Abstracts tagged "Osteoarthritis"

Abstract Number: 859 • 2017 ACR/ARHP Annual Meeting
Identifying Pain Susceptibility Phenotypes in Those Free of Knee Pain with or at Risk for Knee Osteoarthritis and Their Relation to Developing Knee Pain
Lisa Carlesso¹, Neil Segal², Laura Frey-Law³, Yuqing Zhang⁴, Na Lu⁵, Cora E. Lewis⁶, Michael C. Nevitt⁷ and Tuhina Neogi⁵, ¹School of Rehabilitation, Université de Montréal, Montreal, QC, Canada, ²University of Kansas, Shawnee, KS, ³UIowa, Iowa City, IA, ⁴Clinical Edpidemiology Reserach and Training Unit, Boston University School of Medicine, Boston, MA, ⁵Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁶University of Alabama Birmingham, Birmingham, AL, ⁷Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA
Background/Purpose: It is well recognized that factors beyond structural features contribute to the pain experience in people with knee osteoarthritis (OA). Independent of structural pathology,…
Abstract Number: 2199 • 2017 ACR/ARHP Annual Meeting
Feasibility of a Novel Approach to Studying Early Knee Osteoarthritis: An Offspring Study
Grace H. Lo¹, Jane A. Cauley², Michael T. Strayhorn³, Mary Jansen⁴, Michael J Hannon⁵, Donna White⁶, Stephanie Green⁷ and C. Kent Kwoh^8,9, ¹Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, ²Department of Epidemiology, Univ of Pittsburgh, Pittsburgh, PA, ³VA HSR&D Center for Innovations in Quality, Effectiveness and Safety; Department of Medicine, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX, ⁴University of Pittsburgh, Pittsburgh, PA, ⁵Medicine, University of Pittsburgh, Pittsburgh, PA, ⁶Baylor College of Medicine, Houston, TX, ⁷Univeristy of Pittsburgh, Houston, PA, ⁸University of Arizona, Tucson, AZ, ⁹1501 N. Campbell Avenue, Room 8303, The University of Arizona Arthritis Center, Tucson, AZ
Background/Purpose: Much of osteoarthritis (OA) research has focused on identifying treatments for late stage disease. However, interventions in early disease may be most effective. Capitalizing…
Abstract Number: 2946 • 2017 ACR/ARHP Annual Meeting
Identifying Rapid Structural Disease Progression in Knee Osteoarthritis
Jamie E. Collins^1,2, Jeffrey N. Katz^2,3 and Elena Losina^1,2, ¹Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham & Women's Hospital, Boston, MA, ²Harvard Medical School, Boston, MA, ³Rheumatology, Immunology, and Allergy, Brigham & Women's Hospital, Boston, MA
Background/Purpose: Knee OA is a heterogeneous disease, with some patients experiencing rapid deterioration and others experiencing slow disease progression. Identifying patients likely to experience rapid…
Abstract Number: 931 • 2017 ACR/ARHP Annual Meeting
Dose-Response Effects of Tai Chi and Physical Therapy Exercise Interventions in Symptomatic Knee Osteoarthritis
Augustine Lee¹, William F. Harvey², Lori Lyn Price^3,4, Xingyi Han¹, Jeffrey B. Driban¹, Maura D. Iversen^5,6, Raveendhara R. Bannuru¹ and Chenchen Wang², ¹Rheumatology, Tufts Medical Center, Boston, MA, ²Rheumatology, Center of Integrative Medicine and Division of Rheumatology, Tufts Medical Center, Boston, MA, Boston, MA, ³Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, ⁴Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁵Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁶Department of Physical Therapy, Movement & Rehabilitation Sciences, Northeastern University, Boston, MA
Background/Purpose: Therapeutic exercise is the recommended non-pharmacological treatment for knee osteoarthritis (OA). However, the optimal treatment dose and clinically meaningful treatment durations remain unclear. Our…
Abstract Number: 2203 • 2017 ACR/ARHP Annual Meeting
Association of Hip Bone Geometry and Volumetric Density with Hip Osteoarthritis
