Abstracts tagged "Osteoarthritis"

Abstract Number: 1961 • 2019 ACR/ARP Annual Meeting
Mitochondrial DNA Sub-haplogroup H1 Influences the Risk of Rapidly Progressive Osteoarthritis of the Knee: Data from the Osteoarthritis Initiative
Alejandro Duran-Sotuela¹, Mercedes Fernandez-Moreno ², María E. Vázquez-Mosquera ³, Paula Ramos-Louro ¹, Andrea Dalmao-Fernández ³, Sara Relaño ¹, Natividad Oreiro ¹, Francisco J. Blanco ¹ and Ignacio Rego-Pérez ¹, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ²Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España. CIBER-BBM, A Coruña, Spain, ³Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Galicia, Spain
Background/Purpose: There is a need to identify the rapid progressive phenotype of Osteoarthritis (OA). Our aim is to analyze the effect of mitochondrial haplogroups in…
Abstract Number: 2056 • 2019 ACR/ARP Annual Meeting
Opioids Use Among Medicare Beneficiaries with Knee Osteoarthritis: Prevalence and Correlates of Chronic Use
Elena Losina¹, Shuang Song ² and Jeffrey Katz ³, ¹Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Brigham and Women's Hospital/Harvard Medical School, Boston
Background/Purpose: Osteoarthritis (OA) of the knee is prevalent among Medicare beneficiaries. Effective pain control is critical for managing this chronic disease. In the last decade,…
Abstract Number: 2188 • 2019 ACR/ARP Annual Meeting
The Association of Plasma Fatty Acids Levels with Hand and Knee Osteoarthritis
Marieke Loef¹, Andreea Ioan-Facsinay ¹, Dennis O Mook-Kanamori ², Ko Willems van Dijk ¹, Renée de Mutsert ¹, Margreet Kloppenburg ¹ and Frits R Rosendaal ¹, ¹Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Obesity is one of the most important risk factors for osteoarthritis, and is strongly associated with increased levels of circulating fatty acids, which may…
Abstract Number: 2760 • 2019 ACR/ARP Annual Meeting
A Phase 2 Double-Blind Clinical Trial to Examine the Comparative Effects on Osteoarthritic Knee Pain of CGS-200-1 (1% Capsaicin Topical Liquid), CGS-200-5 (5% Capsaicin Topical Liquid), and CGS-200-0 (Vehicle, No Capsaicin)
Michael Billard ¹, John Todhunter ¹, Margaret Fleming ¹, Tim Warneke¹, Yuhui Qiu ², Nhu Ly ², William Aronstein ² and William Moore ¹, ¹Vizuri Health Sciences, LLC, Columbia, MD, ²CTI Clinical Trial & Consulting, Covington, KY
Background/Purpose: There is considerable unmet medical need for an osteoarthritic knee pain (OAKP) treatment that does not require regular daily use, does not carry gastrointestinal…
Abstract Number: 1129 • 2019 ACR/ARP Annual Meeting
Direct Medical and Societal Cost of Opioid Use in Symptomatic Knee Osteoarthritis Patients in the United States
Jamie Huizinga¹, Elizabeth Stanley ¹, Shuang Song ¹, James Sullivan ², Jeffrey Katz ³ and Elena Losina ⁴, ¹Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, ³Brigham and Women's Hospital/Harvard Medical School, Boston, ⁴Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Symptomatic knee OA affects 14 million adults in the US. Recent estimates suggest that about 40% of people with knee OA are taking prescription…
Abstract Number: 1317 • 2019 ACR/ARP Annual Meeting
Frail Patients Have Worse Function After Total Knee Replacement
Lisa Mandl¹, Charles Cornell ¹, Michael Cross ¹, Alejandro Gonzalez Della Valle ¹, Mark Figgie ¹, Seth Jerabek ¹, Marianna Frey ², John Roberts IV ³, Justin Do ³, Mayu Sasaki ³, Nathaniel Hupert ⁴, Jackie Finik ³ and Steven Magid ¹, ¹Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, New York, NY, ²Hospital for Special Surgery, New York, NY, New York, ³Hospital for Special Surgery, New York, NY, New York, NY, ⁴Weill Cornell Medicine, New York, NY, New York, NY
Background/Purpose: To determine whether frailty is associated with patient outcomes 1 year after total knee replacement (TKR).Methods: Patients ≥65yo scheduled for elective primary TKR for…
Abstract Number: 1968 • 2019 ACR/ARP Annual Meeting
A Drug Repurposing Story: New Therapeutic Tools Ready to Block Innate Immune Responses in Osteoarthritis
Eloi Franco-Trepat¹, Ana Alonso-Pérez ¹, Maria Guillán-Fresco ¹, Alberto Jorge-Mora ², Ana Lois Iglesias ³, Oreste Gualillo ⁴ and Rodolfo Gómez ¹, ¹Institute IDIS - Musculoskeletal Pathology Group, Santiago de Compostela, Spain, ²Institute IDIS - Musculoskeletal Pathology Group, Santiago de Compostela, ³Institute IDIS - Musculoskeletal Pathology Group, Santiago de Compostela, Galicia, Spain, ⁴Institute IDIS - NEIRID Lab - SERGAS, Santiago de Compostela, Spain
Background/Purpose: Rheumatic diseases, also known as musculoskeletal pathologies, are steadily rising their prevalence. This worldwide phenomenon is depriving our society of their life quality and…
Abstract Number: 2057 • 2019 ACR/ARP Annual Meeting
Cross-sectional Associations of Multiple Joint Osteoarthritis in the Osteoarthritis Initiative
Charles Eaton¹, Mary Roberts ², Jeffrey Driban ³, Michael Nevitt ⁴, Jeffrey Duryea ⁵ and Timothy McAlindon ⁶, ¹Warren Alpert Medical School of Brown University, Pawtucket, RI, ²Center for Primary Care and Prevention, Pawtucket, ³Tufts Medical Center, Boston, ⁴University of California at San Francisco, San Francisco, CA, ⁵Harvard Medical School Department of Radiology Brigham and Women's Hospital, Boston, MA, ⁶Tufts Medical Center, Boston, MA
