Abstract Number: 1104 • ACR Convergence 2020
The Disability Associated with Hand Osteoarthritis Is Substantial in a Cohort of Post-menopausal Women : The QUALYOR Study
Background/Purpose: Osteoarthritis (OA) is a highly prevalent disease, affecting more than 400 millions individuals around the world. Hand osteoarthritis (HOA) is the most frequent form…Abstract Number: 1120 • ACR Convergence 2020
A Comparison of Opioid-Related Outcomes Among Commercially-Insured Osteoarthritis Patients Treated with Tramadol vs. Non-Tramadol Opioids
Background/Purpose: In 2019, the American College of Rheumatology conditionally recommended tramadol for patients with hip and knee osteoarthritis (OA). While tramadol is known to be…Abstract Number: 1486 • ACR Convergence 2020
Long-term Efficacy and Safety of Intra-articular Sprifermin in Patients with Knee Osteoarthritis: Results from the 5-Year Forward Study
Background/Purpose: The 5-year Phase II FORWARD study assessed the efficacy and safety of the potential disease-modifying osteoarthritis drug (DMOAD) sprifermin (recombinant human fibroblast growth factor…Abstract Number: 1646 • ACR Convergence 2020
Use of Prescription Nonsteroidal Anti-inflammatory Drugs (NSAIDs) in Adults with Hip/Knee Osteoarthritis (OA) at Increased Risk for NSAID-related Adverse Events
Background/Purpose: NSAIDs are commonly used for OA pain, but the benefits of pain relief must be carefully weighed against the potential risk for gastrointestinal (GI),…Abstract Number: 1662 • ACR Convergence 2020
Do Weight-bearing versus Non-weight-bearing Pain Reflect Different Pain Mechanisms in Knee Osteoarthritis?: The Multicenter Osteoarthritis Study
Background/Purpose: Pain with weightbearing in knee OA is thought to be related to the activation of nociceptors; however, this is not considered the sole mechanism…Abstract Number: 0543 • ACR Convergence 2020
Exercise Among Older Adults Living with Rheumatic Disease: Physical Activity Habits and Patient Reported Outcomes
Background/Purpose: Among patients with rheumatic disease, physical activity is important for maintaining health and improving outcomes. EULAR recommendations suggest at least 30 min of vigorous…Abstract Number: 0705 • ACR Convergence 2020
lncRNA H19 and Micro RNA 675-3p Are Altered by Visfatin During Osteogenesis
Background/Purpose: Long non-coding (lnc-)RNAs are transcribed from DNA similar to mRNA. lncRNA are able to interact directly with DNA, RNA and proteins. Some lncRNAs contain…Abstract Number: 1105 • ACR Convergence 2020
RANK-L Activity: Understanding the Pathogenesis of Erosive Osteoarthritis
Background/Purpose: Erosive osteoarthritis (EOA) is characterized by osteoarthritic findings with central erosions and collapse of the interphalangeal joint subchondral bone plate. A number of studies…Abstract Number: 1121 • ACR Convergence 2020
Osteoarthritis in the Million Veterans Program: Integrating the Electronic Medical Record with Precision Medicine
Background/Purpose: Osteoarthritis (OA) had profound impacts on societal and patient-centered outcomes, including disability. As the first step to leverage the rich resource of the Million…Abstract Number: 1487 • ACR Convergence 2020
Biclustering Reveals Potential Knee Osteoarthritis Phenotypes in Exploratory Analyses: Data from the Osteoarthritis Initiative
Background/Purpose: To utilize novel methodologies to explore subgroups within the OAI clinical data.Methods: From the OAI baseline dataset (n=4796 individuals with or at risk of…Abstract Number: 1647 • ACR Convergence 2020
An Oleuropein-based Dietary Supplement Improves Joint Function in Older People with High Knee Joint Pain
Background/Purpose: The aim of this study was to investigate the effects of a 6-month intervention with an Olive Leaf Extract (OLE) standardized for oleuropein content…Abstract Number: 1663 • ACR Convergence 2020
Walking for Exercise May Be Symptom and Structure Modifying for Those with Established OA and with Varus Alignment – Data from the Osteoarthritis Initiative
Background/Purpose: Walking for exercise is recommended for knee osteoarthritis (OA) management though benefits have not been demonstrated in epidemiologic studies. We aimed to assess the…Abstract Number: 0551 • ACR Convergence 2020
Physical Performance as a Mediator of the Association Between Depression and Pain in Knee Osteoarthritis
Background/Purpose: Depression is common in knee osteoarthritis (OA), and leads to reduced physical function, which may mediate the effect of depression on pain. However, research…Abstract Number: 0706 • ACR Convergence 2020
Adenosine A2A Receptor Activation Reduces Markers of Chondrocyte Senescence and Cartilage Inflammation Associated with Osteoarthritis
Background/Purpose: Osteoarthritis is an aging-associated disorder linked to dysfunctional metabolism, chronic inflammation, oxidative stress, and cellular senescence. Cellular senescence is associated with stable cell cycle…Abstract Number: 1106 • ACR Convergence 2020
MMP Mediated Type I Collagen Degradation Is Associated with Erosive Hand Osteoarthritis in a Hospital-based Observational Cohort – the NOR-HAND Study
Background/Purpose: Hand osteoarthritis (OA) is a common degenerative joint disease affecting mainly the interphalangeal and first carpometacarpal joints. The disease manifests as inflammation and deterioration…
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