ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "osteoclastogenesis"

  • Abstract Number: 1661 • ACR Convergence 2022

    Osteoclastogenesis and Vascular Endothelial Growth Factor Blood Levels in Patients with Systemic Sclerosis with and Without Calcinosis Cutis

    Antonia Valenzuela1, Guillermo Perez2, Carolina Iturriaga2 and Rebeca Montalva2, 1Pontificia Universidad Catolica de Chile, Santiago, Chile, 2Pontificia Universidad Catolica de Chile, Santiago de Chile, Chile

    Background/Purpose: Calcinosis cutis is a debilitating complication of systemic sclerosis (SSc) with no effective treatments. Although the pathogenesis of SSc-related calcinosis remains unknown, there is…
  • Abstract Number: 0054 • ACR Convergence 2022

    MDSCs in Inflammatory Joints of SKG Mice Suppress T Cells and Differentiate into Osteoclasts

    Yoshikazu Fujikawa1, Sho Sendo2, Takumi Nagamoto3, Yuzuru Yamamoto1, Takaichi Okano4, Keisuke Nishimura3, Yo Ueda5 and Jun Saegusa5, 1Hyogo Prefectural Harima-Himeji General Medical Center, Himeji, Japan, 2University California, San Diego (UCSD), La Jolla, CA, 3Kobe University, Kobe, Japan, 4Kobe University Hospital, Kobe, Japan, 5Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan

    Background/Purpose: Myeloid-derived suppressor cells (MDSCs) are heterogeneous immature myeloid cells with suppressive functions. It is known that MDSCs are expanded in inflammatory sites after migrating…
  • Abstract Number: 0578 • ACR Convergence 2022

    Interleukin-6 Trans-Signaling Induces Synovial Fibroblast Invasiveness by Utilizing Ets2 Protein

    Anil Singh, Paul Panipinto, Farheen Sultan Shaikh and Salahuddin Ahmed, Washington State university, Spokane, WA

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease with a complex interplay of synovial cells and soluble factors that create the signatures of chronic inflammation…
  • Abstract Number: 0588 • ACR Convergence 2022

    S-nitrosoglutathione Reductase (GSNOR) Regulates Osteoclast Differentiation

    Toshihiro Tanioka1, Kohei Maeda1, Rei Takahashi1 and Takeo Isozaki2, 1Division of Pathogenesis and Translational Medicine, Department of Clinical Pharmacy, Showa University School of Pharmacy, Tokyo, Japan, 2Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan

    Background/Purpose: S-nitrosoglutathione (GSNO) reductase (GSNOR) is an enzyme which decomposes GSNO and downregulates protein S-nitrosylation. It has been reported that GSNOR KO mice have enhanced…
  • Abstract Number: 0030 • ACR Convergence 2021

    Interleukin-9 Enhances the Osteoclastogenesis in Rheumatoid Arthritis

    Santanu Kar1, Dipendra Mitra2, Vijay Kumar D1 and Sushmita Chakraborty1, 1AIIMS, New Delhi, India, 2ALL INDIAN INSTITUTE OF MEDICAL SCIENCES, New Delhi, India

    Background/Purpose: Rheumatoid Arthritis (RA) is a chronic inflammatory disease characterized by synovial inflammation leading to bone destruction. Bone erosion in RA results from excessive resorption…
  • Abstract Number: 0996 • ACR Convergence 2021

    The Stimulator of Interferon Genes (STING) Protects from Bone Loss Through Regulation of Tonic and Induced Type I Interferon Pathways

    Susan MacLauchlan1, Priyanka Kushwaha1, Albert Tai2, Jia (Sijia) Chen3, Catherine Manning1, Katherine Fitzgerald4, Shruti Sharma2 and Ellen Gravallese5, 1Brigham and Women's Hospital, Boston, MA, 2Tufts University School of Medicine, Boston, MA, 3Brigham and Women's Hospital, Cambridge, MA, 4University of Massachusetts Medical School, Worcester, MA, 5Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA

