Abstracts tagged "Osteoarthritis"

Abstract Number: 1101 • ACR Convergence 2025
Distinct Clinical Phenotypes of Immune Checkpoint Inhibitor–Associated Arthritis: Comparative Analysis of Inflammatory Arthritis, Polymyalgia Rheumatica-like, Activated Crystalline, and Activated Osteoarthritis
Heba Altarawneh¹, Gregory Challener², Mazen Nasrallah³, Janeth Yinh⁴, Hyon K. Choi⁵ and Minna Kohler⁶, ¹Mass General Hospital, Boston, MA, ²MGH, Boston, MA, ³MGB-Salem Hospital, Lynn, MA, ⁴Massachusetts General Hospital, Boston, MA, ⁵MASSACHUSETTS GENERAL HOSPITAL, Lexington, MA, ⁶Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Immune checkpoint inhibitor (ICI)–associated arthritis has been classified into distinct phenotypes, including inflammatory arthritis (IA), polymyalgia rheumatica (PMR)-like syndrome, activated crystalline arthritis, and activated…
Abstract Number: 0333 • ACR Convergence 2025
Diagnostic Test Accuracy of Artificial Intelligence in Early Diagnosis of Osteoarthritis: A Systematic Review and Meta-Analysis of 45,588 Knees
Mohamed Abdelsalam¹, Hadeer Hafez², Omar Sameh Nabil El Sedafy¹, Nourhan Abouelella³, Ahmed Abdulhafeez Hamza³, Omnia Samy El-Sayed⁴, Mohamed Reda Awad⁵, Gihan Omar³ and Hazem E. Mohammed⁶, ¹Misr University For Science and Technology, ⁶ october, Al Jizah, Egypt, ²⁶th October University, ⁶ october, Al Jizah, Egypt, ³Faculty of Medicine, Misr University for Science and Technology, ⁶ october, Al Jizah, Egypt, ⁴Misr University For Science and Technology, Nasr City, Al Qahirah, Egypt, ⁵Al Azhar University, Cairo, Egypt, Giza, Al Jizah, Egypt, ⁶Faculty of Medicine, Assiut university, Assiut, Egypt, assyut, Asyut, Egypt
Background/Purpose: Artificial intelligence (AI) rapid advancement opens new opportunities in the field of rheumatology. With better imaging, AI may help find early osteoarthritic changes that…
Abstract Number: 0317 • ACR Convergence 2025
“No matter how great my doctor is, he hasn’t had a knee replacement, he doesn’t understand all that pain” Program Evaluation of the Moving Well Peer Coach Intervention for Total Knee Replacement
Cara Murphy¹, Sarah Young², Vanessa Madrigal³, Noelia Hernandez⁴, Daniel Garcia⁵, Yuliana Dominguez Paez⁶, Monika Safford³, Iris Navarro-Millan⁷ and Mackenzie Brown⁸, ¹HSS, New York, NY, ²Weill Cornell Medicine, Johnson City, NY, ³Weill Cornell Medicine, New York, ⁴Weill Cornell Medicine, New York, NY, ⁵Weill Cornell, Brooklyn, NY, ⁶Albert Einstein College of Medicine, The Bronx, NY, ⁷Weill Cornell Medicine, Hospital for Special Surgery, Poughkeepsie, NY, ⁸Weill Cornell Medicine, Brooklyn, NY
Background/Purpose: Moving Well was a pre-habilitation peer coach intervention aimed at reducing levels of anxiety, depression, and pain among individuals undergoing total knee replacement (TKR)1.…
Abstract Number: 2102 • ACR Convergence 2025
Construct Validity of the Six-Minute Walk Test in Knee Osteoarthritis
Sivakami Mylvaganam¹, Ian stanaitis², Gillian Hawker³ and Lauren King³, ¹Department of Medicine, University of Toronto, Toronto, Canada, ²Research and Innovation Institute, Women’s College Hospital, Toronto, ON, Canada, Toronto, ON, Canada, ³University of Toronto, Toronto, ON, Canada
Background/Purpose: Knee osteoarthritis (OA) significantly affects physical function, making function a core outcome in OA research. The Osteoarthritis Research Society International recommends the six-minute walk…
Abstract Number: 2085 • ACR Convergence 2025
Estimating the Association between Effusion-synovitis and Knee Pain in a Subset of Participants with Radiographic Knee Osteoarthritis: Data from the Osteoarthritis Initiative (OAI)
