Abstracts tagged "Pediatric rheumatology"

Abstract Number: 0402 • ACR Convergence 2025
Risk Factors for Anti-Adalimumab Antibody Development in Pediatric Patients Using Adalimumab for Rheumatic Disease and Associated Conditions
Dawn Gist¹, Andrea Ramirez¹, Jamie Lai², Duc Nguyen¹ and Kexin Guo¹, ¹Baylor College of Medicine, Houston, TX, ²Baylor College of Medicine, The Woodlands, TX
Background/Purpose: Adalimumab is a monoclonal antibody against TNF-α that is commonly used to treat JIA, hidradenitis suppurativa (HS), chronic uveitis, sarcoidosis, and chronic nonbacterial osteomyelitis…
Abstract Number: 0126 • ACR Convergence 2025
Performance of the 2023 and 2006 APS Classification Criteria in Pediatric Patients Diagnosed with APS: A Multisite Cohort Study
Jacqueline Madison¹, Elizabeth Sloan², Cristina Saez³, Olivia Kwan⁴, Kevin Lewis¹, Jonathan Marilao⁵, Blake Baay⁶, Rasha Elrefai⁴, Marissa Dale⁷, Deborah McCurdy⁸, Jheel Bhatt⁹, Sasidhar Goteti¹⁰, Ekemini Ogbu¹¹, Jason S. Knight¹ and Yu (Ray) Zuo¹, ¹University of Michigan, Ann Arbor, MI, ²UT Southwestern, Children's Medical Center, and Scottish Rite for Children, Dallas, TX, ³Children's Hospital Colorado, Glendale, CO, ⁴Baylor College of Medicine, Houston, TX, ⁵University of Texas Southwestern, Dallas, TX, ⁶Scottish Rite for Children, Dallas, TX, ⁷Hospital for Special Surgery/NYP Cornell, New York, NY, ⁸UCLA Medical Center, Los Angeles, CA, ⁹Advent Health Orlando, Orlando, FL, ¹⁰University of Utah, Salt Lake City, UT, ¹¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Antiphospholipid syndrome (APS) is a thrombo-inflammatory disorder that causes significant morbidity and mortality, even in children. The 2023 ACR/EULAR classification criteria, which use weighted…
Abstract Number: 2537 • ACR Convergence 2025
Variation in Treatment Approaches in IgA-Vasculitis Among Pediatricians and Pediatric rheumatologists: A Cross-Sectional International Survey
Merav Heshin Bekenstein¹, Tali Elbaz², Yael Illous² and Barak Kandell³, ¹Tel Aviv Medical Center Israel, Binyamina, Tel Aviv, Israel, ²School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv, Israel, ³The Academic College of Tel Aviv-Yafo, Tel Aviv, Israel
Background/Purpose: IgA Vasculitis (IgAV) is the most common small-vessel vasculitis in children. Although there is no evidence-based recommendations for treating IgAV, the European SHARE recommendations…
Abstract Number: 2154 • ACR Convergence 2025
Whole-Body MRI Findings in a Cohort of Children with Chronic Nonbacterial Osteomyelitis
Mara Rodriguez¹, Maurice Davenport Munoz², Kiery Braithwaite³, Lori Ponder⁴, Kelly Rouster-Stevens⁵, Solveig Argeseanu Cunningham⁶ and Sampath Prahalad⁷, ¹Emory University School of Medicine / Children's Healthcare of Atlanta, Atlanta, GA, ²Emory University School of Medicine, Pediatrics, Atlanta, ³Children's Healthcare of Atlanta, Atlanta, GA, ⁴Emory University, Atlanta, GA, ⁵Emory University/Children's Healthcare of Atlanta, Peachtree Corners, GA, ⁶Emory Rollins School of Public Health Department of Global Health, Atlanta, GA, ⁷Emory + Children's Pediatric Institute, Atlanta, GA
Background/Purpose: Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disorder characterized by multifocal, sterile bone inflammation in childhood. Whole-body magnetic resonance imaging (WB-MRI) allows for…
Abstract Number: 2130 • ACR Convergence 2025
Systemic juvenile idiopathic arthritis- Fifteen-year experience from a tertiary centre at Bristol, United Kingdom
