Abstracts tagged "Osteoarthritis"

Abstract Number: 281 • 2019 ACR/ARP Annual Meeting
Frequency of Ultrasound Features of Knee Osteoarthritis and Their Association with Radiographic Features and Symptoms in a Community-Based Cohort
Nadiya Yerich¹, Carolina Alvarez ², Todd Schwartz ³, Sue Savage-Guin ², Catherine Bakewell ⁴, Minna Kohler ⁵, Janice Lin ⁶, Jonathan Samuels ⁷ and Amanda Nelson ², ¹University of North Carolina at Chapel Hill, Chapel Hill, NC, ²University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ³University of North Carolina at Chapel Hill Department of Biostatistics, Chapel Hill, NC, ⁴Intermountain Medical Center, Salt Lake City, UT, ⁵MGH, Boston, ⁶Stanford University, Palo Alto, CA, ⁷NYU Langone Medical Center, New Yort, NY
Background/Purpose: To evaluate the frequency and associations of osteoarthritis (KOA) features on knee ultrasound (KUS) in a community-based cohort study with radiographic and symptomatic data…
Abstract Number: 1303 • 2019 ACR/ARP Annual Meeting
Intra-Articular TPX-100 Significantly Delays Pathological Bone Shape Change at 6 and 12 Months in Moderate to Severe Tibiofemoral OA
Dawn McGuire¹, Michael Bowes ², Alan Brett ², Neil Segal ³, Meghan Miller ⁴, David Rosen ⁴ and Yoshinari Kumagai ⁴, ¹OrthoTrophix, Orinda, CA, ²Imorphics, Manchester, England, United Kingdom, ³University of Kansas Medical Center, Kansas City, KS, ⁴OrthoTrophix, Oakland, CA
Background/Purpose: Pathological bone shape changes in the femur precede cartilage changes in knee OA and predict disease onset and progression to joint failure (Neogi 2013;…
Abstract Number: 1325 • 2019 ACR/ARP Annual Meeting
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Healthy Male Japanese Subjects of the ADAMTS-5 Inhibitor S201086/GLPG1972, a Potential New Treatment in OA
Agnès Lalande ¹, Nadya Kuzniatsova-Mouchette ², Florian Chassereau ¹, Julia Geronimi ¹, Staffan Larsson ³, Andre Struglics ³, Stefan Lohmander ³ and Maria Pueyo¹, ¹Institut de Recherches Internationales Servier, Suresnes, France, Suresnes, France, ²Institut de Recherches Internationales Servier, Suresnes, France, Suresnes, ³Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden, Lund, Sweden
Background/Purpose: The disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5) is a key enzyme in OA (Verma P, et al. J Cell Biochem 2011;112:3507-14). In preclinical models…
Abstract Number: 1979 • 2019 ACR/ARP Annual Meeting
What Is the Pathogenic Meaning of Chondrocyte Hypertrophy in Osteoarthritis? Effect of Evc Deletion Through Hedgehog Signaling
Ana Lamuedra¹, Paula Gratal ¹, Víctor Luis Ruiz-Perez ², Adrián Palencia-Campos ³, Sergio Portal-Nuñez ⁴, Gabriel Herrero-Beaumont ⁵ and Raquel Largo ⁵, ¹IIS - Fundacion Jimenez Diaz, Madrid, Madrid, Spain, ²Instituto de Investigaciones Biomédicas 'Alberto Sols', Madrid, Madrid, Spain, ³Adrián Palencia Campos [[email protected]], Madrid, Madrid, Spain, ⁴Applied Molecular Medicine Institute (IMMA), Universidad San Pablo-CEU, Alcorcón, Madrid, Spain, ⁵IIS-Fundación Jiménez Díaz, Madrid, Madrid, Spain
Background/Purpose: Osteoarthritis (OA) is mainly characterized by the progressive damage of articular cartilage, where chondrocytes acquire a hypertrophic-like phenotype. Indian Hedgehog levels are increased in…
Abstract Number: 2178 • 2019 ACR/ARP Annual Meeting
Associations Between Baseline and Longitudinal Quantitative Joint Space Width and Incident Hip Osteoarthritis: The Johnston County Osteoarthritis Project
Jacquelyn Smith¹, Carolina Alvarez ¹, Liubov Arbeeva ¹, Jordan Renner ², Louise Murphy ³, Joanne Jordan ¹, Yvonne Golightly ⁴, Jeffrey Duryea ⁵ and Amanda Nelson ¹, ¹University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ²University of North Carolina at Chapel Hill Department of Radiology, Chapel Hill, NC, ³Centers for Disease Control and Prevention, Division of Population Health, Atlanta, ⁴University of North Carolina at Chapel Hill Department of Epidemiology and Thurston Arthritis Research Center, Chapel Hill, NC, ⁵Harvard Medical School Department of Radiology Brigham and Women's Hospital, Boston, MA
