ACR Meeting Abstracts

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Abstracts tagged "Pathology Bone Joint"

  • Abstract Number: 0726 • ACR Convergence 2021

    Joint Safety of Tanezumab versus NSAIDs; A Combined Assessment of Benefit and Harm

    Robert Fountaine1, Robert Dworkin2, Anne Hickman1, Glenn Pixton3, Ed Whalen4, Christine West1 and Kenneth Verburg1, 1Pfizer Inc., Groton, CT, 2University of Rochester, Rochester, NY, 3Pfizer Inc., Morrisville, NC, 4Pfizer Inc., New York, NY

    Background/Purpose: Tanezumab, a monoclonal antibody against nerve growth factor, is in development for the relief of signs and symptoms of moderate to severe osteoarthritis (OA)…
  • Abstract Number: 1890 • ACR Convergence 2021

    Cellular Origin and Functions of Osteoclasts in Inflammatory Arthritis

    Hannah Nelson1, Ellen Gravallese2, Julia Charles1 and Christian Jacome-Galarza1, 1Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA

    Background/Purpose: Inflammatory arthritis (IA) is an autoimmune disease targeting multiple joints and characterized by joint destruction caused by osteoclasts (OC), leading to physical disability. However,…
  • Abstract Number: 1897 • ACR Convergence 2021

    A Randomized Double-Blind Controlled Trial of Intensive Serum Urate Lowering with Oral Urate-Lowering Therapy for Erosive Gout

    Nicola Dalbeth1, Anthony Doyle1, Karen Billington1, Gregory Gamble1, Paul Tan1, Kieran Latto1, Trish Parshu Ram1, Ravi Narang1, Rachel Murdoch1, David Bursill1, Borislav Mihov1, Lisa Stamp2 and Anne Horne1, 1University of Auckland, Auckland, New Zealand, 2University of Otago, Christchurch, Christchurch, New Zealand

    Background/Purpose: Bone erosion is a common consequence of tophaceous gout, and leads to joint deformity and disability. In small case series, intensive urate-lowering with intravenous…
  • Abstract Number: 0085 • ACR Convergence 2020

    Classifications of Inflammatory Myopathies: Differentially Expressed Membrane-Bound Complement Regulators Allow Specific Patterns of Membrane Attack Complex Deposition

    Fadi Charouf1, Netanel Karbian1, Itamar Altman1, Yakov Fellig1 and Dror Mevorach1, 1Hadassah-University Hospital, Jerusalem, Yerushalayim, Israel

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) are a group of heterogeneous disorders that typically present with proximal muscle weakness. According to the classification criteria, IMs are…
  • Abstract Number: 0793 • ACR Convergence 2020

    Topological Laser Capture Microscopy (LCM)-RNAseq to Map the Rheumatoid Arthritis (RA) Synovial Transcriptome

    Benjamin Van Espen1, Andrew Wilson1, Gregory Seumois2, Narayanan Perumal3, Robert Benschop4, Gary Firestein5, Nunzio Bottini5 and Stephanie Stanford1, 1University of California, San Diego, La Jolla, 2La Jolla Institute for Immunology, La Jolla, 3Eli Lilly, Indianapolis, 4Eli Lilly and Company, Indianapolis, IN, 5University of California, San Diego, La Jolla, CA

    Background/Purpose: Understanding pathogenic processes in the diseased tissue in rheumatoid arthritis (RA) is a critical step to defining disease pathogenesis and identifying novel therapeutic targets.…
  • Abstract Number: 0796 • ACR Convergence 2020

    Development of a Tool to Assess Synovial Tissue Infiltrates and Derive Histological Pathotype in Inflammatory Arthritis: Relationship to Clinical and Ultrasound Variables

    Hayley Carr1, Ilfita Sahbudin1, Mark Maybury1, Bernard Dyke2, Jason Turner3, Nicola Gullick4, Karim Raza5, Dagmar Scheel-Toellner1 and Andrew Filer1, 1Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, 2Institute of Inflammation and Ageing, University of Birmingham, Birmingham, England, United Kingdom, 3Rheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, United Kingdom, 4University Hospitals Coventry & Warwickshire, Coventry, United Kingdom, 5Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom

    Background/Purpose: Evidence suggests that histological pathotypes are linked to pathogenic mechanisms in inflammatory arthritis and may be useful as biomarkers of outcome. The frequently used…
  • Abstract Number: 0875 • ACR Convergence 2020

    Secukinumab Provides Sustained Improvements in Subgroup Analyses of Joint Tenderness and Swelling in Patients with Psoriatic Arthritis: 5‑Year Results from the Phase 3 FUTURE 2 Study

    Iain McInnes1, Hector Chinoy2, Darren Asquith3, Abigail White3 and Corine Gaillez4, 1Institute of Infection, Immunity, and Inflammation, University of Glasgow, Glasgow, United Kingdom, 2The University of Manchester, Manchester, United Kingdom, 3Novartis Pharmaceuticals UK Ltd., London, United Kingdom, 4Novartis Pharma AG, Basel, Switzerland

    Background/Purpose: Secukinumab, a fully human monoclonal antibody that neutralizes interleukin‑17A, has shown long-term efficacy and tolerability in patients with psoriatic arthritis (PsA) in FUTURE 2.…
  • Abstract Number: 1854 • ACR Convergence 2020

    NGF/TrkA System Regulates Pain and the Pannus Formation: Targeting NGF-TrkA in Psoriatic Arthritis

    Siba Raychaudhuri1 and Smriti Raychaudhuri2, 1UC Davis, School of Medicine, Davis, CA, 2VA Sacramento Medical Center, Davis, CA

    Background/Purpose: Function of Nerve Growth Factor (NGF) in the nervous system and its regulatory role in pain is well defined. We have shown earlier that…
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ACR Pediatric Rheumatology Symposium 2020

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