Abstracts tagged "Osteoarthritis"

Abstract Number: 2762 • 2019 ACR/ARP Annual Meeting
The Preparation and Recovery Experience from Total Knee Replacement of Patients with Osteoarthritis: A Qualitative Study
Iris Navarro-Millan¹, Sarah Young ², Geyanne Lui ¹, Marianna Frey ³, Janey Peterson ¹, Susan Goodman ⁴, Monika Safford ¹ and Lisa Mandl ⁵, ¹Weill Cornell Medicine, New York, ²Binghamton University, Binghamton, ³Hospital for Special Surgery, New York, NY, New York, ⁴Hospital For Special Surgery/Weill Cornell Medicine, New York, NY, ⁵Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, New York, NY
Background/Purpose: Up to 30% of patients may have persistent pain post-total knee arthroplasty (TKA). One possible approach to improve these outcomes is to optimize muscle…
Abstract Number: 1139 • 2019 ACR/ARP Annual Meeting
Lifetime Direct Medical and Indirect Cost of Knee Osteoarthritis: Impact of Pain and Structural Severity
Elizabeth Stanley¹, James Sullivan ², Jamie Huizinga ¹, Jamie Collins ³, Jeffrey Katz ⁴ and Elena Losina ⁵, ¹Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, ³Brigham and Women's Hospital and Harvard Medical School, Boston, ⁴Brigham and Women's Hospital/Harvard Medical School, Boston, ⁵Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Symptomatic knee OA is a debilitating condition that affects 14 million adults in the US. We estimated the variability of lifetime OA-related direct and…
Abstract Number: 1319 • 2019 ACR/ARP Annual Meeting
Impact of ACL Injury Management on the Development of Knee Osteoarthritis: A Meta-analysis
stéphanie Ferrero¹, marion louvois ¹, Thomas Barnetche ², Thao Pham ³, Véronique Breuil ¹ and christian roux ⁴, ¹University of Nice, nice, France, ²FHU ACRONIM, Department of Rheumatology, Centre Hospitalier Universitaire, Bordeaux, France, Bordeaux, France, ³Aix-Marseille University, CHU Marseille, department of Rheumatology, 13,000 Marseille, France, Marseille, France, ⁴CHU Pasteur Nice, Nice, France
Background/Purpose: Background: The development of knee's osteoarthritis after anterior cruciate ligament ACL injury is now widely recognized. The impact of surgical or rehabilitative management on…
Abstract Number: 1970 • 2019 ACR/ARP Annual Meeting
Mechanism of Chondroprotective Effects of 4-Methylumbelliferone and 2-Deoxyglucose
Kenya Terabe¹, Nobunori Takahashi ¹, Yoshifumi Ohashi ², Toshihisa Kojima ¹, Naoki Ishiguro ¹, Cheryl Knudson ² and Warren Knudson ², ¹Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan, ²East Carolina University, Greenville
Background/Purpose: We recently reported that the inhibitor of hyaluronan (HA) biosynthesis, 4-methylumbelliferone (4-MU) blocked IL-1β activation of MMP13 mRNA and protein expression in human osteoarthritic…
Abstract Number: 2083 • 2019 ACR/ARP Annual Meeting
Understanding Knee Function and Symptom Management in Individuals with Risk Factors for Knee Osteoarthritis
Jason Jakiela¹, Daniel White ², Hiral Master ², Meredith Christiansen ¹, Dana Voinier ¹, Lauren Neely ¹ and Louise Thoma ³, ¹University of Delaware, Newark, ²University of Delaware, Newark, DE, ³University of North Carolina at Chapel Hill, Newark
Background/Purpose: Worse knee function and frequent use of knee symptom management strategies are common in people with symptomatic knee osteoarthritis (SxOA). There are several risk…
Abstract Number: 2191 • 2019 ACR/ARP Annual Meeting
Construct Validity of OMERACT Ultrasound Knee Scores with Pain, Other Symptoms, Radiographic and MRI Findings
Win Min Oo¹, James Linklater ², Kimberly Bennell ³, Shirley Yu ¹, Xia Wang ¹, Vicky Duong ¹ and David Hunter ¹, ¹Rheumatology Department, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Australia, Sydney, New South Wales, Australia, ²Department of Musculoskeletal Imaging, Castlereagh Sports Imaging Center, St. Leonards, Sydney, Australia, Sydney, New South Wales, Australia, ³Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, School of Health Sciences, Faculty of Medicine Dentistry & Health Sciences, The University of Melbourne, Melbourne, VIC, Australia., Parkville, Victoria, Australia
Background/Purpose: To investigate the construct validity of Outcome Measures in Rheumatology (OMERACT) ultrasound scores for knee osteoarthritis (OA) with pain, other symptoms, and OA severity…
