Abstracts tagged "Osteoarthritis"

Abstract Number: 3250 • 2015 ACR/ARHP Annual Meeting
Systemic Inflammation and Pain Sensitization in Knee Osteoarthritis: The Multicenter Osteoarthritis Study
Tuhina Neogi¹, Laura Frey-Law², Devyani Misra¹, Michael C. Nevitt³, Lars Arendt-Nielsen⁴, Emily K. Quinn⁵ and Cora E. Lewis⁶, ¹Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ²UIowa, Iowa City, IA, ³Epidemiology and Biostatistics, UCSF, San Francisco, CA, ⁴Aalborg University, Aalborg, Denmark, ⁵Data Coordinating Center, Boston University School of Public Health, Boston, MA, ⁶Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Pain sensitization is associated with pain severity in knee osteoarthritis (OA), but its cause in humans is not well-understood. We recently demonstrated that local…
Abstract Number: 138 • 2015 ACR/ARHP Annual Meeting
Identification and Documentation of Secondary Osteoarthritis in Patients with Primary Inflammatory Arthritides Using a Patient MDHAQ/RAPID3 and a Physician Estimate of Joint Damage to Recognize Patient Complexity and Inform Management Decisions
Kathryn A. Gibson¹, Annie Huang², Katherine J. Bryant³ and Theodore Pincus², ¹Liverpool Hospital, Liverpool, Australia, ²Rheumatology, Rush University Medical Center, Chicago, IL, ³University of New South Wales, Sydney, Australia
Background/Purpose: Patients with inflammatory arthritides may have secondary osteoarthritis (OA), which affects decisions concerning clinical management. For example, in one study, about 20% of patients…
Abstract Number: 1589 • 2015 ACR/ARHP Annual Meeting
Impact of Osteoarthritis of the Hand on Disease Activity Scores and Health Status in Patients with Rheumatoid Arthritis
Hector Fabricio Espinosa Ortega¹, Cesar Alejandro Arce Salinas² and Emmanuel Ruiz Medrano³, ¹Rheumatology, Hospital Central Sur Alta Especialidad Pemex, Mexico City, Mexico, ²Rheumatology, Hospital Central Sur de Alta Especialidad Pemex, Mexico, Mexico, ³Hospital Central Sur de Alta Especialidad Pemex, Mexico, Mexico
Background/Purpose: Rheumatoid arthritis (RA) is a polyarticular autoimmune inflammatory disease characterized for pain, joint edema and functional limitation. Some items in evaluation could be affected…
Abstract Number: 3252 • 2015 ACR/ARHP Annual Meeting
Impact of Knee Pain Frequency on Physical Function in the Osteoarthritis Initiative
Jin Zhou¹, Erin Ashbeck², Lynn Hamilton² and C. Kent Kwoh³, ¹Epidemiology & Biostatistics, University of Arizona, Tucson, AZ, ²Arthritis Center, University of Arizona, Tucson, AZ, ³Rheumatology, University of Arizona, Tucson, AZ
Background/Purpose: Knee pain is a prominent symptom among patients with knee osteoarthritis (OA), but the impact of knee pain frequency on physical function has been…
Abstract Number: 182 • 2015 ACR/ARHP Annual Meeting
Agreement Between Ultrasound and Radiography for the Detection of Rhizarthrosis
Maria de los Angeles Gallardo¹, Facundo Vergara¹, Emmanuel Bertiller², Javier Rosa³, Santiago Ruta¹, Ricardo Garcia-Monaco⁴ and Enrique R. Soriano⁵, ¹Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ²Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, ³Rheumatology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁴Radiology and Imagenology Department, Hospital italiano de Buenos Aires, Buenos Aires, Argentina, ⁵Internal Medicine, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
Background/Purpose: Trapeziometacarpal (TMC) joint is a common site of osteoarthritis (OA)(rhizarthrosis). Its diagnosis is based on clinical and radiological (X-ray) features. It is not clear…
Abstract Number: 2008 • 2015 ACR/ARHP Annual Meeting