    Background/Purpose: The intracellular DNA sensing Stimulator of Interferon Genes (STING) pathway is critical for detection of viral and bacterial pathogen DNA. Hyperactivating mutations in this…
  • Abstract Number: 1472 • ACR Convergence 2021

    Characterization and Function of Tumor Necrosis Factor α and Interleukin-6–Induced Osteoclasts in Rheumatoid Arthritis

    Kazuhiro Yokota1, Kojiro Sato2, Yoshimi Aizaki3, Shinya Tanaka4, Miyoko Sekikawa4, Noritsune Kozu5, Yuho Kadono4, Hiromi Oda6 and Toshihide Mimura7, 1Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, 2Jichi Medical University, Tochigi, Japan, 3Saitama Medical University, Saitama, Japan, 4Department of Orthopaedic Surgery, Saitama Medical University, Saitama, Japan, 5Kozu Orthopaedic Clinic, Chiba, Japan, 6Department of Orthopaedic Surgery, National Hospital Organization Ibusuki Medical Center, Kagoshima, Japan, 7Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama, Japan

    Background/Purpose: We have previously reported that stimulation of mouse bone marrow–derived macrophages with a combination of tumor necrosis factor α (TNFα) and interleukin-6 (IL-6) induces…
  • Abstract Number: 1479 • ACR Convergence 2021

    CD14, a Toll-like Receptor Co-Factor, Influences Osteoclast Differentiation and Activity, but Does Not Alter Osteoblastic Potential of Bone-Marrow Precursors in Mice

    Jerahme Martinez, Vu Nguyen, Cheng Zhou, George Dodge and Carla Scanzello, University of Pennsylvania, philadelphia, PA

    Background/Purpose: Changes in subchondral bone structure (SCB) occur in osteoarthritis (OA), and are visible by imaging as subchondral sclerosis on radiographs, and bone marrow lesions…
  • Abstract Number: 0074 • ACR Convergence 2020

    The Intracellular DNA Sensor STING Protects Against Bone Loss Through Regulation of Type I Interferons

    Susan MacLauchlan1, Catherine Manning2, Sijia Chen3, Katherine Fitzgerald4, Shruti Sharma5 and Ellen Gravallese1, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women’s Hospital, Boston, 3Brigham and Women's Hospital, Boston, 4University of Massachusetts medical school, Worcester, MA, 5Tufts University, Boston, MA

    Background/Purpose: The intracellular DNA sensor Stimulator of Interferon Genes (STING) is essential for detection of viral and bacterial pathogen DNA. As with other pathways in…
  • Abstract Number: 1407 • ACR Convergence 2020

    Resolvin D5 Modulates Th17/Treg Cell Differentiation and Suppresses Osteoclastogenesis

    Hirotaka Yamada1, Jun Saegusa2, Sho Sendo3, Yo Ueda4, Takaichi Okano1, Yoshikazu Fujikawa5, Yuzuru Yamamoto6, Takumi Nagamoto1, Yoshihide Ichise1, Ikuko Naka1, Kengo Akashi7, Akira Onishi7, Masakazu Shinohara1 and Akio Morinobu7, 1Kobe University, Kobe, Japan, 2Department of Clinical Laboratory, Kobe University Hospital, Kobe, Japan, 3Kobe University, Kobe, 4Kobe UniversityRheumatology and Clinical Immunology, Kobe University Hospital, Kobe, Japan, 5Kobe University, Kobe city, Japan, 6Kobe University, Kobe-city, Japan, 7Rheumatology and Clinical Immunology, Kobe University Hospital, Kobe, Japan

    Background/Purpose: Over the last two decades, it has become increasingly clear that resolution of acute inflammation is not a passive process, but requires active modulation.…
  • Abstract Number: 1 • 2019 ACR/ARP Annual Meeting

    Interleukin-6 Promotes Osteoclast-like Phenotype in Human Rheumatoid Arthritis Synovial Fibroblasts

