Abstracts tagged "Osteoarthritis"

Abstract Number: 1301 • 2019 ACR/ARP Annual Meeting
Rates of Incident Radiographic Knee Osteoarthritis and Knee Replacement by Sex and Race, Across Three Large, Diverse Cohorts
C. Kent Kwoh¹, Amanda Nelson ², Yvonne Golightly ³, Erin Ashbeck ⁴, Liubov Arbeeva ⁵, Na Wang ⁶, Jeffrey Duryea ⁷ and Tuhina Neogi ⁶, ¹University of Arizona, Tucson, AZ, ²University of North Carolina at Chapel Hill, Chapel Hill, NC, ³University of North Carolina at Chapel Hill Department of Epidemiology and Thurston Arthritis Research Center, Chapel Hill, NC, ⁴The University of Arizona Arthritis Center, University of Arizona, Tuccson, AZ, Tucson, AL, ⁵University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ⁶Boston University School of Medicine, Boston, MA, ⁷Harvard Medical School Department of Radiology Brigham and Women's Hospital, Boston, MA
Background/Purpose: Previous studies have suggested differences in the development of incident radiographic knee osteoarthritis (RKOA) and the receipt of knee replacement (KR) by sex and…
Abstract Number: 1323 • 2019 ACR/ARP Annual Meeting
Autologous Conditioned Serum and Plasma Rich in Growth Factors Show Stronger Evidence of Efficacy Than Other Kinds of Platelet-Rich Plasma
Lilian SOLE¹, Arthur Beck ¹, Thomas Barnetche ² and Pascale Vergne-Salle ³, ¹CHU de Limoges, LIMOGES, France, ²CHU, Toulouse, France, ³CHU limoges, Limoges, France
Background/Purpose: While there is growing evidences for the efficacy of platelet-rich plasma (PRP), there is still no standardized composition. There are 3 major types of…
Abstract Number: 1976 • 2019 ACR/ARP Annual Meeting
Regulation of Interleukin-1β (IL-1β)-induced COX-2 Expression and IL-6 and MMP-1 Production in Human OA Synovial Fibroblasts by Guanylate Binding Protein 5
Mahamudul Haque¹, Madeline McDougal ¹, Anil Singh ¹ and Salahuddin Ahmed ², ¹Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, SPOKANE, WA, ²Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA. Division of Rheumatology, University of Washington School of Medicine, Seattle, WA, Spokane, WA
Background/Purpose: Osteoarthritis (OA) is a chronic degenerative joint disease caused by synovial inflammation and cartilage degradation primarily driven by interleukin-1beta (IL-1β). Studies suggest that TNF-stimulated…
Abstract Number: 2176 • 2019 ACR/ARP Annual Meeting
A Novel Composite Score Reflecting Disease Activity Predicts Future Knee Replacements: Data from the Osteoarthritis Initiative
Jeffrey Driban¹, Matthew Harkey ², Lori Lyn Price ³, Grace Lo ⁴, Jincheng Pang ⁵, Ming Zhang ⁶ and Timothy McAlindon ¹, ¹Tufts Medical Center, Boston, MA, ²Tufts Medical Center, University of Massachusetts Medical School, Boston, MA, ³Tufts Medical Center, Tufts University, Boston, MA, ⁴Center of Excellence Michael E. DeBakey VAMC, Baylor College of Medicine, Houston, TX, ⁵Pfizer, Inc., Cambridge, MA, ⁶Tufts Medical Center, Wentworth Institute of Technology, Boston, MA
Background/Purpose: While knee osteoarthritis (KOA) leads to cumulative damage to a diarthrodial joint there are also more dynamic processes that fluctuate throughout the disease process…
Abstract Number: 2199 • 2019 ACR/ARP Annual Meeting
Is There an Association of Serum LDL, HDL and Total Cholesterol with the Development of Knee Osteoarthritis?
