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Abstracts tagged "prognostic factors"

  • Abstract Number: 849 • 2015 ACR/ARHP Annual Meeting

    A Computational Tool for Individualized Prognosis of Percent of Predicted Forced Vital Capacity Trajectories in Systemic Sclerosis

    Peter Schulam1, Colin Ligon2, Robert Wise3, Laura K. Hummers4, Fredrick M. Wigley5 and Suchi Saria1,6, 1Department of Computer Science, Johns Hopkins University, Baltimore, MD, 2Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 3Department of Pulmonology, Johns Hopkins University School of Medicine, Baltimore, MD, 4Johns Hopkins University School of Medicine, Baltimore, MD, 5Rheum Div/Mason F Lord, Johns Hopkins University School of Medicine, Baltimore, MD, 6Departments of Biostatistics, and Health Policy and Management, Bloomberg School of Public Health, Baltimore, MD

    Background/Purpose: Interstitial lung disease (ILD) is a common cause of mortality in systemic sclerosis (Ssc). Decreased forced vital capacity (FVC) in Ssc-ILD is associated with…
  • Abstract Number: 2589 • 2015 ACR/ARHP Annual Meeting

    Associations Between 49 Susceptibility SNPs and Disease Activity Including Radiographic Damage in Early Untreated Rheumatoid Arthritis

    Christian G. Ammitzbøll1, Rudi Steffensen2, Martin Bøgsted3,4, Kaspar Rene Nielsen2, Torkell Ellingsen5, Merete Lund Hetland6, Peter Junker5, Jan Pødenphant7, Mikkel Østergaard8, Julia Johansen9, Kim Hørslev-Petersen10 and Kristian Stengaard-Pedersen1, 1Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 2Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, 3Department of Haematology, Aalborg University Hospital, Aalborg, Denmark, 4Department of Mathematical Sciences, Aalborg University, Aalborg, Denmark, Aalborg, Denmark, 5Department of Rheumatology, Odense University Hospital, Odense, Denmark, 6DANBIO, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Glostrup, Denmark, 7Department of Rheumatology, Copenhagen University Hospital at Gentofte, Glostrup, Denmark, 8Rigshospitalet-Glostrup, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, Glostrup, Denmark, 9Departments of Medicine and Oncology, Copenhagen University Hospital at Herlev, Copenhagen, Denmark, 10Rheumatology, Research Unit at King Christian X Hospital for Rheumatic Diseases, Graasten, Graasten, Denmark

    Background/Purpose: Genome-wide association studies (GWAS) and meta-GWAS studies have identified >50 single nucleotide-polymorphisms (SNPs) that are associated with susceptibility to rheumatoid arthritis (RA). It is,…
  • Abstract Number: 2964 • 2015 ACR/ARHP Annual Meeting

    Influences of Various Factors on Survival of Patients Treated with Pulmonary Arterial Hypertension-Specific Drugs Combination Therapy in Patients with Connective Tissue Diseases

    Sumiaki Tanaka1, Yu Matsueda2, Eisuke Ogawa1, Jun Okada3 and Shunsei Hirohata1, 1Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, 2Rheumatology and Infectious diseases, Kitasato University School of Medicine, Kanagawa, Japan, 3Rheumatology, Kitasato University Hospital, Sagamihara, Japan

    Background/Purpose: In patients with connective tissue disease (CTD), especially systemic sclerosis (SSc), several mechanisms have been implicated for the development of pulmonary hypertension (PH), including…
  • Abstract Number: 2925 • 2014 ACR/ARHP Annual Meeting

    Serum MMP-3 Predicts a Subgroup with No Radiographic Progression in Rheumatoid Arthritis Patients with Low-Dose Methotrexate (MTX) Monotherapy

    Kazuko Shiozawa1, Takashi Yamane2, Miki Murata1, Chihiro Tanaka1, Noriaki Yo2, Ryosuke Yoshihara1, Yasushi Tanaka1, Ken Tsumiyama3 and Shunichi Shiozawa4, 1The Rheumatic Diseases Center, Kohnan Kakogawa Hospital, Kakogawa, Japan, 2Kohnan Kakogawa Hospital, Kakogawa, Japan, 3Department of Rheumatology, Kyushu University Beppu Hospital, Beppu, Japan, 4Department of Medicine, Rheumatic Diseases Unit, Kyushu University Beppu Hospital, Beppu, Japan

    Background/Purpose: Studies have shown that treating rheumatoid patients with methotrexate (MTX) monotherapy initially and later providing an option to step up to combination therapy produces…
  • Abstract Number: 2914 • 2014 ACR/ARHP Annual Meeting

    The Clinical and Radiographic Course of Early Undifferentiated Arthritis Under Treatment Is Not Dependent on the Amount of Erosions at Diagnosis. Results from the Swiss Prospective Observational Cohort

