ACR Meeting Abstracts

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Abstracts tagged "proteomics"

  • Abstract Number: 0886 • ACR Convergence 2024

    A Longitudinal Cohort Study Uncovers Plasma Protein Biomarkers Predating Clinical Onset and Treatment Response of Rheumatoid Arthritis

    Chenxi Zhu1, Siyu He2, Yi Liu3, Rui Sun1 and Yi Zhao4, 1Department of Rheumatology and Immunology, West China Hospital,Sichuan University, Chengdu, Sichuan, China, chengdu, China (People's Republic), 2West China Hospital Sichuan University, chengdu, China (People's Republic), 3Department of Rheumatology and Immunology, West China Hospital,Sichuan University, Chengdu, Sichuan, China, chengdu, 4Department of Rheumatology and Immunology, West China Hospital,Sichuan University, Chengdu, Sichuan, China, Sichuan, China (People's Republic)

    Background/Purpose: Rheumatoid arthritis (RA) is a complex systemic inflammatory autoimmune disease with a high incidence, primarily affecting the joints. However, it currently lacks definitive biomarkers…
  • Abstract Number: 1781 • ACR Convergence 2024

    Tear Proteomics as a Classifier of Disease Type and Activity Status in Pediatric Uveitis

    Melissa Lerman1, Devlin Eckardt1, Stefanie Davidson2 and Edward Behrens3, 1Children's Hospital of Philadelphia, Philadelphia, PA, 2University of Pennsylvania/CHOP, Philadelphia, PA, 3Children's Hospital of Philadelphia, West Chester, PA

    Background/Purpose: Measurement of proteins from tear fluid represents a non-invasive means to assess the local biology of ocular autoimmune disease such as uveitis. Pediatric uveitis…
  • Abstract Number: 0888 • ACR Convergence 2024

    Genetically Determined Peptidylglycine Alpha-amidating Monooxygenase (PAM) Mediated Amidation Regulates Tissue Damage by Rheumatoid Arthritis Synovial Fibroblasts

    Kevin Sheridan1, Emma Doris1, Maria Pimenta1, Jemma Falkov1, Matthew Fisher2, Munitta Muthana2, Denis Shields1, Richard Mains3, Betty Eipper3, Christopher Buckley4 and Anthony Wilson5, 1University College Dublin, Dublin, Ireland, 2University of Sheffield, Sheffield, United Kingdom, 3University of Connecticut, Connecticut, 4University of Oxford, Oxford, United Kingdom, 5UCD, Dublin, Dublin, Ireland

    Background/Purpose: The SNP rs26232 is associated with both risk and severity of rheumatoid arthritis (RA), with the C allele associated with the susceptibility to RA,…
  • Abstract Number: 1813 • ACR Convergence 2024

    Elucidating the Molecular Correlates of Treatment Response in Lupus Nephritis via Imaging Mass Cytometry Proteomics and Machine Learning

    Frank Sen Hee Tay1, Anto Sam Crosslee Louis Sam Titus2, Vinaika Maruvada2, Sandy Lim1, Jiacai Cho1, Thomas Thamboo1 and Chandra Mohan3, 1National University Hospital, Singapore, Singapore, 2University of Houston, Houston, 3University of Houston, Houston, TX

    Background/Purpose: Lupus nephritis (LN) is a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE).  Despite the advances in the management…
  • Abstract Number: 0895 • ACR Convergence 2024

    Procoagulant Extracellular Vesicles in Patients with Livedo Reticularis

    Avital Baniel1, Cristina Ricco2, Rohan Dhiman3, Ahmed Eldaboush4, Caroline Stone4, Daniella Faden4, Luca Musante4, MIng-lin Liu4 and Victoria Werth5, 1Perelman School of Medicine, UPENN, Philadelphia, PA, 2university of pennsylvania, Philadelphia, 3University of Pennsylvania, Newport Coast, CA, 4University of pennsylvania, Philadelphia, PA, 5University of Pennsylvania, Wynnewood, PA

    Background/Purpose: Procoagulant activity is an important property of EVs. Connective tissue disease (CTD) patients with livedo reticularis (LR) are known for their procoagulant conditions. The…
  • Abstract Number: 1825 • ACR Convergence 2024

    Proteomic and Transcriptomic Analysis Reveal Elevated Senescent Signature in Systemic Sclerosis Fibrosis

    Poulami Dey, Hiroshi Kato, Suiyuan Huang, Johann Gudjonsson, Dinesh Khanna, John Varga and Eliza Pei-Suen Tsou, University of Michigan, Ann Arbor, MI

