Abstract Number: 0865 • ACR Convergence 2026
The endothelial activation and stress index (EASIX) predicts Clinical Progression to Antiphospholipid Syndrome in Antiphospholipid Antibody Carriers
Background/Purpose: Endothelial dysfunction is a key mechanism in antiphospholipid syndrome (APS). However, biomarkers able to predict clinical progression in asymptomatic antiphospholipid antibody (aPL) carriers are…Abstract Number: 1917 • ACR Convergence 2026
Enhancing SLE Clinical Trial Efficiency With Prognostic Score Covariate Adjustment
Background/Purpose: Adjusting for prognostic covariates or prognostic scores (PS) that capture baseline predictors of disease progression is a method supported by the regulatory agencies to…Abstract Number: 0004 • ACR Convergence 2026
Baseline and early longitudinal serum biomarkers in Polymyalgia Rheumatica: kinetics and associations with clinical course
Background/Purpose: Polymyalgia rheumatica (PMR) is characterized by systemic inflammation and rapid response to glucocorticoids (GC), but its biological heterogeneity and molecular effects of early treatment…Abstract Number: 0894 • ACR Convergence 2026
Risk Factors For Progression Of SI joint Structural Lesions On MRI In Early Axial SpA: 2-year Results From The SPondyloArthritis Caught Early Cohort
Background/Purpose: Structural lesions of the SI joints (SIJ) may be present in early axial SpA (axSpA), but data on risk factors for progression of such…Abstract Number: 2129 • ACR Convergence 2026
A deep learning model predicting the survival of Anti-neutrophil cytoplasmic antibody -associated vasculitis
Background/Purpose: Objective: To comprehensively identify prognostic risk factors and predict survival outcomes in antineutrophil cytoplasmic antibody-associated vasculitis (AAV) utilizing deep learning techniques.Methods: Methods: We analyzed…Abstract Number: 0181 • ACR Convergence 2026
Neurological involvement and elevated erythrocyte sedimentation rate may predict relapse in the Takayasu Arteritis Early Inception Cohort
Background/Purpose: Takayasu arteritis (TAK) is a rare large-vessel vasculitis for which long-term prognostic data remain limited and are mostly derived from retrospective studies. This study…Abstract Number: 0954 • ACR Convergence 2026
Serial Quantitative Changes in Anti-Scl-70 Autoantibodies Are Associated with Lung Function Decline in Systemic Sclerosis
Background/Purpose: Anti-topoisomerase I autoantibodies (anti-Scl-70) are associated with systemic sclerosis-associated interstitial lung disease (SSc-ILD), but prior prognostic studies have largely focused on cross-sectional autoantibody status.…Abstract Number: 2172 • ACR Convergence 2026
Forced Vital Capacity Trajectories During the Treatment-Naïve Period in Systemic Sclerosis: A 20-Year Ambispective Cohort Study
Background/Purpose: Systemic sclerosis (SSc) is a rare autoimmune disease in which pulmonary involvement is a major cause of mortality. Despite its clinical importance, the natural…Abstract Number: 0194 • ACR Convergence 2026
Baseline ‘aggregate index of systemic inflammation’ reflects current high activity and predicts all-cause mortality in patients with antineutrophil cytoplasmic antibody-associated vasculitis
Background/Purpose: The aggregate index of systemic inflammation (AISI) was recently introduced as a prognostic index in various inflammatory diseases. This study investigated the clinical utility…Abstract Number: 1019 • ACR Convergence 2026
Genetic predisposition to Systemic Lupus Erythematosus increases Decoy receptor 3 levels, which associate with disease severity and progression
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a heterogeneous autoimmune disease characterized by loss of tolerance to self-antigens, immune complex formation and activation of the interferon…Abstract Number: 2175 • ACR Convergence 2026
Initial Presentation Of Systemic Sclerosis (SSc) Defines Clinically Meaningful SSc Phenotypes
Background/Purpose: To enhance early recognition of systemic sclerosis (SSc), the Very Early Diagnosis of Systemic Sclerosis (VEDOSS) criteria were developed to identify patients with Raynaud…Abstract Number: 0220 • ACR Convergence 2026
High-Intensity Immunosuppression with Autologous Stem Cell Transplantation Versus Modern Standard Care in Poor-Prognosis Diffuse Cutaneous Systemic Sclerosis: A Propensity-Matched Study
Background/Purpose: The 2023 EULAR update recommends high-intensity immunosuppression followed by autologous hematopoietic stem-cell transplantation (HI-IS/HSCT) for selected patients with poor-prognosis early diffuse cutaneous systemic sclerosis…Abstract Number: 1134 • ACR Convergence 2026
High Visual Burden and Distinct Cranial Phenotype in an Irish Giant Cell Arteritis Cohort
Background/Purpose: Giant cell arteritis (GCA) demonstrates heterogenous clinical phenotypes with variable cranial, systemic and visual involvement. Visual loss remains the most feared complication of GCA…Abstract Number: 2176 • ACR Convergence 2026
Neutrophil-to-Lymphocyte Ratio Is Associated With Progression From VEDOSS to Definite Systemic Sclerosis
Francesco Bonomi1, Cristiano Barbetta2, Martina Iacubino3, Veronica De Silvestri4, Silvia Peretti5, Lorenzo Beretta6, Chiara Bellocchi7 and Silvia Bellando Randone8 Affiliations: 1Azienda Ospedaliera Universitaria Careggi, Florence, Italy, 2Department of Experimental and Clinical Medicine, Division of Rheumatology, Florence, Italy, 3Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, 4University Hospital Careggi, Florence, Italy, 5Department of Internal Medicine, Careggi University Hospital, Florence, Italy, 6Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di MIlano, Milan, Milan, Italy, 74. Department of Clinical Sciences and Community Health, University of Milan, Milano, Italy, 8Department of Experimental and Clinical Medicine, University of Florence, Rheumatology Division, Scleroderma Unit. AOU Careggi, Florence, Italy, Florence, Italy
Background/Purpose: Risk stratification in VEDOSS remains challenging, as only a proportion of patientsprogress to definite systemic sclerosis (SSc) during follow-up. Current predictors are mainlyclinical, serological…Abstract Number: 0234 • ACR Convergence 2026
Evidence-based predictors of systemic sclerosis-interstitial lung disease patients: the EUSTAR-PPFstudy (CP number 148)
Background/Purpose: Interstitial lung disease(ILD) is the leading cause of mortality in systemic sclerosis(SSc). Identifying patients at risk of progression remains a major clinical challenge.Methods: SSc-ILD…
