Abstracts tagged "Osteoarthritis"

Abstract Number: 1988 • 2019 ACR/ARP Annual Meeting
Establishing an in Vitro Model of Hand Osteoarthritis by Generating Induced Pluripotent Stem Cells (iPSc) That Carry Single Nucleotide Polymorphisms Associated with Hand Osteoarthritis Risk
Rocío Castro-Viñuelas¹, Clara Sanjurjo-Rodríguez ², María Piñeiro-Ramil ¹, Silvia Rodríguez-Fernández ¹, Tamara Hermida-Gómez ³, Francisco J. De Toro ⁴, Isaac Fuentes-Boquete ¹, Francisco J. Blanco ⁵ and Silvia Díaz-Prado ¹, ¹Grupo de investigación en Terapia Celular y Medicina Regenerativa. Departamento de Fisioterapia, Medicina y Ciencias Biomédicas. Universidade da Coruña. Agrupación estratégica CICA-INIBIC. A Coruña, España., A Coruña, Spain, ²Grupo de investigación en Terapia Celular y Medicina Regenerativa. Departamento de Fisioterapia, Medicina y Ciencias Biomédicas. Universidade da Coruña. Agrupación estratégica CICA-INIBIC. A Coruña, España; University of Leeds; Newcastle University, A Coruña, Spain, ³Unidad de Bioingeniería Tisular y Terapia Celular (GBTTC-CHUAC). Grupo de Investigación en Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC). Sergas. Centro de Investigaciones Científicas Avanzadas (CICA), A Coruña, Spain, ⁴University Hospital A Coruña, A Coruña, Spain, ⁵Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain
Background/Purpose: Knowledge and research results in the field of hand osteoarthritis (hOA) are currently limited, mainly due to the unavailability of tissue samples to develop…
Abstract Number: 2185 • 2019 ACR/ARP Annual Meeting
MRI-detected Abnormalities in Prediction Models of Incident Radiographic Knee Osteoarthritis over 10 Years of Follow-up
C. Kent Kwoh¹, Frank Roemer ², Erin Ashbeck ³, ChengCheng Hu ¹, Edward Bedrick ¹, Leena Sharma ⁴ and Ali Guermazi ⁵, ¹University of Arizona, Tucson, AZ, ²University of Erlangen-Nuremberg, Erlangen, Germany, ³The University of Arizona Arthritis Center, University of Arizona, Tuccson, AZ, Tucson, AL, ⁴Northwestern University, Chicago, IL, ⁵Boston Medical Center, Boston
Background/Purpose: MRI Osteoarthritis Knee Score (MOAKS) is a semi-quantitative scoring system used to assess MRI-detected structural abnormalities including over 100 raw scores representing multiple joint…
Abstract Number: 2756 • 2019 ACR/ARP Annual Meeting
Subcutaneous Tanezumab versus NSAID for the Treatment of Osteoarthritis: Joint Safety Events in a Randomized, Double-Blind, Active-Controlled, 80-Week, Phase-3 Study
Marc C. Hochberg¹, John Carrino ², Thomas Schnitzer ³, Ali Guermazi ⁴, David Walsh ⁵, Alexander White ⁶, Satoru Nakajo ⁷, Robert Fountaine ⁸, Anne Hickman ⁸, Glenn Pixton ⁹, Lars Viktrup ¹⁰, Mark T. Brown ⁸, Christine R. West ⁸ and Kenneth M. Verburg ⁸, ¹University of Maryland School of Medicine, Baltimore, MD, ²Hospital for Special Surgery, New York, NY, ³Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Boston Medical Center, Boston, ⁵Sherwood Forest Hospitals NHS Foundation Trust, Nottingham, United Kingdom, ⁶Progressive Medical Research, Port Orange, FL, ⁷Nakajo Orthopaedic Clinic, Miyagi, Japan, ⁸Pfizer Inc, Groton, CT, ⁹Pfizer Inc, Morrisville, NC, ¹⁰Eli Lilly and Company, Indianapolis, IN
Background/Purpose: Tanezumab, a monoclonal antibody inhibiting nerve growth factor (NGF), is under investigation for the treatment of chronic pain conditions. In prior osteoarthritis (OA) studies,…
Abstract Number: 891 • 2019 ACR/ARP Annual Meeting
Lorecivivint (SM04690), a Potential Disease-Modifying Osteoarthritis Drug, Inhibits CLK2 and DYRK1A, Novel Molecular Regulators of Wnt Signaling, Chondrogenesis, and Inflammation