    Background/Purpose: Systemic sclerosis (SSc) is marked by persistent fibrosis affecting both the skin and internal organs. Some regard SSc as a manifestation of expedited aging,…
  • Abstract Number: 0899 • ACR Convergence 2024

    Proteomic Insights into JAK Inhibitor Therapeutic Response in Rheumatoid Arthritis

    Ting-Shuan Wu1 and Yi-Ming Chen2, 1Chung Shan Medical University, Taichung, Taiwan (Republic of China), 2Taichung Veterans General Hospital, Taiwan, Taichung, Taiwan (Republic of China)

    Background/Purpose: Rheumatoid arthritis (RA) is a common and complex inflammatory polyarthritis. Janus kinase inhibitors (JAKi) have shown superior efficacy compared to traditional treatments, but predictors…
  • Abstract Number: 2081 • ACR Convergence 2024

    Proteomic Profiling of Urine Reveals Biomarker Candidates for Idiopathic Inflammatory Myopathies

    Xueting Yuan1, Zhengguang Guo2, Jia Shi1, Shuang Zhou3, Chanyuan Wu4, Jiuliang Zhao3, Dong Xu5, Mengtao Li6, Wei Sun2, qian wang6 and Xiaofeng Zeng7, 1Peking Union Medical College, Beijing, China, 2Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China, 3Peking union medical college hospital, Beijing, China, 4Peking Union Medical College Hospital, Chinese Academy of Medical Sciences& Peking Union Medical College, Beijing, China, 5Peking Union Medical College Hospital, Dong Cheng District, Beijing, China, 6Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China 2National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China, 7Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) are a rare heterogeneous group of autoimmune diseases characterized by immune-mediated muscle injury. We aimed to examine urine proteomic signatures…
  • Abstract Number: 0044 • ACR Convergence 2024

    Synovial Phosphoproteomic Profiling in Early and Advanced Rheumatoid Arthritis (R4RA Trial) Identifies Specific Signaling Pathways Linked to Distinct Pathotypes

    Cankut Cubuk1, Rachel Lau1, Vinothini Rajeeve2, Pedro Cutillas2, Rebecca Hands1, Liliane Fossati-Jimack1, Anna Surace1, Alessandra Nerviani1, Felice Rivellese1, Myles Lewis3 and Costantino Pitzalis4, and the R4RA Collaborative Group, 1Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London and Barts NIHR BRC & NHS Trust, London, EC1M 6BQ, London, United Kingdom, 2Cell Signalling and Proteomics Group, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, London, United Kingdom, 3Queen Mary University of London, London, United Kingdom, 4QMUL, Bromley Kent, United Kingdom

    Background/Purpose: Rheumatoid arthritis (RA) is an incurable autoimmune disease where response to therapy is heterogenous. Clinically indistinguishable RA patients can be classified histo-pathologically into three…
  • Abstract Number: 0906 • ACR Convergence 2024

    Proteomic Signatures of Difficult-to-Treat Rheumatoid Arthritis: Identifying Predictive Biomarkers

    Klára Mocová1, Jiri Baloun1, Aneta Prokopcová2, Kristýna Brábníková Marešová1, Herman Mann3, Jiří Vencovský2, Karel Pavelka4 and Ladislav Šenolt2, 1Institute of Rheumatology, Prague, Czech Republic, 2Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 3Revmatologický ústav, Praha, Czech Republic, 4Institute of Rheumatology and Charles University, Praha, Czech Republic

    Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by persistent synovial inflammation, progressive joint destruction and extra-articular manifestations. Despite the advancements in the…
  • Abstract Number: 2229 • ACR Convergence 2024

    Aptamer Based Proteomic Profiling Demonstrates Significant Differences in Methotrexate Responders versus Non-responders in Newly Diagnosed Rheumatoid Arthritis and Adds Potential Value to Clinical Examination

    Kaien Gu1, Leanne Lac1, Nathalie Carrier2, Liam O'Neil1, Gilles Boire3, Pingzhou Hu4 and Carol Hitchon1, 1University of Manitoba, Winnipeg, MB, Canada, 2Universite de Sherbrooke, Sherbrooke, QC, Canada, 3Retired, Sherbrooke, QC, Canada, 4Western University, London, ON, Canada

    Background/Purpose: Despite methotrexate (MTX) being the cornerstone of rheumatoid arthritis (RA) therapy, uncertainty exists around who will respond to MTX. We aimed to determine the…
  • Abstract Number: 1633 • ACR Convergence 2023

    Dose Dependent Modulation of a B Cell Protein Signature by Ianalumab in Patients with Sjögren’s Disease

