Abstracts tagged "physical function"

Abstract Number: 1341 • ACR Convergence 2025
Physical Function Across Age in Patients With Rheumatoid Arthritis and Population Controls: A Cross-Sectional Study of Four Performance Measures
Saskia Truijen¹, Annelies Boonen¹, Sofia Ramiro² and Marloes van Onna¹, ¹Maastricht University Medical Centre+ & Maastricht University, Maastricht, Limburg, Netherlands, ²Leiden University Medical Center, Bunde, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) may accelerate age-related functional decline compared to the general population. This study aimed to examine whether four performance measures of physical…
Abstract Number: 1249 • ACR Convergence 2025
Association between Positive Emotions and Physical Function in Early Rheumatoid Arthritis Patients
Burcu Aydemir¹, Jing Song², Lutfiyya muhammad¹, Dorothy Dunlop³, Rowland Chang¹, Wendy Marder⁴, Kevin Deane⁵, Clifton Bingham⁶, Vivian Bykerk⁷, Robert Edwards⁸, Judy Moskowitz¹ and Yvonne Lee⁹, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²Northwestern University Feinberg School of Medicine, Worthington, MN, ³Northwestern University Feinberg School of Medicine, Chicago, ⁴University of Michigan, Ann Arbor, MI, ⁵University of Colorado Denver Anschutz Medical Campus, Aurora, CO, ⁶Johns Hopkins University, Baltimore, MD, ⁷Hospital For Special Surgery, New York, NY, ⁸Brigham and Women's Hospital & Harvard Medical School, Boston, MA, ⁹Northwestern University, Chicago, IL
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease that can significantly impair physical function and quality of life. While physical symptoms such as joint…
Abstract Number: 1230 • ACR Convergence 2025
Chronic pain phenotypes in older adults: Identifying patterns of musculoskeletal pain and associated burden
Gillian Fennell¹, Sarah Tilley², Sayali Dhamne³, Robert Edwards⁴, Mary Gheller³, Angelo Demalia³, Margaret Clancy³, Michael LaValley⁵, Emelia J Benjamin³ and Tuhina Neogi⁶, ¹Boston University Medical, Boston, MA, ²Boston University School of Medicine, Somerville, MA, ³Boston University Chobanian & Avedisian School of Medicine, Boston, MA, ⁴Brigham and Women's Hospital & Harvard Medical School, Boston, MA, ⁵Boston University School of Public Health, Arlington, MA, ⁶Boston University School of Medicine, Boston, MA
Background/Purpose: Over a third of older Americans experience chronic pain, typically occupying multiple musculoskeletal body sites. While number of pain sites (NPS) is often touted…
Abstract Number: 1216 • ACR Convergence 2025
Measurement Properties of a Shorter Health Assessment Questionnaire (HAQ-II) in Patients with Inflammatory Myopathies
Sung-Ki Lee¹, Kristin Wipfler², Ethan Ritz³, Burcu Aydemir⁴, Kaleb Michaud⁵ and Didem Saygin⁶, ¹Rush Medical College, Chicago, IL, ²FORWARD, The National Databank for Rheumatic Diseases, Omaha, NE, ³Rush Research Informatics Core, Rush University Medical Center, Chicago, IL, ⁴Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵University of Nebraska Medical Center, Omaha, NE, ⁶Rush University Medical Center, Chicago, IL
Background/Purpose: Idiopathic inflammatory myopathies (IIM) are a group of autoimmune disorders characterized by chronic skeletal muscle inflammation leading to muscle weakness and limitations in physical…
Abstract Number: 1149 • ACR Convergence 2025
Patient Symptom State Demonstrates Validity for the Assessment of Disease Activity and Patient-reported Outcomes in Adults with SAPHO and Chronic Nonbacterial Osteomyelitis – A Longitudinal Response Profile Analysis in The SAPHO-CNO Study
Aleksander Lenert¹, Robyn Domsic², Jenna Thomason³, Melanie smith⁴, Petar Lenert⁵, Yongdong (Dan) Zhao⁶, Jonathan Templin¹, Mary Vaughan-Sarrazin¹, Daniel Solomon⁷ and Polly Ferguson⁸, ¹University of Iowa, Iowa City, IA, ²University of Pittsburgh, Pittsburgh, PA, ³University of Washington, Seattle, WA, ⁴Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ⁵University of Iowa Hospitals and Clinics, Iowa City, IA, ⁶Seattle Children’s Research Institute, Redmond, WA, ⁷Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, MA, ⁸University of Iowa Carver College of Medicine, Iowa City, IA
Background/Purpose: Patient symptoms are important in the assessment of disease activity. The Patient Acceptable Symptom State (PASS) is defined as the minimum symptom score beyond…
Abstract Number: 2102 • ACR Convergence 2025
Construct Validity of the Six-Minute Walk Test in Knee Osteoarthritis
Sivakami Mylvaganam¹, Ian stanaitis², Gillian Hawker³ and Lauren King³, ¹Department of Medicine, University of Toronto, Toronto, Canada, ²Research and Innovation Institute, Women’s College Hospital, Toronto, ON, Canada, Toronto, ON, Canada, ³University of Toronto, Toronto, ON, Canada