Vishal Deshmukh¹, Alyssa O'Green ¹, Carine Bossard ¹, Tim Seo ¹, Lisa Lamangan ¹, Maureen Ibanez ¹, Abdullah Ghias ¹, Carolyn Lai ¹, Long Do ¹, Shawn Cho ¹, Joseph Cahiwat ¹, Kevin Chiu ¹, Melinda Pedraza ¹ and Yusuf Yazici ¹, ¹Samumed, LLC, San Diego, CA
Background/Purpose: In the synovial joint, Wnt pathway upregulation contributes to osteoarthritis (OA) by increasing osteocyte differentiation, cartilage thinning, and inflammation. Lorecivivint (LOR; SM04690), a novel…
Abstract Number: 1312 • 2019 ACR/ARP Annual Meeting
Knee Morphology Associates with Tibio-Femoral and Patello-Femoral Osteoarthritis: A Case-Control Study
Anand Ramachandran Nair¹, Weiya Zhang ², Michael Doherty ² and Abhishek Abhishek ³, ¹Academic Rheumatology, School of Medicine, University of Nottingham, Nottingham, UK, Nottingham, England, United Kingdom, ²Academic Rheumatology, Division of Rheumatology,School of Medicine, University of Nottingham, Nottingham, UKArthritis Research UK Pain Centre, Nottingham, UKNational Institute for Health Research, Nottingham Biomedical Research Centre, Nottingham, UK, Nottingham, England, United Kingdom, ³Academic Rheumatology, School of Medicine, University of Nottingham,Nottingham,UK National Institute for Health Research, Nottingham Biomedical Research Centre, Nottingham,UK, Nottingham, England, United Kingdom
Background/Purpose: Although several morphological features of the hip joint predispose to hip osteoarthritis (OA), only a few are known to associate with knee OA. The…
Abstract Number: 1878 • 2019 ACR/ARP Annual Meeting
Quantifying the Placebo Effect After Intra-Articular Injections: Implications for Trials and Practice
Sebastian Rodriguez-Garcia¹, Raul Castellanos-Moreira ², Jacqueline Uson-Jaeger ³, ESPERANZA NAREDO ⁴ and Loreto Carmona ⁵, ¹Rheumatology Department. Hospital Clínic Barcelona, Barcelona, Spain, ²Rheumatology Department. Hospital Clínic Barcelona, Barcelona, Catalonia, Spain, ³Hospital Universitario de Mostoles, Madrid, Spain, ⁴Rheumatology Department, Joint and Bone Research Unit. Hospital Universitario Fundación Jiménez Díaz, Universidad Autónoma, MADRID, Spain, ⁵Instituto de Salud Musculoesquelética - Inmusc., Madrid, Spain
Background/Purpose: In recent years, diverse compounds for intra-articular (IA) administration were brought into the market with a subsequent significant and heterogeneous literature production. Understanding the efficacy…
Abstract Number: 1993 • 2019 ACR/ARP Annual Meeting
Inhibition of Choline Kinase Alpha Improves Synovitis and Cartilage Damage in Animal Models of Osteoarthritis
Roxana Coras¹, Leening P Liu ², Serena Z Shi ², Anyan Cheng ³, Alexandra Stubelius ⁴, Elsa Sanchez-Lopez ⁵, Robert Sah ⁶, Ru Liu-Bryan ⁷ and Monica Guma ⁸, ¹Department of Medicine, University of California San Diego, La Jolla, San Diego, CA, ²Department of Bioengineering, University of California San Diego, La Jolla, San Diego, ³Department of Medicine, University of California San Diego, La Jolla, San Diego, ⁴Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, San Diego, ⁵Department of Pharmacology, University of California San Diego, La Jolla, San Diego, ⁶Department of Bioengineering and Medicine, University of California San Diego, La Jolla, San Diego, ⁷San Diego VA/UCSD, La Jolla, CA, ⁸Department of Medicine, School of Medicine. University of California San Diego, La Jolla, United States
Background/Purpose: Osteoarthritis (OA) is a disease of the whole joint, affecting cartilage, ligaments, menisci, bone and synovial tissue. We previously found that choline kinase alpha…
Abstract Number: 2186 • 2019 ACR/ARP Annual Meeting
What Is an Important Difference in Gait Speed in Adults with Knee Osteoarthritis?
