Abstracts tagged "Osteoarthritis"

Abstract Number: 1189 • 2017 ACR/ARHP Annual Meeting
Favorable Human Safety, Pharmacokinetics and Pharmacodynamics of the Adamts-5 Inhibitor GLPG1972, a Potential New Treatment in Osteoarthritis
Ellen van der Aar¹, Sonia Dupont², Liesbeth Fagard¹, Marina De Smet¹, David Amantini², Staffan Larsson³, André Struglics³, L. Stefan Lohmander⁴, Frédéric Vanhoutte¹ and Julie Desrivot², ¹Galapagos NV, Mechelen, Belgium, ²Galapagos SASU, Romainville, France, ³Clinical Sciences, Lund University, Lund, Sweden, ⁴Orthopaedics, Clinical Sciences Lund, Lund University, Lund, Sweden
Background/Purpose: Increased aggrecanase activity is a well-known trigger factor for osteoarthritis (OA), initiating loss of cartilage aggrecan that precedes more severe cartilage degradation. A disintegrin…
Abstract Number: 2213 • 2017 ACR/ARHP Annual Meeting
“Generalized Osteoarthritis”: Update to a Systematic Review
Terese R. Gullo^1,2 and Amanda Nelson³, ¹Thurston Arthritis Research Center, Chapel Hill, NC, ²Ohio State University College of Medicine, Columbus, OH, ³Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: To perform a systematic review of the definitions of generalized osteoarthritis (GOA). An initial systematic review of the literature for GOA was published in…
Abstract Number: 1197 • 2017 ACR/ARHP Annual Meeting
Exploring Determinants Predicting Response to Intra-Articular Hyaluronic Acid Treatment in Symptomatic Knee Osteoarthritis
Jean-Pierre Pelletier¹, Jean-Pierre Raynauld¹, François Abram², Marc Dorais³, Philippe Delorme⁴ and Johanne Martel-Pelletier¹, ¹Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ²Medical Imaging Research & Development, ArthroLab Inc., Montreal, QC, Canada, ³StatSciences Inc., Notre-Dame-de-l’Île-Perrot, QC, Canada, ⁴ArthroLab Inc., Montreal, QC, Canada
Background/Purpose: A major challenge regarding intraarticular hyaluronic acid (IAHA) treatment in knee osteoarthritis (OA) is identifying patients who will benefit most. This study aimed to…
Abstract Number: 2214 • 2017 ACR/ARHP Annual Meeting
Contrary to Current Understanding of Osteoarthritis Pathogenesis, Only Gender and Radiographic Status Predict Progression: A Machine Learning Study of 9,254 Knees from the Osteoarthritis Initiative
Michael A Bowes¹, Oras Alabas², Gwenael Guillard¹, Graham R. Vincent¹, Alan Brett³ and Philip G. Conaghan⁴, ¹Imorphics Ltd, Manchester, United Kingdom, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, United Kingdom, Leeds, United Kingdom, ³Imorphics Ltd, MANCHESTER, United Kingdom, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom
Background/Purpose: Currently there are a large number of postulated predictors for OA progression, proposed on the basis of relatively small studies (100’s), and measurement approaches…
Abstract Number: 1204 • 2017 ACR/ARHP Annual Meeting
Radiographic Outcomes Were Associated with Pain and Function Responses: Post-Hoc Analysis of Results from a Phase 2 Study of a Small Molecule Wnt Pathway Inhibitor, SM04690, for Knee Osteoarthritis Treatment
Yusuf Yazici¹, Timothy E. McAlindon², Allan Gibofsky³, Nancy E. Lane⁴, Nebojsa Skrepnik⁵, Eddie Armas⁶, Christopher J. Swearingen¹, Anita DiFrancesco¹, Jeymi Tambiah¹ and Marc Hochberg⁷, ¹Samumed, LLC, San Diego, CA, ²Division of Rheumatology, Tufts Medical Center, Boston, MA, ³Rheumatology, Weill Cornell Medicine, and Hospital for Special Surgery, New York, NY, ⁴Center for Musculoskeletal Health, University of California, Davis School of Medicine, Sacramento, CA, ⁵Tuscon Orthopedics Institute, Tuscon, AZ, ⁶Well Pharma Medical Research, Miami, FL, ⁷Head, Division of Rheumatology & Clinical Immunology; Vice Chair, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Knee osteoarthritis (OA) is characterized by pain, disability and joint deformity due to articular cartilage degradation and bone remodeling. Wnt signaling is involved in…