WISP1 Aggravates Osteoarthritis By Modulation of TGF-β Signaling and Positive Regulation of Canonical Wnt Signaling
Martijn H. van den Bosch¹, Arjen Blom¹, Azusa Maeda², Tina Kilts², Wim van den Berg¹, Floris Lafeber³, Peter van Lent¹, Marian Young² and Peter van der Kraan¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²NIDCR/NIH, Bethesda, MD, ³Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Many osteoarthritis (OA) patients show synovial activation, which is suggested to be involved in joint destruction. Previously, we found synovial overexpression of Wnt ligands in experimental…
Abstract Number: 215 • 2015 ACR/ARHP Annual Meeting
Calcium Hydroxyapatite Crystals Inhibit Interleukin-6- and Interferon-γ –Induced Anti-Osteoclastogenic Signaling in Human Osteoclast Precursors
Geraldine M. McCarthy¹, Clare C. Cunningham², Emma M. Corr³ and Aisling Dunne³, ¹University College Dublin, Dublin, Ireland, ²School of Biochemistry and Immunology, Trinity College Dublin, Dubln, Ireland, ³School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
Background/Purpose: Intra-articular calcium hydroxyapatite (HA) crystals are present in the majority of osteoarthritic (OA) joints. They activate macrophages, synovial fibroblasts and articular chondrocytes, resulting in…
Abstract Number: 2092 • 2015 ACR/ARHP Annual Meeting
Knee Pain Burden Is Associated with Decreased Moderate to Vigorous Physical Activity: Data from the Osteoarthritis Initiative
Javad Razjouyan¹, Bijan Najafi², Erin Ashbeck³, Dorothy D. Dunlop⁴, Julia (Jungwha) Lee⁵, Lynn Hamilton³ and C. Kent Kwoh⁶, ¹Consortium on Advanced Motion Performance (iCAMP), Department of Surgery, University of Arizona, Tucson, AZ, ²Department of Surgery and Department of Biomedical Engineering, University of Arizona, Tucson, AZ, ³Arthritis Center, University of Arizona, Tucson, AZ, ⁴Institute for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Department of Preventive Medicine, Biostatistics Collaboration Center, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Rheumatology, University of Arizona, Tucson, AZ
Knee Pain Burden is Associated with Decreased Motor Performance: Data from the Osteoarthritis InitiativeBackground/Purpose: The influence of knee pain perception on daily life motor performance…
Abstract Number: 2237 • 2014 ACR/ARHP Annual Meeting
Interleukin-1 Dual-Variable Domain Immunoglobulin Reduces Multiple Inflammatory Markers in Knee Osteoarthritis Patients
Susanne X. Wang¹, Jeroen Medema¹, Matthew Kosloski¹, Wei Liu¹, Mary Saltarelli¹ and Morten Asser Karsdal², ¹AbbVie Inc., North Chicago, IL, ²Nordic Bioscience, Biomarkers and Research, Herlev, Denmark
Background/Purpose: Osteoarthritis (OA) may comprise multiple phenotypes, one of which is inflammation-driven OA. Consequently, a selected subpopulation of OA patients may benefit from optimally targeted…
Abstract Number: 257 • 2014 ACR/ARHP Annual Meeting
Quality of Life Assessment of Adults Patients with X-Linked Hypophosphoremia
Karine Briot¹, Hélène Ché¹, Adrien Etcheto¹, Anya Rothenbuhler², Peter Kamenicky,², Agnès Linglart² and Christian Roux³, ¹Cochin Hospital, Paris Descartes University, Paris, France, ²Hôpital Bicêtre, Kremlin Bicêtre, France, ³Paris Descartes University, Cochin Hospital, Paris, France
Background/Purpose: X-Linked Hypophosphatemia (XLH) is the most common form of heritable rickets. Although disease severity is variable, adults with XLH may suffer from skeletal symptoms…
Abstract Number: 2243 • 2014 ACR/ARHP Annual Meeting
Comparison Between Two Diclofenac Diethylamine Gel Formulations, 1.16% Vs 2.32%: Is It Only Increasing the Strength of the Active Ingredient Enough?
