Abstracts tagged "Osteoarthritis"

Abstract Number: 215 • 2015 ACR/ARHP Annual Meeting
Calcium Hydroxyapatite Crystals Inhibit Interleukin-6- and Interferon-γ –Induced Anti-Osteoclastogenic Signaling in Human Osteoclast Precursors
Geraldine M. McCarthy¹, Clare C. Cunningham², Emma M. Corr³ and Aisling Dunne³, ¹University College Dublin, Dublin, Ireland, ²School of Biochemistry and Immunology, Trinity College Dublin, Dubln, Ireland, ³School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
Background/Purpose: Intra-articular calcium hydroxyapatite (HA) crystals are present in the majority of osteoarthritic (OA) joints. They activate macrophages, synovial fibroblasts and articular chondrocytes, resulting in…
Abstract Number: 2092 • 2015 ACR/ARHP Annual Meeting
Knee Pain Burden Is Associated with Decreased Moderate to Vigorous Physical Activity: Data from the Osteoarthritis Initiative
Javad Razjouyan¹, Bijan Najafi², Erin Ashbeck³, Dorothy D. Dunlop⁴, Julia (Jungwha) Lee⁵, Lynn Hamilton³ and C. Kent Kwoh⁶, ¹Consortium on Advanced Motion Performance (iCAMP), Department of Surgery, University of Arizona, Tucson, AZ, ²Department of Surgery and Department of Biomedical Engineering, University of Arizona, Tucson, AZ, ³Arthritis Center, University of Arizona, Tucson, AZ, ⁴Institute for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Department of Preventive Medicine, Biostatistics Collaboration Center, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Rheumatology, University of Arizona, Tucson, AZ
Knee Pain Burden is Associated with Decreased Motor Performance: Data from the Osteoarthritis InitiativeBackground/Purpose: The influence of knee pain perception on daily life motor performance…
Abstract Number: 314 • 2015 ACR/ARHP Annual Meeting
A Double-Blind, Randomized, Controlled, Four Parallel Arm, Dose-Finding Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Single Intra-Articular (IA) Injections of Fasitibant in Patients with Symptomatic OA of the Knee
Claudia Gabriele Werner¹, Karel Pavelka², Andrea Nizzardo³, Cristina Rossi³, Simona Scartoni³, Maria Paola Contini³, Serena di Molfetta³, Monica Bertolotti³, Angela Capriati³ and Carlo Alberto Maggi⁴, ¹Clinical Research, A. Menarini Research & Business Service GmbH, Berlin, Germany, ²Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ³Clinical Research Department, Menarini Ricerche S.p.A., Florence, Italy, ⁴Menarini Ricerche S.p.A., Florence, Italy
Background/Purpose: Fasitibant (FAS) is a competitive, potent and selective antagonist of the bradykinin B2 receptor administered IA for SOAK. In response to positive outcomes in…
Abstract Number: 2164 • 2015 ACR/ARHP Annual Meeting
Burden of Symptomatic Knee Osteoarthritis in the United States: Impact of Race/Ethnicity, Age and Sex
Bhushan Deshpande¹, Jeffrey N. Katz², Daniel H. Solomon², Edward H. Yelin³ and Elena Losina², ¹Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³University of California, San Francisco, San Francisco, CA
Background/Purpose : Growing evidence suggests that the prevalence and incidence of knee OA is rising, partially due to increasing life expectancy and the growing obesity…
Abstract Number: 322 • 2015 ACR/ARHP Annual Meeting
Reduction of Treatment Needed for Knee Osteoarthritis after Bariatric Surgery
Evan Wilder¹, Janice Lin¹, Fernando Bomfim¹, Thayer Mukherjee¹, Lucy O'Shaughnessy¹, Lauren Browne¹, Myriam Weill¹, Kevin Gernavage¹, Farah Taufiq¹, Renata La Rocca Vieira², Christine Ren-Fielding³, Manish Parikh⁴, Steven B. Abramson⁵ and Jonathan Samuels⁶, ¹NYU Langone Medical Center, New York, NY, ²Department of Radiology, NYU Langone Medical Center, New York, NY, ³Department of Surgery, New York University School of Medicine, New York, NY, ⁴Department of Surgery, NYU Langone Medical Center, New York, NY, ⁵Dept of Rheumatology/Medicine, Hosp for Joint Diseases/NYU, New York, NY, ⁶Rheumatology, NYU - Hospital for Joint Diseases, New York, NY
Background/Purpose: Medical treatment for knee osteoarthritis (KOA) can be limited and risk morbidity. Weight loss reduces the arthritis burden and may preclude aggressive treatment. Bariatric…
