Abstracts tagged "Osteoarthritis"

Abstract Number: 0704 • ACR Convergence 2020
The Murine Ear Wound Cartilage Superhealer Trait, Mediated by the Gut Microbiome, Is Transgenerationally Heritable Following Cecal Transplantation
Christopher Dunn¹, Cassandra Garman², Cassandra Velasco², Vladislav Izda², Jake Martin² and Matlock Jeffries², ¹University of Oklahoma Health Sciences Center, Oklahoma City, ²University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: MRL/MpJ mice are substantially protected from developing post-traumatic osteoarthritis (OA), a trait with strong correlation to the ability to heal ear wounds. We have…
Abstract Number: 1104 • ACR Convergence 2020
The Disability Associated with Hand Osteoarthritis Is Substantial in a Cohort of Post-menopausal Women : The QUALYOR Study
Maxime Auroux¹, Blandine Merle², Eric Lespessailles³ and Roland Chapurlat¹, ¹Hospices Civils de Lyon, Lyon Cedex 03, Rhone-Alpes, France, ²INSERM UMR 1033, Université de Lyon, Lyon Cedex 03, Rhone-Alpes, France, ³Regional Hospital and University of Orleans, Orléans, France
Background/Purpose: Osteoarthritis (OA) is a highly prevalent disease, affecting more than 400 millions individuals around the world. Hand osteoarthritis (HOA) is the most frequent form…
Abstract Number: 1120 • ACR Convergence 2020
A Comparison of Opioid-Related Outcomes Among Commercially-Insured Osteoarthritis Patients Treated with Tramadol vs. Non-Tramadol Opioids
Stuart Silverman¹, James Rice², Alan White², Catherine Fernan², Michael Somma², Craig Beck³, Rebecca Robinson⁴ and Patricia Schepman⁵, ¹Cedars-Sinai Medical Center, Los Angeles, CA, ²Analysis Group, Boston, MA, ³Pfizer, London, ⁴Eli Lilly and Company, Indanapolis, IN, ⁵Pfizer, New York City, NY
Background/Purpose: In 2019, the American College of Rheumatology conditionally recommended tramadol for patients with hip and knee osteoarthritis (OA). While tramadol is known to be…
Abstract Number: 1486 • ACR Convergence 2020
Long-term Efficacy and Safety of Intra-articular Sprifermin in Patients with Knee Osteoarthritis: Results from the 5-Year Forward Study
Felix Eckstein¹, Marc Hochberg², Hans Guehring³, Flavie Moreau⁴, Victor Ona⁴, Asger Bihlet⁵, Inger Byrjalsen⁵, Jeppe Andersen⁵, Benjamin Daelken³, Oliver Guenther³, Christoph Ladel³, Martin Michaelis³ and Philip G Conaghan⁶, ¹Paracelsus Medical University, Salzburg, Austria, ²University of Maryland School of Medicine, Baltimore, MD, ³Merck KGaA, Darmstadt, Germany, ⁴EMD Serono (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ⁵Nordic Bioscience, Herlev, Denmark, ⁶Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and National Institute for Health Research Leeds Biomedical Research Centre, Leeds, United Kingdom
Background/Purpose: The 5-year Phase II FORWARD study assessed the efficacy and safety of the potential disease-modifying osteoarthritis drug (DMOAD) sprifermin (recombinant human fibroblast growth factor…
Abstract Number: 1646 • ACR Convergence 2020
Use of Prescription Nonsteroidal Anti-inflammatory Drugs (NSAIDs) in Adults with Hip/Knee Osteoarthritis (OA) at Increased Risk for NSAID-related Adverse Events
Jayeshkumar Patel¹, Wenhui Wei², Raveendhara Bannuru³, Ravi Iyer⁴, Nazneen Fatima Shaikh¹, Traci LeMasters¹, Chibuzo Iloabuchi¹, Degang Wang² and Usha Sambamoorthi¹, ¹West Virginia University School of Pharmacy, Morgantown, WV, ²Regeneron Pharmaceuticals, Tarrytown, NY, ³Tufts Medical Center, Boston, MA, ⁴Teva Pharmaceutical Industries, West Chester, PA
Background/Purpose: NSAIDs are commonly used for OA pain, but the benefits of pain relief must be carefully weighed against the potential risk for gastrointestinal (GI),…
Abstract Number: 1662 • ACR Convergence 2020
Do Weight-bearing versus Non-weight-bearing Pain Reflect Different Pain Mechanisms in Knee Osteoarthritis?: The Multicenter Osteoarthritis Study
Jean Liew¹, John Farrar², Na Wang³, Lisa Carlesso⁴, Kosaku Aoyagi³, Laura Frey Law⁵, Cora Lewis⁶, Michael Nevitt⁷ and Tuhina Neogi³, ¹University of Washington, Seattle, WA, ²University of Pennsylvania, Philadelphia, PA, ³Boston University School of Medicine, Boston, MA, ⁴McMaster University, Hamilton, ON, Canada, ⁵University of Iowa, Iowa City, IA, ⁶University of Alabama Birmingham, Birmingham, AL, ⁷University of California, San Francisco, San Francisco, CA