Ashwini Batchu Prithvi, Chaitra Govardhan, Bushra Aladaileh and Athimalaipet V Ramanan, Bristol Royal Hospital for Children, Bristol, United Kingdom
Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is a chronic disease that results in significant morbidity and mortality in children1. Improved understanding of the pathophysiology of…
Abstract Number: 1815 • ACR Convergence 2025
New-Onset Juvenile Spondyloarthritis is Characterized by Bone Metabolism Disturbances with Biomarker Potential
Brittney Newby¹, Timothy Brandon¹, Pamela Weiss² and E. John Wherry³, ¹Children's Hospital of Philadelphia, Philadelphia, PA, ²Childrens Hospital of Philadelphia, Philadelphia, PA, ³University of Pennsylvania, Philadelphia, PA
Background/Purpose: Juvenile spondyloarthritis (JSpA) management is hindered by the lack of reliable biomarkers to predict which patients will develop progressive structural changes, such as erosions…
Abstract Number: 1672 • ACR Convergence 2025
Classification criteria, disease phenotypes and long-term outcomes of childhood Sjögren’s Disease into adulthood
Coziana Ciurtin¹, Ruby Gotch², Hannah Peckham¹, Robert Wilson², Muthana AlObaidi³ and Elizabeth C Jury¹, ¹University College London, London, United Kingdom, ²University College London Hospital NHS Trust, London, United Kingdom, ³Great Ormond Street Hospital, London, United Kingdom
Background/Purpose: Childhood Sjögren Disease (cSjD) is a rare clinical phenotype lacking research on long-term outcomes and impact on the quality of life of young people…
Abstract Number: 1293 • ACR Convergence 2025
Synovitis and periarticular soft tissues abnormalities in childhood-onset systemic lupus erythematosus: an ultrasonography study
Marianna Freire¹, Jean Paulo Veronese de Souza¹, Ana Renata Oliveira¹, Renata Kobayasi², Vitor Paula³, Clovis Artur Silva⁴ and Lucia Maria Campos⁵, ¹Pediatric Rheumatology Unit, Instituto da Criança e do Adolescente, Hospital das Clínicas HCFMUSP, São Paulo, Sao Paulo, Sao Paulo, Brazil, ²Centro de Desenvolvimento de Educação Médica do Hospital das Clínicas HCFMUSP, São Paulo, Sao Paulo, Sao Paulo, Brazil, ³Pediatric Radiology Unit, Instituto da Criança e do Adolescente, Hospital das Clínicas HCFMUSP, São Paulo, Sao Paulo, Sao Paulo, Brazil, ⁴University of São Paulo, São Paulo, São Paulo, Brazil, ⁵Instituto da Criança e do Adolescente, São Paulo, São Paulo, Brazil
Background/Purpose: Musculoskeletal (MSK) involvement occurs in up to 70% of childhood-onset systemic lupus erythematosus (cSLE). MSK ultrasound (US) has emerged as a tool with greater…
Abstract Number: 1277 • ACR Convergence 2025
Combination Therapy with Rituximab and Cyclophosphamide for Treating Pediatric Patients with Severe Manifestations of Rheumatic Disease
Eileen Rife¹, Daniel Reiff², John Bridges³, Emily Smitherman¹, randy Cron¹, Matthew Stoll¹, Melissa Mannion¹, Peter Weiser⁴ and Livie Timmerman⁵, ¹University of Alabama at Birmingham, birmingham, AL, ²Boys Town Hospital, Omaha, ³University of Alabama at Birmingham/Children's of Alabama, Birmingham, AL, ⁴University of Alabama at Birmingham, Birmingham, ⁵University of Alabama at Birmingham, Gardendale, AL
Background/Purpose: Current practice guidelines recommend either rituximab (RTX) or cyclophosphamide (CYC) for treatment of organ-threatening manifestations of systemic vasculitis or connective tissue disease (e.g., diffuse…
Abstract Number: 0427 • ACR Convergence 2025
Maternal Smoking During Pregnancy and Risk of Juvenile Idiopathic Arthritis (JIA): Triangulating Evidence from Polygenic Risk Scores and Meta-Analysis in Scandinavian Birth Cohorts
