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Abstracts tagged "proteomics"

  • Abstract Number: 0029 • ACR Convergence 2020

    Urine Proteomic Classifiers Predict Renal Histological Activity and Chronicity Indices and May Predict Treatment Response in Lupus Nephritis

    Emma Weeding1, Andrea Fava1, Jill Buyon2, H. Michael Belmont3, Peter Izmirly4, Robert Clancy5, Jose Monroy-Trujillo6, Derek Fine6, William Apruzzese7, Harald Mischak8 and Michelle Petri9, 1Johns Hopkins University, Baltimore, MD, 2Department of Medicine, NYU School of Medicine, New York, NY, 3NYU School of Medicine, New York, NY, 4Department of Medicine, New York University School of Medicine, New York, NY, 5New York University School of Medicine, New York, NY, 6Johns Hopkins University, Baltimore, 7., Boston, 8Multiple Institutions, Glasgow, United Kingdom, 9Johns Hopkins University School of Medicine, Baltimore

    Background/Purpose: Current management of lupus nephritis (LN) is guided by histopathological features on kidney biopsy and measurement of proteinuria. Urine proteomics is a non-invasive source…
  • Abstract Number: 0038 • ACR Convergence 2020

    Protein Biomarkers May Differentiate Responders and Non-Responders to Adalimumab, a Tumour Necrosis Factor Inhibitor, in Ankylosing Spondylitis Patients – The Bioefficacy SpA Study

    Ana Fernandes1, Atlas Mashayekhi Sardoo2, Miguel Bernardes3, Patrícia Pinto4, Helena Santos5, João Lagoas Gomes6, José Tavares-Costa7, José A. P. da Silva8, João Madruga-Dias9, Alexandra Bernardo10, Jean-Charles Gaillard11, Lúcia Domingues12, Sara Maia12, Jean Armengaud11, Jaime C. Branco13, Ana Varela Coelho14 and Fernando Pimentel-Santos15, 11.Instituto de Tecnologia Química e Biológica, Universidade NOVA de Lisboa; 2.Universidade de Trás-os-Montes e Alto Douro, Vila Real, Portugal, Oeiras, Portugal, 23. CEDOC, NOVA Medical School, Faculdade de Ciências Médicas da Universidade NOVA de Lisboa, Lisboa, Portugal, Lisbon, Portugal, 34.Centro Hospitalar de S. João (Rheumatology Department) , Porto, Portugal, Porto, Portugal, 45. Centro Hospitalar de Vila Nova de Gaia/Espinho (Rheumatology Department), Vila Nova de Gaia, Portugal, Vila Nova de Gaia, Portugal, 56.Instituto Português de Reumatologia (Rheumatology Department), Lisboa, Portugal, Lisboa, Portugal, 67.Hospital Egas Moniz (CHLO) (Rheumatology Department), Lisboa, Portugal, Lisboa, Portugal, 78.Unidade Local de Saúde do Alto Minho (Rheumatology Department), Ponte de Lima, Portugal, Ponte de Lima, Portugal, 89.Centro Hospitalar e Universitário Coimbra (Rheumatology Department), Coimbra, Portugal, Coimbra, Portugal, 910.Centro Hospital Médio Tejo (Rheumatology Department), Torres Novas, Portugal, Dublin, Ireland, 105.Centro Hospitalar de Vila Nova de Gaia/Espinho (Rheumatology Department), Vila Nova de Gaia, Portugal, Vila Nova de Gaia, Portugal, 1111.Centre d énergie atomique (Laboratoire Innovations technologiques pour la Détection et le Diagnostic (Li2D), Service de Pharmacologie et Immunoanalyse (SPI)), Avignon, France, Avignon, France, 123.CEDOC, NOVA Medical School. Faculdade de Ciências Médicas da Universidade NOVA de Lisboa, Lisboa, Portugal, Lisboa, Portugal, 133.CEDOC, NOVA Medical School, Faculdade de Ciências Médicas da Universidade NOVA de Lisboa, Lisboa, Portugal; 7.Hospital Egas Moniz (CHLO) (Rheumatology Department), Lisboa, Portugal, Lisboa, Portugal, 141.Instituto de Tecnologia Química e Biológica, Universidade NOVA de Lisboa, Oeiras, Portugal, Oeiras, Portugal, 153.CEDOC, NOVA Medical School, Faculdade de Ciências Médicas da Universidade NOVA de Lisboa, Lisboa, Portugal; 7.Hospital Egas Moniz (CHLO) (Rheumatology Department), Lisboa, Portugal, Lisbon, Portugal