Background/Purpose: Pain with weightbearing in knee OA is thought to be related to the activation of nociceptors; however, this is not considered the sole mechanism…
Abstract Number: L05 • 2019 ACR/ARP Annual Meeting
Safety, Tolerability, Pharmacokinetics, and Clinical Outcomes Following Single-Dose IA Administration of UBX0101, a Senolytic MDM2/p53 Interaction Inhibitor, in Patients with Knee OA
Benjamin Hsu¹, Jennifer Visich ², Mark Genovese ³, Kimberly Walter ², Mahru An ⁴, Remi-Martin Laberge ⁴ and Jamie Dananberg ⁴, ¹Unity Biotechnology, Brisbane, ²Unity Biotechnology, Brisbane, California, ³Stanford University, Stanford, CA, ⁴Unity Biotechnology, Brisbane, CA
Background/Purpose: A non-drug biomarker study showed senescent cell (SnC) burden in OA synovial tissue to correlate with disease severity, inflammation, and knee pain (C. Yohn,…
Abstract Number: 1300 • 2019 ACR/ARP Annual Meeting
Predictor of Placebo Response in Hand Osteoarthritis: A Post Hoc Analysis of Two Randomized Controlled Trials
Se Han Ahn¹, Jin Kyun Park ², Kichul Shin ³, Yun Jong Lee ⁴, Yeong-Wook Song ⁵, Yunhee Choi ⁶ and Eun Bong Lee ⁷, ¹Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Gwacheon-si, Kyonggi-do, Republic of Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, seoul, Republic of Korea, ³Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea., seoul, Republic of Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea, ⁵Seoul National University Hospital, Seoul, Republic of Korea, ⁶Division of Medical Statistics, Medical Research Collaborating Center, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea., seoul, Republic of Korea, ⁷Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, seoul
Background/Purpose: Osteoarthritis (OA) in hands is common in middle-aged and elderly population. The mainstay treatment of hand OA is to control the symptoms with a combination of non-pharmacological and…
Abstract Number: 1322 • 2019 ACR/ARP Annual Meeting
Evaluation of Intra-articular CNTX-4975 in Subjects with Painful Bilateral Knee Osteoarthritis: Effects on Pain with Walking and Patient Impression of Change in Pain
Randall Stevens ¹, Kimberly Guedes ¹, Nilam Mistry ¹, Paul Tiseo ², Duncan Lascelles ³, Mario Mendoza¹ and David Ball ⁴, ¹Centrexion Therapeutics Corp, Boston, MA, ²Centrexion Therapeutics Corp, Boston, ³Translational Research in Pain, North Carolina State University, Raleigh, NC, ⁴MAC Clinical Research, Manchester, United Kingdom
Background/Purpose: A double-blind, randomized, placebo-controlled trial (TRIUMPH; NCT02558439) with a single 1 mg intra-articular (IA) injection of CNTX-4975 (highly purified trans-capsaicin) into one knee for…
Abstract Number: 1975 • 2019 ACR/ARP Annual Meeting
Fibrates as Drugs with Senolytic and Autophagic Activity for Osteoarthritis Treatment
Uxia Nogueira-Recalde¹, Irene Lorenzo-Gomez ², Francisco J. Blanco ³, María I. Loza ⁴, Diego Grassi ⁵, Valery Shirinsky ⁶, Ivan Shirinsky ⁶, martin lotz ⁷, Paul D. Robbins ⁸, Eduardo Domínguez ⁴ and Beatriz Carames ², ¹Grupo de Biología del Cartílago, Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña, Sergas, A Coruña, Spain, A Coruña, Spain, ²Grupo de Biología del Cartílago, Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña, Sergas, A Coruña, Spain, A Coruna, Spain, ³Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ⁴Biofarma Research Group, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, Santiago de Compostela, Spain, ⁵Institute for Interdisciplinary Neuroscience (IINS), Bordeaux, Nouvelle-Aquitaine, France, Bordeaux, France, ⁶Scientific Research Institute of Clinical immunology, Novosibirsk, Rusia, Novosibirsk, Russia, ⁷Department of Molecular Medicine. Scripps Research, La Jolla, CA, USA, La Jolla, CA, ⁸Institute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN
Background/Purpose: . Increasing evidence suggest that osteoarthritis (OA) is associated with hallmarks of ageing, including cellular senescence or defective autophagy, that could promote disease onset.…
