annual Meeting

    Quantitative Proteomic Analysis of Synovial Fluid and Skin Identifies Putative Psoriatic Arthritis Biomarkers

    Daniela Cretu1, Kun Liang2, Dafna D. Gladman3, Eleftherios Diamandis4 and Vinod Chandran3, 1Laboratory Medicine and Pathobiology, Unviersity of Toronto, Mount Sinai Hospital, Ontario, Canada, Toronto, ON, Canada, 2Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, 3University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 4Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

    Background/Purpose Psoriatic arthritis (PsA) is a unique form of arthritis occurring in 30% of psoriasis patients. There is a high prevalence of undiagnosed PsA in…
  • Abstract Number: 92 • 2014 ACR/ARHP Annual Meeting

    Long Noncoding RNA Nron Regulates the Activity of NFAT5 through Ubiquitin-Independent Proteasome Pathway in Rheumatoid Arthritis

    Kunihiko Umekita1,2, Michelle Trenkmann1, Christoph Kolling3, Akihiko Okayama4, Renate Gay1, Steffen Gay1 and Mojca Frank Bertoncelj5, 1Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland, 2Department of Rheumatology, Infectious diseases and Laboratory medicine, University of Miyazaki, Miyazaki, Japan, 3Schulthess Clinic, Zurich, Switzerland, 4Department of Rheumatology, Infectious Diseases and Laboratory Medicine, University of Miyazaki, Miyazaki, Japan, 5Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland

    Background/Purpose: Long noncoding RNAs (lncRNAs) are increasingly recognized as master regulators of gene expression. The lncRNA NRON, noncoding repressor of nuclear factor of activated T…
  • Abstract Number: 560 • 2012 ACR/ARHP Annual Meeting

    Proteomic Profiling of Synovial Fluid Reveals Candidate Psoriatic Arthritis Biomarkers

    Daniela Cretu1, Ihor Batruch2, Punit Saraon3, Dafna D. Gladman4, Fawnda Pellett5, Eleftherios Diamandis6 and Vinod Chandran7, 1Department of Laboratory Medicine and Pathobiology, University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, ON, Canada, 2Department of Pathology and Lab Medicine,, Mount Sinai Hospital, Toronto, ON, Canada, 3Department of Pathology and Lab Medicine, Mount Sinai Hospital, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada, 4Division of Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, 5Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 6Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada, 7Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Psoriatic arthritis (PsA) is a unique form of arthritis occurring in 30% of psoriasis patients. There is a high prevalence of undiagnosed PsA in…
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