Abstracts tagged "osteoclastogenesis"

Abstract Number: 0050 • ACR Convergence 2024
Elucidating Androgen Effects on Osteoclast Precursor Populations and Osteoclastogenesis
Kiana Chen¹, Lauren Benoodt², Michael Christof³ and Homaira Rahimi⁴, ¹University of Rochester School of Medicine and Dentistry, Rochester, NY, ²University of Rochester Medical Center, Rochester, NY, ³University of Rochester, Irvington, NY, ⁴University of Rochester, Rochester, NY
Background/Purpose: Rheumatoid arthritis (RA) is a female predominant disease characterized by chronic inflammatory erosive joint disease. Androgen, the dominant sex hormone in males, is anti-inflammatory…
Abstract Number: 0058 • ACR Convergence 2024
Bradykinin Receptor B1 Blockade Suppresses Soluble CD13-Induced Differentiation of Osteoclasts from Monocytes
Sei Muraoka¹, Qi Wu², Mikel Gurrea-Rubio³, Camila Amarista², William Brodie², Megan Mattichak², Yuzo Ikari⁴, Caroline Foster², Phillip Campbell², David Fox⁵ and Pei-Suen Tsou², ¹University of Michigan, Toyko, Japan, ²University of Michigan, Ann Arbor, MI, ³University of Michigan - Ann Arbor, Ann Arbor, MI, ⁴Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ⁵University of Michigan, Dexter, MI
Background/Purpose: CD13 is an ectopeptidase expressed on myeloid cells, endothelial cells, and rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS). Soluble (s) CD13 is generated by matrix…
Abstract Number: 0267 • ACR Convergence 2024
IL-17 Participates in the Pathogenesis of Chronic Gouty Arthritis
Hong Di¹, Xinxin Han¹, Yun Zhang² and Xuejun Zeng¹, ¹Peking Union Medical College Hospital, Beijing, China, ²Peking Union Medical College Hospital (CAMS), Beijing, China
Background/Purpose: Chronic gouty arthritis (CGA) is different from acute gouty arthritis (AGA), its main characteristics include repeated or even persistent joint symptoms, tophus and bone destruction.…
Abstract Number: 0400 • ACR Convergence 2024
Osteoclastogenesis from Peripheral Blood Mononuclear Cells in Children with Chronic Nonbacterial Osteomyelitis Are Similar to Those from Healthy Children
Jacqueline Bui¹, Jacob Curry², Jessica Kent³, Payton Danosky⁴, Kellen Sanders⁴, Sriya Paluvayi⁴, Wendy Garcia⁴, Alejandra Ruppe⁴, Megan Cheung⁴, Anna Saack⁴, Xinrui Bao⁴, Audrey Luey⁴, Michelle Kim⁴, Emily McDaniel⁴, Amanda Chiu⁴, Sophia Ahn⁵, Ji-Won Park⁴, Sudheshna Thirunahari⁴, Cammie Wei⁴, Liau Adriel⁵, Sophia Pham⁴, Sadie Van Den Bogaerde⁴, Joshua Scheck⁴, Ian Muse⁶, Ava Klein⁵, Xing Wang⁷, James Cassat⁸ and Yongdong Zhao⁶, ¹Seattle Children’s Research Institute, University of Washington, Bellevue, WA, ²Seattle Children’s Research Institute, Vanderbilt University Medical Center, Seattle, WA, ³Seattle Children’s Research Institute, Medical College of Wisconsin, Seattle, WA, ⁴Seattle Children’s Research Institute, University of Washington, Seattle, WA, ⁵Seattle Children’s Research Institute, University of Washington, Seattle, ⁶Seattle Children's Research institute, Seattle, WA, ⁷Biostatistics Epidemiology and Analytics in Research, Seattle Children’s Research Institute, Seattle, WA, ⁸Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disease in which osteoclastogenesis may play a critical role. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) was shown…
Abstract Number: 2134 • ACR Convergence 2024
PEX5 Acts as a Negative Regulator of RANKL-induced Osteoclastogenesis In Vitro and Inflammatory Calvarial Bone Destruction In Vivo