Background/Purpose: Multiple joint osteoarthritis (MJOA) may represent a unique phenotype of osteoarthritis related to systemic factors associated with pathologic aging. We tested the hypothesis that metabolic…
Abstract Number: 2189 • 2019 ACR/ARP Annual Meeting
Reference Curves for the Knee Injury and Osteoarthritis Outcome Score in the Middle-aged Dutch Population
Marieke Loef¹, Féline PB Kroon ¹, Stephan Böhringer ¹, Frits R Rosendaal ¹ and Margreet Kloppenburg ¹, ¹Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands
Background/Purpose: The Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaire is a widely used patient-reported outcome tool, developed to evaluate short- and long-term knee symptoms…
Abstract Number: 2762 • 2019 ACR/ARP Annual Meeting
The Preparation and Recovery Experience from Total Knee Replacement of Patients with Osteoarthritis: A Qualitative Study
Iris Navarro-Millan¹, Sarah Young ², Geyanne Lui ¹, Marianna Frey ³, Janey Peterson ¹, Susan Goodman ⁴, Monika Safford ¹ and Lisa Mandl ⁵, ¹Weill Cornell Medicine, New York, ²Binghamton University, Binghamton, ³Hospital for Special Surgery, New York, NY, New York, ⁴Hospital For Special Surgery/Weill Cornell Medicine, New York, NY, ⁵Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, New York, NY
Background/Purpose: Up to 30% of patients may have persistent pain post-total knee arthroplasty (TKA). One possible approach to improve these outcomes is to optimize muscle…
Abstract Number: 1139 • 2019 ACR/ARP Annual Meeting
Lifetime Direct Medical and Indirect Cost of Knee Osteoarthritis: Impact of Pain and Structural Severity
Elizabeth Stanley¹, James Sullivan ², Jamie Huizinga ¹, Jamie Collins ³, Jeffrey Katz ⁴ and Elena Losina ⁵, ¹Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, ³Brigham and Women's Hospital and Harvard Medical School, Boston, ⁴Brigham and Women's Hospital/Harvard Medical School, Boston, ⁵Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Symptomatic knee OA is a debilitating condition that affects 14 million adults in the US. We estimated the variability of lifetime OA-related direct and…
Abstract Number: 1319 • 2019 ACR/ARP Annual Meeting
Impact of ACL Injury Management on the Development of Knee Osteoarthritis: A Meta-analysis
stéphanie Ferrero¹, marion louvois ¹, Thomas Barnetche ², Thao Pham ³, Véronique Breuil ¹ and christian roux ⁴, ¹University of Nice, nice, France, ²FHU ACRONIM, Department of Rheumatology, Centre Hospitalier Universitaire, Bordeaux, France, Bordeaux, France, ³Aix-Marseille University, CHU Marseille, department of Rheumatology, 13,000 Marseille, France, Marseille, France, ⁴CHU Pasteur Nice, Nice, France
Background/Purpose: Background: The development of knee's osteoarthritis after anterior cruciate ligament ACL injury is now widely recognized. The impact of surgical or rehabilitative management on…
Abstract Number: 1970 • 2019 ACR/ARP Annual Meeting
Mechanism of Chondroprotective Effects of 4-Methylumbelliferone and 2-Deoxyglucose
Kenya Terabe¹, Nobunori Takahashi ¹, Yoshifumi Ohashi ², Toshihisa Kojima ¹, Naoki Ishiguro ¹, Cheryl Knudson ² and Warren Knudson ², ¹Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan, ²East Carolina University, Greenville
Background/Purpose: We recently reported that the inhibitor of hyaluronan (HA) biosynthesis, 4-methylumbelliferone (4-MU) blocked IL-1β activation of MMP13 mRNA and protein expression in human osteoarthritic…
Abstract Number: 2083 • 2019 ACR/ARP Annual Meeting
Understanding Knee Function and Symptom Management in Individuals with Risk Factors for Knee Osteoarthritis
Jason Jakiela¹, Daniel White ², Hiral Master ², Meredith Christiansen ¹, Dana Voinier ¹, Lauren Neely ¹ and Louise Thoma ³, ¹University of Delaware, Newark, ²University of Delaware, Newark, DE, ³University of North Carolina at Chapel Hill, Newark
Background/Purpose: Worse knee function and frequent use of knee symptom management strategies are common in people with symptomatic knee osteoarthritis (SxOA). There are several risk…
Abstract Number: 2191 • 2019 ACR/ARP Annual Meeting
Construct Validity of OMERACT Ultrasound Knee Scores with Pain, Other Symptoms, Radiographic and MRI Findings
Win Min Oo¹, James Linklater ², Kimberly Bennell ³, Shirley Yu ¹, Xia Wang ¹, Vicky Duong ¹ and David Hunter ¹, ¹Rheumatology Department, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Australia, Sydney, New South Wales, Australia, ²Department of Musculoskeletal Imaging, Castlereagh Sports Imaging Center, St. Leonards, Sydney, Australia, Sydney, New South Wales, Australia, ³Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, School of Health Sciences, Faculty of Medicine Dentistry & Health Sciences, The University of Melbourne, Melbourne, VIC, Australia., Parkville, Victoria, Australia
Background/Purpose: To investigate the construct validity of Outcome Measures in Rheumatology (OMERACT) ultrasound scores for knee osteoarthritis (OA) with pain, other symptoms, and OA severity…

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