Dagoberto Robles¹, Greg Gilles², Nathaniel H. Christiansen³, Luke Grawer⁴, Karim Jayyusi⁴, Ali Shaikh⁴, Rongrong Tang⁵, Mihra S. Taljanovic⁴, Jeffrey Duryea⁶, Edward J. Bedrick⁵ and C. Kent Kwoh⁷, ¹University of Arizona, Tucson, AZ, ²University of Arizona Arthritis Center, The University of Arizona College of Medicine, Tucson, AZ, ³University of Arizona, Stockton, NJ, ⁴University of Arizona, Tucson, ⁵The University of Arizona Arthritis Center, University of Arizona, Tucson, ⁶Brigham and Women’s Hospital, Boston, MA, ⁷The University of Arizona Arthritis Center, University of Arizona, Tucson, AZ
Background/Purpose: Even though knee pain is ubiquitous in knee osteoarthritis (KOA) patients, currently there are limited treatment options which are only minimally or moderately efficacious…
Abstract Number: 1804 • ACR Convergence 2025
Pharmacology of LEVI-04, a novel treatment for OA
Simon Westbrook¹ and Kerry af Forselles², ¹Levicept Ltd, Sandwich, United Kingdom, ²Levicept, Sandwich, United Kingdom
Background/Purpose: LEVI-04 is a novel fusion protein comprising the extracellular domain of p75 neurotrophin receptor (p75NTR) coupled to IgG1 Fc, being developed for the treatment…
Abstract Number: 1782 • ACR Convergence 2025
Mapping The Synovial Innervation Of The Human Knee Joint
alia obeidat¹, Jun Li¹, Spencer Fullam², Roderick Carter², Merissa Olmer³, Bella Mehta⁴, Miguel Otero⁵, Daniel Ramirez⁶, Richard Miller⁷, Dana Orange⁸, Martin Lotz⁹, Rachel Miller¹⁰ and Anne-Marie Malfait², ¹Rush University Medical Center, Chicago, ²rush university, CHICAGO, IL, ³Scripps Research Institute, La Jolla, CA, ⁴Hospital for Special Surgery, Weill Cornell Medicine, Jersey City, NJ, ⁵Hospital For Special Surgery, New York, ⁶Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ⁷Northwestern University, Chicago, ⁸Rockefeller University, New York, ⁹Scripps Research, La Jolla, CA, ¹⁰Rush University Medical Center, Chicago, IL
Background/Purpose: Knee joints are densely innervated by sensory neurons, predominantly nociceptors. Knowledge about innervation of healthy human synovium and the changes that accompany osteoarthritis (OA)…
Abstract Number: 1011 • ACR Convergence 2025
Model-based Evaluation of the Potential Public Health Impact of Expanding Medicare Coverage for Weight Loss Medications for Beneficiaries with Knee Osteoarthritis and Obesity in the US.
Ethan Eickmann¹, Daniel Betensky¹, Karen Smith¹, Candace Feldman¹, Jason Kim², Ankur Pandya³, Jeffrey Katz⁴ and Elena Losina⁵, ¹Brigham and Women's Hospital, Boston, MA, ²Arthritis Foundation, Atlanta, GA, ³Harvard School of Public Health, Boston, ⁴Brigham and Women's Hospital, Brookline, MA, ⁵BWH, Boston, MA
Background/Purpose: US federal law currently does not allow Medicare Part D coverage for weight loss medications without additional indications, such as diabetes. Several glucagon-like peptide-1…
Abstract Number: 0332 • ACR Convergence 2025
Safety, Short- and Long-Term Efficacy of Methotrexate in Osteoarthritis: A Systematic Review and Meta-Analysis
Mohamed Abdelsalam¹, Maryam Lasheen², Hadeer Hafez³, Bassant Elaraby Elsayed Badwy⁴, Omar Sameh Nabil El Sedafy¹ and Mohamed Reda Awad⁵, ¹Misr University For Science and Technology, ⁶ october, Al Jizah, Egypt, ²Misr University For Science and Technology, Helwan, Al Qahirah, Egypt, ³⁶th October University, ⁶ october, Al Jizah, Egypt, ⁴Misr University For Science and Technology, Nasr City, Al Qahirah, Egypt, ⁵Al Azhar University, Cairo, Egypt, Giza, Al Jizah, Egypt
Background/Purpose: Methotrexate (MTX), traditionally used for inflammatory conditions like rheumatoid arthritis, has well-established anti-inflammatory properties, recently gained interest as a potential therapeutic option for osteoarthritis…
Abstract Number: 0315 • ACR Convergence 2025
Cross-sectional analysis of association between erosive hand osteoarthritis and cardiovascular disease.
