Abstracts tagged "Osteoarthritis"

Abstract Number: 0011 • ACR Convergence 2021
Differential Inflammation-mediated Function of Prokineticin 2 in the Synovial Fibroblasts of Patients with Rheumatoid Arthritis Compared to Osteoarthritis
Kentaro Noda, Bianca Dufner and Rainer Straub, Laboratory of Experimental Rheumatology and Neuroendocrine Immunology, Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
Background/Purpose: Prokineticin 2 (PK2) is a secreted protein involved in several pathological and physiological processes, including the regulation of inflammation, sickness behaviors, and the circadian…
Abstract Number: 0223 • ACR Convergence 2021
The Association of Clinical and Structural Knee Osteoarthritis with Physical Activity in the Middle-aged Population: The Netherlands Epidemiology of Obesity Study
Sietse Terpstra¹, Jeroen van der Velde¹, Renée de Mutsert¹, Dieuwke Schiphof², Monique Reijnierse¹, Frits Rosendaal¹, Lotte van de Stadt¹, Margreet Kloppenburg¹ and Marieke Loef¹, ¹Leiden University Medical Center, Leiden, Netherlands, ²Erasmus Medical Center, Rotterdam, Netherlands
Background/Purpose: Physical activity is a potential target for interventions in knee OA. However, most of the available studies concerning physical activity in individuals with knee…
Abstract Number: 0726 • ACR Convergence 2021
Joint Safety of Tanezumab versus NSAIDs; A Combined Assessment of Benefit and Harm
Robert Fountaine¹, Robert Dworkin², Anne Hickman¹, Glenn Pixton³, Ed Whalen⁴, Christine West¹ and Kenneth Verburg¹, ¹Pfizer Inc., Groton, CT, ²University of Rochester, Rochester, NY, ³Pfizer Inc., Morrisville, NC, ⁴Pfizer Inc., New York, NY
Background/Purpose: Tanezumab, a monoclonal antibody against nerve growth factor, is in development for the relief of signs and symptoms of moderate to severe osteoarthritis (OA)…
Abstract Number: 0943 • ACR Convergence 2021
Metabolomic Profiling of Synovial Tissue of Patients with Osteoarthritis
Jessica Murillo Saich¹, Roxana Coras², Robert Meyer³ and Monica Guma⁴, ¹University of California San Diego, La Jolla, CA, ²University of California San Diego/Department of Medicine, Autonomous University of Barcelona, San Diego, CA, ³San Diego VA Healthcare Service, La Jolla, CA, ⁴University of California San Diego/San Diego VA Healthcare Service/Department of Medicine, Autonomous University of Barcelona, La Jolla, CA
Background/Purpose: Increasing evidence indicates that osteoarthritis (OA) progression is mediated not simply by progressive degeneration of cartilage, but also by low-grade synovial inflammation (synovitis) that…
Abstract Number: 1123 • ACR Convergence 2021
“It’s a Dance Between Managing Both [Diabetes and Osteoarthritis]”: A Qualitative Study Exploring Perspectives of Persons with Knee Osteoarthritis and Type 2 Diabetes Mellitus on the Impact of Osteoarthritis on Diabetes Management and Daily Life
Lauren King¹, Esther Waugh¹, Crystal McKay¹, Ian Stanaitis² and Gillian Hawker¹, ¹University of Toronto, Toronto, ON, Canada, ²Women's College Hospital, Toronto, ON, Canada
Background/Purpose: The links between osteoarthritis (OA) and other common chronic conditions, such as type 2 diabetes mellitus (T2DM), are increasingly being appreciated in epidemiological studies.…
Abstract Number: 1468 • ACR Convergence 2021
Intra-articular (IA) Injection of Empty Large Multilamellar Vesicles Liposomes Reduces Cartilage Degeneration in Rat Osteoarthritis Model
Alison Bendele¹, Jacob Favret¹, Gadi Sarfati², Ronny Pinkus² and Roni Wechsler², ¹Bolder BioPATH Inc., Boulder, CO, ²Moebius Medical LTD, Tel Aviv, Israel
Background/Purpose: A suspension of empty large multilamellar vesicles (MLV) liposomes composed of dimyristoylphosphatidylcholine (DMPC) and dipalmitoylphosphatidylcholine (DPPC), is currently under clinical development for symptomatic knee…
Abstract Number: 0026 • ACR Convergence 2021
Synovial Fibroblasts Acquire a Proinflammatory and Destructive Phenotype After Exposure to αS1-Casein (CSN1S1)
Nadine Honke¹, Tim Appel¹, Matthias Schneider² and Georg Pongratz³, ¹Department of Rheumatology, Hiller Research Center Rheumatology, University Hospital Düsseldorf, Germany (* contributed equally), Düsseldorf, Germany, ²Policlinic & Hiller Research Unit Rheumatology, UKD, Heinrich-Heine University, Düsseldorf, Germany, ³Polyclinic and Functional Area for Rheumatology & Hiller Research Center Rheumatology, University Hospital Düsseldorf, Düsseldorf, Germany
Background/Purpose: The milk protein αS1-Casein (CSN1S1) was described to be overexpressed in synovial tissue of patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Recently we…
Abstract Number: 0224 • ACR Convergence 2021
Effects of Kinesiophobia and Physical Function on Physical Activity in Adults with Knee Osteoarthritis
Burcu Aydemir and Kharma Foucher, University of Illinois at Chicago, Chicago, IL
Background/Purpose: Only a small proportion of people with knee osteoarthritis (OA) meet the recommended guidelines for physical activity and it is still unclear why. Lacking…
Abstract Number: 0727 • ACR Convergence 2021
Total Joint Replacements in Three Phase 3 Studies of Tanezumab in Patients with Osteoarthritis
