Abstracts tagged "Osteoarthritis"

Abstract Number: 1052 • ACR Convergence 2021
Female Reproductive Factors and Risk of Joint Replacement Arthroplasty of the Knee and Hip Due to Osteoarthritis in Postmenopausal Women: A Nationwide Cohort Study of 1.36 Million Women
Yeonghee Eun¹, Jung Eun Yoo², Kyungdo Han³, Dahye Kim³, Jaejoon Lee¹, Dong-Yun Lee¹, Dae-Hee Lee¹, Dong Wook Shin¹ and Hyungjin Kim¹, ¹Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea, ²Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Republic of Korea, ³Soongsil University, Seoul, Republic of Korea
Background/Purpose: Previous studies of the relationships between female reproductive factors and osteoarthritis (OA) have shown conflicting results. In this study, we aimed to explore the…
Abstract Number: 1129 • ACR Convergence 2021
Cost-effectiveness of Weight Loss Interventions Prior to Total Knee Replacement for Patients with Advanced Knee Osteoarthritis and Class III Obesity
Aleksandra Kostic¹, Valia Leifer², Tuhina Neogi³, David Hunter⁴, Lisa Suter⁵, Faith Selzer⁶, Jeffrey Katz¹ and Elena Losina⁷, ¹Brigham and Women's Hospital, Brookline, MA, ²The Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) at Brigham and Women's Hospital, Boston, MA, ³Boston University School of Medicine, Boston, MA, ⁴Institute of Bone and Joint Research, University of Sydney, St Leonards, Australia, ⁵Yale School of Medicine, New Haven, CT, ⁶Brigham and Women's Hospital, Amesbury, MA, ⁷Brigham and Women's Hospital, Boston, MA
Background/Purpose: Class III obesity, defined by BMI >40kg/m2, is linked to increased risk of complications post total knee replacement (TKR). This has led to recommendations…
Abstract Number: 1477 • ACR Convergence 2021
Circulating MicroRNAs in Hand Osteoarthritis
Aneta Pekacova¹, Jiri Baloun¹, Olga Sleglova¹, Jiri Vencovsky¹, Karel Pavelka², Ladislav Senolt² and Olga Ruzickova¹, ¹Institute of Rheumatology, Prague, Czech Republic, ²Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
Background/Purpose: microRNAs (miRNAs) are small non-coding RNAs that can ignite the degradation of mRNAs or inhibit the protein translation and are therefore essential for several…
Abstract Number: 0213 • ACR Convergence 2021
Quantitative Assessment of Volumetric Change in Hip Effusion Using Artificial Intelligence in Patients with Osteoarthritis of the Hip
Jacob Jaremko¹, Banafshe Felfeliyan², Abhilash Hareendranathan¹, Bashiar Thejeel¹, Vanessa Quinn-Laurin¹, Mikkel Ostergaard³, Philip Conaghan⁴, Robert Lambert¹, Janet Ronsky² and Walter Maksymowych¹, ¹University of Alberta, Edmonton, AB, Canada, ²University of Calgary, Calgary, AB, Canada, ³Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, and Department of Clinical Medicine, University of Copenhagen, Glostrup, Denmark, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom
Background/Purpose: Accurate quantification of hip effusion volume may aid effective OA management as synovitis of the hip has been associated with pain and structural damage…
Abstract Number: 0482 • ACR Convergence 2021
Metformin Use Reduces the Risk of Developing Osteoarthritis: A Propensity Score Matching Study
Khushboo Sheth¹, Di Lu², Rong Lu², William Robinson³ and Matthew Baker⁴, ¹Stanford University/VA Palo Alto, Atherton, CA, ²Stanford University, Stanford, ³Stanford University, Palo Alto, CA, ⁴Stanford University, Menlo Park, CA
Background/Purpose: Preclinical and observational data suggest a protective effect of metformin against developing osteoarthritis (OA).1,2 In this retrospective cohort study, we evaluated the time to…
Abstract Number: 0735 • ACR Convergence 2021
Walking Ability 12 Months After Total Knee Arthroplasty for Osteoarthritis – Gap Between Expectations and Reality: The BEST Knee Cohort Study
Lauren King, Esther Waugh and Gillian Hawker, University of Toronto, Toronto, ON, Canada
Background/Purpose: Improved ability to walk is a key driver for people with knee osteoarthritis (OA) to seek total knee arthroplasty (TKA). However, the extent to…
Abstract Number: 1057 • ACR Convergence 2021
Impact of Osteoarthritis in Younger Adults
Elizabeth Badley¹, Jessica Wilfong² and Anthony Perruccio¹, ¹Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada, ²Shcroeder Arthritis Institute, University Health Network, Toronto, ON, Canada
Background/Purpose: OA is a disease frequently perceived as a disease of the elderly and an inevitable result of aging. Consequently, epidemiological and clinical studies of…
