Abstracts tagged "Pediatric rheumatology"

Abstract Number: 2679 • ACR Convergence 2025
Early-Life Nutrition and Gene-Environment Interactions Influencing Juvenile Idiopathic Arthritis Risk: Results from a Pregnancy Cohort
Vilde Øverlien Dåstøl¹, Ida Henriette Caspersen², Kristine Løkås Haftorn³, Sigrid Hestetun⁴, Siri Eldevik Håberg⁵, Karen H. Costenbader⁶, Marin Strøm⁷, Sjurdur Frodi Olsen⁸, Anne Lise Brantsæter⁹, Ketil Størdal¹⁰ and Helga Sanner¹, ¹Oslo University Hospital, Oslo, Norway, ²Norwegian Institute of Public Health, Centre for Fertility and Health/Oslo University Hospital, Oslo, Norway, ³Oslo University Hospital, Department of Rheumatology, Oslo, Norway, ⁴Oslo University Hospital, Department of Rheumatology/University of Oslo, Oslo, Norway, ⁵Norwegian Institute of Public Health, Centre for Fertility and Health/University of Bergen, Oslo, Norway, ⁶Harvard Medical School and Brigham and Women's Hospital, Boston, MA, ⁷Statens Serum Institut, Department of Epidemiology Research, Copenhagen, Denmark, ⁸Statens Serum Institut,Biobank, congenital disorders, and vaccines preparedness/Harvard T.H. Chan School of Public Health, Copenhagen, Denmark, ⁹Norwegian Institute of Public Health, Department of Food Safety and Centre for Sustainable Diets, Oslo, Norway, ¹⁰Oslo University Hospital, Department of Pediatric and Adolescent Medicine/University of Oslo, Oslo, Norway
Background/Purpose: Early-life nutrition may influence the risk of immune-mediated diseases like juvenile idiopathic arthritis (JIA). The benefits of breastfeeding are well established, but findings related…
Abstract Number: 2161 • ACR Convergence 2025
Perceptions of the Importance of Pediatric Rheumatology Education in Pediatric Residency: A Needs Assessment
Katherine Nowicki¹, Lori Silveira², Megan Curran¹ and Laura Lockwood¹, ¹University of Colorado | Children's Hospital Colorado, Aurora, CO, ²University of Colorado, Aurora, CO
Background/Purpose: The shortage of pediatric rheumatologists and resulting limited patient access necessitates that pediatricians receive adequate training in core pediatric rheumatology (PR) topics to address…
Abstract Number: 2136 • ACR Convergence 2025
Confirming The Validity Of The New EULAR/ACR Classification Criteria For Pediatric Chronic Nonbacterial Osteomyelitis
Greta Mastrangelo¹, Edan Itzkovitz², Katherine Sawicka³, Ingrid Goh⁴, Ari Bitnun⁵, Sevan Hopyan⁵, Paul Nathan², Ronald laxer¹ and Brian Feldman¹, ¹The Hospital for Sick Children, Toronto, ON, Canada, ²The Hospital for Sick Children, Toronto, ³The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, ⁴University of Toronto The Hospital for Sick Children, Toronto, ON, Canada, ⁵The Hospital for Sick Children, Toronto, Canada
Background/Purpose: Chronic nonbacterial osteomyelitis (CNO) is a noninfectious autoinflammatory bone disease which remains a diagnosis of exclusion, as existing diagnostic criteria are not widely accepted.…
Abstract Number: 1822 • ACR Convergence 2025
The Circulating Immune Profile of Systemic JIA Patients with HLA-DRB1*15 alleles, Eosinophilia, and Lung Disease