Jing Song ¹, David Cella ², Abigail Gilbert³, Rowland Chang ² and Dorothy Dunlop ², ¹Northwestern University Feinberg School of Medicine, Worthington, OH, ²Northwestern University Feinberg School of Medicine, Chicago, IL, ³University of North Carolina, Chapel Hill, NC
Background/Purpose: Little is known regarding what difference in functional performance measures are clinically significant in individuals with a chronic medical disease. This study examines the…
Abstract Number: 2757 • 2019 ACR/ARP Annual Meeting
Clinical Effectiveness of Ultrasound-guided Intra-articular Corticosteroid and Local Anaesthetic Injections for Hip Osteoarthritis: A Randomised Controlled Trial (HIT)
Zoe Paskins ¹, Kieran Bromley ², Martyn Lewis ², Gemma Hughes ², Emily Hughes ², Andrea Cherrington ², Alison Hall ², Melanie Holden ³, Raymond Oppong ⁴, Kay Stevenson ², Ajit Menon ⁵, Philip Roberts ⁶, George Peat ², Clare Jinks ⁷, Nadine Foster ², Christian Mallen ⁸ and Edward Roddy⁹, ¹Research Institute for Primary Care and Health Sciences, Keele University, Keele, United Kingdom, ²Keele University, Keele, United Kingdom, ³Research Institute for Primary Care and Health Sciences and Keele CTU, Keele University, Keele, England, United Kingdom, ⁴University of Birmingham, Birmingham, United Kingdom, ⁵Midlands Partnership NHS Foundation Trust, Stoke-on-Trent, United Kingdom, ⁶University Hospitals North Midlands NHS Trust, Stoke-on-Trent, United Kingdom, ⁷Research Institute for Primary Care and Health Sciences, Keele University, Keele, England, United Kingdom, ⁸Research Institute for Primary Care and Health Sciences, Keele University, UK, Keele, United Kingdom, ⁹Research Institute for Primary Care and Health Sciences and Keele Clinical Trials Unit, Keele, United Kingdom
Background/Purpose: Evidence of the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis (OA) is limited and conflicting. The HIT trial compared the clinical effectiveness of…
Abstract Number: 912 • 2019 ACR/ARP Annual Meeting
Co-morbidities Associated with Discordance Between Structural Severity and Pain in Osteoarthritis: Implications for Clinical Trial Design in OA – a Post-Hoc Analysis of Data from Two Randomized Controlled Trials
Jonathan Bjerre-Bastos¹, Inger Byrjalsen ², Morten Karsdal ³, Jeppe Andersen ¹ and Asger Bihlet ¹, ¹Nordic Bioscience Clinical Development, Herlev, Denmark, ²Nordic Bioscience, Herlev, Denmark, ³Nordic Bioscience, Copenhagen, Denmark
Background/Purpose: Development of new disease-modifying drugs in osteoarthritis (DMOADs) has proven difficult and is complicated by heterogeneous study populations and insensitive endpoints of structural change,…
Abstract Number: 1315 • 2019 ACR/ARP Annual Meeting
Relation of MRI-detected Structural Damage in the Patellofemoral Joint to Pain and Performance Based Function: The MOST Study
Jessica Maxwell¹, Tuhina Neogi ², Kay Crossley ³, Erin Macri ⁴, Daniel White ⁵, Ali Guermazi ⁶, Frank Roemer ⁷, Michael Nevitt ⁸, Beth Lewis ⁹, James Torner ¹⁰ and Joshua Stefanik ¹¹, ¹Northeastern University, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³La Trobe University, Victoria, Australia, ⁴Erasmus MC, Rotterdam, Netherlands, ⁵University of Delaware, Newark, DE, ⁶Boston Medical Center, Boston, ⁷University of Erlangen-Nuremberg, Erlangen, Germany, ⁸University of California at San Francisco, San Francisco, CA, ⁹University of Alabama at Birmingham, Birmingham, AL, ¹⁰University of Iowa at Iowa City, Iowa City, ¹¹Northeastern University, Boston
