Abstracts tagged "osteoporosis"

Abstract Number: 1973 • ACR Convergence 2020
Treatment Sequences with Romosozumab Before or After Antiresorptive Medication
Felicia Cosman¹, David Kendler², Bente Langdahl³, Benjamin Z Leder⁴, E Michael Lewiecki⁵, Akimitsu Miyauchi⁶, Maria Rojeski⁷, Michele McDermott⁷, Mary Oates⁷, Cassandra E Milmont⁸, Cesar Libanati⁹ and Serge Ferrari¹⁰, ¹Columbia University, New York, NY, ²University of British Columbia, Vancouver, BC, Canada, ³Aarhus University Hospital, Aarhus, Denmark, ⁴Mass General Hospital, Harvard Medical School, Boston, MA, Boston, MA, ⁵New Mexico Clinical Research & Osteoporosis Center, Albuquerque, NM, ⁶Miyauchi Medical Center, Osaka, Japan, ⁷Amgen Inc., Thousand Oaks, CA, ⁸Amgen Inc., Thousand Oaks, ⁹UCB Pharma, Brussels, Belgium, ¹⁰Geneva University Hospital, Geneva, Switzerland
Background/Purpose: Prior studies of anabolic/antiresorptive treatment sequences indicate that using teriparatide first followed by an antiresorptive results in greater bone mineral density (BMD) gains, particularly…
Abstract Number: 0115 • ACR Convergence 2020
Improving Osteoporosis Screening in Men at a Resident-run Primary Care Clinic: A Quality Improvement Project
Khiem Vu¹, Chima Ohadugha¹, Kevin Dao¹, Rabih Nayfe² and Andrew Mangano¹, ¹Grand Strand Medical Center, Myrtle Beach, SC, ²Carolina Health Specialists - Rheumatology, Myrtle Beach, SC
Background/Purpose: There are known indications for osteoporosis screening in women. However, osteoporosis also occurs in men and fragility fractures are linked to increased morbidity and…
Abstract Number: 0188 • ACR Convergence 2020
The Risk of Fractures in a Community-based Cohort of Patients with Rheumatoid Arthritis Compared with the Background Population
Lisa Theander¹, Jan Åke Nilsson², Minna Willim³, Lennart T.H. Jacobsson⁴ and Carl Turesson⁵, ¹Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Sweden, Malmö, Sweden, ²Rheumatology, Department of Clinical Sciences, Malmö, Lund University. Department of Rheumatology, Skåne University Hospital, Malmö and Lund, Sweden, Malmö, Sweden, ³Rheumatology, Department of Clinical Sciences, Lund, Lund University. Department of Rheumatology, Skåne University Hospital, Malmö and Lund, Sweden, Malmö, Sweden, ⁴Rheumatology, Department of Clinical Sciences, Malmö, Lund University. Department of Rheumatology and inflammation research, Institute of Medicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden., Gothenburg, Sweden, ⁵Rheumatology, Department of Clinical Sciences Malmö, Lund University, Department of Rheumatology, Skåne University Hospital, Malmö, Sweden., Malmö, Sweden
Background/Purpose: Rheumatoid Arthritis (RA) has been associated with increased risk of osteoporosis and fractures. We have recently presented results on DXA measurements over 10 years…
Abstract Number: 1974 • ACR Convergence 2020
Validation of a Deep Learning Based Algorithm to Diagnose Vertebral Compression Fractures
John Page¹, Franklin Moser², Marcel Maya³, Ravi Prasad³ and Barry Pressman², ¹Amgen, Inc, Thousand Oaks, CA, ²Cedars-Sinai Medical Center, Los Angeles, CA, ³Cedars-Sinai Medical Center, Los Angeles
Background/Purpose: Vertebral Compression Fractures are common in patients above age 50, but are often undiagnosed. Patients with one VCF are at higher risk of other…
Abstract Number: 1167 • 2019 ACR/ARP Annual Meeting
To Evaluate Spine Ankylosis, Vertebral Fractures and Bone Fragility on a Single Imaging Exam in Patients with Ankylosing Spondylitis: Myth or Reality?
