Abstract Number: 1459 • ACR Convergence 2020
The Association of Frequent Knee Bending with Trajectories of Pain and Physical Function over 8 Years in Knee Osteoarthritis
Background/Purpose: Frequent bending increases loading at the knee and is a risk factor for worsening knee pain associated with knee osteoarthritis (OA). Knee bending is…Abstract Number: 1564 • ACR Convergence 2020
Feasibility of Ultra-low-dose, Short-duration, Total-body Evaluation of Inflammatory Arthritis Using uEXPLORER 18F-FDG PET/CT
Background/Purpose: The uEXPLORER system enables the unique, simultaneous acquisition of PET data over the entire adult human body with a high-sensitivity, alongside concurrent CT data.…Abstract Number: 1654 • ACR Convergence 2020
The Relationship Between Patient-Reported Readiness for Total Knee Arthroplasty and the Likelihood of a Good Outcome at One Year
Background/Purpose: In prior qualitative research, we found that patients with knee osteoarthritis (OA) equated appropriateness for total knee arthroplasty (TKA) with candidacy for the procedure.…Abstract Number: L05 • 2019 ACR/ARP Annual Meeting
Safety, Tolerability, Pharmacokinetics, and Clinical Outcomes Following Single-Dose IA Administration of UBX0101, a Senolytic MDM2/p53 Interaction Inhibitor, in Patients with Knee OA
Background/Purpose: A non-drug biomarker study showed senescent cell (SnC) burden in OA synovial tissue to correlate with disease severity, inflammation, and knee pain (C. Yohn,…Abstract Number: 888 • 2019 ACR/ARP Annual Meeting
Mitochondrial DNA Impact on Joint Degeneration Process Using DMM OA and Spontaneous Aging Conplastic Mice Models
Background/Purpose: Accumulated data indicated that osteoarthritis has a strong genetic component with a prevalent role of mitochondria and mtDNA variations. In the present work, we…Abstract Number: 1311 • 2019 ACR/ARP Annual Meeting
Prevalence of Symptomatic Axial Osteoarthritis and Poliarticular Phenotypes in Spain: EPISER 2016 Study
Background/Purpose: Osteoarthritis (OA) is a heterogeneous group of diseases with common clinical and radiographic manifestations involving the peripheral and axial skeletal. OA is the most…Abstract Number: 1846 • 2019 ACR/ARP Annual Meeting
Does Cartilage Loss Cause Pain in Osteoarthritis?
Background/Purpose: Treatment development in osteoarthritis continues to focus on chondroprotection, but it is unclear if delaying cartilage loss would reduce joint pain. In published studies,…Abstract Number: 1988 • 2019 ACR/ARP Annual Meeting
Establishing an in Vitro Model of Hand Osteoarthritis by Generating Induced Pluripotent Stem Cells (iPSc) That Carry Single Nucleotide Polymorphisms Associated with Hand Osteoarthritis Risk
Background/Purpose: Knowledge and research results in the field of hand osteoarthritis (hOA) are currently limited, mainly due to the unavailability of tissue samples to develop…Abstract Number: 2185 • 2019 ACR/ARP Annual Meeting
MRI-detected Abnormalities in Prediction Models of Incident Radiographic Knee Osteoarthritis over 10 Years of Follow-up
Background/Purpose: MRI Osteoarthritis Knee Score (MOAKS) is a semi-quantitative scoring system used to assess MRI-detected structural abnormalities including over 100 raw scores representing multiple joint…Abstract Number: 2756 • 2019 ACR/ARP Annual Meeting
Subcutaneous Tanezumab versus NSAID for the Treatment of Osteoarthritis: Joint Safety Events in a Randomized, Double-Blind, Active-Controlled, 80-Week, Phase-3 Study
Background/Purpose: Tanezumab, a monoclonal antibody inhibiting nerve growth factor (NGF), is under investigation for the treatment of chronic pain conditions. In prior osteoarthritis (OA) studies,…Abstract Number: 891 • 2019 ACR/ARP Annual Meeting
Lorecivivint (SM04690), a Potential Disease-Modifying Osteoarthritis Drug, Inhibits CLK2 and DYRK1A, Novel Molecular Regulators of Wnt Signaling, Chondrogenesis, and Inflammation
Background/Purpose: In the synovial joint, Wnt pathway upregulation contributes to osteoarthritis (OA) by increasing osteocyte differentiation, cartilage thinning, and inflammation. Lorecivivint (LOR; SM04690), a novel…Abstract Number: 1312 • 2019 ACR/ARP Annual Meeting
Knee Morphology Associates with Tibio-Femoral and Patello-Femoral Osteoarthritis: A Case-Control Study
Background/Purpose: Although several morphological features of the hip joint predispose to hip osteoarthritis (OA), only a few are known to associate with knee OA. The…Abstract Number: 1878 • 2019 ACR/ARP Annual Meeting
Quantifying the Placebo Effect After Intra-Articular Injections: Implications for Trials and Practice
Background/Purpose: In recent years, diverse compounds for intra-articular (IA) administration were brought into the market with a subsequent significant and heterogeneous literature production. Understanding the efficacy…Abstract Number: 1993 • 2019 ACR/ARP Annual Meeting
Inhibition of Choline Kinase Alpha Improves Synovitis and Cartilage Damage in Animal Models of Osteoarthritis
Background/Purpose: Osteoarthritis (OA) is a disease of the whole joint, affecting cartilage, ligaments, menisci, bone and synovial tissue. We previously found that choline kinase alpha…Abstract Number: 2186 • 2019 ACR/ARP Annual Meeting
What Is an Important Difference in Gait Speed in Adults with Knee Osteoarthritis?
Background/Purpose: Little is known regarding what difference in functional performance measures are clinically significant in individuals with a chronic medical disease. This study examines the…
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