Abstract Number: 2794 • 2019 ACR/ARP Annual Meeting
Predictors of Incident and Worsening Lumbar Spine Degeneration: The Johnston County Osteoarthritis Project
Adam Goode¹, Rebecca Cleveland ², David Hu ³, Steven George ⁴, Virginia Byers Kraus ⁵, Todd Schwartz ⁶, Richard Gracely ⁷, Louis DeFrate ⁸, Joanne Jordan ⁹ and Yvonne Golightly ¹⁰, ¹Duke University, Department of Orthopedic Surgery, Duke Clinical Research Institute, and Department of Population Health Sciences, Durham, NC, ²Thurston Arthritis Research Center, Chapel Hill, NC, ³Thurston Arthritis Center, University of North Carolina - Chapel Hill, Chapel Hill, NC, ⁴Duke University, Department of Orthopedic Surgery and Duke Clinical Research Institute, Durham, NC, ⁵Duke University, Department of Orthopedic Surgery, Duke Molecular Physiology Laboratory, Durham, NC, ⁶University of North Carolina at Chapel Hill Department of Biostatistics, Chapel Hill, NC, ⁷Department of Endodontics, Adams School of Dentistry, University of North Carolina, Chapel Hill, Chapel Hill, NC, ⁸Duke University, Department of Orthopedic Surgery, Department of Mechanical Engineering and Materials Science and Department of Biomedical Engineering, Durhham, NC, ⁹University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ¹⁰University of North Carolina at Chapel Hill Department of Epidemiology and Thurston Arthritis Research Center, Chapel Hill, NC
Background/Purpose: Our aim was to determine whether demographics, clinical characteristics or appendicular joint osteoarthritis predict the incidence and worsening of lumbar spine disc space narrowing…
Abstract Number: 1162 • 2019 ACR/ARP Annual Meeting
Changes in Novel Composite Scores of Disease Activity and Cumulative Damage Are Prognostic of Accelerated Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Matthew Harkey¹, Julie Davis ², Bing Lu ³, Lori Lyn Price ⁴, Robert Ward ⁵, James MacKay ⁶, Charles Eaton ⁷, Grace Lo ⁸, Mary Barbe ⁹, Ming Zhang ⁵, Jincheng Pang ¹⁰, Alina Stout ¹¹, Lavalley Michael ¹², Timothy McAlindon ¹³ and Jeffrey Driban ¹³, ¹University of Massachusetts Medical School, Worcester, ²George Washington University, Washington DC, ³Brigham and Women's Hospital, Boston, MA, ⁴Tufts Medical Center, Tufts University, Boston, MA, ⁵Tufts Medical Center, Boston, ⁶University of Cambridge, Cambridge, United Kingdom, ⁷Brown University Center for Primary Care and Prevention, Pawtucket, ⁸Center of Excellence Michael E. DeBakey VAMC, Baylor College of Medicine, Houston, TX, ⁹Temple University, Philadelphia, ¹⁰Pfizer, Inc., Cambridge, MA, ¹¹Northeastern University, Boston, ¹²Boston University, Boston, ¹³Tufts Medical Center, Boston, MA
Background/Purpose: Composite imaging scores that reflect cartilage damage, bone marrow lesions (BMLs), and effusion-synovitis may enable us to conceptualize knee osteoarthritis (KOA) disease progression as…
Abstract Number: 1320 • 2019 ACR/ARP Annual Meeting
Individual Socio-economic Status and Symptomatic Hip and Knee Osteoarthritis: A Longitudinal Study, Results from the KHOALA Cohort
Pauline Baudart¹, Anne-Christine Rat ², Christian Marcelli ¹ and Joséphine Bryère ³, ¹CHU Caen, rheumatology department, Caen Normandie University, Caen, France, ²CHU Caen, rheumatology department, Caen Normandie University, Université de Lorraine, EA 4360 APEMAC, Caen, France, ³Inserm, university of Caen research U1086 Anticipe, Caen, France
Background/Purpose: We analyzed the association between individual socio-economic status (SES) variables and clinical symptoms (function, pain and quality of life) in patients with symptomatic knee…
Abstract Number: 1972 • 2019 ACR/ARP Annual Meeting
Identification of Distinct Lipidomic Profiles in Synovial Membranes from Inflammatory Arthritis by Mass Spectrometry Imaging
