Abstracts tagged "osteoporosis"

Abstract Number: 0445 • ACR Convergence 2021
Safety and Efficacy of Denosumab vs Risedronate in Patients with Glucocorticoid-Induced Osteoporosis and Rheumatoid Arthritis
Jonathan Adachi¹, Arkadi Chines², Shuang Huang², Kenneth Saag³, Willem Lems⁴ and Piet Geusens⁵, ¹McMaster University/St. Joseph's Healthcare, Hamilton, ON, Canada, ²Amgen Inc., Thousand Oaks, CA, ³University of Alabama at Birmingham, Birmingham, AL, ⁴VUmc, Amsterdam, Netherlands, ⁵Maastricht University, Genk, Belgium
Background/Purpose: Denosumab (DMAb) is approved for the treatment of glucocorticoid (GC)–induced osteoporosis (GiOP). In a phase 3, international, active-controlled, double-blind, double-dummy study, treatment with DMAb…
Abstract Number: 0446 • ACR Convergence 2021
Clinical Characteristics, Including History of Myocardial Infarction and Stroke, Among US PMO Women Initiating Treatment with Romosozumab and Other Anti-osteoporosis Therapies
Jay Lin¹, Carrie Nielson¹, Mary Oates¹, Cynthia Deignan² and Zhigang Yu¹, ¹Amgen Inc., Thousand Oaks, CA, ²Amgen, Inc., Agoura Hills, CA
Background/Purpose: This study is an ongoing USFDA post-marketing requirement (2020-2024) to assess the impact of boxed warning on romosozumab (romo) treatment and the feasibility of…
Abstract Number: 0447 • ACR Convergence 2021
Bone Anabolic Effects of a Novel Orally-Available Small Molecule SIK2/SIK3 Inhibitor
Cheng-Chia Tang¹, Shiv Verma¹, Steve De Vos², David Amantini³, Philippe Clement-Lacroix³, Nicolas Desroy³, Antonio Speziale⁴, Daniel Brooks⁵, Mary Bouxsein⁵, Janaina da Silva Martins¹, Yingshe Zhao⁶, Henry Kronenberg¹ and Marc Wein¹, ¹MGH Endocrine Unit, Boston, MA, ²Galapagos NV, Mechelen, Belgium, ³Galapagos SASU, Romainville, France, ⁴Galapagos GmbH, Basel, Switzerland, ⁵Beth Israel Deaconess Medical Center, Boston, MA, ⁶MGH Endocrine Unnit, Boston, MA
Background/Purpose: Orally-available bone anabolic agents represent a major unmet medical need for patients with osteoporosis. Widespread use of parathyroid hormone (PTH)-based osteo-anabolic therapies is limited…
Abstract Number: 0448 • ACR Convergence 2021
Bone Microarchitecture Assessed by 3D High-resolution Peripheral Quantitative Computed Tomography (HR-pQCT) as Predictor of Incident Fracture in Rheumatic Disease Patients on Long-term Glucocorticoid- a Five-year Longitudinal Study
ho SO¹, Xerox Lau¹, Vivian Hung¹, Steve Pang², Shirley Ying³, Kitty Kwok⁴, Ka Lai Lee⁵, Jolly Lee⁶, Jack Lee¹, James Griffith¹, Ling Qin¹ and Lai-Shan Tam⁷, ¹The Chinese University of Hong Kong, Hong Kong, Hong Kong, ²Kwong Wah Hospital, Hong Kong, Hong Kong, ³Prince Margaret Hospital, Hong Kong, Hong Kong, ⁴Queen Elizabeth Hospital, Hong Kong, Hong Kong, ⁵Pamela Youde Nethersole Eastern Hospital, Hong Kong, Hong Kong, ⁶Tai Po Hospital, Hong Kong, Hong Kong, ⁷Department of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China (People's Republic)
Background/Purpose: Impaired bone quality and strength estimated by high resolution peripheral quantitative computer tomography (HR-pQCT) in patients with rheumatic diseases on long-term glucocorticoid (LTGC) therapy…
Abstract Number: 0653 • ACR Convergence 2021
Adherence to the 2015 ACR Guidelines for the Management of Polymyalgia Rheumatica and Screening for Osteoporosis at a Tertiary Care Medical Center
Padmini Parameswaran¹ and Michael Lucke², ¹Allegheny Health Network Medical Education Consortium, Pittsburgh, PA, ²Allegheny Health Network, Pittsburgh, PA
Background/Purpose: Since the first description of polymyalgia rheumatica (PMR) in the early 1950s, the ideal dose and duration of glucocorticoid therapy has varied. In 2015,…
Abstract Number: 1135 • ACR Convergence 2021
