Abstracts tagged "Osteoarthritis"

Abstract Number: 0036 • ACR Convergence 2020
Molecular Phenotyping of Late-Stage Knee Osteoarthritis Synovium Through Total RNA-Sequencing
Anusha Ratneswaran¹, Chiara Pastrello¹, Pratibha Potla², Osvaldo Espin-Garcia², Starlee Lively², Anthony Perruccio³, Raj Rampersaud², Rajiv Gandhi² and Mohit Kapoor⁴, ¹University Health Network, Toronto, ON, Canada, ²Krembil RI, Toronto, Canada, ³Krembil Research Institute, UHN; University of Toronto, Toronto, ON, Canada, ⁴Krembil RI, Toronto, ON, Canada
Background/Purpose: Knee Osteoarthritis (OA) is a painful, disabling condition and molecular mechanisms underlying this disease are poorly understood. In recent years, OA is increasingly viewed…
Abstract Number: 0564 • ACR Convergence 2020
Incidence and Progression of Foot Osteoarthritis
Rami Eltaraboulsi¹, Amanda Nelson², Carolina Alvarez³, Jordan Renner⁴, Catherine Bowen⁵, Lucy Gates⁵ and Yvonne Golightly⁶, ¹University of North Carolina at Chapel Hill, Apex, NC, ²University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ³University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Miami, FL, ⁴University of North Carolina, Chapel Hill, NC, ⁵University of Southampton, Southampton, United Kingdom, ⁶University of North Carolina at Chapel Hill Dept of Epidemiology, Chapel Hill, NC
Background/Purpose: Foot osteoarthritis (OA) is a common cause of disability in older adults yet remains an understudied area. The purpose of this study was to…
Abstract Number: 0709 • ACR Convergence 2020
Anatomical Distribution of Mrgprd-expressing Nonpeptidergic C-fibers in the Mouse Knee
Alia Obeidat¹, Rachel Miller¹ and Anne-Marie Malfait¹, ¹Rush University, CHICAGO, IL
Background/Purpose: The voltage-gated sodium channel, NaV1.8, marks the majority of C-fiber nociceptors. We have used NaV1.8 tdTomato reporter mice to describe the nociceptive innervation of…
Abstract Number: 1109 • ACR Convergence 2020
Pain in Women with Knee and/or Hip Osteoarthritis Is Related to Systemic Inflammation and to Adipose Tissue Dysfunction and Distribution: A Cross-sectional Metabolic Biomarkers Cohort Study
Jeremie Sellam¹, Anne-Christine Rat², Soraya Fellahi³, Jean-Philippe Bastard⁴, Willy NGUEYON SIME⁵, Hang Korng EA⁶, Pascal Richette⁷, Jacqueline Capeau⁸, Francis Guillemin⁹ and Francis Berenbaum¹, ¹AP-HP, Hôpital Saint-Antoine, Service de Rhumatologie, Centre de Recherche Saint-Antoine, INSERM UMR_S 938,Sorbonne Université, Paris, 75012, France, Paris, France, ²Universite de Caen Normandie and Université de Lorraine, EA 4360, Caen, France, ³AP-HP INSERM, Paris, France, ⁴INSERM AP-HP UPEC, Paris, France, ⁵Universite de Lorraine, INSERM, CIC, Nancy, France, ⁶Universite de Paris, AP-HP, INSERM, paris, France, ⁷Department of Rheumatology, Lariboisière Hospital, Paris, France, ⁸INSERM Sorbonne Universite, Paris, France, ⁹Universite de Lorraine CIC INSERM, Nancy, France
Background/Purpose: Beyond the link between metabolic diseases and osteoarthritis (OA) risk, some studies have suggested an association between metabolic syndrome or visceral obesity and OA-related…
Abstract Number: 1189 • ACR Convergence 2020
Serum High-sensitive Cardiac Troponin at Baseline Predict Cardiovascular Events in Rheumatoid Arthritis and Osteoarthritis
M. Elaine Husni¹, Daniel H Solomon², Mingyuan Shao³, Katherine Wolski³, Steven Nissen³, Stanley Hazen⁴ and WH Wilson Tang⁴, ¹Cleveland Clinic, Cleveland, OH, ²Brigham and Women's Hospital, Boston, MA, ³Cleveland Clinic Foundation, Cleveland, OH, ⁴Cleveland Clinic Foundation, Cleveland
Background/Purpose: In rheumatoid arthritis (RA), excess mortality and inflammation has been attributed to cardiovascular (CV) diseases. High-sensitivity cardiac troponins (hscTnT) allow measurement of cardiac troponin…
