Abstracts tagged "Osteoarthritis"

Abstract Number: 0218 • ACR Convergence 2021
Synovitis Does Not Mediate the Relationship Between Body Mass Index and Progression of Radiographic Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Marina Bañuls¹, Alecio Lombardi¹, Eric Chang¹, Aladdin H Shadyab¹, Nancy Lane² and Monica Guma³, ¹University of California San Diego, San Diego, CA, ²University of California Davis, Hillsborough, CA, ³University of California San Diego, La Jolla, CA
Background/Purpose: Synovial inflammation is associated with knee osteoarthritis (KOA) progression. Body mass index (BMI) has also been associated with KOA progression. Yet, it is unclear…
Abstract Number: 0593 • ACR Convergence 2021
Labour Force Participation Among Individuals with Osteoarthritis, Rheumatoid Arthritis/Other Arthritis Types, or with Joint Symptoms but Without a Diagnosis: An Age-Stratified Population-Based Study
Shatabdy Zahid, Elizabeth Badley and Anthony Perruccio, Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada
Background/Purpose: Having arthritis is known to affect labour force participation. Most research has focused on individuals with doctor-diagnosed rheumatoid arthritis (RA) and, to a lesser…
Abstract Number: 0850 • ACR Convergence 2021
Regression Methods for Modeling Western Ontario and McMaster Universities Arthritis Index (WOMAC) Pain Scores for Early Stage Knee Osteoarthritis
Benjamin Sweigart and Michael LaValley, Boston University School of Public Health, Boston, MA
Background/Purpose: The Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score [range 0-20] is a common outcome measure for clinical trials and observational studies…
Abstract Number: 1119 • ACR Convergence 2021
Systematic Review of Non-surgical Therapies for Hand Osteoarthritis
Haonan Mi, Christopher Oh and Tanveer Towheed, Queen's University, Kingston, ON, Canada
Background/Purpose: This systematic review evaluated all published randomized controlled trials (RCTs) assessing pharmacological and non-pharmacological therapies in patients with hand osteoarthritis (HOA).Methods: The following electronic…
Abstract Number: 1168 • ACR Convergence 2021
Barriers to Effectiveness of Non-surgical Treatments for Knee Osteoarthritis in a Diverse Racial/Ethnic Population: A Nominal Group Qualitative Study
Jasvinder Singh, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Knee osteoarthritis (OA) has worse outcome in racial/ethnic minorities, who also have more severe pain, disability and worse outcomes. However, most qualitative studies include…
Abstract Number: 1671 • ACR Convergence 2021
COVID-19 in Patients with Rheumatoid Arthritis Compared to Patients with Osteoarthritis During the Pandemic in New York City
Jonah Levine¹, Vivian Bykerk², Lindsay Lally¹, Lisa Mandl¹ and Medha Barbhaiya¹, ¹Hospital for Special Surgery, New York, NY, ²Division of Rheumatology, Hospital for Special Surgery, New York City, NY
Background/Purpose: COVID-19 in patients with rheumatoid arthritis (RA) is poorly understood. A recent study of mostly men with RA demonstrated increased COVID-19 risk in RA…
Abstract Number: 0219 • ACR Convergence 2021
Intra-Articular Mineralization on Knee CT and Risk of Cartilage Loss: The Multicenter Osteoarthritis Study
Jean Liew¹, John Lynch², Ali Guermazi¹, Mohamed Jarraya³, David Felson¹, Na Wang¹, Cora Lewis⁴, James Torner⁵, Michael Nevitt⁶ and Tuhina Neogi⁷, ¹Boston University, Boston, MA, ²University of California San Francisco, San Francisco, CA, ³Massachusetts General Hospital, Boston, MA, ⁴University of Alabama Birmingham, Birmingham, AL, ⁵University of Iowa, Iowa City, IA, ⁶University of California San Francisco, Orinda, CA, ⁷Boston University School of Medicine, Boston, MA
Background/Purpose: Intra-articular (IA) mineralization due to crystal deposition may contribute to OA pathology through inflammation, release of pro-catabolic factors, or altered cartilage biomechanical properties. Prior…
Abstract Number: 0723 • ACR Convergence 2021
Size of Regression to the Mean in First-Line Interventions for Osteoarthritis: An Illusion of Effectiveness
Martin Englund and Aleksandra Turkiewicz, Lund University, Lund, Sweden
Background/Purpose: Persons who seek treatment for osteoarthritis (OA) are likely doing so when experiencing a flare-up in pain. Due to natural fluctuation of pain, this…
Abstract Number: 0851 • ACR Convergence 2021
Application of a Modified Recursive Feature Elimination Machine Learning Algorithm to Select Predictors of Mortality in Those with and Without Osteoarthritis