Vilde Øverlien Dåstøl¹, Kristine Løkås Haftorn², Maria Christine Magnus³, Sigrid Hestetun⁴, Siri Eldevik Håberg⁵, Lisa Rider⁶, Karen H. Costenbader⁷, Ida Henriette Caspersen⁸, Sjurdur Frodi Olsen⁹, Ketil Størdal¹⁰ and Helga Sanner¹, ¹Oslo University Hospital, Oslo, Norway, ²Oslo University Hospital, Department of Rheumatology, Oslo, Norway, ³Norwegian Institute of Public Health, Centre for Fertility and Health, Oslo, Norway, ⁴Oslo University Hospital, Department of Rheumatology/University of Oslo, Oslo, Norway, ⁵Norwegian Institute of Public Health, Centre for Fertility and Health/University of Bergen, Oslo, Norway, ⁶National Institute of Environmental Health Sciences/National Institutes of Health, Environmental Autoimmunity Group, Bethesda, MD, ⁷Harvard Medical School and Brigham and Women's Hospital, Boston, MA, ⁸Norwegian Institute of Public Health, Centre for Fertility and Health/Oslo University Hospital, Oslo, Norway, ⁹Statens Serum Institut,Biobank, congenital disorders, and vaccines preparedness/Harvard T.H. Chan School of Public Health, Copenhagen, Denmark, ¹⁰Oslo University Hospital, Department of Pediatric and Adolescent Medicine/University of Oslo, Oslo, Norway
Background/Purpose: Maternal smoking during pregnancy has been associated with a seemingly lower risk of juvenile idiopathic arthritis (JIA) in the child (1), contrasting with smoking’s…
Abstract Number: 0401 • ACR Convergence 2025
Longitudinal Effectiveness of Abatacept in JIA: Results From an Ongoing JIA Registry
Daniel Lovell¹, Nicolino Ruperto², Jennifer Huggins³, Ekaterina Alexeeva⁴, Colleen Correll⁵, John Bohnsack⁶, Stacey Tarvin⁷, Gabriele Simonini⁸, Thomas Griffin⁹, Andrew Zeft¹⁰, Gerd Horneff¹¹, Pierre Quartier¹², Iionka Orban¹³, Heather Walters¹⁴, Valda Stanevica¹⁵, Julisa Patel¹⁶, Adam M Huber¹⁷, Margalit Rosenkranz¹⁸, Daniel Kingsbury¹⁹, Rosie Scuccimarri²⁰, Gabriel Vega Cornejo²¹, Joost Swart²², Robert Carroll²³, Hermine Brunner¹, Tina Sherrard²⁴, Chiara Pallotti²⁵, Clara Malattia²⁶ and Alberto Martini²⁶, ¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Università degli Studi Milano-Bicocca, Milan, Italy, ³Cincinnati Children's Medical Center, Cincinnati, OH, ⁴National Medical Research Center for Children’s Health Federal State Autonomous Institution of the Russian Federation Ministry of Health and I.M. Sechenov First Moscow State Medical University (Sechenovskiy University), Moscow, Russia, ⁵University of Minnesota, Minneapolis, MN, ⁶University of Utah, Salt Lake City, UT, ⁷Riley Hospital for Children at Indiana University, Indianapolis, IN, ⁸Rheumatology Unit, ERN-ReCONNET center, Meyer Children's Hospital IRCCS, Firenze, Firenze, Italy, ⁹Atrium Health Levine Children’s Hospital, Charlotte, NC, ¹⁰Cleveland Clinic, Cleveland, OH, ¹¹Asklepios Klinik, Hamburg, Germany, ¹²Hôpital Necker-Enfants Malades, Paris, France, ¹³Department of Rheumatology and Clinical Immunology of Semmelweis University, Budapest, Hungary, ¹⁴Northwell, New Hyde Park, NY, ¹⁵Riga Stradiņš University, Riga, Latvia, ¹⁶Children’s Hospital of Georgia, Augusta University, Augusta, GA, ¹⁷IWK Grace Health Centre, Halifax, NS, Canada, ¹⁸University of Pittsburgh, Pittsburgh, PA, ¹⁹Randall Children’s Hospital at Legacy Emanuel, Portland, OR, ²⁰McGill University Health Centre, Montreal, QC, Canada, ²¹Clinica de reumatología Guadalajara, Guadalajara, Jalisco, Mexico, ²²Wilhelmina Children's Hospital / UMC Utrecht, Utrecht, Utrecht, Netherlands, ²³Bristol Myers Squibb, London, United Kingdom, ²⁴Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ²⁵Istituto G. Gaslini, Servizio di Sperimentazioni Cliniche Pediatriche, Genova, Italy, ²⁶Istituto G. Gaslini Pediatria II Reumatologia and University of Genova, Genova, Italy