Abstract Number: 2248 • 2015 ACR/ARHP Annual Meeting
Knee Pain Burden Is Associated with Decreased Motor Performance: Data from the Osteoarthritis Initiative
Javad Razjouyan¹, Bijan Najafi², Erin Ashbeck³, Dorothy D. Dunlop⁴, Julia (Jungwha) Lee⁵, Lynn Hamilton³ and C. Kent Kwoh⁶, ¹Consortium on Advanced Motion Performance (iCAMP), Department of Surgery, University of Arizona, Tucson, AZ, ²Department of Surgery and Department of Biomedical Engineering, University of Arizona, Tucson, AZ, ³Arthritis Center, University of Arizona, Tucson, AZ, ⁴Institute for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Department of Preventive Medicine, Biostatistics Collaboration Center, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Rheumatology, University of Arizona, Tucson, AZ
Background/Purpose: Knee pain is the presenting symptom in knee osteoarthritis (OA), but the impact of knee pain burden in OA has been understudied. We examined…
Abstract Number: 336 • 2015 ACR/ARHP Annual Meeting
Lack of Uniform Diagnostic Criteria for Erosive OA: A Systematic Review
Supraja Yeturi¹, Payal Patel², Gazeley David² and Ann K. Rosenthal³, ¹Rheuamtology, Medical college of Wisconsin, Milwaukee, WI, ²Medical College of Wisconsin, Milwaukee, WI, ³Div of Rheumatology, Medical College of WI, Milwaukee, WI
Background/Purpose: Erosive osteoarthritis (EOA) is a potentially important subtype of osteoarthritis initially described in the 1960s. Since that time, EOA has been the focus of…
Abstract Number: 2325 • 2015 ACR/ARHP Annual Meeting
Quantitative Clues to Recognize and Document Comorbid Fibromyalgia in Routine Care of Patients with Other Rheumatic Diagnoses on a 10 Cm Distress Visual Analog Scale Found on 1-Page Physician Rheumetric Checklist
Kathryn A. Gibson¹, Katherine J. Bryant² and Theodore Pincus³, ¹Liverpool Hospital, Liverpool, Australia, ²University of New South Wales, Sydney, Australia, ³Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: A physician global estimate (DOCGL) is commonly used to assess patients with rheumatic diseases. Fibromyalgia (FM) has been reported as a comorbidity in 10-35%…
Abstract Number: 337 • 2015 ACR/ARHP Annual Meeting
Construct Validity of the Doyle Index in the Outcome Domain of Joint Activity in Hand Osteoarthritis Patients
W. Damman¹, R. Liu¹, M.C. Kortekaas^1,2, F.R. Rosendaal³, D. van der Heijde⁴ and M. Kloppenburg¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Department of Rheumatology, Flevoziekenhuis, Almere-Stad, Netherlands, ³Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands, ⁴Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: The Outcome Measures in Rheumatology (OMERACT) working group on hand osteoarthritis (OA) has endorsed a preliminary set of core domains for outcome measures in…
Abstract Number: 2385 • 2015 ACR/ARHP Annual Meeting
Arthritis Management in Primary Care and Adherence to National Guidelines – a Swedish Survey Based on the Canadian Physiotherapists Arthritis Care Questionnaire
Siv Folkhammar Andersson¹, Stefan Bergman^2,3,4 and Ann Bremander^3,4,5, ¹Unit of Rehabilitation, Kalmar County Council, Samrehab, Oskarshamn, Sweden, Oskarshamn, Sweden, ²Primary Health Care Unit, Department of Public Health and Community Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, ³Department of Clinical Sciences, Lund, Section of Rheumatology, Lund University, Lund, Sweden, ⁴FoU Spenshult, Halmstad, Sweden, ⁵School of Business, Engineering and Science, Halmstad University, Halmstad, Sweden
Background/Purpose: For patients with osteoarthritis (OA) physical therapy is recommended first line treatment and performed in primary care while patients with rheumatoid arthritis (RA) may…
Abstract Number: 1969 • 2014 ACR/ARHP Annual Meeting
Neurotrophin Receptor p75 (CD271) Defines a Distinct Synovial Fibroblast Subset in Rheumatoid and Osteoarthritic Synovial Tissues with Enhanced Proinflammatory Potential