Siyeon Kim¹, Siqi Xiang¹, Liubov Arbeeva¹, Carolina Alvarez¹, Amanda Nelson¹, Yvonne Golightly¹, Leigh Callahan², Michael Kosorok¹ and Becki Cleveland³, ¹University of North Carolina at Chapel Hill, Chapel Hill, NC, ²University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC, ³Thurston Arthritis Research Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC
Background/Purpose: Radiographic osteoarthritis (rOA) and joint symptoms at the knee and hip are predictors of mortality. However, questions remain about the nature of the relationship…
Abstract Number: 1120 • ACR Convergence 2021
Effectiveness of Stretching and Bracing for the Treatment of Osteoarthritis-associated Joint Contractures Prior to Joint Replacement: A Systematic Review
T Mark Campbell¹, Bahareh Ghaedi², Elizabeth Ghogomu³, Marie Westby⁴ and Vivian Welch⁵, ¹Elisabeth Bruyere Hospital, Ottawa, ON, Canada, ²Ottawa Hospital Research Institute, Ottawa, ON, Canada, ³Bruyere Research Institute, Ottawa, ON, Canada, ⁴Centre for Hip Health and Mobility, Vancouver, BC, Canada, ⁵Bruyère Research Institute, Ottawa, ON, Canada
Background/Purpose: Many patients with osteoarthritis (OA) develop range of motion (ROM) restrictions in their affected joints (contractures), leading to worse pain and function. OA-related contractures…
Abstract Number: 1169 • ACR Convergence 2021
Patient Preferences for Outcome Measures for a Pragmatic Knee Osteoarthritis (OA) Clinical Trial: Results of a Cross-Sectional Patient Survey That Included Racial/Ethnic Minorities
Jasvinder Singh, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Many effective treatments are available for knee osteoarthritis (OA), however comparative effectiveness research (CER) of various treatments to each other is limited. One of…
Abstract Number: 1902 • ACR Convergence 2021
Gait Alterations Associated with Worsening Knee Pain over 2 Years: A Machine-learning Approach in the MultiCenter Osteoarthritis Study
Kathryn Bacon¹, David Felson², S. Reza Jafarzadeh¹, Vijay Kolachalama¹, Jeff Hausdorff³, Eran Gazit⁴, Neil Segal⁵, Cora Lewis⁶, Michael Nevitt⁷ and Deepak Kumar², ¹Boston University School of Medicine, Boston, MA, ²Boston University, Boston, MA, ³Tel Aviv University, Tel Aviv, Israel, ⁴Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ⁵University of Kansas Medical Center, Iowa City, IA, ⁶University of Alabama Birmingham, Birmingham, AL, ⁷University of California San Francisco, San Francisco, CA
Background/Purpose: Altered gait is related to structural worsening of knee osteoarthritis (OA). However, it is not known if altered gait is associated with increased risk…
Abstract Number: 0220 • ACR Convergence 2021
Relation of Knee Extensor Power to Worsening Cartilage Damage in the Knee: The MOST Study
Joshua Stefanik¹, David Felson², Cara Lewis³, Gabriela Rabasa², Ali Guermazi², Frank Roemer⁴, Michael Nevitt⁵, Cora Lewis⁶ and Neil Segal⁷, ¹Northeastern University, Boston, MA, ²Boston University, Boston, MA, ³Boston University, Brookline, MA, ⁴Friedrich-Alexander University Erlangen-Nurnberg, Erlangen, Germany, ⁵University of California San Francisco, Orinda, CA, ⁶University of Alabama Birmingham, Birmingham, AL, ⁷University of Kansas Medical Center, Iowa City, IA
Background/Purpose: The relation between knee extensor muscle weakness and osteoarthritis (OA) outcomes has been well-studied. Muscle power, another measure of knee extensor function, however, has…
Abstract Number: 0724 • ACR Convergence 2021
Dose (Exposure) Efficacy Response of Tanezumab Following Intravenous and Subcutaneous Administration Across Phase 2 and Phase 3 Studies in Patients with Osteoarthritis of Hip and Knee
Martin Boucher¹, Kenneth Verburg², Puneet Gaitonde² and Scott marshall¹, ¹Pfizer R&D Ltd., Sandwich, United Kingdom, ²Pfizer Inc., Groton, CT
Background/Purpose: Tanezumab is a humanized monoclonal antibody against nerve growth factor that has been evaluated for relief of chronic osteoarthritis pain by subcutaneous (SC) or…
Abstract Number: 0852 • ACR Convergence 2021
Bone Marrow Lesion Segmentation Using Synthetic Data and Deep Learning Models
Barak Michaely¹, Ming Zhang² and Juan Shan¹, ¹Pace University, New York, NY, ²Wentworth Institute of Technology, Boston, MA
Background/Purpose: Bone marrow lesions (BML) are indicators for knee osteoarthritis (OA) and can be detected from magnetic resonance imaging (MRI). Due to the small size,…

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