    Ruediger Mueller1, Toni Kaegi2, Sarah Haile3 and Johannes von Kempis4, 1Rheumatology, Kantonsspital St. Gallen, St. Gallen, Switzerland, 2Division of Rheumatology, Kantonsspital St. Gallen, St. Gallen, Switzerland, 3Division of Biostatistics, Institute for Social and Preventive Medicine,, University of Zurich, Switzerland, Zurich, Switzerland, 4Rheumatology, St. Gallen Hospital, CH- 9007 St.Gallen, Switzerland

    Background/Purpose To analyse whether early arthritis patients who do not fulfil the ACR/EULAR 2010 classification criteria for rheumatoid arthritis (RA) have a different course of…
  • Abstract Number: 1693 • 2014 ACR/ARHP Annual Meeting

    Progressive Disease in Systemic Sclerosis after One Year of Follow-up;  Results of a Standardized Multidisciplinary Health Care Program

    Jessica Meijs1, Anne Schouffoer2, Nina Ajmone Marsan3, Lucia Kroft4, Maarten K. Ninaber5, T.W.J. Huizinga1 and Jeska K. De Vries-Bouwstra1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Leiden University Medical Center, Leiden, Netherlands, 3Cardiology, Leiden University Medical Center, Leiden, Netherlands, 4Deparment of Radiology, Leiden University Medical Center, Leiden, Netherlands, 5Pulmonology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: The aim of this study is to evaluate disease course of systemic sclerosis (SSc) patients participating in a single centre multidisciplinary health-care program over…
  • Abstract Number: 1666 • 2014 ACR/ARHP Annual Meeting

    The Relevance of Urinary Podocyte Number and Urinary Podocalyxin Level with Response to Treatment and 1 Year Renal Prognosis in Systemic Lupus Erythematosus

    Hiroshi Kajiyama1, Keiju Hiromura2, Daisuke Ikuma1, Hidekazu Ikeuchi2, Hiroyuki Kurosawa3, Yoshiaki Hirayama3, Fumio Gondaira3, Masanori Hara4, Yoshihisa Nojima2 and Toshihide Mimura5, 1Department of Rheumatology and Applied Immunology, Saitama Medical University, Saitama, Japan, 2Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan, 3Department of reagent research and development, Denka Seiken Co. Ltd., Niigata, Japan, 4Department of Pediatrics, Yoshida Hospital, Niigata, Japan, 5Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan

    Background/Purpose Podocytes are glomerular visceral epithelial cells, whose number decrease due to death and/or detachment from capillary wall leads to severe proteinuria and end stage…
  • Abstract Number: 1549 • 2014 ACR/ARHP Annual Meeting

    The Swedish Early Psoriatic Arhtritis (SWEPSA) Registry 5-Yeear Follow-up: Slow Radiographic Progression with Highest Scores in Male Feet and in Patients with Baseline X-Ray Abnormalities

    Elke Theander1, Tomas Husmark2, Ulla Lindqvist3, Per T Larsson4, Annika Teleman5, Gerd-Marie Alenius6 and Mats Geijer7, 1Skane University Hospital Malmö, Lund University, Malmö, Sweden, 2Rheumatology, Falu Hospital, Falun, Sweden, 3Rheumatology, Department of Medical Sciences, Rheumatology, University Hospital, Uppsala university, Uppsala, Sweden, 4Rheumatology, Department of Rheumatology, Karolinska University Hospital, Stockholm, Sweden, 5Rheumatology, Spenshult Rheumatological Hospital, Oskarström, Sweden, 6Rheumatology, Department of Public Health and Clinical Medicine, Rheumatology, Umeå University Hospital, Umeå, Sweden, 7Skåne University Hospital, Lund, Center for Medical Imaging and Physiology, Lund, Sweden

    Background/Purpose: The aim of this study is to describe early X-ray findings in psoriatic arthritis (PsA) patients from the SwePsA registry using the Wassenberg score,…
  • Abstract Number: 944 • 2014 ACR/ARHP Annual Meeting

    Predict the Chance of Remission for Your RA Patient in Real Life

    Till Uhlig1, Vibeke Norvang2, Elisabeth Lie1, Erik Rødevand3, Knut Mikkelsen4, Åse S. Lexberg5, Synøve Kalstad6 and Tore K. Kvien1, 1Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 2Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 3Dept. of Rheumatology, St. Olavs Hospital, Trondheim, Norway, 4Revmatismesykehuset, Lillehammer, Norway, 5Dept. of Rheumatology, Vestre Viken Hospital, Drammen, Norway, 6Rheumatology, University Hospital of Northern Norway, Tromsø, Norway

    Background/Purpose: Clinical remission (REM) is the treatment target in rheumatoid arthritis (RA), and there are several composite REM criteria available. Knowledge on how disease duration affects REM…
  • Abstract Number: 722 • 2014 ACR/ARHP Annual Meeting

    Prediction of Improvement in Skin Fibrosis in Diffuse Cutaneous Systemic Sclerosis