Beatriz Rocha¹, Berta Cillero-Pastor ², Cristina Ruiz-Romero ³, Andrea Cuervo ⁴, Ron M A Heeren ², Juan Cañete ⁵ and Francisco J. Blanco ⁶, ¹Proteomics Group-ProteoRed/ISCIII, Grupo de Investigación de Reumatología (GIR), INIBIC – Hospital Universitario de A Coruña, A Coruña, Spain, A Coruña, Galicia, Spain, ²The Maastricht Multimodal Molecular Imaging Institute (M4I), Division of Imaging Mass Spectrometry, Maastricht University, The Netherlands., Maastricht, Limburg, Netherlands, ³Proteomics Group-ProteoRed/ISCIII, CIBER-BBN, Grupo de Investigación de Reumatología (GIR), INIBIC – Hospital Universitario de A Coruña, A Coruña, Spain., A Coruña, Spain, ⁴Arthritis Unit, Rheumatology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain., Barcelona, Catalonia, Spain, ⁵Rheumatology Department, Hospital Clínic and IDIBAPS,, Barcelona, Spain, ⁶Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain
Background/Purpose: Early diagnosis of inflammatory arthritis is associated with improved patient outcomes. However, accurate diagnosis can be challenging because of their complexity and heterogeneous nature.…
Abstract Number: 2089 • 2019 ACR/ARP Annual Meeting
Restricting Activity to Evade Knee Symptoms Is Associated with Worse Physical Function and Radiographic Osteoarthritis
Louise Thoma¹, Jason Jakiela ², Hiral Master ¹, Dana Voinier ², Meredith Christiansen ² and Daniel White ¹, ¹University of Delaware, Newark, DE, ²University of Delaware, Newark
Background/Purpose: Activity restriction (i.e. limiting or avoiding normal activity) is a common strategy to reduce, and sometimes eliminate, knee symptoms. Knee symptoms, such as pain,…
Abstract Number: 2192 • 2019 ACR/ARP Annual Meeting
Stabilization of Patellar Bone-Shape Correlates Significantly with Reduced Knee Pain Frequency After IA TPX-100 in Subjects with Bilateral Patellofemoral OA
Dawn McGuire¹, Michael Bowes ², Alan Brett ², Neil Segal ³, Meghan Miller ⁴, David Rosen ⁴ and Yoshinari Kumagai ⁴, ¹OrthoTrophix, Orinda, CA, ²Imorphics, Manchester, England, United Kingdom, ³University of Kansas Medical Center, Kansas City, KS, ⁴OrthoTrophix, Oakland, CA
Background/Purpose: Based on data from the Osteoarthritis Initiative (OAI), MRI-based analyses of bone shape changes in the knee predict symptomatic and radiographic progression of knee…
Abstract Number: 2797 • 2019 ACR/ARP Annual Meeting
Exploring Possible Predictors of Physical Activity in Knee Replacement Patients
Brandy Tanenbaum ¹, Aileen Davis², Deborah Kennedy ³ and Junaid Bhatti ⁴, ¹Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ²Krembil Research Institute, University Health Network, Toronto, ON, Canada, ³Sunnybrook Health Sciences Centre - Holland Bone and Joint Program, Toronto, ON, Canada, ⁴Institute of Clinical Evaluative Studies, Toronto, ON, Canada
Background/Purpose: Following total knee replacement (TKR), patients do not achieve recommended physical activity for overall health. The implications of physical inactivity on individuals and the…
Abstract Number: 1298 • 2019 ACR/ARP Annual Meeting
A Randomised Clinical Trial of Curcuma Longa Extract for Treating Symptoms and Effusion-Synovitis of Knee Osteoarthritis
Zhiqiang Wang ¹, Graeme Jones ², Tania Winzenberg ¹, Guoqi Cai ¹, Laura Laslett ², Dawn Aitken ¹, Ingrid Hopper ³, Robert Jones ⁴, Changhai Ding ², Jurgen Fripp ⁵ and Benny Antony², ¹Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia, ²Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ³Department of Epidemiology, Monash University, Melbourne, Victoria, Australia, ⁴Royal Hobart Hospital, Hobart, Tasmania, Australia, ⁵The University of Queensland, Brisbane, Queensland, Australia
Background/Purpose: Pharmacological therapies are limited, associated with off-target effects, are frequently contraindicated, and only modestly effective for pain in osteoarthritis (OA). Effusion and synovitis are…
Abstract Number: 1321 • 2019 ACR/ARP Annual Meeting
What Is the Relationship Between the 3 Knee Bones in Osteoarthritis? Baseline and Longitudinal Associations Using a Latent Growth Modelling Approach on 37,583 MR Images from the Osteoarthritis Initiative
Bright Dube¹, Michael Bowes ², Elizabeth Hensor ¹, Sarah Kingsbury ³ and Philip G Conaghan ⁴, ¹University of Leeds, LEEDS, England, United Kingdom, ²Imorphics, Manchester, England, United Kingdom, ³University of Leeds, Leeds, United Kingdom, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom
Background/Purpose: 3D femur bone shape measured by statistical shape modelling (SSM) provides a responsive biomarker of knee OA. However it is unclear how the 3…

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