Osteoporosis Assessment and Outcomes in Candidates for Liver Transplantation in a Tertiary Center
Cristina Rodríguez-Alvear¹, MARIANO ANDRES¹, Maria-Luisa Peral-Garrido², Irene Calabuig³, Ernesto Tovar-Sugrañes¹, Mari-Carmen López-González¹, Pilar Bernabeu¹, Agustín Martínez-Sanchis¹, Ximo Esteve¹, Paloma Vela¹, Cayetano Miralles¹ and Maria Vega Jovani Casano⁴, ¹Hospital General Universitario de Alicante-ISABIAL, Alicante, Spain, ²Hospital General Universitario de Alicante-ISABIAL, Novelda, Spain, ³Hospital General Universitario de Alicante, Alicante, Spain, ⁴National Health system, Alicante, Spain
Background/Purpose: A rapid loss of bone mass and an increase in fractures have been described in the first six months after liver transplantation. This phenomenon…
Abstract Number: 1137 • ACR Convergence 2021
REMS Technology for the Assessment of Bone Health in a Male Population
Delia Ciardo¹, Paola Pisani¹, Fiorella Anna Lombardi¹, Marco Di Paola¹, Roberto Franchini¹, Maurizio Muratore², Francesco Conversano¹ and Sergio Casciaro¹, ¹National Research Council, Institute of Clinical Physiology, Lecce, Italy, Lecce, Italy, ²Vito Fazzi Hospital, ASL-LE, O.U. of Rheumatology, Lecce, Italy, Lecce, Italy
Background/Purpose: This study aimed to evaluate the diagnostic accuracy of the ultrasound-based densitometric technology called Radiofrequency Echographic Multi Spectrometry (REMS) in the diagnosis of osteoporosis…
Abstract Number: 1138 • ACR Convergence 2021
Assessing Trends in Dual Energy X-Ray Absorptiometry (DXA) Utilization Among Medical Providers in the United States
Timothy Edgil¹, Kenneth Saag², Jeffrey Curtis³ and Maria I. Danila², ¹Division of General Internal Medicine, University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham, AL, ³Division of Clinical Immunology and Rheumatology, Department of Medicine, Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: The twenty first century has seen falling reimbursement rates for dual energy X-ray absorptiometry (DXA) testing coupled with a rising elderly population in the…
Abstract Number: 1139 • ACR Convergence 2021
Fracture Liaison Service Outcomes at a Southern California County Hospital Highlights Need for Health System Improvements
Muntarin Karim¹, lorien ahn², Jordan Thompson¹, Christina Downey³, Lorena Salto⁴ and Karina Torralba⁵, ¹Loma Linda University, Redlands, CA, ²loma linda university medical center, Loma Linda, CA, ³Loma Linda University Medical Center, Redlands, CA, ⁴Loma Linda University Health, Loma Linda, CA, ⁵Division of Rheumatology, Department of Medicine, Loma Linda University Healthcare, Loma Linda, CA
Background/Purpose: Osteoporosis causes significant morbidity and mortality in the elderly. Despite the benefits of treatment, < 25% of elderly patients who fracture receive treatment. A…
Abstract Number: 0112 • ACR Convergence 2020
Description of Risk Factors at Baseline and Need of Bone Agent According to Hadji Recommendations in Patients Taking Aromatase Inhibitors as Breast Cancer Therapy
David Montero-Seisdedos¹, Oihane Ibarguengoitia-Barrena², Lucía Vega-Álvarez², Carmen Lucía García Gomez², Itziar Calvo-Zorrilla³, Juan M. Blanco-Madrigal², Maria Esther Ruiz-Lucea², María Luz García-Vivar², Eva Galindez-Agirregoikoa², Ana R. Inchaurbe-Pellejero², Olaia Fernandez-Berrizbeitia², Clara E. Perez-Velasquez², Eduardo Cuende-Quintana⁴, Amaia Bilbao-González³ and Iñaki Torre-Salaberri³, ¹Basurto University Hospital, Bilbao, Pais Vasco, Spain, ²Basurto University Hospital, Bilbao, Spain, ³University Hospital of Basurto, Bilbao, Pais Vasco, Spain, ⁴Basurto University Hospital, Madrid, Spain
Background/Purpose: A well-known adverse effect of aromatase inhibitors (AI) in the bone is the loss of mineral density with the consequent increased risk of fracture…