CHONG HYUK CHUNG¹, Myeung-Su Lee¹, Chang-hoon Lee², Ju-Young Kim³, Yoon-Hee Cheon⁴, So Young Eun³ and Gyeung Do Park³, ¹Wonkwang University Hospital, Iksan, South Korea, ²Wonkwang University Hospital, Iksan Jeonbuk, South Korea, ³Musculoskeletal and Immune Disease Research Institute, School of Medicine, Wonkwang University, Iksan, Republic of Korea, ⁴Musculoskeletal and Immune Disease Research Institute, School of Medicine, Wonkwang University, Iksan, Cholla-bukto, Republic of Korea
Background/Purpose: Peroxisomal biogenesis factor 5 (PEX5) is essential for regulating peroxisome function by recognizing and transporting peroxisome target sequence receptor substrate proteins to peroxisomes. PEX5…
Abstract Number: 1770 • ACR Convergence 2023
Dual Inhibition of TNF-α and OX40L on Synovial Inflammation and Osteoclastogenesis in Rheumatoid Arthritis
Hee Sung Kwon¹, Mi Hyeon Kim², Jeoung Yeon Kim², Seon Uk Kim², Hae Rim Kang¹, Seo Yoon Ban³, Gyong Sik Ha⁴, Chung Min Lee⁴, Jeong Seok Lee⁵ and Eun Young Lee², ¹Interdisciplinary Program in Cancer Biology, Integrated Major in Innovative Medical Science, Seoul National University, Seoul, South Korea, ²Seoul National University College of Medicine, Seoul, South Korea, ³Department of Cancer biology, Graduate School of College of Medicine, Seoul National University, Seoul, South Korea, ⁴Research institute, IMBiologics Corp, Suwon, South Korea, ⁵Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Seoul, South Korea
Background/Purpose: Rheumatoid arthritis (RA) is a chronic, inflammatory disease that leads to progressive cartilage and bone destruction. TNF superfamily member OX40 ligand (OX40L; CD252) is…
Abstract Number: 2150 • ACR Convergence 2023
Novel Biologic IRL201805 Inhibits Osteoclastogenesis in Monocytic Cells from RA Patients
Yuriko Yamamura¹, Valerie Corrigall², Lara Ravanetti³, Jorge De Alba³, Roly Foulkes⁴, Paul Eggleton⁵ and Carl Goodyear⁶, ¹School of Infection & Immunity, University of Glasgow, Glasgow, United Kingdom, ²Revolo Biotherapeutics, Tadworth, United Kingdom, ³Revolo Biotherapeutics, London, United Kingdom, ⁴Revolo Biotherapeutics, Slough, United Kingdom, ⁵Revolo Biotherapeutics, Exeter, United Kingdom, ⁶University of Glasgow, Glasgow, United Kingdom
Background/Purpose: In Rheumatoid arthritis (RA), osteoclasts derived from CD14+ Monocytes are associated with a risk of progressive bone and joint destruction, which fundamentally impacts quality-of-life.…
Abstract Number: 0881 • ACR Convergence 2023
Deficiency of the Pattern-recognition Receptor CD14 Protects Against LPS-induced Inhibition of Osteoclastogenesis in Vitro
Lance Murphy¹, Kevin Burt², Baofeng Hu³, Vu Nguyen², Robert Mauck² and Carla Scanzello², ¹University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA, ³University of Pennsylvania, Wynnewood, PA
Background/Purpose: Osteoarthritis is associated with bone changes such as subchondral sclerosis, bone marrow lesions, and osteophyte formation (Donel S, 2019). Prior work has demonstrated that…
Abstract Number: 1679 • ACR Convergence 2023
Effects of Janus Kinase Inhibitor on TNF-a and IL-6-Induced Osteoclasts and RANKL-Induced Osteoclasts in Peripheral Blood Monocytes from Patients with Rheumatoid Arthritis
Kazuhiro Yokota¹, Yoshimi Aizaki², Takuma Tsuzuki Wada¹, Hiroshi Kajiyama¹, Yasuto Araki², Hiroaki Yazawa², Yuji Akiyama² and Toshihide Mimura¹, ¹Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Iruma-gun, Japan, ²Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan
Background/Purpose: We have previously demonstrated that a combination of TNF-a and IL-6 induces mouse osteoclast-like cells with bone resorption activity both in vitro and in…