Background/Purpose: Abatacept is a selective T-cell co-stimulation modulator approved for use in JIA. Efficacy and safety of abatacept in patients (pts) with JIA have been…
Abstract Number: 0119 • ACR Convergence 2025
Thrombin Generation Assays Inform Hypercoagulability Mediated by Antiphospholipid Antibodies in Children with Systemic Lupus Erythematosus
Elizabeth Sloan¹, Blake Baay², Lynnette Walters², Paola Sparagana², Kristina Ciaglia¹, Simrat Morris¹, Julie Fuller¹, Lorien Nassi¹, Tracey Wright¹ and Ayesha Zia³, ¹UT Southwestern, Children's Medical Center, and Scottish Rite for Children, Dallas, TX, ²Scottish Rite for Children, Dallas, TX, ³UT Southwestern and Children's Medical Center, Dallas, TX
Background/Purpose: In pediatric systemic lupus erythematosus (SLE), antiphospholipid antibodies (aPL) are independent risk factors for thrombosis. However, data are limited on how aPL impact hypercoagulability.…
Abstract Number: 2535 • ACR Convergence 2025
Behçet’s syndrome: distinct features in 344 pediatric and adult patients in a non-endemic region
Ricardo Machado¹, Thales Souza², Matheus França³, Vinicius Matias⁴, Sylvia Farhat¹, Carolina Siqueira⁴, Maria Carolina Santos⁴, Lia Steuer¹, Luisa Forero¹, Rafael Bassara Macedo⁵, Thiago Freitas⁶, barbara Bayeh⁷, Carolina Ejnisman⁸, Pedro Araujo⁹, Rafael Cordeiro¹⁰, Fabio Specian⁵, Verena Balbi¹, Nadia Emi Aikawa¹¹, Katia Kozu¹, Clovis Artur Silva¹², Lucia Maria Campos¹³, Adriana Elias¹⁴ and Henrique Giardini⁶, ¹Instituto da Criança e do Adolescente, Hospital das Clinicas, Sao Paulo, Sao Paulo, Brazil, ²Faculdade de Medicina da Universidade de Brasilia, Brasilia, Distrito Federal, Brazil, ³Instituto da Criança e do Adolescente, Hospital das Clinicas, University of Sao Paulo Medical School, Sao Paulo, Sao Paulo, Brazil, ⁴Faculdade de Ciências Medicas da Santa Casa de Sao Paulo, Sao Paulo, Sao Paulo, Brazil, ⁵Rheumatology Division, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (USP), Sao Paulo, Sao Paulo, Brazil, ⁶Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, São Paulo, Brazil, ⁷Hospital das Clínicas, University of Sao Paulo Medical School, Sao Paulo, Sao Paulo, Brazil, ⁸Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, Sao Paulo, Brazil, ⁹Universidade de São Paulo, Sao Paulo, São Paulo, Brazil, ¹⁰Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, São Paulo, Sao Paulo, Brazil, ¹¹Rheumatology Division and Pediatric Rheumatology Unit, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, Sao Paulo, São Paulo, Brazil, ¹²University of São Paulo, São Paulo, São Paulo, Brazil, ¹³Instituto da Criança e do Adolescente, São Paulo, São Paulo, Brazil, ¹⁴Pediatric Rheumatology Unit, Instituto da Criança e do Adolescente, Hospital das Clinicas, University of Sao Paulo Medical School, São Paulo, São Paulo, Brazil
Background/Purpose: Behçet’s syndrome (BS) is a chronic inflammatory disorder characterized by a heterogeneous clinical presentation, occurring primarily in young adults and very rarely in children…
Abstract Number: 2153 • ACR Convergence 2025
Giant Coronaries in Children with Kawasaki Disease: A Single Centre Experience