Giuseppa Quartarone¹ and Nathalie Hasler-Nguyen², ¹Medical Affairs, Novartis CH R&D OU Italy Greece, Milan, Italy, ²Pre-Cinical Development, Novartis CH Global R&D, Nyon, Switzerland
Background/Purpose Topically applied non-steroidal anti-inflammatory drugs (NSAIDs) can produce clinically effective drug concentrations at a peripheral site, but with low systemic concentrations and thus a…
Abstract Number: 249 • 2014 ACR/ARHP Annual Meeting
A Phase 3 Open-Label Trial of Low-Dose Solumatrix Diclofenac in Patients with Osteoarthritis Pain: Impact of Long-Term Administration on Patient-Reported Outcomes
Vibeke Strand¹, Allan Gibofsky², Marc Hochberg³, Roy Altman⁴, Byron Cryer⁵, Alan Kivitz⁶, Olaolu Imasogie⁷ and Clarence Young⁸, ¹Stanford University, Palo Alto, CA, ²Medicine and Public Health, Hospital for Special Surgery, New York, NY, ³University of Maryland School of Medicine, College Park, MD, ⁴University of California–Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁵University of Texas Southwestern Medical Center, Dallas, TX, ⁶Altoona Center for Clinical Research, Duncansville, PA, ⁷Iroko Pharmaceuticals LLC, Philadelphia, PA, ⁸150 Rouse Boulevard, Iroko Pharmaceuticals, LLC, Phila, PA
Background/Purpose: Diclofenac is used for the treatment of osteoarthritis (OA), but, like other NSAIDs, it is associated with serious dose-related adverse events. The FDA has…
Abstract Number: 2247 • 2014 ACR/ARHP Annual Meeting
Bariatric Surgery Improves Quality of Life in Patients with Osteoarthritis and Obesity Compared to Non-Surgical Weight Loss
Christopher Chong¹, Sangeeta Kashyap², Philip Schauer², Colin O'Rourke³ and M. Elaine Husni⁴, ¹Rheumatology, Cleveland Clinic, Cleveland, OH, ²Cleveland Clinic, Cleveland, OH, ³Quantitative Health Sciences, JJN3-01, Cleveland Clinic, Cleveland, OH, ⁴Rheumatology Dept A50, Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: Numerous studies support obesity as a strong risk factor for development and progression of knee osteoarthritis (OA). The potential benefits of massive weight loss,…
Abstract Number: 222 • 2014 ACR/ARHP Annual Meeting
OA Phenotypes Rather Than Disease Stage Drive Structural Progression – Identification of Structural Progressors from 2 Phase III Randomized Clinical studies with Symptomatic Knee OA
Morten Asser Karsdal¹, Anne C. Bay-Jensen², Asger Bihlet³, Peter Alexandersen⁴, Inger Byrjalsen³, Bente J. Riis³ and Claus Christiansen³, ¹Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ²Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ³Nordic Bioscience, Herlev, Denmark, ⁴Center for Clinical and Basic Research, Vejle, Denmark
Background/Purpose: Osteoarthritis (OA) is a heterogeneous disorder, with several possible drivers of disease progression. Up to 50% of OA patients do not structurally progress, emphasizing…
Abstract Number: 2141 • 2014 ACR/ARHP Annual Meeting
Sensitivity to Change of Joint Space Width Measurements in Hand Osteoarthritis in a Two Year Follow-up Study
W. Damman¹, S.E. de Bruin¹, B.C. Stoel², R. van 't Klooster² and M. Kloppenburg¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Radiology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Cartilage loss, represented by joint space width (JSW) on radiographs, is an important outcome measure in hand OA disease course. JSW can be assessed…

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