    Anil Singh1, Mahamudul Haque 1, Bhanupriya Madarampalli 2 and Salahuddin Ahmed 3, 1Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, Spokane, WA, 2University of Washington, Seattle, WA, 3Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA. Division of Rheumatology, University of Washington School of Medicine, Seattle, WA, Spokane, WA

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disorder characterized by chronic inflammation and joint destruction caused by pro-inflammatory cytokines. Progressive joint damage is also an…
  • Abstract Number: 25 • 2019 ACR/ARP Annual Meeting

    Altered Distribution and Enhanced Osteoclastogenesis of Mucosal-associated Invariant T Cells in Gouty Arthritis

    Yong-Wook Park1, Young-Nan Cho 1, Hae-Seong Jeong 1, Hye-Mi Jin 1 and Seung-Jung Kee 1, 1Department of Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea

    Background/Purpose: Mucosal-associated invariant T (MAIT) cells are subsets of innate invariant T cells and rapidly produce Th1/Th17 cytokines including interferon (IFN)-γ, tumor necrosis factor (TNF)-α,…
  • Abstract Number: 1948 • 2019 ACR/ARP Annual Meeting

    The Mechanism of DC-STAMP-Mediated Signaling in Cell-Cell Fusion and Osteoclast Maturation

    Ananta Paine1, Kerstin Tiedemann 2, Maria de la luz Garcia-Hernandez 1, Svetlana Komarova 2 and Christopher Ritchlin 1, 1Division of Allergy, Immunology and Rheumatology, Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA, Rochester, NY, 2Faculty of Dentistry, McGill University, Montreal, Quebec, Canada; Shriners Hospital for Children-Canada, Montreal, Quebec, Canada, Montréal, QC, Canada

    Background/Purpose: Osteoclasts (OC) are bone-resorbing, multinuclear cells that originate from myeloid progenitor cells through repetitive cycles of cell-cell fusion. Dendritic cell-specific transmembrane protein (DC-STAMP) is…
  • Abstract Number: 1981 • 2019 ACR/ARP Annual Meeting

    Functional Differences Between Osteoclasts and Osteoclast-like Cells Differentiated from Peripheral Blood Mononuclear Cells in Patients with Rheumatoid Arthritis

    Kazuhiro Yokota1, Yoshimi Aizaki 1, Shinya Tanaka 2, Kojiro Sato 3, Yasuto Araki 1, Noritsune Kouzu 4, Yuho Kadono 2, Hiromi Oda 5 and Toshihide Mimura 1, 1Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, 2Department of Orthopaedic Surgery, Saitama Medical University, Saitama, Japan, 3Division of Rheumatology and Clinical Immunology, Department of Medicine, Jichi Medical University, Tochigi, Japan, 4Medical Kouzu orthopedic and Yachiyo radiation center, Chiba, Japan, 5Department of Orthopedic Surgery, Faculty of Medicine, Saitama Medical University, Saitama, Japan

    Background/Purpose: Osteoclasts (OCs) are giant multinucleated cells formed from precursors of the monocyte/macrophage lineage and are believe to play a major role in the bone…
  • Abstract Number: 2020 • 2019 ACR/ARP Annual Meeting

    Metabolic Changes Induced by Anti-Malondialdehyde Antibodies Promote Osteoclast Development

    Koji Sakurabas1, Akilan Krishnamurthy 2, Cheng Xu 3, Khaled Amara 4, Vivianne Malmström 4, Sergiu-Bogdan Catrina 3, Caroline Grönwall 4, Bence Rethi 5 and Anca Catrina 6, 1Rheumatology unit, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Solna, stockholm, Sweden, 2Rheumatology unit, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Solna, Stockholm, 3Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden, 4Rheumatology Unit, Department of Medicine, Karolinska University Hospital and Institutet, Stockholm, Sweden., Stockholm, Sweden, 5Rheumatology unit Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, Stockholm, 6Rheumatology unit Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden

    Background/Purpose: Malondialdehyde (MDA) is highly reactive compound produced by lipid-peroxidation in situations associated with oxidative stress. MDA can irreversibly modify proteins (e.g. lysine, arginine and histidine…
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