Jennifer Cheng¹, Alexandra Pommier², Ki Pui Lam³, Evan Hsu⁴, Courtney Leson⁵, Kyle McBrearty¹, Itohan Aigbekaen¹, Maryam Ashoor⁶, Ahmad Bakhsh¹, Carrie Bryant¹, Siobhan Case⁷, Mia Chandler¹, Margaret Chang¹, Ezra Cohen⁸, Fatma Dedeoglu¹, Olha Halyabar⁹, Jonathan Hausmann¹⁰, Melissa Hazen¹, Sonia Iosim¹, Liyoung Kim⁶, Jeffrey Lo¹, Mindy Lo¹, Emma Materne¹, Esra Meidan¹¹, Megan Perron¹², Helene Powers¹³, Mary Beth Son¹, Holly Wobma¹, Peter Nigrovic⁶, Alicia Casey¹, Joyce Chang¹, Pui Lee⁴ and Lauren Henderson¹⁴, ¹Boston Children's Hospital, Boston, MA, ²Harvard Medical School, Boston, MA, ³Division of Immunology, Boston Childrens Hospital, Harvard Medical School, Boston, MA, ⁴Boston Children's Hospital, Newton, MA, ⁵Boston Children's Hospital, Boston, ⁶Boston Children's Hospital, Brookline, MA, ⁷UpToDate, Brigham and Women's Hospital, Boston Children's Hospital, Boston, MA, ⁸Bmc, NEEDHAM, MA, ⁹Children's Hospital/Boston Medical Center, Newton, MA, ¹⁰Boston Children's Hospital / Massachusetts General Hospital, Cambridge, MA, ¹¹Boston Children's Hospital, Somerville, MA, ¹²Boston Children's Hospital, Natick, MA, ¹³Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, ¹⁴Boston Children's Hospital, Watertown, MA
Background/Purpose: We aimed to explore the association between HLA-DRB1*15 alleles, eosinophilia, and lung disease (LD) in patients with systemic juvenile idiopathic arthritis (sJIA) through proteomic…
Abstract Number: 1704 • ACR Convergence 2025
Relationships between Neighborhood Disadvantage, Cumulative Social Disadvantage, and JIA Outcomes: A CARRA Registry Study
William Soulsby¹, John Boscardin², Daniel Horton³, Andrea Knight⁴, Karine Toupin-April⁵ and Emily von Scheven², ¹University of California, San Francisco, San Francisco, CA, ²UCSF, San Francisco, CA, ³Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, ⁴Hospital for Sick Children, Toronto, ON, Canada, ⁵University of Ottawa, Ottawa, ON, Canada
Background/Purpose: Social determinants of health (SDOH) operate across individual, family, and community levels. We previously demonstrated that cumulative social disadvantage, comprised of individual and family-level…
Abstract Number: 1298 • ACR Convergence 2025
Identifying Psychosocial Profiles in Youth with Chronic Musculoskeletal Pain: A K-Means Clustering Analysis of Resilience Subgroups
Sabrina Gmuca¹, Jan Leonard², Alexis Z. Tomlinson², Mackenzie McGill², Nellie Butler², Rui Xiao³, Peter F. Cronholm³, Tonya M. Palermo⁴, Jami F. Young⁵, Abby R. Rosenberg⁶ and Pamela Weiss⁷, ¹Children's Hospital of Philadelphia; University of Pennsylvania, Philadelphia, PA, ²Children's Hospital of Philadelphia, Philadelphia, ³University of Pennsylvania, Philadelphia, PA, ⁴University of Washington School of Medicine; Seattle Children’s Research Institute, Seattle, ⁵Children's Hospital of Philadelphia; University of Pennsylvania, Philadelphia, ⁶Dana-Farber Cancer Institute; Boston Children’s Hospital; Harvard Medical School, Boston, ⁷Childrens Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Psychological resilience is low among youth with chronic musculoskeletal pain (CMP) at baseline. We aimed to explore resilience profiles among youth with CMP during…
Abstract Number: 1281 • ACR Convergence 2025
Ethnic Disparities in Mental Health Screening, Diagnoses, and Outcomes in Patients with Childhood-Onset Systemic Lupus Erythematosus
Alicia Tran¹, Indrani Das², Zhaoyu Ding³, Daniela Dominguez⁴, Sefi Kronenberg⁵, Lawrence Ng⁶, Alene Toulany¹, Gwyneth Zai⁷, Deborah Levy¹, Andrea Knight⁸ and Linda Hiraki¹, ¹The Hospital for Sick Children, Toronto, ON, Canada, ²University of Toronto, Toronto, ON, Canada, ³SickKids Research Institute, Toronto, ON, Canada, ⁴The Hospital for Sick Children, Toronto, Canada, ⁵Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada, ⁶The Hospital for Sick Children, Toronto, Canada, Toronto, ON, Canada, ⁷Centre for Addiction & Mental Health, Toronto, ON, Canada, ⁸Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Patients with childhood-onset systemic lupus erythematosus (cSLE) face higher risks of depression and anxiety compared to healthy peers. In 2022, standardized mental health (MH)…
