Abstracts tagged "Osteoarthritis"

Abstract Number: 2094 • ACR Convergence 2025
Evaluating the Accuracy of Knee Acoustic Emissions Classification of Varus Thrust
Kari Falaas¹, Ahmet Emirdagi², Christopher Nichols² and David Ewart³, ¹University of Minnesota, Minneapolis, ²Georgia Institute of Technology, Atlanta, ³Minneapolis Veterans Affairs Medical Center, Minneapolis
Background/Purpose: Osteoarthritis (OA) of the knee is a leading cause of disability, healthcare expenditures, and is associated with diminished quality of life and increased mortality.…
Abstract Number: 2621 • ACR Convergence 2025
Erosive Hand Osteoarthritis Is Associated With Increased Risk of Incident Osteoporotic Fractures In Post-menopausal Women (QUALYOR Cohort)
MAXIME AUROUX¹, MERCIER-GUERY Alexandre¹, PIOT Anne², MERLE Blandine³, PRORIOL Mathilde¹, FONTANGES Elisabeth¹, DUVERT Florence¹, Eric LESPESSAILLES⁴ and CHAPURLAT Roland¹, ¹Hospices Civils de Lyon, LYON, France, ²Centre Hospitalier Lucien Hussel, VIENNE, France, ³INSERM U¹⁰³³, LYON, France, ⁴University Hospital of Orléans, Orleans, France
Background/Purpose: Erosive hand osteoarthritis (ErHOA) is a severe form of hand osteoarthritis (HOA) characterized by greater inflammation and higher burden of disease. In this more…
Abstract Number: 0309 • ACR Convergence 2025
A Composite Cumulative Cartilage Damage Metric Predicts Incident Symptomatic Knee OA: Data from the Osteoarthritis Initiative
Julieann Patarini¹, Timothy McAlindon², Jonggyu Baek¹, Emily Kirillov³, Nhung Vo³, Michael Richard³, Ming Zhang⁴, Matthew Harkey⁵, Grace Lo⁶, Shao-Hsien Liu¹, Kate Lapane¹, Charles Eaton⁷, James Mackay⁸ and Jeffrey Driban⁹, ¹UMass Chan Medical School, Worcester, MA, ²UMass Chan School of Medicine, Arlington, MA, ³Tufts Medical Center, Boston, MA, ⁴Boston University, Westford, MA, ⁵Michigan State University, East Lansing, MI, ⁶Baylor College of Medicine / MEDVAMC, Houston, TX, ⁷Brown University, Pawtucket, RI, ⁸University of Cambridge; Norwich Medical School, San Diego, CA, ⁹University of Massachusetts Chan Medical School, Marlborough, NH

Background/Purpose: Cartilage defects are a hallmark of OA progression. We previously developed a composite MRI-based metric that combines cartilage damage from 6 anatomical regions throughout…
Abstract Number: 0326 • ACR Convergence 2025
Gender Disparities in Clinical Outcomes Among Older Adults with Knee Osteoarthritis: A Retrospective Cohort Study
Kinga Grzybowski¹, Ahmer Khan², Samuel Bonomo³ and Arthur Lau⁴, ¹Jefferson Einstein Montgomery Hospital, Maspeth, NY, ²Jefferson Einstein Philadelphia Hospital, Philadelphia, ³Jefferson Einstein Montgomery Hospital, East Norriton, PA, ⁴Jefferson Einstein Hospital, Maple Glen, PA
Background/Purpose: Osteoarthritis (OA) is the most common type of arthritis which classically affects multiple joints, mainly the knees. About 595 million people worldwide suffer from…
Abstract Number: 0771 • ACR Convergence 2025
Radiographic Knee Osteoarthritis and Corticosteroid Injection Use: The Moderating Role of Physical Activity
Sydney Liles¹, Jennifer Copson², Daniel K. White¹ and Jason Jakiela³, ¹University of Delaware, Newark, DE, ²University of Delaware, Wilmington, DE, ³Winston-Salem State University, Winston-Salem, NC
Background/Purpose: Knee osteoarthritis (OA) is a chronic disease with no current cure and a leading cause of disability among adults. Treatment for knee OA focuses…
Abstract Number: 1737 • ACR Convergence 2025
CR10049, the first intra-articular Src family kinase inhibitor as a long-acting symptom- and disease-modifying drug for the inflammatory OA phenotype
Luigino Giancotti, Tiziana Piepoli, Roberto Artusi, Matteo Ghirri, Michela Visintin, Gianfranco Caselli and Lucio Rovati, Rottapharm Biotech, Monza, Italy
Background/Purpose: The inflammatory osteoarthritis (OA) phenotype is characterized by the presence of synovial membrane inflammation, pain and pathological changes in joint structure leading to rapid…
Abstract Number: 1796 • ACR Convergence 2025
Multi-Tissue Molecular and Histopathological Profiling of Facet Joints and Intervertebral Discs