Johann Grapinet¹, Jean-Baptiste Pialat¹, mathilde Proriol¹, Pawel Szulc², Eric Lespessailles³ and Roland Chapurlat⁴, ¹INSERM UMR 1033, LYON, France, ²Epidemiology of Osteoporosis, INSERM UMR 1033, Lyon, France, ³University Orleans, Orleans, France, ⁴INSERM 1033, University of Lyon, E. Herriot Hospital, Hospices Civils de Lyon, Lyon, France
Background/Purpose: Hip osteoarthritis (OA) is a major public health concern. It is associated with hip pain, functional decline and possibly increased cardiovascular mortality. The determinants…
Abstract Number: 2948 • 2017 ACR/ARHP Annual Meeting
Distinct Trajectories of Medial Fixed Joint Space Width Loss over Four Years of Follow-up Among Knees with and at Risk for Knee Osteoarthritis
C. Kent Kwoh^1,2, Di Ran^2,3, Erin L. Ashbeck² and Jeffrey Duryea⁴, ¹Division of Rheumatology, Department of Medicine, The University of Arizona, Tucson, AZ, ²The University of Arizona Arthritis Center, Tucson, AZ, ³Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, Tucson, AZ, ⁴Radiology, Brigham & Women's Hospital/ Harvard Medical School, Boston, MA
Background/Purpose: Knee OA (KOA) is typically described as a slowly progressive disease, though it is recognized that some patients experience rapid structural deterioration. Identification of…
Abstract Number: 933 • 2017 ACR/ARHP Annual Meeting
Longitudinal Association between Sleep Quality and Knee Pain in the Multicenter Osteoarthritis Study
Zhaoli (Joy) Dai¹, Carrie Brown², Tuhina Neogi³ and David T. Felson³, ¹Boston University School of Medicine, Boston, MA, ²Boston University School of Public Health, Boston, MA, ³Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Sleep and pain have been shown to be reciprocally related. Studies have suggested a stronger effect of sleep impairment on chronic pain such as…
Abstract Number: 2205 • 2017 ACR/ARHP Annual Meeting
Trajectories of Knee Bone Shape Change Are Associated with Sex and Osteoarthritis
Barton L Wise¹, Jingbo Niu², Yuqing Zhang³, Felix Liu⁴, Joyce Pang⁵, John A. Lynch⁶ and Nancy E. Lane⁷, ¹Orthopaedics, Internal Medicine, University of California, Davis School of Medicine, Sacramento, CA, ²Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ³School Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁵University of Nevada, Reno, Reno, NV, ⁶Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁷Center for Musculoskeletal Health, University of California, Davis School of Medicine, Sacramento, CA
Background/Purpose: Knee osteoarthritis (OA) is more common in women than men; however, the biological mechanisms for sex difference in knee OA are not well understood.…
Abstract Number: 935 • 2017 ACR/ARHP Annual Meeting
Results from a 52 Week Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of a Novel, Intra-Articular, Wnt Pathway Inhibitor (SM04690) for the Treatment of Knee Osteoarthritis
Yusuf Yazici¹, Timothy E. McAlindon², Allan Gibofsky³, Nancy E. Lane⁴, Daniel J. Clauw⁵, Eddie Armas⁶, Nebojsa Skrepnik⁷, Christopher J. Swearingen¹, Anita DiFrancesco¹, Jeymi Tambiah¹ and Marc Hochberg⁸, ¹Samumed, LLC, San Diego, CA, ²Division of Rheumatology, Tufts Medical Center, Boston, MA, ³Rheumatology, Weill Cornell Medicine, and Hospital for Special Surgery, New York, NY, ⁴Center for Musculoskeletal Health, University of California at Davis, Hillsborough, CA, ⁵Chronic Pain & Fatigue Research Center, University of Michigan, Ann Arbor, MI, ⁶Well Pharma Medical Research, Miami, FL, ⁷Tuscon Orthopedics Institute, Tuscon, AZ, ⁸Head, Division of Rheumatology & Clinical Immunology; Vice Chair, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Knee osteoarthritis (OA) is characterized by pain, disability and joint deformity due to articular cartilage degradation and bone remodeling. Wnt signaling is involved in…