Abstract Number: 0131 • ACR Convergence 2020
Analysis of the Total Body Composition in a Cohort of Patients with Elderly Onset Arthritis
Anahy María Brandy García¹, Melania Martinez-Morillo², Agueda Prior³, Rosa Serrano¹, Lourdes Mateo⁴, Monica Guma⁵ and Laia Gifre², ¹Hospital Germans Trias i Pujol, Badalona, Spain, ²Hospital Germans Trias i Pujol, Barcelona, Spain, ³Department of Rheumatology, Hospital Germans Trias i Pujol, Badalona, Spain, ⁴Department of Rheumatology, Germans Trias i Pujol. University Hospital, Badalona, Badalona, ⁵University of California San Diego, La Jolla, CA
Background/Purpose: Inflammatory arthritis in the elderly leads to greater comorbidity than that of the young patients, however, there are few data on body composition in…
Abstract Number: 1590 • ACR Convergence 2020
Bone Health in ANCA – Associated Vasculitis Patients
Deepa Ragesh Panikkath¹, Sandy Lee² and Christina Downey², ¹Loma Linda University Health, Department of Rheumatology, Loma Linda, CA, ²Loma Linda University Medical Center, Redlands, CA
Background/Purpose: Glucocorticoids (GC) are an important mode of therapy in ANCA associated vasculitis (AAV), and osteoporosis (OP) and fractures are potential adverse effects seen. The…
Abstract Number: 0113 • ACR Convergence 2020
Improving Glucocorticoid-Induced Osteoporosis Screening and Management in Patients with Rheumatic Diseases Using the 2017 ACR Guidelines
Marielys Figueroa Sierra¹, Atefeh Vafa¹, Shu Cao², Yuanyuan Lu³, Helen Bateman⁴, John Carter¹, Yih Chang Lin², Raquel Cuchacovich¹, Marcos Maldonado⁴, Joanne Valeriano-Marcet¹ and Gabriela Montes-Rivera⁴, ¹University of South Florida, Tampa, FL, ²University of South Florida, Morsani College of Medicine, Tampa, FL, ³Biostatistician at Graduate Medical Education Department, Tampa, FL, ⁴James A. Haley VA, Tampa, FL
Background/Purpose: Glucocorticoid-induced osteoporosis (GIOP) is a potentially preventable complication in those who are maintained on glucocorticoid (GC) therapy. It is imperative to identify these patients…
Abstract Number: 0132 • ACR Convergence 2020
Prevalence of Osteoporosis and Fragitlity Fractures Is Not Different Between ACPA Positive Patients Compared to ACPA Negative Patients in a Real World Setting, Despite Longer Disease Duration and Glucocorticoid-Treatment
Edgar Wiebe¹, Desiree Freier¹, Dörte Huscher², Gloria Dallagiacoma³, Sandra Hermann¹, Robert Biesen⁴, Gerd Burmester⁵ and Frank Buttgereit⁶, ¹Charité University Medicine Berlin, Dep. of Rheumatology and Clinical Immunology, Berlin, Germany, ²Charité University Medicine Berlin, Dep. of Biometry and Clinical Epidemiology, Berlin, Germany, ³University of Verona, Dep. of Rheumatology, Verona, Italy, ⁴Charité University Medicine, Dep. of Rheumatology and Clinical Immunology, Berlin, ⁵Charité University Hospital Berlin, Berlin, Germany, ⁶Charité University Medicine, Berlin, Germany
Background/Purpose: Rheumatoid arthritis (RA) is associated with increased systemic bone loss, leading to a high risk for hip, vertebral and non-hip, non-vertebral fractures. Especially ACPA…
Abstract Number: 1591 • ACR Convergence 2020
A Quality Improvement Project to Increase Vitamin D Prescribing for Pediatric Patients on Glucocorticoids
Katherine Kaufman¹, Mary Buckley¹, Laura Cannon¹, Rachel Randell¹, Philip Chu¹, Mithu Maheswaranathan¹, Andrew Johannemann¹, D Ryan Anderson¹, Isaac Smith¹, Akrithi Udupa¹ and David Leverenz¹, ¹Duke University, DURHAM, NC
Background/Purpose: Chronic glucocorticoid treatment in children increases the risk of bone loss, fractures, and reduced adult skeletal mass. The 2017 ACR Glucocorticoid-Induced Osteoporosis (GIOP) guidelines…

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