Nashrah Ahmad¹, Lisa Janssen¹, Hannah Swahn², Rachel Miller³, Anne-Marie Malfait⁴, Merissa Olmer⁵ and Martin Lotz⁶, ¹Scripps Research, San Diego, CA, ²Scripps Research Institute, Carlsbad, CA, ³Rush University Medical Center, Chicago, IL, ⁴Rush University, Oak Park, IL, ⁵Scripps Research Institute, La Jolla, CA, ⁶Scripps Research, La Jolla, CA
Background/Purpose: Intervertebral disc (IVD) degeneration and facet joint (FJ) osteoarthritis (OA) often co-exist, and both are major contributors to lower back pain (LBP). Despite their…
Abstract Number: 2079 • ACR Convergence 2025
Association Between Symptomatic Knee Osteoarthritis and Health-Related Quality of Life in Individuals with Type 2 Diabetes: A Cross-Sectional Study
Abdalmohsen Almodahka¹, Alanna Weisman², Baiju Shah³, Tristan Watson⁴, Ian stanaitis⁵, Amish Parikh⁶, Robert Goldberg⁶, Lorraine Lipscombe⁷, Gillian Hawker¹ and Lauren King¹, ¹University of Toronto, Toronto, ON, Canada, ²University Health Network Toronto General Hospital Site/Sinai Health System, Toronto, ON, Canada, ³Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁴Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ⁵Research and Innovation Institute, Women’s College Hospital, Toronto, ON, Canada, Toronto, ON, Canada, ⁶Division of Endocrinology, Department of Medicine, Trillium Health Partners, Mississauga, ON, Canada, Toronto, ON, Canada, ⁷Department of Medicine, University of Toronto, Research and Innovation Institute, Women’s College Hospital, Toronto, ON, Canada, Toronto, ON, Canada
Background/Purpose: Knee osteoarthritis (OA) and type 2 diabetes (T2D) commonly coexist, but their combined impact on health-related quality of life (HRQoL) remains understudied. Our objective…
Abstract Number: 2095 • ACR Convergence 2025
Trends in Mortality and Disability-Adjusted Life Years (DALYs) from Osteoarthritis in the United States Compared to Global Estimates: A GBD-Based Analysis (1990–2021)
Khadija Mohib¹, Rameez Qasim², ZAUHA FAWAD MEMON³, Muhammad Asjad Saleem⁴, Matia Fawad Memon⁵ and Zaiya Waseem⁶, ¹Kirk Kerkorian School of Medicine at UNLV, Las Vegas, NV, ²Allama Iqbal Medical College Lahore, Lahore, Pakistan, ³Peoples University of Medical and Health Sciences for Women, Tando Allahyar, Sindh, Pakistan, ⁴Indus Hospital Karachi, Karachi, ⁵Peoples University of Medical and Health Sciences for Women, Tando Allahyar, Pakistan, ⁶AtlantiCare Regional Medical Center, New Jersey
Background/Purpose: Osteoarthritis (OA) represents a growing public health concern, particularly among the aging population, contributing significantly to both mortality and Disability-Adjusted Life Years (DALYs). This…
Abstract Number: 2622 • ACR Convergence 2025
Oral Microbiome Dysbiosis and Oral-gut Microbial Network Disruption in Hand Osteoarthritis: Data from the Xiangya Osteoarthritis Study
Jiatian Li¹, Yadan Xiao², Tuo Yang¹, david Hunter³, Weiya Zhang⁴, Michael Doherty⁴, Yuqing Zhang⁵, Zidan Yang¹, Yilun Wang¹, Dongxing Xie¹, Changjun Li¹, Wei Li¹, Zeqin Wen¹, Chao Zeng¹, Guanghua Lei¹ and Jie Wei¹, ¹Xiangya Hospital, Central South University, Changsha, Hunan, China (People's Republic), ²Xiangya School of Public Health, Central South University, Changsha, Hunan, China (People's Republic), ³Sydney Musculoskeletal Health, University of Sydney, St Leonards, New South Wales, Australia, ⁴School of Medicine, University of Nottingham, Nottingham, United Kingdom, ⁵Massachusetts General Hospital, Quincy, MA
Background/Purpose: The oral microbiome plays a critical role in modulating systemic inflammation and maintaining immune homeostasis, partly through its interactions with the gut microbiome. Although…
Abstract Number: 0310 • ACR Convergence 2025
Evaluate Safety, Tolerability, and Pharmacodynamics of a Single Intra-Articular Injection of GNSC-001 Gene Therapy in Subjects with Knee Osteoarthritis: 12-month Results from DONATELLO
Annahita Keravala¹, Philip Conaghan², shanna jackson¹, sharmila Vijay¹, Thomas Chalberg³, Jeyanesh Tambiah⁴ and Laurie Halligan¹, ¹Genascence, Palo Alto, CA, ²University of Leeds, Leeds, United Kingdom, ³Genascence Corp, Palo Alto, CA, ⁴Genascence, San Diego, CA