Background/Purpose: To quantify associations between baseline and change in computer-assisted hip quantitative joint space width (qJSW) with incident radiographic (rHOA) or symptomatic (sxHOA) hip OA.Methods:…
Abstract Number: 2203 • 2019 ACR/ARP Annual Meeting
Impact of Hypothetical Changes in the Use of Analgesics on the Burden of Osteoarthritis: A Population-based Microsimulation Study
Jacek Kopec¹, Eric Sayre ², Anya Okhmatovskaia ³, Jolanda Cibere ⁴, Linda Li ⁵, Nick Bansback ⁶, Hubert Wong ⁵ and John Esdaile ⁷, ¹Arthritis Research Canada and the University of British Columbia, Vancouver, BC, Canada, ²Arthritis Research Canada, Vancouver, BC, Canada, ³McGill University, Montreal, QC, Canada, ⁴Arthritis Research Canada and the University of British Columbia, Vancouver, Canada, ⁵University of British Columbia, Vancouver, BC, Canada, ⁶University of British Columbia, Vancouver, Canada, ⁷Arthritis Research Canada and the University of British Columbia, Richmond, BC, Canada
Background/Purpose: Analgesics are the cornerstone of medical treatment of osteoarthritis (OA) but are associated with serious side effects. A more optimal use of analgesics in…
Abstract Number: 821 • 2019 ACR/ARP Annual Meeting
Trends in Incidence and Prevalence of Osteoarthritis in the United Kingdom: Findings from the Clinical Practice Research Datalink (CPRD)
Subhashisa Swain¹, Aliya Sarmanova ², Christian Mallen ³, Chang Fu Kuo ⁴, Carol Coupland ⁵ and Weiya Zhang ⁶, ¹University of Nottingham, Nottingham, England, United Kingdom, ²2. Bristol Medical School, Population Health Sciences, University of Bristol, UK, Bristol, England, United Kingdom, ³Research Institute for Primary Care and Health Sciences, Keele University, UK, Keele, United Kingdom, ⁴4. Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan (Republic of China), ⁵5. Division of Primary Care, School of Medicine, University of Nottingham, Nottingham, England, United Kingdom, ⁶1. Academic Rheumatology, Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham, Nottingham, England, United Kingdom
Background/Purpose: Osteoarthritis (OA) is by far the most common arthritis.(1) However, its chronological trend in the United Kingdom (UK) is not known. We aimed to…
Abstract Number: 1307 • 2019 ACR/ARP Annual Meeting
A Prospective, Multi-center, Randomized, Clinical Trial Comparing the Effectiveness and Safety of Cooled Radiofrequency Ablation versus a Single Injection of Hyaluronic Acid in the Management of OA Knee Pain
Antonia Chen¹, Fred Khalouf ², Michael DePalma ³, Keith Zora ⁴, Lynn Kohan ⁵, Maged Guirguis ⁶, Douglas Beall ⁷, Eric Loudermilk ⁸, Matthew Pingree ⁹, Ignacio Badiola ¹⁰ and Jeffrey Lyman ¹¹, ¹Brigham and Women’s Hospital, Boston, MA, ²University Orthopedics Center, Altoona, PA, ³Virginia iSpine Physicians, Richmond, VA, ⁴University Orthopedics Center, State College, PA, ⁵University of Virginia School of Medicine, Charlottesville, VA, ⁶Ochsner Clinic Foundation, New Orleans, LA, ⁷Clinical Investigations, Edmond, OK, ⁸PCPMG Clinical Research Unit LLC, Anderson, SC, ⁹Mayo Clinic, Rochester, MN, ¹⁰University of Pennsylvania, Philadelphia, PA, ¹¹Institute for Orthopedic Research and Innovation, Coeur d'Alene, IN
Background/Purpose: This prospective, randomized, multi-center study was conducted to compare pain relief, functional improvement, and the safety of cooled radiofrequency ablation (CRFA) to hyaluronic acid…
Abstract Number: 1326 • 2019 ACR/ARP Annual Meeting
Safety Profile to Date of the Novel, Intra-articular Agent Lorecivivint (LOR; SM04690), a CLK/DYRK1A Inhibitor That Modulates the Wnt Pathway, in Subjects with Knee Osteoarthritis
Ismail Simsek ¹, Chris Swearingen ¹, Sarah Kennedy ¹, Jeyanesh Tambiah ¹, Yusuf Yazici², Nancy Lane ³ and Marc C. Hochberg ⁴, ¹Samumed, LLC, San Diego, ²Samumed, LLC, San Diego, CA, ³University of California at Davis Medical Center, Sacramento, CA, ⁴University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Recent concerns over osteoarthritis (OA) pharmacotherapy safety have led to revision of treatment guidelines and highlight the need for therapies with good safety profiles.…
Abstract Number: 1980 • 2019 ACR/ARP Annual Meeting
Disorganization of Chondrocyte Columns in the Growth Plate During Experimental Osteoarthritis in Mice