    Stephanie Finzel1, Andrea Grioni2, Benjamin A Fisher3, Athena S Papas4, Alexandre Avrameas2, Danny Tuckwell2, Jonas Zierer2, Celine Rauld2, Valeria De Luca2, Enrico Ferrero2, Andre Nogueira da Costa2, Rainer Hillenbrand2, Isabelle Isnardi2 and Wolfgang Hueber2, 1Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany, 2Novartis Pharma AG, Basel, Switzerland, 3University of Birmingham, Birmingham, United Kingdom, 4Division of Oral Medicine, Tufts School of Dental Medicine, Boston, MA

    Background/Purpose: Ianalumab (VAY736) is an afuscosylated monoclonal antibody targeting the B cell activating factor receptor (BAFFR) that depletes B cells via enhanced antibody dependent cellular…
  • Abstract Number: 1637 • ACR Convergence 2023

    IgG-Fc-N-Sialylation and -Galactosylation in Primary Sjögren’s Syndrome (Pss) in Its Potential as Marker of Disease State and Disease Activity

    Helena Achten1, Liselotte Deroo2, Kristel De Boeck3, Matthias Jarlborg1, Tine Decruy1, Joke Deprez1, Emilie Dumas1, Dirk Elewaut4 and isabelle peene5, 1Ghent University, Ghent, Belgium, 2Ghent University, Gent, Belgium, 3Ghent University Hospital, Ghent, Belgium, 4Ghent University and VIB Center for Inflammation Research, Ghent, Belgium, 5University Hospital Ghent, Ghent, Belgium

    Background/Purpose: Loss of galactose and sialic acid structures attached to the IgG-Fc-fragment switches the antibody effector function from anti-inflammatory to pro-inflammatory1. This study investigated the…
  • Abstract Number: 0020 • ACR Convergence 2023

    The Inflammatory Proteome in Sjögren’s Syndrome Identifies New Biomarkers and Relevant Clinical Subgroups

    José Miguel Sequí-Sabater1, Carlos Perez-Sanchez2, Clarissa Meoni3, Tomás Cerdó-Ráez4, Maria del Carmen Abalos-Aguilera5, Desiree Ruiz Vilchez5, Francisco Cepas4, Nuria Barbarroja6, Alejandro Escudero7, Mª Angeles Aguirre8, Chary Lopez-Pedrera9 and Lorenzo Beretta10, 1Agencia Valenciana de Salut/ Hospital Universitari de la Ribera/ Unitat de Reumatología, Gandía, Spain, 2IMIBIC, Córdoba, Spain, 3Ospedale Policlinico di Milano, Milan, Italy, 4Maimonides Institute for Biomedical Research (IMIBIC), Córdoba, Spain, 5Rheumatology Department, Reina Sofia University Hospital/Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain, 6University of Cordoba, Córdoba, Spain, 7SAS, Córdoba, Spain, 8Reina Sofía University Hospital/ Rheumatology Department, Córdoba, Spain, 9IMIBIC - Reina Sofia Hospital, Córdoba, Spain, 10Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di MIlano, Milan, Italy

    Background/Purpose: Primary Sjögren's syndrome (pSS) is an autoimmune disease characterised by glandular involvement of the eye and salivary glands, leading to xerostomia and xerophthalmia. In…
  • Abstract Number: 1696 • ACR Convergence 2023

    Multi-Omic Profiling Reveals Immune Cell Priming Signature Linked to Systemic Lupus Erythematosus Prognosis

    Michael A. Smith1, Dominic Sinibaldi2, Saifur Rahman1, Chia-Chien Chiang2, Anna M. Hansen1, Jill Henault1, Carlos P. Roca3, Shu Wang1, Kamelia Zerrouki1, Rebecca Filippi1, Christopher Groves1, Zerai Manna4, Jun Chu4, Michael Davis4, sarthak gupta4, Christopher Morehouse1, Melissa De los Reyes1, Rachel Ettinger1, Roland Kolbeck1, Mariana Kaplan5, Miguel A. Sanjuan1, Richard M. Siegel6, sarfaraz Hasni4 and Kerry A. Casey1, 1BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, 2Data Science and AI, AstraZeneca, Gaithersburg, MD, 3Data Science and AI, AstraZeneca, Cambridge, United Kingdom, 4Lupus Clinical Trials Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health (NIH), Bethesda, MD, 5Lupus Clinical Trials Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health (NIH); Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health (NIH), Bethesda, MD, 6Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health (NIH), Bethesda, MD

    Background/Purpose: Much of our understanding of systemic lupus erythematosus (SLE) immunopathogenesis is derived from gene profiling studies, where core pathways such as neutrophil dysregulation and…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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