caroline Morizot¹, Marine Fauny ², Edem Allado ³, Frank Verhoeven ⁴, Eliane Albuisson ⁵, Astrid Pinzano-Watrin ⁶, Isabelle Chary-Valckenaere ⁵ and Damien Loeuille ⁷, ¹Department Of rheumatology, Vandoeuvre les Nancy, Lorraine, France, ²CHU Nancy, Vandoeuvre, France, ³CHRU Nancy, VANDOEUVRE, France, ⁴Univeristy of Franche comté, Besancon, France, ⁵Centre Hospitalier Universitaire de Nancy, VANDOEUVRE, France, ⁶IMoPA. UMR 7365 CNRS, Vandoeuvre, France, ⁷Rheumatology, Nancy University Hospital and and UMR 7365 CNRS-UL IMoPA, Université de Lorraine, VANDOEUVRE, France
Background/Purpose: Spine ankylosis is a risk factor of osteoporosis and mortality in ankylosing spondylitis (AS). Recently, thoracic-abdomino-pelvic CT (TAP-CT) has demonstrated its ability to screen…
Abstract Number: 2213 • 2019 ACR/ARP Annual Meeting
Evaluation of Factors Associated with Bone Structure in an SLE Cohort Measured by Clinical 3T MRI and DEXA
Amit Saxena¹, Peter Izmirly ², Jill Buyon ², Stephen Honig ², Xiaoliu Zhang ³, Punam Saha ⁴, H. Michael Belmont ⁵ and Gregory Chang ², ¹New York University School of Medicine, New York, NY, ²NYU School of Medicine, New York, ³University of Iowa, Iowa City, ⁴University of Iowa Healthcare, Iowa City, ⁵New York University School of Medicine, Ney York
Background/Purpose: Osteoporosis and bone fractures are a frequent cause of morbidity in systemic lupus erythematosus (SLE), and are felt to be related both to disease…
Abstract Number: 2730 • 2019 ACR/ARP Annual Meeting
Efficacy and Safety of Romosozumab vs Placebo Among Patients with Mild-to-Moderate Chronic Kidney Disease
Paul Miller¹, Arkadi Chines ², Ben-Hur Albergaria ³, Evelien Gielen ⁴, Bente Langdahl ⁵, Akimitsu Miyauchi ⁶, Mark Vanderkelen ⁷, Cassandra Milmont ², Judy Maddox ² and Jonathan Adachi ⁸, ¹Colorado Center for Bone Research at Panorama Orthopedics and Spine Center, Golden, CO, ²Amgen Inc., Thousand Oaks, CA, ³Federal University of Espirito Santo, Vitória, Brazil, ⁴Gerontology and Geriatrics, Department of Chronic Diseases, Metabolism and Aging, KU Leuven & Center for Metabolic Bone Diseases, UZ Leuven, Leuven, Belgium, ⁵Aarhus University Hospital, Aarhus, Denmark, ⁶Miyauchi Medical Center, Osaka, Japan, ⁷UCB Pharma, Brussels, Belgium, ⁸McMaster University and St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada
Background/Purpose: Osteoporosis and renal insufficiency are coexisting disease states in a substantial proportion of postmenopausal women. Since bisphosphonates are generally contraindicated in patients with estimated…
Abstract Number: 1192 • 2019 ACR/ARP Annual Meeting
Effect of a Clinical Decision Support System on a Quality Indicator of Glucocorticoid-induced Osteoporosis and Trends of Drug Treatment in a Japanese Hospital
Hiroki Ozawa¹, Sho Fukui ¹, Genki Kidoguchi ¹, Takehiro Nakai ², Satoshi Kawaai ¹, Ayako Koido ¹, Yukihiko Ikeda ¹, Masei Suda ¹, Haruyuki Yanaoka ¹, Hisanori Shimizu ¹, Hiromichi Tamaki ¹, Tokutaro Tsuda ¹, Mitsumasa Kishimoto ³, Kenichi Yamaguchi ¹ and Masato Okada ¹, ¹St.Luke International Hospital Immuno-Rheumatology Center, Tokyo, Japan, ²St.Luke International Hospital Immuno-Rheumatology Center, Tokyo, Tokyo, Japan, ³Immuno-Rheumatology Center, St. Luke’s International Hospital, Tokyo, Japan
Background/Purpose: Glucocorticoid-induced osteoporosis (GIOP) is a common, preventable and treatable complication of glucocorticoid therapy. We defined quality indicator (QI) for GIOP and took a hospital-wide…
Abstract Number: 2214 • 2019 ACR/ARP Annual Meeting
Assessment of Bone Quality by Trabecular Bone Score (TBS) in Systemic Lupus Erythematosus Patients
Andrea Casabella ¹, Sabrina Paolino ², Alberto Sulli³, Elisa Alessandri ⁴, Vanessa Smith ⁵, Barbara Ruaro ⁶, Carmen Pizzorni ² and Maurizio Cutolo ⁷, ¹1 Research Laboratory and Academic Division of the Clinical Rheumatology Department of Internal Medicine, University of Genova, IRCCS San Martino Polyclinic Hospital, Genoa, Italy, Genoa, Italy, ²Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS San Martino Polyclinic Hospital, Genoa, Italy, Genoa, Italy, ³Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, Genoa, Italy, ⁴Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS San Martino Polyclinic Hospital, Genoa, Italy, Genova, ⁵Dept. of Rheumatology, Ghent University Hospital, Ghent, Belgium; Dept. of Internal Medicine, Ghent University, Ghent, Belgium; Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC), Ghent, Belgium, Gent, Belgium, ⁶1 Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Ospedale Policlinico San Martino, Genoa, Italy; 2 Cardinal Ferrari Centre, S. Stefano Rheabilitation, Fontanellato (Parma), Italy, Genoa, Italy, ⁷Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, Genoa, Italy