Abstract Number: 1736 • ACR Convergence 2023
The Effect of Resolvin E1 and Resolvin D1 Specialised Pro-resolving Mediators on the Inhibition of Osteoclastogenesis
Patricia Riedlova¹, Kieran Woolcock², Cecilia Ansalone² and Carl Goodyear², ¹University of Glasgow - School of Infection & Immunity, Glasgow, United Kingdom, ²University of Glasgow, Glasgow, United Kingdom
Background/Purpose: Osteoclasts (OCs) are multinucleated bone-resorbing cells playing a key role in rheumatoid arthritis (RA). Under physiological conditions, OCs are in balance with bone-forming osteoblasts,…
Abstract Number: 0054 • ACR Convergence 2022
MDSCs in Inflammatory Joints of SKG Mice Suppress T Cells and Differentiate into Osteoclasts
Yoshikazu Fujikawa¹, Sho Sendo², Takumi Nagamoto³, Yuzuru Yamamoto¹, Takaichi Okano⁴, Keisuke Nishimura³, Yo Ueda⁵ and Jun Saegusa⁵, ¹Hyogo Prefectural Harima-Himeji General Medical Center, Himeji, Japan, ²University California, San Diego (UCSD), La Jolla, CA, ³Kobe University, Kobe, Japan, ⁴Kobe University Hospital, Kobe, Japan, ⁵Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan
Background/Purpose: Myeloid-derived suppressor cells (MDSCs) are heterogeneous immature myeloid cells with suppressive functions. It is known that MDSCs are expanded in inflammatory sites after migrating…
Abstract Number: 0578 • ACR Convergence 2022
Interleukin-6 Trans-Signaling Induces Synovial Fibroblast Invasiveness by Utilizing Ets2 Protein
Anil Singh, Paul Panipinto, Farheen Sultan Shaikh and Salahuddin Ahmed, Washington State university, Spokane, WA
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease with a complex interplay of synovial cells and soluble factors that create the signatures of chronic inflammation…
Abstract Number: 0588 • ACR Convergence 2022
S-nitrosoglutathione Reductase (GSNOR) Regulates Osteoclast Differentiation
Toshihiro Tanioka¹, Kohei Maeda¹, Rei Takahashi¹ and Takeo Isozaki², ¹Division of Pathogenesis and Translational Medicine, Department of Clinical Pharmacy, Showa University School of Pharmacy, Tokyo, Japan, ²Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan
Background/Purpose: S-nitrosoglutathione (GSNO) reductase (GSNOR) is an enzyme which decomposes GSNO and downregulates protein S-nitrosylation. It has been reported that GSNOR KO mice have enhanced…
Abstract Number: 1661 • ACR Convergence 2022
Osteoclastogenesis and Vascular Endothelial Growth Factor Blood Levels in Patients with Systemic Sclerosis with and Without Calcinosis Cutis
Antonia Valenzuela¹, Guillermo Perez², Carolina Iturriaga² and Rebeca Montalva², ¹Pontificia Universidad Catolica de Chile, Santiago, Chile, ²Pontificia Universidad Catolica de Chile, Santiago de Chile, Chile
Background/Purpose: Calcinosis cutis is a debilitating complication of systemic sclerosis (SSc) with no effective treatments. Although the pathogenesis of SSc-related calcinosis remains unknown, there is…
Abstract Number: 0030 • ACR Convergence 2021
Interleukin-9 Enhances the Osteoclastogenesis in Rheumatoid Arthritis
Santanu Kar¹, Dipendra Mitra², Vijay Kumar D¹ and Sushmita Chakraborty¹, ¹AIIMS, New Delhi, India, ²ALL INDIAN INSTITUTE OF MEDICAL SCIENCES, New Delhi, India
Background/Purpose: Rheumatoid Arthritis (RA) is a chronic inflammatory disease characterized by synovial inflammation leading to bone destruction. Bone erosion in RA results from excessive resorption…

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