Jessica Barlow¹, Xianbang Sun ², Michael Nevitt ³, James Torner ⁴, Beth Lewis ⁵, Nirupa Matthan ⁶, Alice Lichtenstein ⁶ and David Felson ⁷, ¹Boston University School of Medicine, Department of Rheumatology, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³University of California at San Francisco, San Francisco, CA, ⁴University of Iowa at Iowa City, Iowa City, ⁵University of Alabama at Birmingham, Birmingham, AL, ⁶Tufts University, Boston, MA, ⁷Boston University School of Medicine, Department of Rheumatology, Boston
Background/Purpose: Recent data have suggested an association between elevated serum cholesterol levels, particularly low density lipoprotein (LDL), and the development of osteoarthritis (OA). Within the…
Abstract Number: 2926 • 2019 ACR/ARP Annual Meeting
Knee Injury and Transitions Among States of Knee Osteoarthritis in the Johnston County Osteoarthritis Project: A Multi-State Time-To-Event Modeling Approach
Yvonne Golightly¹, Carolina Alvarez ², Liubov Arbeeva ², Rebecca Cleveland ³, Todd Schwartz ⁴, Louise Murphy ⁵, Jordan Renner ⁶, Leigh Callahan ³, Joanne Jordan ² and Amanda Nelson ⁷, ¹University of North Carolina at Chapel Hill Department of Epidemiology and Thurston Arthritis Research Center, Chapel Hill, NC, ²University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ³Thurston Arthritis Research Center, Chapel Hill, NC, ⁴University of North Carolina at Chapel Hill Department of Biostatistics, Chapel Hill, NC, ⁵Centers for Disease Control and Prevention, Division of Population Health, Atlanta, ⁶University of North Carolina at Chapel Hill Department of Radiology, Chapel Hill, NC, ⁷University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Musculoskeletal injury is a known risk factor for osteoarthritis (OA). Cumulative effects of comorbid conditions on the association of injury and OA have not…
Abstract Number: 269 • 2019 ACR/ARP Annual Meeting
Attitudes and Beliefs About Opioid Medications: Determining Treatment Use in Osteoarthritis
Ernest Vina¹, Jazmin Dagnino ¹ and C. Kent Kwoh ¹, ¹University of Arizona, Tucson, AZ
Background/Purpose: Considering the growing opioid epidemic in the US, it is imperative to have a good understanding of what patient characteristics predict the use of…
Abstract Number: 1302 • 2019 ACR/ARP Annual Meeting
Subcutaneous Tanezumab vs NSAID for the Treatment of Osteoarthritis: Efficacy and General Safety Results from a Randomized, Double-Blind, Active-Controlled, 80-Week, Phase-3 Study
Marc C. Hochberg¹, John Carrino ², Thomas Schnitzer ³, Ali Guermazi ⁴, Eric Vignon ⁵, David Walsh ⁶, Alexander White ⁷, Satoru Nakajo ⁸, Robert Fountaine ⁹, Anne Hickman ⁹, Glenn Pixton ¹⁰, Lars Viktrup ¹¹, Mark T. Brown ⁹, Christine R. West ⁹ and Kenneth M. Verburg ⁹, ¹University of Maryland School of Medicine, Baltimore, MD, ²Hospital for Special Surgery, New York, NY, ³Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Boston Medical Center, Boston, ⁵Université Claude Bernard Lyon 1, Lyon, France, ⁶Sherwood Forest Hospitals NHS Foundation Trust, Nottingham, United Kingdom, ⁷Progressive Medical Research, Port Orange, FL, ⁸Nakajo Orthopaedic Clinic, Miyagi, Japan, ⁹Pfizer Inc, Groton, CT, ¹⁰Pfizer Inc, Morrisville, NC, ¹¹Eli Lilly and Company, Indianapolis, IN
Background/Purpose: Tanezumab is a monoclonal antibody that inhibits nerve growth factor and is under investigation for chronic pain treatment. Tanezumab administered intravenously was effective and…
Abstract Number: 1324 • 2019 ACR/ARP Annual Meeting
Visceral Fat Deposition Associated with Pain in Osteoarthritis
Shanshan Li ¹, Nancy Desai², Tuhina Neogi ³, Ann Schwartz ⁴, Lavalley Michael ¹, Na Wang ³, Xianbang Sun ¹, Michael Nevitt ⁵, Beth Lewis ⁶, Ali Guermazi ², Frank Roemer ⁷, Neil Segal ⁸ and David Felson ⁹, ¹Boston University, Boston, ²Boston Medical Center, Boston, ³Boston University School of Medicine, Boston, MA, ⁴University of California San Francisco, San Francisco, ⁵University of California at San Francisco, San Francisco, CA, ⁶University of Alabama at Birmingham, Birmingham, AL, ⁷University of Erlangen-Nuremberg, Erlangen, Germany, ⁸University of Kansas Medical Center, Kansas City, KS, ⁹Boston University School of Medicine, Department of Rheumatology, Boston
Background/Purpose: Animal model studies have demonstrated the significant role of inflammation in the pathogenesis of osteoarthritis (OA) and of pain. Visceral fat, rather than subcutaneous…
Abstract Number: 1977 • 2019 ACR/ARP Annual Meeting