Pavneet Kaur¹, Mayank Goyal², Shivaprasad P Mohankumar², Lamk Kidyani², Sanjeev Kumar², Saurabh Gupta³, Sivasubramanian Ramakrishnan² and Narendra Bagri⁴, ¹All India Institute of Medical Sciences, New Delhi, India, ²AIIMS, New Delhi, India, New Delhi, Delhi, India, ³All India Institute of Medical Sciences, New Delhi, Delhi, ⁴ALL INDIA INSTITUTE OF MEDICAL SCIENCES, New Delhi, Delhi, India
Background/Purpose: Coronary artery abnormalities (CAA) are a dreaded yet potentially preventable stigmata of Kawasaki disease (KD). Giant CAA are rare but at higher risk of…
Abstract Number: 2128 • ACR Convergence 2025
Prevalence of Risks and Complications in a Longitudinal International Cohort of Children with Chronic Nonbacterial Osteomyelitis (CNO)
Jessica Kent¹, Eveline Wu², Melissa Oliver³, Sivia Lapidus⁴, Ummusen Akca⁵, Adriel Liau⁶, Pratyush Kore⁷, Ian Muse⁸, Ava Klein⁶, Emily Deng⁶, Iris Hamilton⁶, Haodong Chen⁷, Megan Nguyen⁷, Tianai Li⁹, Avril Wilson⁷, Jasmine Morden⁷, Shima Yasin¹⁰, Aleksander Lenert¹¹, Sara M. Stern¹², Antonella Insalaco¹³, Manuela Pardeo¹⁴, Gabriele Simonini¹⁵, Edoardo Marrani¹⁶, Xing Wang⁶, Bin Huang¹⁷, Leonard Kovallick¹⁸, Natalie Rosenwasser¹⁹, Erin Balay-Dustrude²⁰, Doaa Mosa²¹, Katerina Bouchalova²², Andrea Cabova²³, Jenna Thomason²⁰, Lori Tucker²⁴, Hermann Girschick²⁵, Ronald laxer²⁶, Marinka Twilt²⁷, Georgina Tiller²⁸, Jonathan Akikusa²⁹, Christian Hedrich³⁰, Karen Onel³¹, Fatma Dedeoglu³², Seza Özen³³, Polly Ferguson³⁴ and Yongdong (Dan) Zhao³⁵, ¹Medical College of Wisconsin, Wauwatosa, WI, ²UNC Chapel Hill, Chapel Hill, NC, ³Indiana University, Indianapolis, IN, ⁴Joseph M. Sanzari Children's Hospital, Center for Discovery and Innovation, Hackensack Meridian School of Medicine, Montclair, NJ, ⁵Hacettepe University, Ankara, Turkey, ⁶Seattle Children's Hospital, Seattle, ⁷Seattle Children’s Research Institute, Seattle, ⁸University of Washington, Department of Pediatrics, Seattle Children's Hospital, Seattle, ⁹Seattle Children's Research institute, Seattle, ¹⁰Univeristy of Iowa, Iowa City, ¹¹University of Iowa, Iowa City, IA, ¹²University of Utah, Salt Lake City, UT, ¹³IRCCS Ospedale Pediatrico Bambino Gesu', Rome, Italy, ¹⁴IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, Rome, Italy, ¹⁵Rheumatology Unit, ERN-ReCONNET center, Meyer Children's Hospital IRCCS, Firenze, Firenze, Italy, ¹⁶University of Florence, Firenze, Italy, ¹⁷Cincinnati Children's Hospital, Cinciannati, OH, ¹⁸The University of North Carolina at Chapel Hil, Chapel Hill, ¹⁹Seattle Children's Hospital, seattle, WA, ²⁰University of Washington, Seattle, WA, ²¹Mansoura University Hospitals, Mansoura City, Egypt, ²²Palacký University Olomouc, Olomouc, Czech Republic, ²³Faculty of Medicine and Dentistry Palacky University Olomouc, Olomouc, Czech Republic, ²⁴BC Children's Hospital, Vancouver, BC, Canada, ²⁵Vivantes Clinic Friedrichshain, Wuerzburg, Germany, ²⁶The Hospital for Sick Children, Toronto, ON, Canada, ²⁷Alberta Children's Hospital, Alberta, Canada, ²⁸Royal Children’s Hospital, Melborne, Australia, ²⁹The Royal Children's Hospital, Parkville, Victoria, Australia, ³⁰University of Liverpool, Liverpool, United Kingdom, ³¹HSS, New York, NY, ³²Boston Children's Hospital, Boston, MA, ³³Hacettepe University Medical Faculty, Ankara, Turkey, ³⁴University of Iowa Carver College of Medicine, Iowa City, IA, ³⁵Seattle Children’s Research Institute, Redmond, WA
Background/Purpose: Chronic nonbacterial osteomyelitis (CNO) is associated with various comorbidities and long-term complications. The CHronic nonbacterial Osteomyelitis International Registry (CHOIR) is a multi-national database that…

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