    Background/Purpose: Axial Spondyloarthritis (AS) is amongst the most common forms of inflammatory arthritis. Widely used in the treatment of axSpA, adalimumab is an engineered antibody…
  • Abstract Number: 0502 • ACR Convergence 2020

    Integration of Clinical and Protein Markers Through Machine Learning to Distinguish Patients with Psoriasis Arthritis from Those with Psoriasis Without Psoriatic Arthritis

    Sara Rahmati1, Fatima Abji1, Proton Rahman2 and Vinod Chandran3, 1University Health Network, Toronto, ON, Canada, 2Memorial University of Newfoundland, Department of Medicine, St John's, Canada, 3Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: Psoriatic Arthritis (PsA) is a progressive inflammatory arthritis that occurs in about 24% of psoriasis patients. Early diagnosis of PsA is associated with better…
  • Abstract Number: 0513 • ACR Convergence 2020

    Mass Spectrometry Identifies Novel Biomarkers in Giant Cell Arteritis, Useful in Patients on Interleukin-6 Receptor Blockade

    Sebastian Unizony1, Robert Morris2, Johannes Kreuzer2, Wilhelm Haas2 and John H. Stone1, 1Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, 2Massachusetts General Hospital, Boston, MA

    Background/Purpose: We aimed to identify biomarkers of disease activity in giant cell arteritis (GCA) patients treated with prednisone monotherapy and with prednisone in combination with…
  • Abstract Number: 0752 • ACR Convergence 2020

    Serum Proteomics Implicates Neutrophil Degranulation in Rheumatoid Arthritis Disease Activity

    Liam O'Neil1, Vidyanand Anaparti1, Dana Wiens1, Irene Smolik1, Xiaobo Meng1 and Hani El-Gabalawy1, 1University of Manitoba, Winnipeg, MB, Canada

    Background/Purpose: Though targeted therapeutics have improved outcomes in Rheumatoid Arthritis (RA) treatment, the understanding of the underlying biological mechanisms that mediate inflammatory arthritis in RA…
  • Abstract Number: 0763 • ACR Convergence 2020

    Plasmatic Proteome in Individuals with Arthralgia at Risk of Developing Rheumatoid Arthritis

    Klára Prajzlerová1, Nora Petrovská1, Monika Gregová1, Jiří Baloun2, Petra Hánová2, Karel Pavelka1, Jiří Vencovský1, Ladislav Šenolt1 and Mária Filková1, 1Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 2Institute of Rheumatology, Prague, Czech Republic

    Background/Purpose: The presence of antibodies against citrullinated proteins (ACPA) significantly increases the risk of developing rheumatoid arthritis (RA). EULAR characterised individuals with arthralgia suspicious for…
  • Abstract Number: 0936 • ACR Convergence 2020

    Urine Proteomics and Single Cell Transcriptomics Identify IL-16 as a Biomarker for Lupus Nephritis

    Andrea Fava1, Jill Buyon2, Chandra Mohan3, Ting Zhang3, H. Michael Belmont4, Peter Izmirly5, Robert Clancy6, Jose Monroy-Trujillo7, Celine Berthier8, Anne Davidson9, Nir Hacohen10, David Wofsy11, Deepak Rao12, Soumya Raychaudhuri13, The Accelerating Medicines Partnership in SLE Network14, William Apruzzese15 and Michelle Petri16, 1Johns Hopkins University, Baltimore, MD, 2Department of Medicine, NYU School of Medicine, New York, NY, 3UT Houston, Houston, 4New York University, New York, NY, 5Department of Medicine, New York University School of Medicine, New York, NY, 6NYU School of Medicine, New York, 7Johns Hopkins University, Baltimore, 8University of Michigan, Ann Arbor, 9Northwell Health, New York, 10Broad Institute, Boston, 11University of California San Francisco, San Francisco, CA, 12Brigham and Women's Hospital, Boston, MA, 13Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 14Multiple Institutions, Multiple Cities, 15., Boston, 16Johns Hopkins University School of Medicine, Timonium, MD