Abstract Number: 2215 • 2017 ACR/ARHP Annual Meeting
Effect of Single 6 Ml Intraarticular Injection of Hylan G-F 20 in Patients with Knee Osteoarthritis: Results of a Single Centre Study
SUNIL KUMAR PANDEY¹ and SAT PAL SINGH², ¹ORTHOPEDIC DEPARTMENT, SAFDARJUNG HOSPITAL, VMMC, NEW DELHI, NEW DELHI, India, ²DEPARTMENT OF MEDICINE, SAFDARJUNG HOSPITAL,VMMC, NEW DELHI, NEW DELHI, India
Background/Purpose: To evaluate the effect of single 6ml intraarticular injection of hylan G-F 20 in patients with knee osteoarthritis. Author: Dr. Pandey Sunil Kumar*, Dr.…
Abstract Number: 1875 • 2017 ACR/ARHP Annual Meeting
Assessment of Structural Damage of the Thumb Base in Patients with Hand Osteoarthritis: Comparing the Newly Developed Omeract Magnetic Resonance Imaging Scoring System with Standard Radiography
S. van Beest¹, F.P.B. Kroon¹, W. Damman¹, R. Liu¹, H.M. Kroon² and M. Kloppenburg³, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Radiology, Leiden University Medical Center, Leiden, Netherlands, ³Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Thumb base osteoarthritis (OA) is characterized by structural damage, most commonly evaluated by radiography. However radiography is insensitive. Magnetic resonance (MR) imaging could be…
Abstract Number: 2247 • 2017 ACR/ARHP Annual Meeting
Secondary Fibromyalgia Is Not Associated with Higher Likelihood of Patient-Physician Discordance in Global Assessment in Patients with Osteoarthritis and Rheumatoid Arthritis
Isabel Castrejón, Shakeel M. Jamal and Najia Shakoor, Division of Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Pain is the strongest driver of patient-physician discordance in global assessment in patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Having secondary fibromyalgia (FM),…
Abstract Number: 1929 • 2017 ACR/ARHP Annual Meeting
Sustained Efficacy of Intra-Articular SB-061, a Novel Matrix Regulator Inspired By Aggrecan, in a Rat Model of Osteoarthritis
Kate Stuart¹, Julia Chen¹, Sharmi Saha¹, Harsha Kabra¹, Athene Chan¹, Kamal Egodoge¹, Jennifer Oskins², Chaohua Lin², Morten Karsdal³, Mark Chambers² and John Paderi¹, ¹Symic Bio, Emeryville, CA, ²Lilly Research Laboratories, Indianapolis, IN, ³Biomarkers and Reseacrh, Nordic Bioscience, Herlev, Denmark
Background/Purpose: No therapy for osteoarthritis (OA) has yet to deliver both structural and symptomatic benefits. Symic is approaching this unmet clinical need with a novel…
Abstract Number: 2264 • 2017 ACR/ARHP Annual Meeting
Low Educational Attainment Is Associated with Poor Patient Status in Rheumatoid Arthritis (RA) or Osteoarthritis (OA) at the Initial Rheumatology Visit, with Remarkably Similar Patterns in Either Diagnosis
Juan Schmukler¹, Jacquelin R. Chua¹, Shakeel M. Jamal¹, Isabel Castrejón¹, Joel A Block¹ and Theodore Pincus², ¹Division of Rheumatology, Rush University Medical Center, Chicago, IL, ²Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Low educational attainment is associated with higher prevalence, morbidity, and mortality of many diseases, including rheumatoid arthritis1 (RA) and osteoarthritis2 (OA). These associations often…
Abstract Number: 1947 • 2017 ACR/ARHP Annual Meeting
Thy1 Is a Positive Regulator of Osteoblast Differentiation and Modulates Bone Homeostasis in Obese Mice
Ananta Paine¹, Collynn Woeller², Nelson Huertas¹, Maria de la Luz Garcia-Hernandez³, Richard Phipps² and Christopher T. Ritchlin⁴, ¹Department of Medicine, Division of Allergy, Immunology and Rheumatology, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA, Rochester, NY, ²Department of Environmental Medicine, School of Medicine and Dentistry,, Department of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA, Rochester, NY, ³Department of Medicine,, Division of Allergy, Immunology and Rheumatology, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA, Rochester, NY, ⁴Division of Allergy, Immunology and Rheumatology, School of Medicine and Dentistry, Division of Allergy, Immunology and Rheumatology, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA, Rochester, NY