Background/Purpose: Systemic lupus erythematosus (SLE) patients show an increased risk of low bone mass as a result of multifactorial events: physical inactivity, persistent inflammation, low…
Abstract Number: 1333 • 2019 ACR/ARP Annual Meeting
The Comparative Risk of Osteoporotic Fractures Among Patients with Rheumatoid Arthritis Receiving TNF Inhibitors versus Other Biologics: A Nation-wide Cohort Study in Korea
Eun Hye Park¹, Anna Shin ², Yaa-Hui Dong ³, You-Jung Ha ¹, Yun Jong Lee ⁴, Eun Bong Lee ⁵, Yeong-Wook Song ⁶ and Eun Ha Kang ¹, ¹Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea, Seongnam, Republic of Korea, ²Seoul National University Bundang Hospital, Seongnam, Republic of Korea, ³Graduate Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan (Republic of China), ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea, Seongnam, Republic of Korea, ⁵Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, seoul, ⁶Seoul National University Hospital, Seoul, Republic of Korea
Background/Purpose: Rheumatoid arthritis (RA) is associated with an increased risk of osteoporosis and osteoporotic fracture, but little is known about comparative risk of osteoporotic fractures between…
Abstract Number: 2215 • 2019 ACR/ARP Annual Meeting
Modeling-Based Bone Formation Persists in the Femoral Neck Despite Remodeling Inhibition in Subjects Treated with Denosumab
David Dempster¹, Peter Butler ², Mathias Bostrom ³, Jeri Nieves ¹, Hua Zhou ⁴, Li Chen ², Nicola Pannacciulli ², Rachel Wagman ² and Felicia Cosman ¹, ¹Columbia University, New York, NY, ²Amgen Inc., Thousand Oaks, CA, ³Hospital for Special Surgery, New York, NY, ⁴Helen Hayes Hospital, West Haverstraw, NY
Background/Purpose: Denosumab (DMAb) is a potent antiresorptive agent, but findings in non-human primates suggest that modeling-based bone formation (MBBF) may persist despite DMAb treatment (Ominsky…
Abstract Number: 1872 • 2019 ACR/ARP Annual Meeting
Worsening Trends in Osteoporosis Management in the Medicare Population: 2010-2014
Jeffrey Curtis¹, Shanette G. Daigle ², Setareh A. Williams ³, Richard Weiss ³, Yamei Wang ⁴ and Tarun Arora ², ¹University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham, ³Radius Health, Inc, Waltham, ⁴Radius Health, Inc, Waltham
Background/Purpose: Osteoporotic fractures are an important public health burden, and with an increasing aging population, the number of Americans at risk of fractures is projected…
Abstract Number: 2216 • 2019 ACR/ARP Annual Meeting
Bone Mineral Density of the Spine, Hip, and Distal Radius in Patients with Postmenopausal Osteoporosis
KEN NAKASEKO¹, ¹Department of Orthopaedic Surgery and Rheumatology Kuwana City Medical Center, kuwana mie, Japan
Background/Purpose: Bone mineral density (BMD) is used for the diagnosis of osteoporosis, predicting future fracture risk, and monitoring osteoporosis treatment. Osteoporosis is defined as BMD…
Abstract Number: 1873 • 2019 ACR/ARP Annual Meeting
Geisinger HiROC Performance 2017-2018: Continuing to Narrow the Post-Fracture Treatment Gap
Thomas Olenginski¹ and Karen Mackiewicz ², ¹Geisinger Medical Center, Danville, PA, ²Geisinger, Danville, PA
Background/Purpose: The morbidity and mortality of osteoporotic fractures threaten our aging population. Despite advances in new therapies for osteoporosis and technology to more effectively communicate, fewer…
Abstract Number: 2217 • 2019 ACR/ARP Annual Meeting
DEXA Does Not Accurately Reflect FRAX Score in Patients with Autoimmune Disease on Corticosteroids
Sima Terebelo¹, Madina Abduraimova ¹, Latoya Freeman-Beman ¹, Naureen Kabani ², Joshy Pathiparampil ¹, Olga Dvorkina ² and Ellen M Ginzler ³, ¹SUNY Downstate Medical Center, Brooklyn, NY, ²SUNY Downstate Medical Center, Brooklyn, ³State University of New York Downstate Medical Center, Brooklyn, NY
Background/Purpose: Osteoporosis (OP) is a problem in the aging population. Patients with autoimmune disease are at increased risk for OP given their history of steroid…

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