Manuel J. Del Rey¹, Regina Faré¹, Gabriel Criado², Alicia Usategui¹, Vanessa Miranda¹, Juan D. Cañete³ and Jose L. Pablos¹, ¹Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ²Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ³Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain
Background/Purpose Synovial mesenchynmal or stromal cells constitute a heterogeneous cell population difficult to characterize ex vivo due to a paucity of cell markers and are…
Abstract Number: 207 • 2014 ACR/ARHP Annual Meeting
Changes in Knee Compartment Distriubtion of Cartilage Loss and Bone Marrow Lesions over 7 Years: The MOST Study
Joshua Stefanik¹, Ali Guermazi², Jingbo Niu³, Frank Roemer⁴, C.E. Lewis⁵, Neil A. Segal⁶, Michael Nevitt⁷ and David T. Felson⁸, ¹Clinical Epidemiology, Boston University, Boston, MA, ²Radiology, Boston University School of Medicine, Boston, MA, ³Clinical Epidemiology Research and Training Unit, Boston University, Boston, MA, ⁴Klinikum Augsburg, Augsburg, Germany, ⁵University of Alabama at Birmingham, Birmingham City, AL, ⁶Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA, ⁷Epidemiology and Biostatistics, UCSF, San Francisco, CA, ⁸Clinical Epidemiology Research & Training Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Knee osteoarthritis (OA) occurs in both the patellofemoral joint (PFJ) and tibiofemoral joint (TFJ). Little is known about the natural history of OA and…
Abstract Number: 1820 • 2014 ACR/ARHP Annual Meeting
Discordance of Hip Pain with Radiographic Hip Osteoarthritis: The Osteoarthritis Initiative
Chan Kim¹, Michael C. Nevitt², Pia M. Jungmann³, Irina Tolstykh⁴, Nancy E. Lane⁵, Thomas M. Link⁶ and David T. Felson⁷, ¹Rheumatology, Boston University, Boston, MA, ²Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ³Radiology, Technische Universitaet Muenchen, Munich, Germany, ⁴Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁵Internal Medicine, Center for Musculoskeletal Health, UC Davis School of Medicine, Sacramento, CA, ⁶Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, ⁷Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom
Background/Purpose It is assumed that persons with hip pain from osteoarthritis (OA) are likely to have radiographic OA, making it possible to readily diagnose disease,…
Abstract Number: 200 • 2014 ACR/ARHP Annual Meeting
Leg Length Inequality and Hip Osteoarthritis
Chan Kim¹, Jingbo Niu², Mary Clancy³, Ali Guermazi⁴, Michael C. Nevitt⁵, Neil A. Segal⁶, William F. Harvey⁷, Cora E Lewis⁸ and David T. Felson⁹, ¹Rheumatology, Boston University, Boston, MA, ²Clinical Epidemiology Research and Training Unit, Boston University, Boston, MA, ³Clinical Epidemiology, Boston University Sch Med, Boston, MA, ⁴Radiology, Boston University School of Medicine, Boston, MA, ⁵Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁶Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA, ⁷Rheumatology, Tufts Medical Center, Boston, MA, ⁸Division of Preventive Medicine, University of Alabama Birmingham School of Medicine, Birmingham, AL, ⁹Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom
Background/Purpose Leg length inequality (LLI), a side-to-side difference in lower limb lengths, is common. In the Multicenter Osteoarthritis Study (MOST), in persons with LLI, the…
Abstract Number: 1800 • 2014 ACR/ARHP Annual Meeting
Objectively Measured Sedentary Behavior Is a Distinct Risk Factor from Low Moderate-to-Vigorous Activity in Predicting Subsequent Frailty: Evidence from Osteoarthritis Initiative
Jing Song¹, Lee A. Lindquist¹, Rowland W. Chang¹, Pamela A. Semanik², Linda S. Ehrlich-Jones³, Jungwha Lee⁴, Min-Woong Sohn¹ and Dorothy D. Dunlop¹, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²Rush University Medical Center, Chicago, IL, ³Rehabilitation Institute of Chicago, Chicago, IL, ⁴Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Physical frailty represents a state of high vulnerability for adverse health outcomes including disability and mortality. Physical activity interventions to improve health have largely…

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