Abstract Number: 0824 • ACR Convergence 2025
Characterizing Immune Responses in Abatacept-treated Patients with Limited Juvenile Idiopathic Arthritis
Lwiza AitDowd¹, Ekaterina Murzin², Alexandra Pommier³, Ki Pui Lam⁴, Claudia Harris⁵, Melanie Kohlheim⁶, Grant Schulert⁷, Marc Sudman⁸, Eveline Wu⁹, Laura Schanberg¹⁰, Peter Nigrovic¹¹, James Lederer¹² and Lauren Henderson¹³, ¹Boston Children's Hospital, Harvard Medical School, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Harvard Medical School, Boston, MA, ⁴Division of Immunology, Boston Childrens Hospital, Harvard Medical School, Boston, MA, ⁵Division of Immunology, Boston Childrens Hospital, Boston, MA, ⁶CARRA, Granville, OH, ⁷Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁸Cincinnati Children's Hospital Medical Center, Cincinnati, ⁹UNC Chapel Hill, Chapel Hill, NC, ¹⁰Duke University Medical Center, DURHAM, NC, ¹¹Boston Children's Hospital, Brookline, MA, ¹²Brigham and Women's Hospital, Millis, MA, ¹³Boston Children's Hospital, Watertown, MA
Background/Purpose: Our ability to tailor treatments to individual patients with JIA remains limited. To identify candidate biomarkers that may be associated with treatment response, we…
Abstract Number: 0418 • ACR Convergence 2025
Evaluation of Disease Activity in the Knee Joint Through Clinical, Radiologic, Synovial Fluid and Histopathologic Measurements of Inflammation in Children with Juvenile Idiopathic Arthritis
Patricia Vega-Fernandez¹, Kelly Rogers², Alyssa Sproles², Sherry Thornton¹, Lexi Auld³, Jackeline Rodriguez-Smith¹, Ekemini Ogbu¹, Kara Murphy Schmidt⁴, McKenzie Vater⁵, Katelyn Banschbach⁶, Grant Schulert¹, Alexei Grom¹, Sheila Angeles-Han², Hermine Brunner¹, Jennifer Huggins⁷, Daniel Lovell¹, Amy Cassedy⁸, Yuriy Baglaenko², Tracy Ting¹ and Sara Szabo¹, ¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Cincinnati Children's Hospital, Cincinnati, OH, ³Cincinnati Children's Hospital Medical Center, Division of Rheumatology, Cincinnati, OH, ⁴Cincinnati Children’s Hospital Medical Center, Louisville, KY, ⁵Cincinnati Children's Hospital Medical Center, Fort Thomas, KY, ⁶cincinnati Children's hospital, Villa Hills, KY, ⁷Cincinnati Children's Medical Center, Cincinnati, OH, ⁸Cincinnati Children's hospital medical center, cincinnati, OH
Background/Purpose: Clinical, radiologic and biomarker data are measurements used in the assessment of juvenile idiopathic arthritis (JIA) disease activity. The development of ultrasound-guided synovial biopsy…
Abstract Number: 0193 • ACR Convergence 2025
Evaluation of electronic health record and efficiency tool utilization by pediatric subspecialists
Samantha Coss¹, Alison Brittain², Jennifer Lee³, Julie Young¹, Ivana Stojkic¹, John Mahan⁴ and Alysha Taxter⁵, ¹Nationwide Children's Hospital, Columbus, OH, ²Nationwide Children's Hospital, Canal Winchester, OH, ³Department of Gastroenterology, Nationwide Children's Hospital, Columbus, OH, ⁴Department of Nephrology, Nationwide Children's Hospital, Columbus, OH, ⁵Nationwide Children's, Columbus, OH
Background/Purpose: Excessive interaction with the electronic health record (EHR) is frequently cited as a common source of physician burnout. The administrative burden and extended documentation…