Background/Purpose: Knee osteoarthritis (OA) significantly affects physical function, making function a core outcome in OA research. The Osteoarthritis Research Society International recommends the six-minute walk…
Abstract Number: 1027 • ACR Convergence 2025
GLP-1 Receptor Agonists to Facilitate Weight Loss and Improve Disease Activity, Pain and Function in Patients With Rheumatic and Musculoskeletal Disease: Real-World Evidence From the Rheumatology Informatics System for Effectiveness (RISE) Registry
Nick McCormick¹, Jingyi Zhang², Emily Holladay², Fenglong Xie³ and Jeffrey Curtis⁴, ¹Auburn University, Auburn, AL, ²University of Alabama at Birmingham, Birmingham, AL, ³The University of Alabama at Birmingham, Birmingham, AL, ⁴Foundation for Advancing Science, Technology, Education and Research, Birmingham, AL
Background/Purpose: Glucagon-like peptide-1 receptor agonists (GLP-1 RA) such as semaglutide (SEM; GLP-1) and tirzepatide (TIR; GIP/GLP-1), were initially approved for type 2 diabetes management but…
Abstract Number: 2101 • ACR Convergence 2025
LEVI-04, a Novel Neurotrophin-3 Inhibitor, Demonstrates Clinically Meaningful Improvements in Pain and Physical Function across a Range of OA Outcomes, Including the Staircase-Evoked Pain Procedure (StEPP)
Philip Conaghan¹, nathaniel katz², Asger Bihlet³, Laus W Wullum⁴, Kerry af Forselles⁵, C Michael Perkins⁵, Bernadette Hughes⁶, Claire Herholdt⁷ and Iwona Bombelka⁸, ¹University of Leeds, Leeds, United Kingdom, ²Rin Sof Innovation, Ltd, Boston, MA, ³NBCD A/S, Herlev, Denmark, ⁴Omicron A/S, Copenhagen, Denmark, ⁵Levicept, Sandwich, United Kingdom, ⁶Levicept, Ashtead, United Kingdom, ⁷Levicept Ltd, Ashtead, United Kingdom, ⁸Levicept, Sandwich, Kent, United Kingdom
Background/Purpose: When evaluating new osteoarthritis (OA) therapies, we need to understand their clinical meaningfulness. LEVI-04, a first-in-class p75 neurotrophin receptor-Fc fusion protein that primarily inhibits…
Abstract Number: 0769 • ACR Convergence 2025
Increased Gait Variability at Preferred Walking Speeds is Associated with Increased Physical Activity Measures in People with Knee Osteoarthritis
Ogundoyin Ogundiran, Steven Garcia, Joy Itodo, Oiza Peters and Kharma Foucher, UNIVERSITY OF ILLINOIS, CHICAGO, Chicago, IL
Background/Purpose: People with knee osteoarthritis (OA) often exhibit reduced physical activity levels and increased fall risk. Gait variability, specifically center of mass (COM) variability is…
Abstract Number: 2055 • ACR Convergence 2025
Construct Validity of Total Improvement Score (TIS) as an Endpoint for Clinically Meaningful Improvement in Multiple Patient-Centered Outcome Measures in Dermatomyositis
Anjana Chandrasekhara Pillai¹, Shiri Keret², Siamak Moghadam-Kia³, Chester V. Oddis⁴ and Rohit Aggarwal⁵, ¹PPCP, Pittsburgh, PA, ²Bnai Zion Medical Center, Atlit, Israel, ³University of Pittsburgh Medical Center, Pittsburgh, PA, ⁴University of Pittsburgh, Pittsburgh, PA, ⁵University of Pittsburgh, Rheumatology and Clinical Immunology, Pittsburgh, United States of America, Pittsburgh, PA
Background/Purpose: Total Improvement Score (TIS), as defined by the ACR/EULAR myositis response criteria, is increasingly employed as a primary endpoint in clinical trials for dermatomyositis…
Abstract Number: 0446 • ACR Convergence 2025
A Balancing Act: The Interplay Between Resilience and Frailty in Rheumatoid Arthritis
Hannah Brubeck¹, Kylie Riggles¹, Adrienne Tanus¹, Nadine El-ayache², George Mount², Elizabeth Wahl², Courtney Loecker³, Jose Garcia⁴, Dolores Shoback⁵, Joshua Baker⁶, Patti Katz⁷, Ariela Orkaby⁸ and Katherine Wysham⁹, ¹VA Puget Sound Health Care System, Seattle, WA, ²VA Puget Sound Health Care System & University of Washington, Seattle, WA, ³University of Nebraska Medical Center, Omaha, ⁴VA Puget Sound Health Care System, VA GRECC, and University of Washington, Seattle, WA, ⁵San Francisco VA Medical Center & University of California San Francisco, San Francisco, CA, ⁶University of Pennsylvania, Philadelphia, PA, ⁷UCSF, San Rafael, CA, ⁸VA Boston Healthcare System & Division of Aging, Brigham and Women’s Hospital, Harvard Medical School & VA Geriatrics Research Education and Clinical Center, Boston, MA, ⁹VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA
Background/Purpose: Frailty, a state of decreased physiological reserve and heightened vulnerability to stressors, occurs prematurely in rheumatoid arthritis (RA) and is associated with poor health…
Abstract Number: 1977 • ACR Convergence 2025
The Westergren Sedimentation Rate: To Be or Not to Be! The Westergren Sedimentation Rate is being “Killed” but has not “Died”.