    Background/Purpose: Treatment of lupus nephritis relies on renal histopathological features. However, renal biopsies do not capture patient-specific active biological pathways. Urine proteomic biomarkers could revolutionize…
  • Abstract Number: 0953 • ACR Convergence 2020

    Long-term Xanthine Oxidase Inhibitor Treat to Target Urate Lowering Therapy Coordinately Re-wires the Mononuclear Leukocyte Mitochondrial and Inflammatory Proteome in Gout

    Jacob Wozniak1, Ru Bryan2, David Gonzalez3 and Robert Terkeltaub4, 1UC San Diego, San Diego, CA, 2UCSD, San Diego, CA, 3UC San Diego, San Diego, CO, 4VA Medical Center/UC San Diego, San Diego, CA

    Background/Purpose: In gout, long-term xanthine oxidase inhibitor treat to target urate lowering therapy (XOIT2T) markedly reduces flares and synovitis, despite delayed resolution of tissue crystal…
  • Abstract Number: 1359 • ACR Convergence 2020

    Targeted Serum Proteomic Analysis Following Upadacitinib Treatment in Ankylosing Spondylitis Shows Robust Suppression of Innate and Adaptive Immune Pathways with Tissue Repair Modulation

    Thierry Sornasse1, In-Ho Song2, Timothy Radstake3 and Dennis McGonagle4, 1AbbVie Immunology Clinical Development, Redwood City, 2AbbVie Inc., North Chicago, IL, 3AbbVie Immunology Clinical Development, North Chicago, 4The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Leeds, United Kingdom

    Background/Purpose: Upadacitinib (UPA), an oral JAK inhibitor selective for JAK1, demonstrated efficacy in patients with active ankylosing spondylitis (AS) with an inadequate response (IR) to…
  • Abstract Number: 1809 • ACR Convergence 2020

    Serum Cytokine Profiling in Systemic Lupus Erythematosus, Analysed Using Unsupervised Machine Learning, Reveals Clinically Relevant Clusters

    Fabien Vincent1, Jannina Ong1, Alberta Hoi2, Sarah Boyd1, Hieu Nim1 and Eric Morand3, 1Monash University, Clayton, Victoria, Australia, 2Monash University, Melbourne, Victoria, Australia, 3Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia

    Background/Purpose: SLE is a heterogeneous disease, where a better understanding of molecular differences between patients is needed in order to direct therapy. Existing approaches generally…
  • Abstract Number: 1822 • ACR Convergence 2020

    Serum Proteomics from a Phase III, Randomized, Placebo-Controlled Study of Patients with Active Lupus Nephritis: Correlation with Baseline Disease Characteristics and Response to Therapy

    Shiliang Wang1, Richard Furie2, Mary Anne Dooley3, David Wofsy4, Tsutomu Takeuchi5, Ana Malvar6, Andrea Doria7, Juanita Romero-Díaz8, Tak Mao Chan9, Gerald Appel10, David Jayne11, Sarah Hu12, Sheng Gao13 and Michael Maldonado12, 1Bristol-Myers Squibb Company (at the time of analysis), Princeton, NJ, 2Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, 3University of North Carolina, Chapel Hill, NC, 4University of California San Francisco, San Francisco, CA, 5Division of Rheumatology, Department of internal Medicine, School of Medicine, Keio University, Tokyo, Japan, 6Organizacion Medica de Investigacion, Buenos Aires, Argentina, 7University of Padua, Padua, Italy, 8Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 9University of Hong Kong, Hong Kong, Hong Kong, 10Columbia University Medical Center, New York, NY, 11Department of Medicine, Vasculitis and Lupus Research Group, University of Cambridge, Cambridge, UK, Cambridge, United Kingdom, 12Bristol-Myers Squibb Company, Princeton, NJ, 13Bristol-Myers Squibb Company (at the time of analysis), Princeton, NY

    Background/Purpose: The ALLURE study compared efficacy and safety of abatacept (ABA) vs placebo (PBO) on background MMF and CS for the treatment of active proliferative…
  • Abstract Number: 1909 • ACR Convergence 2020

    High-density Proteomic Analysis of Skin Blister Fluid and Plasma in Systemic Sclerosis Identifies Local and Systemic Differences for Key Proteins

