ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 1549

The Swedish Early Psoriatic Arhtritis (SWEPSA) Registry 5-Yeear Follow-up: Slow Radiographic Progression with Highest Scores in Male Feet and in Patients with Baseline X-Ray Abnormalities

Elke Theander1, Tomas Husmark2, Ulla Lindqvist3, Per T Larsson4, Annika Teleman5, Gerd-Marie Alenius6 and Mats Geijer7, 1Skane University Hospital Malmö, Lund University, Malmö, Sweden, 2Rheumatology, Falu Hospital, Falun, Sweden, 3Rheumatology, Department of Medical Sciences, Rheumatology, University Hospital, Uppsala university, Uppsala, Sweden, 4Rheumatology, Department of Rheumatology, Karolinska University Hospital, Stockholm, Sweden, 5Rheumatology, Spenshult Rheumatological Hospital, Oskarström, Sweden, 6Rheumatology, Department of Public Health and Clinical Medicine, Rheumatology, Umeå University Hospital, Umeå, Sweden, 7Skåne University Hospital, Lund, Center for Medical Imaging and Physiology, Lund, Sweden

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords: Disease Activity, prognostic factors, psoriatic arthritis and radiography

  • Tweet
  • Email
  • Print
Session Information

Session Title: Spondyloarthropathies and Psoriatic Arthritis - Clinical Aspects and Treatment II

Session Type: Abstract Submissions (ACR)

Background/Purpose:

The aim of this study is to describe early X-ray findings in psoriatic arthritis (PsA) patients from the SwePsA registry using the Wassenberg score, evaluate progression of structural damage, analyze correlations to clinical disease parameters and identify predictors of progressive radiographic joint disease.

Methods:  

Out of 197 SwePsA patients followed for 5 years, 72 (38% of the women and 35% of the men) had radiographs of hands and feet performed at the 5-year follow-up. According to the SwePsA protocol hand and feet radiographs should be performed in polyarticular disease or when these joints showed signs of inflammation at baseline, and repeated during follow-up. Reading (MG) in chronological order was centralized. Clinical data were collected according to the SwePsA protocol.

Results:

Mean (SD) baseline age of the 43 women and 29 men was 48.7 (15.0) and 46.4 (14.5) years respectively. While in the total SwePsA cohort women had higher clinical disease activity (Theander et al, ARD 2014), in this sub-cohort mean baseline DAS28 / DAPSA were similar in women and men (3.94 / 22.27 and 3.73 / 21.63, respectively, ns). However, radiographic abnormalities were more pronounced in men:

Baseline x-rays: Total Wassenberg score was 0 (no abnormalities) in 55% of women and 46% of men. Scores over 10 were unusual and only found in one women and one man. Mean (SD) total scores for women and men at baseline were 1.38 (2.44) vs 3.05 (4.04) respectively, p=0.044, erosion scores 0.30 (0.88) vs 1.17 (2.27), p=0.025, proliferation scores 1.30 (1.99) vs 1.79 (2.41), p=0.35. Feet scores at baseline were 0.30 (0.74) vs 0.93 (1.69), p = 0.039.

5-year follow-up x-rays: Total score was 0 in 42% of women but only in 17% of men (p=0.018). Scores over 10 were now found in 7.2% of women and in 17% of men. Mean (SD) total scores for women and men were 3.37 (4.85) vs 7.79 (12.46), p=0.034, erosion scores 0.86 (1.68) vs 3.41 (8.20), p=0.051, proliferation scores 2.56 (3.49) vs 4.62 (4.92), p=0.041. Feet scores at 5-year follow-up were 0.84 (2.13) vs 2.35 (3.92), in women and men, p=0.028, hand scores 2.58 (3.74) vs 5.55 (8.53), p=0.047.

Baseline and 5-year scores were highly correlated (for total scores: Spearman rho 0.752, p=0.000). Baseline total score correlated with ESR (rho: 0.364, p=0.004) and 5-year score with swollen joint count (rho 0.310, p=0.016), higher BASDAI showed a trend to be associated with lower total score (rho -0.285, p= 0.058).

Male gender and higher total baseline score were the only predictors of radiographic abnormalities after 5 years: OR (male/female): 4.42 (95% CI: 0.35-8.49) p=0.034. Baseline total score: OR: 2.23 (1.80-2.65), p=0.000. Only the baseline Wassenberg score was an independent predictor of radiographic progression.

Disease activity, inflammatory markers, joint counts, delay before inclusion and smoking did not predict 5-year Wassenberg score. None of the 15 patients with the highest scores/progression had received TNF-blockers.

Conclusion:

Radiographic progression in early PsA is slow in general, early prevalent in male feet and predicted by baseline radiographic findings. Thus scoring of hand and feet X-rays at baseline cannot be substituted by clinical signs, especially not in men.


Disclosure:

E. Theander,

Abbvie Sweden,

2;

T. Husmark,

Abbvie Sweden,

2;

U. Lindqvist,

Abbvie Sweden,

2;

P. T. Larsson,

Abbvie Sweden,

2;

A. Teleman,

Abbvie Sweden,

2;

G. M. Alenius,

Abbvie Sweden,

2;

M. Geijer,

Abbvie Sweden,

2.

  • Tweet
  • Email
  • Print

« Back to 2014 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/the-swedish-early-psoriatic-arhtritis-swepsa-registry-5-yeear-follow-up-slow-radiographic-progression-with-highest-scores-in-male-feet-and-in-patients-with-baseline-x-ray-abnormalities/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2022 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies