Abstracts tagged "Pathology Bone Joint"

Abstract Number: 2298 • ACR Convergence 2025
When Imaging and Biopsy Disagree: Diagnostic Value of Doppler Ultrasound and Histologic Features beyond the Focus Score
kyung-Ann Lee¹, Yeonhee Kim¹, Se Hee Kim² and Hyun-Sook Kim³, ¹Soonchunhyang University Hospital Seoul: Soonchunhyang University Hospital, Seoul, Republic of Korea, ²Kyung Hee University College of Medicine, Seoul, Republic of Korea, ³Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea
Background/Purpose: Salivary gland ultrasound (SGUS) and minor salivary gland biopsy (MSGB) are widely used in the diagnosis of primary Sjögren’s syndrome (pSS). However, discordance between…
Abstract Number: 0980 • ACR Convergence 2025
Expansion of Viral-Reactive CD8+ T cell Repertoire Stratified by Pathotype in New-onset ACPA+ Rheumatoid Arthritis
Carl Coyle¹, Wittaya Suwakulsiri², Lukas Andriessen³, Megan Soon⁴, Pascale Wehr⁵, Sumera Qureshi⁶, Christopher Altmann⁷, Annabelle Small⁸, Vincent Wong⁹, Andrew Cope⁶, Kevin Wei¹⁰, Hendrik Nel⁵, Mihir Wechalekar¹¹ and Ranjeny Thomas², ¹Kings College London, London, United Kingdom, ²Frazer Institute, University of Queensland, Brisbane, Queensland, Australia, ³Frazer Institute, University of Queensland, Woolloongabba, Queensland, Australia, ⁴Frazer Institute, The University of Queensland, Brisbane, Australia, ⁵University of Queensland, Woolloongabba, Queensland, Australia, ⁶King's College London, London, United Kingdom, ⁷Flinders University, Adelaide, Australia, ⁸Flinders University, Bedford Park, South Australia, Australia, ⁹College of Medicine and Public Health, Bedford Park, South Australia, Australia, ¹⁰Brigham and Women's Hospital at Harvard Medical School, Boston, MA, ¹¹Flinders Medical Centre, Adelaide, Australia
Background/Purpose: Development of Rheumatoid Arthritis (RA) is strongly associated with specific HLA-DRB1 genotypes and the HLA-DR antigen binding groove, the shared epitope. HLA-B*08 also increases…
Abstract Number: 0542 • ACR Convergence 2025
Transition from Psoriasis to Psoriatic Arthritis: Does Family History Influence the Time to Onset of Arthritis in Psoriasis Patients?
Marta Flores¹, Juan de Luque², Mitndbaim Parra³, Alejandro Escudero Contreras⁴, María Dolores López-Montilla⁵ and Clementina López Medina⁶, ¹¹. Rheumatology Department, Reina Sofía University Hospital, Cordoba/IMIBIC/University of Cordoba., Spain, Spain, ²Reina Sofia University Hospital, CÓRDOBA, Andalucia, Spain, ³¹. Rheumatology Department, Reina Sofía University Hospital, Cordoba/IMIBIC/University of Cordoba., Cordoba, Spain, ⁴IMIBIC / Reina Sofia Hospital / University of Cordoba, Córdoba, Spain, ⁵Rheumatology Department, Reina Sofía University Hospital, Cordoba/IMIBIC/University of Cordoba., CORDOBA, Spain, ⁶Department of Medicine, Hospital Universitario Reina Sofia, University of Cordoba, IMIBIC, Cordoba, Spain
Background/Purpose: Psoriatic arthritis (PsA) is a debilitating disease that occurs in up to one-third of patients with psoriasis (Pso), generally manifesting after the onset of…
Abstract Number: 2115 • ACR Convergence 2025
METHOFRACT, a methotrexate osteopathy multicentric binational cohort study.