Abstract Number: 2678 • ACR Convergence 2025
The Association Between Medication Taper Duration and Time to JIA Disease Flare: A Retrospective Cohort Study
Christian-Immanuel Oliveros¹, Kelly Rouster-Stevens², Laura Johnson³ and Sampath Prahalad⁴, ¹Emory University / Children's Healthcare of Atlanta, Atlanta, GA, ²Emory University/Children's Healthcare of Atlanta, Peachtree Corners, GA, ³Emory University, Atlanta, GA, ⁴Emory + Children's Pediatric Institute, Atlanta, GA
Background/Purpose: Once clinically inactive, many patients with oligoarticular (oligoJIA) or polyarticular JIA (polyJIA) are interested in de-escalating therapy in a safe and successful manner. Many…
Abstract Number: 2158 • ACR Convergence 2025
Evaluating Nailfold Capillary Changes as Indicators of Disease Activity in Juvenile Dermatomyositis
Zilan Zheng¹, Laila Metni², Susan Kim³ and Jessica Neely⁴, ¹University of California, San Francisco, San Francisco, CA, ²University of California, Berkeley, Berkeley, CA, ³UCSF Benioff Children's Hospital, San Francisco, CA, ⁴UCSF, San Francisco, CA
Background/Purpose: Juvenile dermatomyositis (JDM) is a rare pediatric autoimmune myopathy characterized by skin and muscle inflammation, resulting in microvascular changes that can be visualized in…
Abstract Number: 2135 • ACR Convergence 2025
Medication Use and Disease Activity in Systemic Juvenile Idiopathic Arthritis in the Childhood Arthritis and Rheumatology Research Alliance Registry
Christina Gulla¹, Mary Beth Son², Tara Lozy³, Yukiko Kimura⁴ and Ginger Janow⁵, ¹Hackensack University Medical Center, Hackensack, NJ, ²Boston Children's Hospital, Boston, MA, ³Joseph M. Sanzari Children's Hospital, Center for Discovery and Innovation, Hackensack Meridian School of Medicine, Nutley, ⁴Hackensack Meridian School of Medicine, New York, NY, ⁵Joseph M. Sanzari Children's Hospital at Hackensack Meridian Health, Hackensack, NJ
Background/Purpose: Historically, treatment for systemic juvenile idiopathic arthritis (sJIA) included high dose glucocorticoids (GC) and conventional systemic (cs) disease modifying anti-rheumatic drugs (DMARDs) with significant…
Abstract Number: 1819 • ACR Convergence 2025
Spatial Transcriptomic Profiling Reveals Interferon Activation and CD8⁺ T Cell Dominance in Systemic Juvenile Idiopathic Arthritis-Macrophage Activation Syndrome Liver Inflammation
Esraa Eloseily¹, Taskin Sabit², Lara Berklite³, Grant Schulert⁴ and Alexei Grom⁴, ¹UT Southwestern Children's Medical Center, Dallas, TX, ²Cincinnati Children's Hospital Medical Center, Division of Rheumatology, Cincinnati, OH, ³Cincinnati Children's Hospital, Cincinnati, OH, ⁴Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Systemic juvenile idiopathic arthritis (SJIA) with macrophage activation syndrome (MAS) involves severe systemic inflammation and hepatocellular injury. Our prior histopathology studies showed increased CD8⁺…
Abstract Number: 1699 • ACR Convergence 2025
Protein-coding Somatic Genetic Variation in Lymphocytes in Systemic Lupus Erythematosus
Siva Kasinathan¹, Minh Pham² and Ansuman Satpathy², ¹Stanford University School of Medicine, Palo Alto, CA, ²Stanford University School of Medicine, Stanford, CA
Background/Purpose: The genetic and environmental factors underlying pathogenesis of systemic lupus erythematosus (SLE) are incompletely resolved. While inherited genetic variation has been extensively queried in…

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