Background/Purpose: Osteoarthritis (OA) of the knee is one of the most common causes of disability in the U.S. Often overlooked, OA specific to the patellofemoral…
Abstract Number: 1946 • 2019 ACR/ARP Annual Meeting
Metabolic Regulation in Cybrids Obtained from Healthy and Osteoarthritic (OA) Patients: Impaired Metabolic Flexibility in OA Process
Andrea Dalmao-Fernández¹, Jenny Lund ², Tamara Hermida-Gómez ³, María E. Vázquez-Mosquera ¹, Ignacio Rego-Pérez ⁴, Francisco J. Blanco ⁴ and Mercedes Fernandez-Moreno ⁵, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Galicia, Spain, ²Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, Oslo, Norway, ³Unidad de Bioingeniería Tisular y Terapia Celular (GBTTC-CHUAC). Grupo de Investigación en Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC). Sergas. Centro de Investigaciones Científicas Avanzadas (CICA), A Coruña, Spain, ⁴Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ⁵Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España. CIBER-BBM, A Coruña, Spain
Background/Purpose: Background: Osteoarthritis (OA) is the most frequent joint disease.The OA is a heterogeneous disorder. With acceptance of the joint as an organ, the pathogenesis…
Abstract Number: 2049 • 2019 ACR/ARP Annual Meeting
National Estimates of Pain Medication Use in Patients with Osteoarthritis
Mohammed Saeed¹, ¹Capital Health, Trenton, NJ
Background/Purpose: The epidemiology of pain medication use among patients with osteoarthritis is not well explored. Chronic kidney disease (CKD) modifies choice of analgesics. The aim…
Abstract Number: 2187 • 2019 ACR/ARP Annual Meeting
A Low Cartilage Formation & Repair Endotype Predicts Radiographic Progression in Symptomatic Knee Osteoarthritis Patients and Identifies Optimal Responders to a Potential OA Treatment
Yunyun Luo ¹, Jonathan Samuels ², Svetlana Krasnokutsky ³, Inger Byrjalsen ¹, Jeppe Andersen ⁴, Asger Bihlet ⁵, Yi He ¹, Morten Karsdal ⁶, Steven Abramson ⁷, Mukundan Attur ³ and Anne Bay-Jensen¹, ¹Nordic Bioscience, Herlev, Denmark, ²NYU Langone Medical Center, New Yort, NY, ³NYU School of Medicine and NYU Langone Orthopedic Hospital, New York City, NY, ⁴Nordic Bioscience, Clinical development, Herlev, Denmark, ⁵Nordic Bioscience Clinical Development, Herlev, Denmark, ⁶Nordic Bioscience, Copenhagen, Denmark, ⁷NYU School of Medicine and NYU Langone Orthopedic Hospital, New York, NY
Background/Purpose: Osteoarthritis (OA) is a highly heterogeneous disease, which suggest that multiple endotypes exist. Identification and characterization of such endotypes may assist in precision medicine…
Abstract Number: 2759 • 2019 ACR/ARP Annual Meeting
Stopping NSAIDs for Arthritis Pain (SNAP): A Randomized Withdrawal Trial Comparing NSAIDs to Cognitive Behavioral Therapy
Liana Fraenkel¹, Eugenia Buta ², Joseph Goulet ³, Matthew Brennan ³, Alicia Heapy ³ and Lisa Suter ³, ¹Yale School of Medicine and VA Connecticut Healthcare System, New Haven, ²Yale University/VA CT Healthcare System, New Havne, ³Yale University/VA CT Healthcare System, New Haven
Background/Purpose: NSAIDs are associated with uncertain long-term benefits and significant toxicity in patients with knee osteoarthritis (OA). Our objective was to evaluate if discontinuing NSAIDs…

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