Abstract Number: 0210 • ACR Convergence 2021
Using Machine Learning to Predict Medial Knee Cartilage Worsening over 2 Years Using Gait and Physical Activity: The MOST Study
Background/Purpose: Identifying knees at risk of worsening osteoarthritis (OA) could help to identify individuals in need of interventions. While gait and physical activity are considered…Abstract Number: 0479 • ACR Convergence 2021
A Novel Semi-automated Classifier of Radiographic Hip Osteoarthritis on DXA Scans Is Strongly Predictive of Pain, Clinical Diagnosis and Joint Replacement: Findings from 40,000 Participants in UK Biobank
Background/Purpose: Radiographic hip osteoarthritis (rHOA) is traditionally defined on hip or pelvic radiographs, using subjective methods such as Kellgren-Lawrence scoring. Associations between subjective rHOA measures…Abstract Number: 0732 • ACR Convergence 2021
Topical Rofecoxib for OA of the Knee
Background/Purpose: Osteoarthritis remains a highly prevalent disease in the elderly, and there are currently no approved treatments that can modify the disease course. Currently, both…Abstract Number: 1044 • ACR Convergence 2021
Older Patients with Rheumatic Disease Are Commonly Prescribed Potentially Inappropriate Medications
Background/Purpose: Reducing exposure to potentially inappropriate medications (PIMs) in older adults may minimize adverse drug events. The American Geriatrics Society (AGS) Beers Criteria® of Potentially…Abstract Number: 1127 • ACR Convergence 2021
Synovial Fluid Cytokines, Chemokines, and MMPs in Osteoarthritis Patients with Knee Pain Compared to RA Patients and Normal Knees
Background/Purpose: A major limitation of synovial fluid (SF) biomarker studies in osteoarthritis (OA) has been difficulty in obtaining SF (SF) in patients with small effusions.…Abstract Number: 1475 • ACR Convergence 2021
Long Term Compressive Loading Modulates the Extracellular Matrix Response to Growth Factors in Bovine Cartilage Explants
Background/Purpose: Mechanical loading of cartilage is an essential part of the function and maintenance of the joint. Despite the apparent importance of continuous mechanical loading,…Abstract Number: 0211 • ACR Convergence 2021
Unsupervised Machine-learning Algorithms for the Identification of Clinical Phenotypes in the Osteoarthritis Initiative Database
Background/Purpose: Osteoarthritis (OA) is a chronic disabling disease, for which there are only limited treatment options. One major challenge in the development of effective treatment…Abstract Number: 0480 • ACR Convergence 2021
Signs of Regression to the Mean in Observational Data from a Nation-Wide Exercise and Education Intervention for Osteoarthritis
Background/Purpose: Patients who enroll in interventions are likely to do so when they experience a flare-up in symptoms. This may create issues in interpretation of…Abstract Number: 0733 • ACR Convergence 2021
A New Wearable Transcutaneous Electrical Nerve Stimulation Device (actiTENS®) Is More Efficient and Better Tolerated Than Weak Opioids in the Treatment of Knee Osteoarthritis Pain
Background/Purpose: Knee osteoarthritis (KOA) is a frequent disease for which therapeutic possibilities are limited. In current recommendations, the first-line analgesic is acetaminophen. However, its low…Abstract Number: 1051 • ACR Convergence 2021
Variance of Joint Space Width Across the Tibiofemoral Joint on Knee Radiographs: A Novel Measure of Structure and Progression
Background/Purpose: The FDA accepts medial minimum joint space width (mJSW) in the tibiofemoral (TF) compartment as the standard for structural change in clinical trials of…Abstract Number: 1128 • ACR Convergence 2021
Inter-relationships Between Multiple Joint Osteoarthritis and Collagen Biomarkers in Men: The Johnston County Osteoarthritis Project
Background/Purpose: To determine inter-relationships between blood-based collagen formation and degradation biomarkers and multiple joint osteoarthritis (MJOA) phenotypes in a community-based cohort.Methods: Data were from Johnston…Abstract Number: 1476 • ACR Convergence 2021
Metabolic Reprogramming: Inhibiting Osteoarthritis-induced Expression of the Pyruvate Dehydrogenase Kinase Preserves Mitochondrial Respiration
Background/Purpose: Osteoarthritis (OA) is the most common degenerative joint disease worldwide, traditionally classified as non-inflammatory. Recently, attention has been drawn to the importance of synovitis…Abstract Number: 0212 • ACR Convergence 2021
Unsupervised Clustering of Histology and Ultrasound Scores Identifies Osteoarthritis Subtypes
Background/Purpose: Osteoarthritis (OA) is a prevalent degenerative joint disease and a major cause of pain and disability worldwide. Inflammation of the synovium and surrounding tissues…Abstract Number: 0481 • ACR Convergence 2021
The Day-to-day Variability of Pain and the Relationship with Physical Activity in People with Knee Osteoarthritis: A Longitudinal, Observational Feasibility Study
Background/Purpose: Pain is a cardinal symptom in people with knee osteoarthritis (OA). However, pain in knee OA is often infrequently measured both in clinical practice…Abstract Number: 0734 • ACR Convergence 2021
Primary Total Knee Arthroplasty for Knee Osteoarthritis Among Younger versus Older Individuals: Cross-sectional Study of Surgical Appropriateness and Surgeon Decision-Making
Background/Purpose: Rising rates of total knee arthroplasty (TKA) in younger adults with knee osteoarthritis (OA) has prompted concern about surgical appropriateness. We compared patient appropriateness…
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