François ROBIN¹, Roba Ghossan², Nadia Mehsen-Cetre³, Louise Triquet¹, Guillaume LARID⁴, Guillaume Coiffier⁵, Marine Mina⁶, Marie-Eva Pickering⁷, Claire Barthe⁸, Julien Paccou⁹, Julien Herman¹⁰, Emmanuel Massy¹¹, Isabelle Roitg¹², Martine Branquet¹³, Julien Lasnier Siron³, Manon Guillouard¹⁴, Camille Desmonet Trousset¹⁵, Aurore Aubrun¹⁶, Bertrand Godfrin¹⁷, Jean-Philippe Hauzeur¹⁸, Emmanuel Chatelus¹⁹, Eugénie Koumakis², Jean-Louis Legrand²⁰, Thierry Schaeverbeke³, Alexia Leloix¹, Maeva Masson²¹, Julia Nicolau¹⁵, Charles Ghiringhelli²², Marijke Decrock¹², Durel Cécile-Audrey²³, Béatrice Bouvard²⁴, Bernard Cortet⁹, Charlotte Casadepax-Soulet²⁵, Olivier Malaise⁶, Rose Marie Javier²⁶, Karine Briot² and Pascal Guggenbuhl¹, ¹Rennes University Hospital, Rennes, France, ²APHP, Paris, France, ³Bordeaux University Hospital, Bordeaux, France, ⁴Poitiers University Hospital - Poitiers University - LITEC Laboratory UR ¹⁵⁵⁶⁰, Poitiers, France, ⁵Dinan Hospital, Dinan, France, ⁶Liege University Hospital, Liège, Belgium, ⁷Clermon-Ferrand University Hospital, Clermont-Ferrand, France, ⁸Clinique Tivoli Ducos, Bordeaux, France, ⁹Lille University Hospital, Lille, France, ¹⁰La Roche Sur Yon Hospital, La Roche-sur-Yon, France, ¹¹Lyon University Hospital, Lyon, France, ¹²Perpignan Hospital, Perpignan, France, ¹³Ploemeur Rheumatology Liberal Structure, Ploemeur, France, ¹⁴Aurillac Hospital, Aurillac, France, ¹⁵Dieppe Hospital, Dieppe, France, ¹⁶Nice Rheumatology Liberal Stucture, Nice, France, ¹⁷St Gaudens Rheumatology Liberal Structure, St Gaudens, France, ¹⁸Liege University Hospital, Liege, Belgium, ¹⁹Department of Rheumatology, University Hospital Strasbourg, France, Strasbourg, France, ²⁰Arras Hospital, Arras, France, ²¹Toulouse University Hospital, Toulouse, France, ²²Pauillac Rheumatology Liberal Structure, Pauillac, France, ²³Saint Joseph Saint Luc Hospital, Lyon, France, ²⁴Angers University Hospital, Angers, France, ²⁵West Reunion Hospital, Saint Paul, France, ²⁶Strasbourg University Hospital, Strasbourg, France
Background/Purpose: Methotrexate-induced osteopathy is a rare condition. The clinical presentation is often typical, associating lower limb involvement with metaphyseal bone fractures/cracks, mainly of the tibia…
Abstract Number: 0852 • ACR Convergence 2024
3-dimensional Shape Changes of the Knee over 4 Years Are Linear and Progressive but Much More Rapid in Osteoarthritic Joints: Data from the Osteoarthritis Initiative
Alan Brett¹, Philip G Conaghan² and Michael Bowes³, ¹Imorphics, Austin, TX, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ³Imorphics, Manchester, United Kingdom
Background/Purpose: The specific bony changes of osteophyte growth and “bone attrition” (broadening and flattening of the femoral condyles) associated with OA have been recognized in…
Abstract Number: 0418 • ACR Convergence 2023
Synovial Fluid Cell Counts Associated with Joint Histopathology in Rheumatoid Arthritis
Edoardo Spolaore¹, Edward DiCarlo², Daniel Ramirez², Melanie Smith², Amit Lakhanpal², Bella Mehta³, Laura Donlin², Susan Goodman² and Dana Orange⁴, ¹HSS, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ⁴The Rockefeller University, New York, NY
Background/Purpose: While analysis of synovial fluid white blood cell counts (WBCs) is performed in clinical practice for diagnosing septic arthritis and differentiating noninflammatory from inflammatory…
Abstract Number: 0503 • ACR Convergence 2023
Spinal Inflammation a Dominant Pathology in Psoriatic Arthritis: Characterization and Quantification by In-Vivo 18F-FDG Total-Body PET/CT Imaging
Siba Raychaudhuri¹, Yasser Abdelhafez², Dario Mazza², Smriti K Raychaudhuri³ and Abhijit Chaudhari⁴, ¹UC Davis, School of Medicine/ VA Medical Center, Sacramento, Davis, CA, ²University of California Davis, Sacramento, CA, ³VA Sacramento Medical Center, Mather, CA, ⁴UC Davis School of Medicine, Sacramento, CA
Background/Purpose: Right and Moll recognized the presence of spinal inflammation/axial disease in psoriatic arthritis (PsA) in their seminal work in 1973. The prevalence of axial…
Abstract Number: 0862 • ACR Convergence 2023
Role of CRTAC1 as a Biomarker of Osteoarthritis
Aneta Pekacova¹, Jiri Baloun², Adela Navratilova³, Lucia Ondrejcakova⁴, Jana Zborovjanova⁴, Petr Fulin⁵, Rastislav Ballay⁶, Michal Tomcik⁷ and Ladislav Senolt⁸, ¹First faculty of medicine, Charles University, Prague, Czech Republic, ²Institute of Rheumatology, Prague, Czech Republic, ³Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Hlavní město Praha, Czech Republic, ⁴Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ⁵First Department of Orthopaedics, First Faculty of Medicine of Charles University and Motol University Hospital, Prague, Czech Republic, ⁶First Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, ⁷Institute of Rheumatology, Prague, Czech Republic, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ⁸Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Praha, Czech Republic