Background/Purpose: IL-1 contributes significantly to osteoarthritis (OA) pathology, driving inflammation and cartilage degradation. Prior therapies targeting IL-1 have shown limited success due to inadequate drug…
Abstract Number: 0327 • ACR Convergence 2025
Structural Severity Assessment of Hand Osteoarthritis Using Radiomic Analysis: Correlation with the Kellgren-Lawrence Score – Results from the DIGICOD Cohort
Laetitia Perronne¹, SELLAM JEREMIE², Antoine Decoux³, Loïc Duron⁴, Constance de Margerie⁵, Maxime Dougados⁶, Simo Saarakala⁷, Emmanuel Maheu⁸, Michel Crema⁸, Anne Miquel⁸, Francis BERENBAUM⁹, Armelle Arnoux³, Jean Denis Laredo¹⁰ and Laure Fournier³, ¹Northwestern University, Chicago, IL, ²Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, F-⁷⁵⁰¹² Paris, France, /Rheumatology Department, AP-HP Saint-Antoine Hospital, ¹⁸⁴, rue du Faubourg Saint-Antoine, ⁷⁵⁰¹², Paris, France., Paris, France, ³Université paris Cité, Paris, France, ⁴Hôpital Fondation Adolphe de Rothschild, Paris, France, ⁵Hôpital Saint Louis, Paris, France, ⁶Department of Medicine, Hopital Cochin, Universite de Paris, Paris, France, ⁷University of Oulu, Oulu, Finland, ⁸Hôpital Saint Antoine, Paris, France, ⁹Sorbonne University/Inserm/AP-HP/⁴Moving Biotech, Paris, France, ¹⁰Hôpital Lariboisière, Paris, France
Background/Purpose: Radiomics involves the high-throughput extraction of quantitative data from medical imaging. This study aimed to develop a radiomic analysis pipeline applied to hand radiographs…
Abstract Number: 0783 • ACR Convergence 2025
Pain reduction and functional improvements following a non-invasive biomechanical intervention for gait rehabilitation may explain a reduction in healthcare claims. An observational study
Eric Freeman and William Vanderveer, Redefine Healthcare. Orthopedic Pain & Spine Center,, New Jersey
Background/Purpose: Musculoskeletal (MSK) conditions significantly impact public health in the United States, affecting approximately 128 million adults and resulting in over $600 billion in annual…
Abstract Number: 1738 • ACR Convergence 2025
Coexpression and Infiltration of Endoplasmic Reticulum Stress Proteins Together With CD34+ Fibroblast-like Synoviocytes In Human Inflamed Synovial Membranes
Zoe Gendebien¹, Pauline Salpetier², Celine Deroyer², Genevieve Paulissen², Alexandre Hego², Gaetan Lefevre², Christophe Poulet², Sophie Neuville², Patrick Durez³, Patrice Hemon⁴, Nadege Marec⁵, Elettra Bianchi², Philippe Delvenne², Clio ribbens² and Dominique de Seny², ¹ULiege, Liège, Belgium, ²ULiege, Liege, Belgium, ³Cliniques Universitaires Saint-Luc – Université catholique de Louvain (UCLouvain) – Institut de Recherche Expérimentale et Clinique (IREC), Rheumatologie, Brussels, Brussels Hoofdstedelijk Gewest, Belgium, ⁴Brest, Brest, Belgium, ⁵Brest, Brest, France
Background/Purpose: A strong crosstalk exists between endoplasmic reticulum (ER) stress and synovitis. Several ER chaperone proteins, besides their function in protein folding, can play a…
Abstract Number: 1797 • ACR Convergence 2025
SEV-101 Exosomes Isolated from Induced Pluripotent Stem Cell – Derived Hyaline Cartilage Tissue – Characterization of Immunomodulatory and Chondro-proliferative Effects In Vitro
Parthasarathy Rangarajan¹, Beth Lindborg², Amanda Vegoe³, Yi Wen Chai⁴, Anna Tran¹, Magie Steinhoff¹, Bernhard Hering¹, Timothy O'Brien⁵ and Sabarinathan Ramachandran⁶, ¹Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, ²Sarcio, Inc., St. Paul, ³Department of Veterinary Population Medicine and Stem Cell Institute, University of Minnesota, Sarcio, Inc, St. Paul, ⁴Stem Cell Institute, University of Minnesota, Minneapolis, ⁵Department of Veterinary Population Medicine and Stem Cell Institute, University of Minnesota, Sarcio, Inc, Minneapolis, ⁶Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN
Background/Purpose: SEV-101 are exosomes that are isolated from cultures of Induced Pluripotent Stem Cell (iPSC)-derived hyaline cartilage tissue. Gene expression profiles of the tissue are…

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