The Synthesis of Hydrogen Sulfide Is Impaired in Osteoarthritic Chondrocytes from Diabetic Patients and in Vitro in Cells Under High Glucose Environment
Carlos Vaamonde-García¹, Tamara Hermida-Gómez ², Francisco J. Blanco ³, Elena F Burguera ³ and Rosa Meijide-Faílde ¹, ¹Tissue Engineering and Regenerative Medicine Group. University of A Coruña, A Coruña, Spain, ²Unidad de Bioingeniería Tisular y Terapia Celular (GBTTC-CHUAC). Grupo de Investigación en Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC). Sergas. Centro de Investigaciones Científicas Avanzadas (CICA), A Coruña, Spain, ³Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain
Background/Purpose: A growing number of findings indicates that type 2 diabetes is an independent risk factor of osteoarthritis (OA). However, the mechanisms underlying the connection…
Abstract Number: 2177 • 2019 ACR/ARP Annual Meeting
Sarcopenia and the Likelihood of Incident Knee Osteoarthritis and Knee Pain Among Older Adults in the Health ABC Study
James Andrews¹, Laura Gold ¹, Michael Nevitt ², Patrick Heagerty ¹ and Peggy Cawthon ³, ¹University of Washington, Seattle, ²University of California at San Francisco, San Francisco, CA, ³University of California San Francisco, San Francisco
Background/Purpose: Osteoarthritis (OA) disproportionately affects older adults. Sarcopenia, or reduced muscle mass and strength, is strongly associated with reduced physical function and poor clinical outcomes…
Abstract Number: 2200 • 2019 ACR/ARP Annual Meeting
Magnetic Resonance Imaging of Knee Joint Protection Following an Intra-Articular Injection of Lipid-Based Dexamethasone Sodium Phosphate Sustained Release Formulation on Subjects with Knee Osteoarthritis
Sheue-Fang Shih¹, Carl Brown ¹, Tien-Tzu Tai ¹ and Wing Chuang ¹, ¹Taiwan Liposome Company, Ltd., Taipei, Taiwan (Republic of China)
Background/Purpose: The most commonly used intra-articular (IA) corticosteroid for osteoarthritis (OA) is triamcinolone acetonide (TA), but its potential chondrotoxicity restricts injection frequency to 3-4 injections…
Abstract Number: 281 • 2019 ACR/ARP Annual Meeting
Frequency of Ultrasound Features of Knee Osteoarthritis and Their Association with Radiographic Features and Symptoms in a Community-Based Cohort
Nadiya Yerich¹, Carolina Alvarez ², Todd Schwartz ³, Sue Savage-Guin ², Catherine Bakewell ⁴, Minna Kohler ⁵, Janice Lin ⁶, Jonathan Samuels ⁷ and Amanda Nelson ², ¹University of North Carolina at Chapel Hill, Chapel Hill, NC, ²University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ³University of North Carolina at Chapel Hill Department of Biostatistics, Chapel Hill, NC, ⁴Intermountain Medical Center, Salt Lake City, UT, ⁵MGH, Boston, ⁶Stanford University, Palo Alto, CA, ⁷NYU Langone Medical Center, New Yort, NY
Background/Purpose: To evaluate the frequency and associations of osteoarthritis (KOA) features on knee ultrasound (KUS) in a community-based cohort study with radiographic and symptomatic data…
Abstract Number: 1303 • 2019 ACR/ARP Annual Meeting
Intra-Articular TPX-100 Significantly Delays Pathological Bone Shape Change at 6 and 12 Months in Moderate to Severe Tibiofemoral OA
Dawn McGuire¹, Michael Bowes ², Alan Brett ², Neil Segal ³, Meghan Miller ⁴, David Rosen ⁴ and Yoshinari Kumagai ⁴, ¹OrthoTrophix, Orinda, CA, ²Imorphics, Manchester, England, United Kingdom, ³University of Kansas Medical Center, Kansas City, KS, ⁴OrthoTrophix, Oakland, CA
Background/Purpose: Pathological bone shape changes in the femur precede cartilage changes in knee OA and predict disease onset and progression to joint failure (Neogi 2013;…
Abstract Number: 1325 • 2019 ACR/ARP Annual Meeting
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Healthy Male Japanese Subjects of the ADAMTS-5 Inhibitor S201086/GLPG1972, a Potential New Treatment in OA
Agnès Lalande ¹, Nadya Kuzniatsova-Mouchette ², Florian Chassereau ¹, Julia Geronimi ¹, Staffan Larsson ³, Andre Struglics ³, Stefan Lohmander ³ and Maria Pueyo¹, ¹Institut de Recherches Internationales Servier, Suresnes, France, Suresnes, France, ²Institut de Recherches Internationales Servier, Suresnes, France, Suresnes, ³Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden, Lund, Sweden
Background/Purpose: The disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5) is a key enzyme in OA (Verma P, et al. J Cell Biochem 2011;112:3507-14). In preclinical models…

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