Abstract Number: 2208 • 2017 ACR/ARHP Annual Meeting
A Novel Omeract MRI Scoring System Providing Insights in the Association of MRI Synovitis and Bone Marrow Lesions with Pain in Thumb Base Osteoarthritis
F.P.B. Kroon¹, S. van Beest¹, W. Damman¹, R. Liu¹, J.L. Bloem², M. Reijnierse² and M. Kloppenburg^1,3, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Radiology, Leiden University Medical Center, Leiden, Netherlands, ³Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Osteoarthritis (OA) in the thumb base joints (first carpometacarpal [CMC1] and scaphotrapeziotrapezoid [STT]) is highly prevalent and disabling, however much is still unknown about…
Abstract Number: 1186 • 2017 ACR/ARHP Annual Meeting
A Simple, Self-Assembled Hydrogel Depot for Localized Treatment of Post-Traumatic Osteoarthritis
Jing Yan¹, Nitin Joshi², Xueyin He², Sachin Bhagchandani², Kai Slaughter², Nicholas Sherman¹, Joerg Ermann¹ and Jeffrey Karp², ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, MA
Background/Purpose: Joint injuries, including sports- or combat-related ligamentous tears and fractures, can lead to post-traumatic osteoarthritis (PTOA), a chronic condition that causes pain, disability and…
Abstract Number: 2210 • 2017 ACR/ARHP Annual Meeting
Thumb Base Osteoarthritis: Associations between Pain and Synovitis on Ultrasound
F.P.B. Kroon¹, S. Ermurat², M. Kortekaas¹, M. Reijnierse³ and M. Kloppenburg^1,4, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Uludag University Medical Faculty, Bursa, Turkey, ³Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁴Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Osteoarthritis (OA) in the first carpometacarpal (CMC1) joint in the thumb base is frequent and has a large contribution in hand pain and disability.…
Abstract Number: 1188 • 2017 ACR/ARHP Annual Meeting
Initial Estimates of Efficacy of Intra-Articular 2.5% Polyacrylamide Hydrogel for the Treatment of Knee Osteoarthritis: An Observational Proof-of-Concept Study
Marius Henriksen^1,2, Anders Overgaard¹ and Henning Bliddal³, ¹The Parker Institute, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark, ²Department of physical therapy, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark, ³The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark
Background/Purpose: There is a draught of available effective treatments of knee osteoarthritis (OA) and tests of new therapies are needed. Polyacrylamide hydrogel (PAAG) is a…
Abstract Number: 2211 • 2017 ACR/ARHP Annual Meeting
Investigation of Self-Reported Painful Joint Count As an Outcome Measure in Hand Osteoarthritis
F.P.B. Kroon¹, J.L. van der Plas¹, S. van Beest¹, W. Damman¹ and M. Kloppenburg^1,2, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Hand osteoarthritis (OA) research is in need of disease-specific validated instruments to measure patient-reported outcomes. Self-reported painful joint count (PJC) could be useful to…
Abstract Number: 1189 • 2017 ACR/ARHP Annual Meeting
Favorable Human Safety, Pharmacokinetics and Pharmacodynamics of the Adamts-5 Inhibitor GLPG1972, a Potential New Treatment in Osteoarthritis
Ellen van der Aar¹, Sonia Dupont², Liesbeth Fagard¹, Marina De Smet¹, David Amantini², Staffan Larsson³, André Struglics³, L. Stefan Lohmander⁴, Frédéric Vanhoutte¹ and Julie Desrivot², ¹Galapagos NV, Mechelen, Belgium, ²Galapagos SASU, Romainville, France, ³Clinical Sciences, Lund University, Lund, Sweden, ⁴Orthopaedics, Clinical Sciences Lund, Lund University, Lund, Sweden
Background/Purpose: Increased aggrecanase activity is a well-known trigger factor for osteoarthritis (OA), initiating loss of cartilage aggrecan that precedes more severe cartilage degradation. A disintegrin…

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