Abstracts tagged "Osteoarthritis"

Abstract Number: 0551 • ACR Convergence 2020
Physical Performance as a Mediator of the Association Between Depression and Pain in Knee Osteoarthritis
Alan Rathbun¹, Elizabeth Stuart², Michelle Shardell¹, Trang Nguyen², Alice Ryan¹, Joseph Gallo², Michelle Yau³, Megan Schuler⁴ and Marc Hochberg¹, ¹University of Maryland School of Medicine, Baltimore, MD, ²Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, ³Hinda and Arthur Marcus Institute for Aging Research, Boston, MA, ⁴RAND Corporation, Boston, MA
Background/Purpose: Depression is common in knee osteoarthritis (OA), and leads to reduced physical function, which may mediate the effect of depression on pain. However, research…
Abstract Number: 0706 • ACR Convergence 2020
Adenosine A2A Receptor Activation Reduces Markers of Chondrocyte Senescence and Cartilage Inflammation Associated with Osteoarthritis
Benjamin Friedman¹ and Bruce Cronstein², ¹NYU Rheumatology, New York, NY, ²NYU Grossman School of Medicine, New York, NY
Background/Purpose: Osteoarthritis is an aging-associated disorder linked to dysfunctional metabolism, chronic inflammation, oxidative stress, and cellular senescence. Cellular senescence is associated with stable cell cycle…
Abstract Number: 1106 • ACR Convergence 2020
MMP Mediated Type I Collagen Degradation Is Associated with Erosive Hand Osteoarthritis in a Hospital-based Observational Cohort – the NOR-HAND Study
Christian Thudium¹, Neha Sharma², Marthe Gløersen³, Peder Frederiksen², Anne C. Bay-Jensen¹ and Ida Haugen³, ¹Nordic Bioscience, Herlev, Denmark, ²Nordic Bioscience, Herlev, ³Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: Hand osteoarthritis (OA) is a common degenerative joint disease affecting mainly the interphalangeal and first carpometacarpal joints. The disease manifests as inflammation and deterioration…
Abstract Number: 1122 • ACR Convergence 2020
Osteoarthritis in a Large Integrated Health System Population: 18-Year Retrospective Review
Jove Graham¹, Tonia Novosat¹, Haiyan Sun¹, Brian Piper², Joseph Boscarino¹, Melissa Kern¹, Vanessa Duboski³, Eric Wright³, Patricia Schepman⁴, Rebecca Robinson⁵, Edward Casey⁶, Craig Beck⁷ and Jerry Hall⁸, ¹Geisinger, Danville, ²Geisinger, Scranton, ³Geisinger, Forty Fort, ⁴Pfizer, New York City, NY, ⁵Eli Lilly and Company, Indianapolis, ⁶Pfizer, New York, ⁷Pfizer, London, ⁸Eli Lilly and Company, Indianapolis, IN
Background/Purpose: Osteoarthritis (OA) is a mechanically and immunologically mediated common disease with a complex pathogenesis. Despite epidemiologic studies proving increasing age, obesity and female gender…
Abstract Number: 1488 • ACR Convergence 2020
Application of the Knee Injury and Osteoarthritis Outcome Score Percentile Curves on Preoperative and up to 2 Years Postoperative Data of Patients Undergoing Total Knee Arthroplasty
Marieke Loef¹, Maaike G. Gademan¹, Daisy A. J. Latijnhouwers¹, Herman Kroon¹, Herman Kaptijn², Willem Marijnissen³, Rob G. H. Nelissen¹, Thea Vliet Vlieland⁴ and Margreet Kloppenburg¹, ¹Leiden University Medical Center, Leiden, Netherlands, ²LangeLand Hospital, Zoetermeer, Netherlands, ³Albert Schweitzer Hospital, Dordrecht, Netherlands, ⁴Leiden University Medical Center, 2300 RC Leiden, Netherlands
Background/Purpose: The interpretation of patient-reported outcomes, such as the Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaire, can prove difficult if benchmarks are lacking. Therefore,…
Abstract Number: 1648 • ACR Convergence 2020
Comparison of Methotrexate and Glucosamine in Primary Knee Osteoarthritis with Inflammation
Biswadip Ghosh¹, Subhankar Haldar² and Meghna Saha², ¹IPGME&R, Kolkata, Kolkata, West Bengal, India, ²IPGME&R, Kolkata, KOLKATA, India
Background/Purpose: Many patients suffering from knee OA show swelling, warmth along with pain which are features of inflammation. There are no accepted pharmacological therapy for osteoarthritis…
Abstract Number: 1664 • ACR Convergence 2020
Walking Energetics, Fatigue, and Physical Activity in People with Knee Osteoarthritis
Kharma Foucher¹, Burcu Aydemir¹ and Chun-Hao Huang¹, ¹University of Illinois at Chicago, Chicago, IL
Background/Purpose: Osteoarthritis (OA) is associated with limitations in physical activity (PA) for many reasons which are not fully understood. While pain can be associated with…
Abstract Number: 0561 • ACR Convergence 2020
Risk Factors for Falls Among Individuals with Knee OA: A Longitudinal Community-based Study
Jessica Wilfong¹, Anthony Perruccio² and Elizabeth Badley², ¹Krembil Research Institute, University Helath Network, Toronto, ON, Canada, ²Krembil Research Institute, UHN; University of Toronto, Toronto, ON, Canada
Background/Purpose: Knee osteoarthritis (OA) is a known risk factor for falling, but little is known about what factors contribute to the risk of falling among…
Abstract Number: 0707 • ACR Convergence 2020
Contribution of NOTUM and Glypicans to the Development of Osteoarthritis