Background/Purpose: Thy1 (CD90) is a glycosylated, glycophosphatidylinositol (GPI)-anchored membrane protein originally identified as a marker for mouse T cells but subsequent reports noted expression on…
Abstract Number: 2428 • 2017 ACR/ARHP Annual Meeting
Epstein-Barr Virus Infection and Epstein-Barr Virus　Nuclear Antigen 1 Variants in the Synovial Tissue of Rheumatoid Arthritis
Shotaro Masuoka¹, Natsuko Kusunoki¹, Shinichi Kawai² and Toshihiro Nanki¹, ¹Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan, ²Department of Inflammation and Pain Control Research, Toho University School of Medicine, Tokyo, Japan
Background/Purpose: Epstein-Barr virus (EBV) infection causes various malignant tumors such as B cell lymphoma and epithelial cell cancer. Previous reports showed several variants in carboxyl-terminal…
Abstract Number: 2179 • 2017 ACR/ARHP Annual Meeting
Comparing Observed with Expected Assessments of Osteoarthritic Pain over Time: Application of Successive Prediction to Data from the Osteoarthritis Initiative
Steven Mongin¹, Naoko Onizuka², Lisa Langsetmo³ and Anna Shmagel⁴, ¹Biostatistics, University of Minnesota School of Public Health, Minneapolis, MN, ²Medicine, University of Minnesota, Minneapolis, MN, ³University of Minnesota School of Public Health, Minneapolis, MN, ⁴Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN
Background/Purpose: High variability in patient-reported outcome scores presents a major challenge in the design and interpretation of clinical studies in osteoarthritis (OA). We present a…
Abstract Number: 2766 • 2017 ACR/ARHP Annual Meeting
Physical Therapy Vs. Internet-Based Exercise Training for Patients with Knee Osteoarthritis: Results of a Randomized Controlled Trial
Kelli Allen¹, Liubov Arbeeva², Leigh F. Callahan³, Yvonne M. Golightly⁴, Adam P. Goode⁵, Bryan Heiderscheit⁶, Carla Hill⁷, Kim Huffman⁸, Herbert Seversen⁹ and Todd A. Schwartz¹⁰, ¹Rheumatology, University of North Carolina at Chapel Hill and Durham VA Medical Center, Durham, NC, ²Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, ⁴Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁵O, Duke University, Durham, NC, ⁶Department of Orthopedics and Rehabilitation, University of Wisconsin, Madison, WI, ⁷University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁸School of Medicine, Division of Rheumatology, Immunology and Molecular Physiology and Durham VA Medical Center, Duke University, Durham, NC, ⁹Oregon Research Institute, Durham, OR, ¹⁰Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: The majority of adults with osteoarthritis (OA) are inactive, highlighting the need for continued efforts to promote regular engagement in exercise. Few studies have…
Abstract Number: 217 • 2017 ACR/ARHP Annual Meeting
Keeping a Balance: Social Engagement and Care Giving
Elizabeth M. Badley^1,2, Dov Millstone² and Anthony V. Perruccio^2,3,4, ¹Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ²Health Care & Outcomes Research, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ³Arthritis Program, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ⁴Institute of Health Policy, Management & Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
Background/Purpose: Arthritis is associated with pain and disability. As a result there has been some interest in examining the receipt of care among those with…

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