Abstract Number: 1130 • ACR Convergence 2021
Osteoarthritis Patients Feel Their Tissue Remodeling
Anne-Christine Bay-Jensen¹, Yi He², Christian Thudium¹ and Morten Karsdal³, ¹Nordic Bioscience, Herlev, Denmark, ²Nordic Bioscience A/S, Herlev, Denmark, ³Nordic Bioscience, Herlev
Background/Purpose: Osteoarthritis (OA) is a chronic disease characterized by pain and disability. Central to the revised FDA guidelines for the approval of a disease modifying…
Abstract Number: 1478 • ACR Convergence 2021
An Orphan Receptor and Osteoarthritis: Mouse Gpr34 Expression in Dorsal Root Ganglia After Partial Meniscectomy
David Thomas¹, Terese Geraghty², Alia Obeidat², Jun Li², Rachel Miller² and Anne-Marie Malfait³, ¹University of Minnesota Internal Medicine Residency, St. Paul, MN, ²Rush University Medical Center, Chicago, IL, ³Rush University, Chicago, IL
Background/Purpose: Osteoarthritis (OA) is one of the leading causes of musculoskeletal pain and disability. Worldwide, an estimated 303 million patients have clinically diagnosed OA, with…
Abstract Number: 0214 • ACR Convergence 2021
Baseline Cam or Pincer Morphology Is Associated with Loss of Quantitative Joint Space Width at the Hip: The Johnston County Osteoarthritis Project
Amanda Nelson¹, Carolina Alvarez¹, Yvonne Golightly¹, Jamie Stiller², Jordan Renner¹, Nigel Arden³, Charles Ratzlaff⁴ and Jeffrey Duryea⁵, ¹University of North Carolina at Chapel Hill, Chapel Hill, NC, ²Alamance Regional Medical Center, Durham, NC, ³University of Oxford, Oxford, United Kingdom, ⁴University of British Columbia, Vancouver, BC, Canada, ⁵Brigham and Women's Hospital, Boston, MA
Background/Purpose: To determine the association between radiographic cam and pincer morphology and loss of hip quantitative joint space width (qJSW) in a community-based cohort.Methods: Data…
Abstract Number: 0483 • ACR Convergence 2021
Frequent Use of Prescription Oral NSAIDs Among People with Knee or Hip Osteoarthritis Despite Contraindications to or Precautions with NSAIDs
Tuhina Neogi¹, Andrea Dell'isola², Martin Englund² and Aleksandra Turkiewicz², ¹Boston University School of Medicine, Boston, MA, ²Lund University, Lund, Sweden
Background/Purpose: Oral NSAIDs are recommended for OA management. However, many patients with OA have contraindications to NSAIDs or have comorbidities that warrant precaution. Because few…
Abstract Number: 0736 • ACR Convergence 2021
Decrease in Prevalence of Self-Reported Anxiety or Depression in Persons with Osteoarthritis After Total Knee Arthroplasty: The BEST KNEE Cohort Study
Owen Krystia, Lauren King, Esther Waugh and Gillian Hawker, University of Toronto, Toronto, ON, Canada
Background/Purpose: While anxiety and depression are highly prevalent in persons with symptomatic knee osteoarthritis (OA), few studies have assessed the effect of treatment of knee…
Abstract Number: 1058 • ACR Convergence 2021
Sex-Specific Associations Between Knee Synovial Fluid Biomarkers and Knee Osteoarthritis Pain
Anthony Perruccio, Elizabeth Badley, J Denise Power, Mayilee Canizares, Nizar Mahomed, Kahlid Syed, Rajiv Gandhi, J. Roderick Davey, Mohit Kapoor, Christian Veillette and Y Raja Rampersaud, Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada
Background/Purpose: Sex has received limited attention in osteoarthritis (OA) clinical studies assessing relationships between biomarkers and pain. In prior work we reported sex-specific associations between…
Abstract Number: 1131 • ACR Convergence 2021
Interleukin 6 Concentration in Synovial Fluid and Its Clinical Significance
Ivars Veckalns and Anna Mihailova, Riga Stradins University, Riga, Latvia
Background/Purpose: Inflammatory arthritis (IA) treated with disease modifying antirheumatic drugs lead to secondary osteoarthritis (OA) due to inflammation, aging, and other factors. Inflammatory arthritis can…
Abstract Number: 1479 • ACR Convergence 2021
CD14, a Toll-like Receptor Co-Factor, Influences Osteoclast Differentiation and Activity, but Does Not Alter Osteoblastic Potential of Bone-Marrow Precursors in Mice
Jerahme Martinez, Vu Nguyen, Cheng Zhou, George Dodge and Carla Scanzello, University of Pennsylvania, philadelphia, PA
Background/Purpose: Changes in subchondral bone structure (SCB) occur in osteoarthritis (OA), and are visible by imaging as subchondral sclerosis on radiographs, and bone marrow lesions…

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