Background/Purpose: Cartilage acidic protein-1 (CRTAC1) has been recently considered a promising biomarker of osteoarthritis (OA) progression (1,2). The aim of this study is to compare…
Abstract Number: 1630 • ACR Convergence 2023
Patient-Reported Fatigue Associated with Joint Histopathology in Rheumatoid Arthritis
Diyu Fisher¹, Dana Orange², Melanie Smith³, Bella Mehta⁴, Edoardo Spolaore⁵, Edward DiCarlo³, Dongmei Sun³, Laura Donlin³ and Susan Goodman³, ¹Stony Brook Medicine, Port Jefferson Station, NY, ²The Rockefeller University, New York, NY, ³Hospital for Special Surgery, New York, NY, ⁴Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ⁵HSS, New York, NY
Background/Purpose: Fatigue or tiredness is an important symptom for patients with rheumatoid arthritis (RA), yet the factors associated with fatigue are poorly understood and may…
Abstract Number: 1919 • ACR Convergence 2023
Arthroplasty Outcomes in Immune Checkpoint Inhibitor-Treated Patients: A Single Center Series
Yasmine Elfarra¹, Edward DiCarlo², Jonathan Vigdorchik², Carlos Aude³, Nilasha Ghosh³, Anne Bass³ and Karmela Kim Chan², ¹Weill Cornell, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Hospital for Special Surgery, Weill Cornell Medicine, New York, NY
Background/Purpose: Immune checkpoint inhibitors (ICI) have changed the landscape of cancer treatment dramatically, but because of their mechanism of action they are also known to…
Abstract Number: 2066 • ACR Convergence 2023
Ultrasound Guided Synovial Biopsy Course: Achievement of Learner Self Efficacy
Diane Horowitz¹, Darren Tabechian², Ami Ben-Artzi³, Karina Torralba⁴ and Arthur Mandelin⁵, ¹Northwell Health, Great Neck, NY, ²University of Rochester Medical Center, Rochester, NY, ³Ami Ben Artzi, MD, San Diego, CA, ⁴Loma Linda University, Loma Linda, CA, ⁵Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Ultrasound guided synovial biopsy (UGSB) is a minimally invasive, safe and effective tool to obtain synovium for clinical and research purposes. Described in Europe…
Abstract Number: 0726 • ACR Convergence 2021
Joint Safety of Tanezumab versus NSAIDs; A Combined Assessment of Benefit and Harm
Robert Fountaine¹, Robert Dworkin², Anne Hickman¹, Glenn Pixton³, Ed Whalen⁴, Christine West¹ and Kenneth Verburg¹, ¹Pfizer Inc., Groton, CT, ²University of Rochester, Rochester, NY, ³Pfizer Inc., Morrisville, NC, ⁴Pfizer Inc., New York, NY
Background/Purpose: Tanezumab, a monoclonal antibody against nerve growth factor, is in development for the relief of signs and symptoms of moderate to severe osteoarthritis (OA)…
Abstract Number: 1890 • ACR Convergence 2021
Cellular Origin and Functions of Osteoclasts in Inflammatory Arthritis
Hannah Nelson¹, Ellen Gravallese², Julia Charles¹ and Christian Jacome-Galarza¹, ¹Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA
Background/Purpose: Inflammatory arthritis (IA) is an autoimmune disease targeting multiple joints and characterized by joint destruction caused by osteoclasts (OC), leading to physical disability. However,…
Abstract Number: 1897 • ACR Convergence 2021
A Randomized Double-Blind Controlled Trial of Intensive Serum Urate Lowering with Oral Urate-Lowering Therapy for Erosive Gout
Nicola Dalbeth¹, Anthony Doyle¹, Karen Billington¹, Gregory Gamble¹, Paul Tan¹, Kieran Latto¹, Trish Parshu Ram¹, Ravi Narang¹, Rachel Murdoch¹, David Bursill¹, Borislav Mihov¹, Lisa Stamp² and Anne Horne¹, ¹University of Auckland, Auckland, New Zealand, ²University of Otago, Christchurch, Christchurch, New Zealand
Background/Purpose: Bone erosion is a common consequence of tophaceous gout, and leads to joint deformity and disability. In small case series, intensive urate-lowering with intravenous…
Abstract Number: 1854 • ACR Convergence 2020
NGF/TrkA System Regulates Pain and the Pannus Formation: Targeting NGF-TrkA in Psoriatic Arthritis
Siba Raychaudhuri¹ and Smriti Raychaudhuri², ¹UC Davis, School of Medicine, Davis, CA, ²VA Sacramento Medical Center, Davis, CA
Background/Purpose: Function of Nerve Growth Factor (NGF) in the nervous system and its regulatory role in pain is well defined. We have shown earlier that…

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