Ana Lamuedra¹, Víctor Luis Ruiz-Perez ², Paula Gratal ¹, Raquel Largo ³ and Gabriel Herrero-Beaumont ³, ¹IIS - Fundacion Jimenez Diaz, Madrid, Madrid, Spain, ²Instituto de Investigaciones Biomédicas 'Alberto Sols', Madrid, Madrid, Spain, ³IIS-Fundación Jiménez Díaz, Madrid, Madrid, Spain
Background/Purpose: Osteoarthritis (OA) is a biomechanical joint disease mainly affecting articular cartilage and subchondral bone. A great variety of animal models, especially mice, are used…
Abstract Number: 2179 • 2019 ACR/ARP Annual Meeting
Erosive Hand Osteoarthritis, Metabolic Syndrome and Knee Osteoarthritis: A Cross-sectional Study Using Data from the PROCOAC Cohort
Natividad Oreiro¹, Ignacio Rego-Pérez ¹, Maria T. Silva ¹, Sara Relaño ¹, Mercedes Fernandez-Moreno ², Paula Ramos-Louro ¹, Alejandro Duran-Sotuela ¹, Sonia Pertega ³ and Francisco J. Blanco ¹, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ²Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España. CIBER-BBM, A Coruña, Spain, ³Unidad de Epidemiología Clínica y Bioestadística. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain
Background/Purpose: Erosive hand osteoarthritis (EOA) is often considered a more severe form of hand OA. However, more data are needed regarding this phenotype to conclude…
Abstract Number: 2220 • 2019 ACR/ARP Annual Meeting
Abaloparatide Followed by Alendronate on Bone Mineral Density and Fracture Incidence in Postmenopausal Women with Osteoporosis and Osteoarthritis
Nancy Lane¹, Richard Weiss ², Bruce Mitlak ³, Yamei Wang ⁴, Guillermo Valenzuela ⁵ and Chad Deal ⁶, ¹University of California at Davis Medical Center, Sacramento, CA, ²Radius Health, Inc, Waltham, ³Radius Health, Inc, Waltham, MA, ⁴Radius Health, Inc, Waltham, ⁵Integral Rheumatology & Immunology Specialists, Plantation, FL, ⁶Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: Osteoporosis (OP) and osteoarthritis (OA) are often comorbid conditions in the elderly, with prevalence of OP in patients with OA reported as high as…
Abstract Number: 875 • 2019 ACR/ARP Annual Meeting
Effect of the Dr. Bart Application on Healthcare Use and Clinical Outcomes in People with Osteoarthritis of the Knee And/or Hip in the Netherlands; A Randomized Controlled Trial
Tim Pelle¹, Karen Bevers ¹, Job van der Palen ², Frank van den Hoogen ³ and Cornelia van den Ende ¹, ¹Sint Maartenskliniek Nijmegen, Nijmegen, Netherlands, ²Department of research methodology, Univeristy of Twente, Enschede, Netherlands, ³Sint Maartenskliniek, Nijmegen, Netherlands
Background/Purpose: Self-management is of paramount importance in non-surgical treatment of knee/hip osteoarthritis (OA). Modern technologies offer the possibility to support self-management 24/7. We developed an…
Abstract Number: 1308 • 2019 ACR/ARP Annual Meeting
Subject Enrichment Criteria for Phase 3 Studies of Lorecivivint (SM04690), a Potential Disease-Modifying Knee Osteoarthritis Drug: A Post Hoc Study on the Effects of Baseline Comorbid Pain and Joint Space Width on Patient-Reported Outcomes
Sarah Kennedy ¹, Chris Swearingen ¹, Jeyanesh Tambiah¹, Daniel Clauw ² and Philip G Conaghan ³, ¹Samumed, LLC, San Diego, ²Division of Rheumatology, Department of Internal Medicine and Division of Anesthesia, Michigan Medicine, Ann Arbor, MI, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom
Background/Purpose: Patient-reported outcomes (PROs) in knee osteoarthritis (OA) trials have been difficult to accurately measure due to heterogenous sources of pain (e.g., from comorbid conditions…
Abstract Number: 1327 • 2019 ACR/ARP Annual Meeting
The Novel, Intra-articular CLK/DYRK1A Inhibitor Lorecivivint (LOR; SM04690), Which Modulates the Wnt Pathway, Improved Responder Outcomes in Subjects with Knee Osteoarthritis: A Post Hoc Analysis from a Phase 2b Trial
Yusuf Yazici¹, Sarah Kennedy ², Chris Swearingen ² and Jeyanesh Tambiah ², ¹Samumed, LLC, San Diego, CA, ²Samumed, LLC, San Diego
Background/Purpose: Lorecivivint (LOR, SM04690) is a small-molecule, intra-articular (IA) CLK/DYRK1A inhibitor which modulates the Wnt pathway and has demonstrated beneficial effects on patient-reported outcomes (PROs)…

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