    Kristina Clark1, Corrado Campochiaro2, Eszter Csomor3, Adam Taylor3, Katherine Nevin3, Mary Morse3, Voon Ong4, Emma Derrett-Smith5, Nicolas Wisniacki3, Shaun Flint3 and Christopher Denton1, 1University College London, London, United Kingdom, 2Royal Free Hospital NHS trust, London, United Kingdom, 3GlaxoSmithKline, Stevenage, United Kingdom, 4UCL, London, United Kingdom, 5University College London Division of Medicine, London, United Kingdom

    Background/Purpose: Simultaneous analysis of multiple proteins in biological fluids offers insight into the pathogenesis of SSc. Here, we report a proteomic analysis of plasma and…
  • Abstract Number: 1944 • 2019 ACR/ARP Annual Meeting

    Two Biomarkers with Predictive Capacity to Diagnosis Pre-Radiographic Knee Osteoarthritis: Data from the Osteoarthritis Initiative

    María Camacho-Encina1, Vanesa Balboa-Barreiro 2, Rocío Paz-González 3, Valentina Calamia 3, Lucía Lourido 4, Patricia Fernández-Puente 3, Cristina Ruiz-Romero 5 and Francisco J. Blanco 6, 1Proteomics Group-ProteoRed/ISCIII, Grupo de Investigación de Reumatología (GIR), INIBIC – Hospital Universitario de A Coruña, A Coruña, Spain., A Coruña, Spain, 2Grupo de Investigación de Reumatología (GIR), INIBIC-Hospital Universitario de A Coruña, A Coruña, Spain, A Coruña, Galicia, Spain, 3Proteomics Group, Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña,15006 A Coruña-Spain, A Coruña, Galicia, Spain, 4Proteomics Group-ProteoRed/ISCIII, RIER, Grupo de Investigación de Reumatología (GIR), INIBIC – Hospital Universitario de A Coruña, A Coruña, Spain., A Coruña, Spain, 5Proteomics Group-ProteoRed/ISCIII, CIBER-BBN, Grupo de Investigación de Reumatología (GIR), INIBIC – Hospital Universitario de A Coruña, A Coruña, Spain., A Coruña, Spain, 6Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain

    Background/Purpose: Osteoarthritis (OA) is the most prevalent rheumatic disorder of the middle-age population. The lack of sensitive diagnostics methods led to an identification of the…
  • Abstract Number: 2405 • 2019 ACR/ARP Annual Meeting

    Protein Biomarkers Predicting the Response to IFX+MTX+LEF Treatment in Patients with Rheumatoid Arthritis

    Jian Chen 1, Meng-shi Tang 2, Li-chang Xu 3, Shu Li 2, Yan Ge 2, Jing Tian 2, Xi Xie 2, Jin-wei Chen 2, Jin-feng Du 2 and Fen Li1, 1Department of Rheumatology and Immunology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China, Changsha, 2Department of Rheumatology and Immunology, The Second Xiangya Hospital, Central South University, Changsha, 3International Department of YALI High School, Changsha

    Background/Purpose: Patients with rheumatoid arthritis (RA) usually receive triple therapy with methotrexate (MTX), leflunomide (LEF) and infliximab (IFX), but nearly one-third of them do not…
  • Abstract Number: 2742 • 2019 ACR/ARP Annual Meeting

    Toward a Liquid Biopsy for Lupus Nephritis: Urine Proteomic Analysis of SLE Identifies Inflammatory and Macrophage Signatures

    Andrea Fava1, Yuji Zhang 2, Jill Buyon 3, H. Michael Belmont 4, Peter Izmirly 5, Chandra Mohan 6, Ting Zhang 7, The Accelerating Medicines Partnership 8 and Michelle Petri 9, 1Johns Hopkins University, Baltimore, 2University of Maryland, Baltimore, 3NYU School of Medicine, New York, 4New York University School of Medicine, Ney York, 5New York University School of Medicine, New York, 6University of Houston, Houston, 7Biomedical Engineering, University of Houston, Houston, TX, 8Multiple Organizations, USA, 9Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Lupus nephritis (LN) complicates up to 60% of patients with systemic lupus erythematosus (SLE) and carries a high morbidity and mortality. The definitive diagnosis…
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