Abstract Number: 2175 • 2019 ACR/ARP Annual Meeting
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Ascending Doses of the Anti-ADAMTS-5 Nanobody®, M6495, in Healthy Male Subjects: A Phase I, Placebo-Controlled, First-in-Human Study
Hans Guehring¹, Torben Balchen ², Kosalaram Goteti ³, Jesper Sonne ⁴, Christoph Ladel ¹, Victor Ona ¹, Flavie Moreau ⁵, Anne Bay-Jensen ⁶ and Asger Reinstrup Bihlet ⁶, ¹Merck KGaA, Darmstadt, Germany, ²DanTrials ApS c/o Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark, ³EMD Serono Research and Development Institute, Inc., Billerica, MA, ⁴Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark, ⁵EMD Serono Research and Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ⁶Nordic Bioscience, Herlev, Denmark
Background/Purpose: Osteoarthritis (OA) is a serious disease characterized by progressive joint failure and cartilage degeneration. In OA, ADAMTS-5 protease is upregulated, resulting in enhanced cleavage…
Abstract Number: 2196 • 2019 ACR/ARP Annual Meeting
Machine Learning Defines the Relationship Between Structural Knee Osteoarthritis and Patient-Important Outcomes: An 8-year Study of 47,858 Knee MRIs from the Osteoarthritis Initiative (OAI)
Michael Bowes¹, Katherine Kacena ², Oras Alabas ³, Alan Brett ¹, Bright Dube ⁴, Neil Bodick ⁵ and Philip G Conaghan ⁶, ¹Imorphics, Manchester, England, United Kingdom, ²BioBridges, Wellesley Hills, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, ⁴University of Leeds, LEEDS, England, United Kingdom, ⁵Flexion Therapeutics, Burlington, ⁶Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom
Background/Purpose: Osteoarthritis (OA) is a slowly progressing disease which may be asymptomatic for many years. Therapy development has been hampered by poor understanding of both…
Abstract Number: 2802 • 2019 ACR/ARP Annual Meeting
High Intensity Interval Training for Knee Osteoarthritis: A Pilot Study
Yvonne Golightly¹, Carolina Alvarez ², Malia Blue ³, Kelli Allen ³, Amanda Nelson ³ and Abbie Smith-Ryan ³, ¹University of North Carolina at Chapel Hill Department of Epidemiology and Thurston Arthritis Research Center, Chapel Hill, NC, ²University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ³University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Physical activity reduces pain and increases physical function in people with knee osteoarthritis (OA), but few achieve recommended levels of physical activity because of…
Abstract Number: 219 • 2019 ACR/ARP Annual Meeting
A Fibromyalgia Assessment Screening Tool on a Multidimensional Health Assessment Questionnaire (MDHAQ) Which Does Not Include a Self-Report RADAI Painful Joint Count (RADAI), FAST3nJC, Recognizes Fibromyalgia Similarly to Other FAST3 Indices Which Include a RADAI
Theodore Pincus¹, Isabel Castrejon ² and Joel Block ², ¹Division of Rheumatology, Rush University Medical Center, Chicago, IL, ²Rush University Medical Center, Chicago, IL
Background/Purpose: Fibromyalgia (FM) generally is easily recognized, but a diagnosis may be difficult, particularly in patients with secondary FM who have other primary diagnoses. Criteria…
Abstract Number: 1301 • 2019 ACR/ARP Annual Meeting
Rates of Incident Radiographic Knee Osteoarthritis and Knee Replacement by Sex and Race, Across Three Large, Diverse Cohorts
C. Kent Kwoh¹, Amanda Nelson ², Yvonne Golightly ³, Erin Ashbeck ⁴, Liubov Arbeeva ⁵, Na Wang ⁶, Jeffrey Duryea ⁷ and Tuhina Neogi ⁶, ¹University of Arizona, Tucson, AZ, ²University of North Carolina at Chapel Hill, Chapel Hill, NC, ³University of North Carolina at Chapel Hill Department of Epidemiology and Thurston Arthritis Research Center, Chapel Hill, NC, ⁴The University of Arizona Arthritis Center, University of Arizona, Tuccson, AZ, Tucson, AL, ⁵University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ⁶Boston University School of Medicine, Boston, MA, ⁷Harvard Medical School Department of Radiology Brigham and Women's Hospital, Boston, MA
Background/Purpose: Previous studies have suggested differences in the development of incident radiographic knee osteoarthritis (RKOA) and the receipt of knee replacement (KR) by sex and…

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