Arkaitz Mucientes¹, Eva Herranz¹, Pia Lois², Gloria Candelas², Lydia Abasolo¹, Luis Rodriguez-Rodriguez¹, Jose Ramon Lamas¹ and Benjamin Fernandez-Gutierrez³, ¹IdISSC, Madrid, Madrid, Spain, ²Hospital Clínico San Carlos, Madrid, Madrid, Spain, ³Hospital Clínico San Carlos / IdISSC, Madrid, Madrid, Spain
Background/Purpose: Osteoarthritis (OA) is a degenerative disease characterized by altered homeostasis of joint cartilage and bone, the functionality of which relies on chondrocytes and osteoblasts,…
Abstract Number: 1107 • ACR Convergence 2020
IL1RN Polymorphism Predicts Weight Loss, Inflammatory Biomarker Changes and Knee Osteoarthritis Pain Relief After Bariatric Surgery
Jonathan Samuels¹, Fernando Bomfim², Mukundan Attur³, Christine Ren-Fielding⁴, Manish Parikh⁵, Renata La Rocca-Vieira⁶ and Steven B. Abramson⁷, ¹NYU Langone, Rye Brook, NY, ²New York University, Department of Medicine, Division of Rheumatology, Millburn, NJ, ³NYU Langone Health, New York, NY, ⁴NYU Langone Health, New YOrk, ⁵Bellevue Hospital, New York, NY, ⁶NYU, New YOrk, ⁷New York University School of Medicine, New York, NY
Background/Purpose: Symptomatic knee osteoarthritis (SKOA) patients with obesity who undergo bariatric surgery experience knee pain relief, though the reduced mechanical load explains only part of…
Abstract Number: 1123 • ACR Convergence 2020
The Patient Journey in Knee OA: Variations in Patient Characteristics and Treatment by Physician Specialty
Angela Bedenbaugh¹, Vinson Lee¹, Gary Oderda², Sarah Kennedy¹, Diana Brixner², Jeyanesh Tambiah³ and Timothy McAlindon⁴, ¹Samumed, LLC, San Diego, CA, ²University of Utah, Salt Lake City, UT, ³Samumed LLC, San Diego, CA, ⁴Tufts Medical Center, Boston, MA
Background/Purpose: Knee osteoarthritis (OA) affects 32.5 million US adults and is typically treated by primary care physicians, rheumatologists (RH), orthopedists (OS), sports medicine (SM) physicians,…
Abstract Number: 1489 • ACR Convergence 2020
Relation of Pain Mechanisms to Development of Knee Pain in Osteoarthritis: The Multicenter Osteoarthritis Study
Tuhina Neogi¹, Na Wang¹, Kosaku Aoyagi¹, Laura Frey Law², Cora Lewis³, Michael Nevitt⁴ and Lisa Carlesso⁵, ¹Boston University School of Medicine, Boston, MA, ²University of Iowa, Iowa City, IA, ³University of Alabama Birmingham, Birmingham, AL, ⁴University of California, San Francisco, San Francisco, CA, ⁵McMaster University, Hamilton, ON, Canada
Background/Purpose: Whether altered nociceptive signaling, such as pain sensitization and abnormal descending pain modulation, impact the risk of developing knee pain, more pain severity, and/or…
Abstract Number: 1649 • ACR Convergence 2020
Effect of Knee Aspiration and Intra-articular Corticosteroid Injection on Gait Biomechanics and Strength Impairment in Patients with Signs of Inflammation Due to Knee Osteoarthritis
Ryan Pinto¹, Trevor Birmingham¹, Holly Philpott², Dominique Arsenault¹, Codie Primeau¹ and Tom Appleton³, ¹Western University, London, Canada, ²Western University, London, ON, Canada, ³The University of Western Ontario, LONDON, ON, Canada
Background/Purpose: Synovial inflammation in knees with OA can be measured with musculoskeletal ultrasound (MSK US), is associated with increased pain and disease progression, and may…
Abstract Number: 1960 • ACR Convergence 2020
Cost-effectiveness of Surgical and Non-Surgical Weight Loss Programs for Morbidly Obese Patients with Knee Osteoarthritis
Valia Leifer¹, Jeffrey Katz², Faith Selzer³, Tuhina Neogi⁴, Jamie Collins⁵ and Elena Losina², ¹The Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) at Brigham and Women's Hospital, Boston, ²Harvard Medical School / The Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) at Brigham and Women's Hospital, Boston, MA, ³The Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) at Brigham and Women's Hospital, Amesbury, MA, ⁴Boston University School of Medicine, Boston, MA, ⁵The Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) at Brigham and Women's Hospital, Boston, MA
Background/Purpose: Growing numbers of knee osteoarthritis (KOA) patients are morbidly obese (BMI ≥ 35 kg/m2). Evolving evidence suggests weight reduction may delay the structural progression…
Abstract Number: 0562 • ACR Convergence 2020
The Relationship Between Heart Disease Risk Profile and Osteoarthritis, Overall and by Multi-/Single-Joint Involvement
Anthony Perruccio¹, Shatabdy Zahid², Calvin Yip³, J Denise Power², Mayilee Canizares², George Heckman⁴ and Elizabeth Badley¹, ¹Krembil Research Institute, UHN; University of Toronto, Toronto, ON, Canada, ²Krembil Research Institute, University Health Network, Toronto, ON, Canada, ³University of Toronto, Toronto, ON, Canada, ⁴University of Waterloo, Waterloo, ON, Canada
Background/Purpose: Osteoarthritis (OA) and heart disease (HD) are among the most common chronic conditions. Several studies have shown that OA increases the risk of HD…

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