    Rucsandra Dobrota1,2, Britta Maurer1, Nicole Graf3, Carina Mihai2, Otylia Kowal-Bielecka4, Yannick Allanore5 and Oliver Distler on behalf of the EUSTAR investigators and co-authors1, 1Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Department of Internal Medicine and Rheumatology, Dr.I.Cantacuzino Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, 3graf biostatistics, Winterthur, Switzerland, 4Department of Rheumatology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland, 5Department of Rheumatology, University Paris Descartes and Cochin Hospital, Paris, France

    Background/Purpose Improvement of skin fibrosis over time is part of the “natural history” of patients with diffuse cutaneous systemic sclerosis (dcSSc). However, in the individual…
  • Abstract Number: 546 • 2014 ACR/ARHP Annual Meeting

    Psoriatic Arthritis Mutilans: Characteristics and Radiographic Progression

    Deepak R. Jadon1, Gavin Shaddick2, William Tillett1, Graham Robinson3, Charlotte Cavill1, Nicola Waldron1, Eleanor Korendowych1 and Neil J McHugh4, 1Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, 2Department of Mathematics, University of Bath, Bath, United Kingdom, 3Royal United Hospital, Bath, United Kingdom, 4Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom

    Background/Purpose: Psoriatic arthritis mutilans (PAM) is a rare extreme subtype of psoriatic arthritis (PsA). Our objectives were to: (1) compare clinical characteristics of PsA patients…
  • Abstract Number: 395 • 2014 ACR/ARHP Annual Meeting

    Could Osteoprotegerin and TNF-Related Apoptosis-Inducing Ligand Assessments Help Us to Manage Early Rheumatoid Arthritis? Results from the Espoir Cohort

    Rachel Audo1, Claire I. Daien2, Laura Papon1, Cédric Lukas3, O Vittecoq4, B Combe5 and Jacques Morel6, 1IGMM, CNRS UMR5535, Montpellier, Montpellier, France, 2Department of Rheumatology, Lapeyronie Hospital, Montpellier, France, 3Immuno-Rhumatologie, Hopital Lapeyronie, Montpellier, France, 4Rouen University Hospital & Inserm U905, Rouen, France, 5Immuno-Rhumatologie, Hôpital Lapeyronie, Montpellier, France, 6Department of Rheumatology, Hôpital Lapeyronie, Montpellier, France

    Background/Purpose : TNF-Related Apoptosis Inducing Ligand (TRAIL) is a member of the TNF familly. Its soluble receptor Osteoprotegerin (OPG) also inhibits Receptor activator of nuclear…
  • Abstract Number: 1537 • 2013 ACR/ARHP Annual Meeting

    Primary & Subsequent Orthopedic Surgeries More Common In Juvenile Vs. Adult-Onset Ankylosing Spondylitis

    Deepak R. Jadon1, Ramani Arumugam1, Gavin Shaddick2, Alison L Nightingale3, Athimalaipet V Ramanan4 and Raj Sengupta1, 1Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, 2Department of Mathematics, University of Bath, Bath, United Kingdom, 3Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom, 4Paediatric Rheumatology, University of Bristol Hospital Trust, Bristol, United Kingdom

    Background/Purpose: Patients experiencing ankylosing spondylitis (AS) symptoms ²16 years-of-age are classified as juvenile-onset AS (JoAS), whilst those ³17 years adult-onset AS (AoAS). We compared JoAS…
  • Abstract Number: 1441 • 2013 ACR/ARHP Annual Meeting

    Predictive Factors Of Response To Tocilizumab In Patients With Active Rheumatoid Arthritis

    Maria Victoria Hernández1, Javier Narvaez2, Raimon Sanmarti3, Delia Reina4, Cesar Diaz-Torne5, Berta Magallares5, Arturo Rodriguez de la Serna5, José María Llobet5, Hector Corominas4 and Joan Miquel Nolla2, 1Rheumatology, Hospital Clínic of Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain, 2Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, 3Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, 4Rheumatology, Hospital de Sant Joan Despí Moisès Broggi, Barcelona, Spain, 5Rheumatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

    Background/Purpose: To analyze the efficacy and identify predictors of response to tocilizumab (TCZ) in patients with rheumatoid arthritis (RA). Methods: A multicenter ambispective observational study…
  • Abstract Number: 1342 • 2013 ACR/ARHP Annual Meeting

    Prognosis In Espoir Rheumatoid Arthritis Cohort At 24 Months According To Remission Status At 12 Months: No Differences In Radiographic Scores According To Prior Remission Status, But Significant Differences In HAQ Scores, Highest For Boolean and RAPID3RJ1 Criteria

    Isabel Castrejón1, Maxime Dougados2, Bernard Combe3, Francis Guillemin4, Bruno Fautrel5 and Theodore Pincus1, 1Rheumatology, Rush University Medical Center, Chicago, IL, 2Cochin Hospital, Paris, France, 3CHU Lapeyronie, Montpellier, France, 4Hopitaux de Brabois, Nancy, France, 5APHP, Pitié-Salpêtrière University Hospital, Paris, France

    Background/Purpose: Different criteria for remission in rheumatoid arthritis (RA) have been developed from a Core Data Set of 7 measures for the DAS28, SDAI, CDAI…
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