Abstract Number: 1491 • ACR Convergence 2020
Association of a Leaky Gut but Not Microbial Dysbiosis with Obesity-related OA: A Translational Study
Richard Loeser¹, Liubov Arbeeva¹, Kathryn Kelley², Anthony Fodor³, Shan Sun³, Veronica Ulici⁴, Lara Longobardi², Yang Cui², Susan Sumner², Andrea Azcarate-Peril², Balfour Sartor², Ian Carrol² and Amanda Nelson¹, ¹University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ²University of North Carolina, Chapel Hill, NC, ³University of North Carolina-Charlotte, Charlotte, NC, ⁴Brown University, Providence, RI
Background/Purpose: To test the hypothesis that an altered gut microbiota (dysbiosis) plays a causal role in the obese OA phenotype (obesity with both hand and…
Abstract Number: 1651 • ACR Convergence 2020
Efficacy and Safety of Multiple Intra-articular Corticosteroid Injections for Osteoarthritis – a Systematic Review and Meta-analysis of Randomised Controlled Trials and Observational Studies
Shazeen Ayub¹, Jaspreet Kaur¹, Michelle Hui², Michelle Hall¹, Michael Doherty³ and Weiya Zhang¹, ¹Academic Rheumatology, School of Medicine, University of Nottingham, UK, Nottingham, United Kingdom, ²Royal Derby Hospital, Derby, UK, Derby, United Kingdom, ³Academic Rheumatology, School of Medicine, University of Nottingham, UK, Nottingham, England, United Kingdom
Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis worldwide and is becoming more prevalent with the increasing age of the population. As Intra-articular…
Abstract Number: 1971 • ACR Convergence 2020
Gut Microbiome Transplantation from MRL/MpJ Mice Prevents Post-Traumatic Osteoarthritis in C57BL6/J Mice
Matlock Jeffries¹, Jake Martin¹, Vladislav Izda¹, Cassandra Garman¹, Cassandra Velasco¹ and Christopher Dunn², ¹University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²University of Oklahoma HSC, Edmond, OK
Background/Purpose: MRL/MpJ mice are substantially protected from developing post-traumatic osteoarthritis (OA), a trait with strong correlation to the ability to heal ear wounds. We have…
Abstract Number: 0063 • ACR Convergence 2020
Novel Repurposed Drugs Against Joint Inflammation Reveal Potential Use for Gout Treatment: An In Silico, In Vitro and Clinical Study
Eloi Franco-Trepat¹, Ana Alonso-Pérez¹, Maria Guillán-Fresco¹, Miriam López-Fagundez¹, Andrés Pazos-Pérez¹, Ana Lois Iglesias², Susana Belén Bravo³, Alberto Jorge-Mora¹, JJ Gómez-Reino⁴ and Rodolfo Gómez¹, ¹IDIS-CHUS - Musculoskeletal Pathology Group, Santiago de Compostela, Spain, ²IDIS-CHUS - Musculoskeletal Pathology Group, A Coruna, Spain, ³IDIS-CHUS - Proteomics Unit, Santiago de Compostela, Galicia, Spain, ⁴IDIS-CHUS - Rheumatology Group, Santiago de Compostela, Spain
Background/Purpose: Joint inflammation is a common feature across multiple rheumatic diseases. To deal with the induction of innate immune factors, targeting therapeutic targets such as…
Abstract Number: 0593 • ACR Convergence 2020
Patient Characteristics and Factors Affecting Decision-Making Regarding Total Knee Replacement by Different Types of Physicians Treating Patients with Knee OA
Angela Bedenbaugh¹, Vinson Lee¹, Gary Oderda², Sarah Kennedy¹, Jeyanesh Tambiah¹, Diana Brixner² and Timothy McAlindon³, ¹Samumed, LLC, San Diego, CA, ²University of Utah, Salt Lake City, UT, ³Tufts Medical Center, Boston, MA
Background/Purpose: Total knee replacement (TKR) is considered an effective knee OA treatment and is a commonly performed orthopedic procedure that relieves pain and improves function and…
Abstract Number: 0926 • ACR Convergence 2020
Risk Factors for Fractures and Osteoporosis Among Patients with Systemic Sclerosis in a United States Cohort