Avanika Mahajan¹, Caroyln Harvey², Andy Abril³ and Megan Sullivan⁴, ¹Mayo Clinic, Scottsdale, ²Mayo Clinic, Phoenix, AZ, ³Mayo Clinic Florida, Jacksonville, ⁴Mayo Clinic Arizona, Scottsdale, AZ
Background/Purpose: Erosive hand osteoarthritis (EHOA) is an inflammatory subtype of hand OA that causes subchondral bone erosion and cortical destruction, often resulting in debilitating symptoms.…
Abstract Number: 2099 • ACR Convergence 2025
Incidence and Prevalence of Osteoarthritis in the United States Compared to Global Trends: Insights from the Global Burden of Disease Study (1990–2021)
Khadija Mohib¹, Rameez Qasim², Nicolas Barnechea Alvarado¹, ZAUHA FAWAD MEMON³ and Muhammad Asjad Saleem⁴, ¹Kirk Kerkorian School of Medicine at UNLV, Las Vegas, NV, ²Allama Iqbal Medical College Lahore, Lahore, Pakistan, ³Peoples University of Medical and Health Sciences for Women, Tando Allahyar, Sindh, Pakistan, ⁴Indus Hospital Karachi, Karachi
Background/Purpose: Osteoarthritis (OA) is the most prevalent musculoskeletal condition, predominantly affecting individuals over the age of 55. According to the World Health Organization (WHO), OA…
Abstract Number: 2084 • ACR Convergence 2025
Predictors of Change in Physical Activity Level Among Veterans with Knee Osteoarthritis in a Behaviorally Designed Incentive Program
Criswell Lavery¹, Ori Needleman¹, Bryant England², Katherine Wysham³, Mercedes Quinones⁴, Marianna Olave⁵, Sarah Wetzel⁶, Hannah Brubeck⁷, Rachel Gillcrist⁸, Natalie Keller⁹, Kimberly Hayes¹⁰, Bibiana Ateh¹¹, Bridget Kramer², Rui Xiao¹, Kaitian Jin¹, Alexis Ogdie¹², Daniel K. White¹³, Tuhina Neogi¹⁴, Carla Scanzello¹ and Joshua Baker¹, ¹University of Pennsylvania, Philadelphia, PA, ²University of Nebraska Medical Center, Omaha, NE, ³VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA, ⁴Washington DC VA Medical Center, Bethesda, MD, ⁵Brown University, Philadelphia, PA, ⁶Drexel University, Pittsburgh, PA, ⁷VA Puget Sound Health Care System, Seattle, WA, ⁸Dartmouth College, Lebanon, NH, ⁹University of Oklahoma, Philadelphia, PA, ¹⁰Teachers College, Columbia University, Philadelphia, PA, ¹¹Washington VA Medical Center, Washington, District of Columbia, ¹²Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Wilmington, DE, ¹³University of Delaware, Newark, DE, ¹⁴Boston University School of Medicine, Boston, MA
Background/Purpose: Physical activity may help reduce symptoms in adults with knee osteoarthritis (KOA), yet few meet the recommended levels. This analysis identified participant characteristics associated…
Abstract Number: 1803 • ACR Convergence 2025
Patching of Damaged Meniscus and Cartilage of Osteoarthritic Animals by MM-II, a Dispersion of Empty Large Multilamellar Liposomes
Roni Wechsler and Rany Rotem, Moebius Medical, Tel Aviv, Israel
Background/Purpose: Cartilage wear in knee osteoarthritis (KOA) is linked to reduced boundary lubrication. Occasionally, the meniscus also wears out in KOA, potentially accelerating the disease.…
Abstract Number: 1783 • ACR Convergence 2025
Nerve Growth Factor Causes Sensitization, Nociceptor Sprouting, Synovitis, And Osteophyte Formation In Naïve Murine Joints
alia obeidat¹, michael Newton², Jun Li¹, Baofeng Hu³, Shingo Ishihara⁴, Lindsey Lammlin², Lucas Junginger², Easton Farrell², Frank Ko¹, Richard Miller⁵, Carla Scanzello⁶, Tristan Maerz⁷, Rachel Miller⁸ and Anne-Marie Malfait⁹, ¹Rush University Medical Center, Chicago, ²University Of Michigan, Ann Arbor, ³University of Pennsylvania, Wynnewood, PA, ⁴Rush University, Chicago, ⁵Northwestern University, Chicago, ⁶University of Pennsylvania, Philadelphia, ⁷University of Michigan, Ann Arbor, MI, ⁸Rush University Medical Center, Chicago, IL, ⁹rush university, CHICAGO, IL
Background/Purpose: The neurotrophin, nerve growth factor (NGF), a key mediator of pain and inflammation, is increased in joints with osteoarthritis (OA). Neutralizing NGF with monoclonal…
Abstract Number: 0919 • ACR Convergence 2025
Proteomic Profiling of Extracellular Vesicles from Synovial Fluid of RA and OA Patients Reveals Cell-type-specific subpopulations and Disease Related Patterns
Stefanie Kurth¹, Andre Tiaden¹, Edveena Hanser¹, Simone Häner¹, Stavros Giaglis¹, Florian Geier¹, Dominik Burri¹, Katarzyna Buczak¹, Ute Heider², Stefan Wild², Yves Acklin¹, Christian Egloff¹ and Diego Kyburz³, ¹University of Basel, Basel, Switzerland, ²Miltenyi Biotec, Bergisch-Gladbach, Germany, ³University Hospital Basel, Basel, Switzerland
Background/Purpose: Extracellular vesicles (EVs) are secreted by virtually all cells and are known to carry bioactive cargo including proteins, RNA, DNA and metabolites. Analysis of…

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