John Goldman¹, Michael Goldman² and Glenn R. Parris³, ¹Emory University St Josephs Hospital, Atlanta, GA, ²SENTA Southeastern Ear, Nose, Throat and Allergy, Atlanta, GA, ³PARRIS & ASSOCIATES, Lilburn, GA
Background/Purpose: The Westergren Sedimentation Rate (WSR) is a simple, cost-effective laboratory test commonly used by rheumatologists to assess systemic inflammation. This study was initiated to…
Abstract Number: 0442 • ACR Convergence 2025
Beyond the Joints: The Impact of Non-Articular Pain on Patient-Reported Function in a Longitudinal Real-World Early RA Cohort
Charis Meng¹, Marie-France Valois², Caci Julia³, Yvonne Lee⁴, Bindee Kuriya⁵, Gilles Boire⁶, Hugues Allard-Chamard⁷, Carol Hitchon⁸, Louis Bessette⁹, Glen Hazlewood¹⁰, Carter Thorne¹¹, Susan J. Bartlett¹², Janet Pope¹³ and Vivian Bykerk¹, ¹Hospital for Special Surgery, New York, NY, ²McGill University, Pointe-Claire, QC, Canada, ³Hospital for Special Surgery, New York, ⁴Northwestern University, Chicago, IL, ⁵Mount Sinai Health, Toronto, Canada, ⁶Retired, Sherbrooke, QC, Canada, ⁷Université de Sherbrooke, Sherbrooke, Canada, ⁸University of Manitoba, Winnepeg, Canada, ⁹Centre de l'Ostéoporose et de Rhumatologie de Québec, Quebec, QC, Canada, ¹⁰University of Calgary, Calgary, AB, Canada, ¹¹Southlake Regional Health Centre, Newmarket, ON, Canada, ¹²McGill University, Beaconsfield, QC, Canada, ¹³University of Western Ontario, London, ON, Canada
Background/Purpose: A third of patients with early (e)RA report pain outside the joint or non-articular pain (NAP) despite RA treatment(1). NAP, both regional and widespread,…
Abstract Number: 1927 • ACR Convergence 2025
Development of the PREVAIL model of care: Optimizing feasibility and acceptability for trial implementation
Louise Thoma¹, Joel Thompson², Jason Sharpe³, Beth Jonas⁴, Patti Katz⁵ and Kelli Allen⁶, ¹University of North Carolina, Chapel Hill, NC, ²University of North Carolina at Chapel Hill, Cary, NC, ³Flatiron Health, Durham, NC, ⁴University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁵UCSF, San Rafael, CA, ⁶University of North Carolina, Durham, NC
Background/Purpose: Exercise guidance and referral to physical therapy are not consistently delivered when appropriate in rheumatology care for adults with rheumatoid arthritis (RA). The PREVAIL…
Abstract Number: 0336 • ACR Convergence 2025
Does Baseline Physical Function Moderate Change in Steps/day Following a Telephone-Delivered Walk With Ease Program?
Nurten Gizem Tore¹, Daniel K. White² and Christine Pellegrini³, ¹University of Delaware, Newark, ²University of Delaware, Newark, DE, ³Arnold School of Public Health, Columbia
Background/Purpose: Adults with knee osteoarthritis with worse physical function are known to benefit more from therapeutic exercise than those with less limitation. However, there is…

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