Sina Famenini¹, Jamie Perin², Kristin Wipfler³, Kaleb Michaud⁴ and Zsuzsanna McMahan⁵, ¹Johns Hopkins School of Medicine, Baltimore, MD, ²JHUSPH, Baltimore, ³FORWARD, The National Databank for Rheumatic Diseases, Omaha, NE, ⁴University of Nebraska Medical Center, Omaha, NE, ⁵Johns Hopkins University, Baltimore
Background/Purpose:Systemic sclerosis (SSc) is associated with several risk factors for osteoporosis and fractures due to malabsorption or malnutrition, physical disability, chronic inflammation, and use of…
Abstract Number: 1110 • ACR Convergence 2020
Osteoarthritis-Related Knee Inflammation Measured by Ultrasound Is Associated with Performance-Based Measures of Function
Holly Philpott¹, Trevor Birmingham², Ryan Pinto², Dominique Arsenault², Codie Primeau², Edward Vasarhelyi³, Steven MacDonald³, Brent Lanting³ and Tom Appleton⁴, ¹Western University, London, ON, Canada, ²Western University, London, Canada, ³London Health Sciences Centre, London, Canada, ⁴The University of Western Ontario, LONDON, ON, Canada
Background/Purpose: Signs of inflammation in knee osteoarthritis (OA), including synovitis, are associated with worse clinical outcomes such as increased pain, risk of progression, and future…
Abstract Number: 1333 • ACR Convergence 2020
Ankylosing Spondylitis Patients at Risk of Developing Aortic Valve Regurgitation, Need for Mandatory Echocardiography?
Milad Baniaamam¹, Sjoerd C. Heslinga², Laura Boekel¹, M. Louis Handoko³, Thelma C. Konings³, Otto Kamp³, Vokko P. van Halm⁴, J. Christiaan van Denderen¹, Irene van der Horst-Bruinsma² and Mike Nurmohamed⁵, ¹Reade, Amsterdam, Netherlands, ²Department of Rheumatology, Amsterdam UMC, location VU University Medical Centre, Amsterdam, Netherlands, ³Department of Cardiology, Amsterdam UMC, location VU University Medical Centre, Amsterdam, Netherlands, ⁴Department of Cardiology, Amsterdam UMC, location VU University Medical Centre, Amsterdam, ⁵Amsterdam Rheumatology and immunology Center, location Reade and Amsterdam UMC, VU medical center, Amsterdam, Netherlands
Background/Purpose: The overall mortality rate in ankylosing spondylitis (AS) patients is increased by 60–90% compared with the general population. This higher mortality rate is predominately…
Abstract Number: 1541 • ACR Convergence 2020
Ultrasound in Knee Osteoarthritis: Reader Performance, Sonographic Features, and Correlation with Radiographic Findings
Ogonna Nwawka¹, Susan Lee¹, Bin Lin², Said Ibrahim³, Collin Brantner⁴, Peter Sculco⁵, Michael Parks¹, Mark Figgie⁶, Laura Donlin¹, Dana Orange⁷, Serene Mirza², Michael Cross¹, Jose Rodriguez¹, Thomas Sculco¹, Miguel Otero², William Robinson⁸, Susan Goodman⁶ and Bella Mehta⁵, ¹Hospital for Special Surgery, Weill Cornell Medicine, New York, ²Hospital for Special Surgery, New York, ³Weill Cornell Medicine, Cleveland, OH, ⁴Hospital for Special Surgery, New York, NY, ⁵Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ⁶Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ⁷Rockefeller University, New York, ⁸Stanford University, Palo Alto, CA
Background/Purpose: Radiography is the most widespread imaging technique used in the evaluation of knee osteoarthritis (KOA), and MRI is known to be specific in characterization…
Abstract Number: 1652 • ACR Convergence 2020
Progression of Knee OA with Use of Intra-articular Corticosteroids (CS) vs Hyaluronic Acid (HA)
Justin Bucci¹, Xiaoyang Chen¹, James Torner², Michael Nevitt³, Cora Lewis⁴ and David Felson⁵, ¹Boston University, Boston, MA, ²University of Iowa, Iowa City, IA, ³University of California, San Francisco, Orinda, CA, ⁴University of Alabama Birmingham, Birmingham, AL, ⁵Boston University School of Medicine, Boston, MA
Background/Purpose: Recent studies have questioned whether CS injections (CSI), a popular treatment recommended by guidelines, hasten progression of knee OA. A recent cohort study suggested…

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