John Carrino¹, Timothy McAlindon², Eric Vignon³, Mark Brown⁴, Aimee Burr⁴, Robert Fountaine⁴, Glenn Pixton⁵, Lars Viktrup⁶, Christine West⁴ and Kenneth Verburg⁴, ¹Hospital for Special Surgery, New York, NY, ²Tufts Medical Center, Arlington, MA, ³Université Claude Bernard Lyon 1, Lyon, France, ⁴Pfizer Inc., Groton, CT, ⁵Pfizer Inc., Morrisville, NC, ⁶Eli Lilly and Company, Indianapolis, IN
Background/Purpose: Tanezumab (TNZ) is an antibody against nerve growth factor that has demonstrated efficacy in the management of osteoarthritis (OA). Due to the potential risk…
Abstract Number: 1028 • ACR Convergence 2021
Knee Osteoarthritis and Mortality: The Osteoarthritic Initiative
Jane Cauley¹, Michael Nevitt², Kai Sun³, Jason Maeda³, C. Kent Kwoh⁴, Leena Sharma⁵, Rebecca Jackson⁶, Susan Rubin³ and Marc Hochberg⁷, ¹University of Pittsburgh Graduate School of Public Health, Pittsbugh, PA, ²University of California San Francisco, Orinda, CA, ³University of California San Francisco, San Francisco, CA, ⁴University of Arizona College of Medicine, Tuscon, AZ, ⁵Northwestern University, Chicago, IL, ⁶Ohio State University, Columbus, OH, ⁷University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: A recent international individual participant data (IPD) meta-analysis (n=10,723) reported a 35-37% increased mortality risk among individuals with painful knees (no radiographic OA) and…
Abstract Number: 1124 • ACR Convergence 2021
Examining the Relationships Between Treatment and Pain and Physical Function Outcomes in Patients with Osteoarthritis: A Mediation Modeling Approach
Lucy Abraham¹, Robert Dworkin², Dennis C. Turk³, John D. Markman², David A. Williams⁴, Andrew G Bushmakin⁵, Jerry A. Hall⁶, David C. Semel⁷, Joseph C Cappelleri⁵ and Ruoyong Yang⁸, ¹Pfizer Ltd., Tadworth, United Kingdom, ²University of Rochester, Rochester, NY, ³University of Washington, Seattle, WA, ⁴University of Michigan, Ann Arbor, MI, ⁵Pfizer Inc, Groton, CT, ⁶Eli Lilly and Company, Indianapolis, IN, ⁷Pfizer, New York, NY, ⁸Pfizer Inc., New York, NY
Background/Purpose: To better understand the complex relationships between treatment and pain and physical function (PF) outcomes, we investigated a set of mediation models of osteoarthritis…
Abstract Number: 1470 • ACR Convergence 2021
Cartilage Epigenetic Changes Induced by Microbial DNA Amplified from Human OA Samples
Vladislav Izda¹, Christopher Dunn², Cassandra Sturdy¹, Jake Martin¹, Cassandra Velasco², Paul Jacob³ and Matlock Jeffries¹, ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Oklahoma Joint Reconstruction Institute, Oklahoma City, OK
Background/Purpose: Strong links between epigenetic changes, particularly alterations in DNA methylation, have been linked with the onset and progression of knee osteoarthritis (OA); however, the…
Abstract Number: 0121 • ACR Convergence 2020
Association of Low Bone Density with Need for Early Revision After Elective Joint Replacement for Osteoarthritis in Postmenopausal Women
Rashmi Dhital¹, P. Daniel Nicholas², Gregory Emkey³ and Anthony Donato², ¹Reading Hospital and Medical Center, West Reading, ²Reading Hospital and Medical Center, West Reading, PA, ³Reading Hospital and Medical Center, Reading, PA
Background/Purpose: Total joint replacement (TJR) is the standard surgical treatment for end-stage hip and knee osteoarthritis (OA). Patient optimization may limit the need for early…
Abstract Number: 0679 • ACR Convergence 2020
Epidemiology of Intra-Articular Mineralization on Knee Dual-Energy Computed Tomography: The Multicenter Osteoarthritis Study
Mohamed Jarraya¹, Tuhina Neogi², John Lynch³, David Felson², Piran Aliabadi⁴, Michael Nevitt³, Cora Lewis⁵, James Torner⁶ and Ali Guermazi², ¹Boston University School of Medicine, Boston, ²Boston University School of Medicine, Boston, MA, ³University of California at San Francisco, San Francisco, ⁴Brigham and Womens Hospital, Boston, ⁵University of Alabama Birmingham, Birmingham, AL, ⁶University of Iowa, Iowa City, IA
Background/Purpose: Computed tomography (CT) has a higher sensitivity for the detection of intraarticular mineralization in comparison with commonly used imaging techniques in knee osteoarthritis (OA)…
Abstract Number: 0961 • ACR Convergence 2020
Development of a Pain Sensitivity Index to Examine the Transition from Intermittent to Constant Pain in Knee Osteoarthritis: The Multicenter Osteoarthritis Study
Kosaku Aoyagi¹, Lisa Carlesso², S. Reza Jafarzadeh¹, Michael LaValley³, Na Wang¹, Laura Frey Law⁴, Beth Lewis⁵, Michael Nevitt⁶ and Tuhina Neogi¹, ¹Boston University School of Medicine, Boston, MA, ²McMaster University, Hamilton, ON, Canada, ³Boston University School of Public Health, Boston, MA, ⁴University of Iowa, Iowa City, IA, ⁵University of Alabama at Birmingham, Birmingham, ⁶University of California, San Francisco, San Francisco, CA
Background/Purpose: Alterations in nociceptive signaling, such as pain sensitization, which is an abnormal ascending pain facilitation, and/or inadequate descending pain modulation, are thought to be…

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