Abstracts tagged "Osteoarthritis"

Abstract Number: 1894 • ACR Convergence 2022
A Phase 2, 104-Week Study of Repeat Lorecivivint Injections Evaluating Safety, Efficacy, and Bone Health Utilizing Quantitative Computed Tomography (qCT) in Knee Osteoarthritis (OA-06)
Yusuf Yazici¹, Christopher Swearingen², Heli Ghandehari³, Jon Britt⁴, ismail simsek⁵, Mark Fineman⁶, Sarah Kennedy², Jeyanesh Tambiah⁷ and Nancy Lane⁸, ¹New York University School of Medicine, La Jolla, CA, ²Biosplice Therapeutics, Inc, San Diego, CA, ³Biosplice Therapeutics, Inc., San Diego, CA, ⁴Biosplice Therapeutics, Inc., Los Angeles, CA, ⁵Alpine Immunesciences, San Diego, CA, ⁶Biosplice Therapeutics, San Diego, CA, ⁷Biosplice Ther Inc., San Diego, CA, ⁸University of California Davis, Hillsborough, CA
Background/Purpose: Knee osteoarthritis (OA) is a common joint disorder associated with pain, disability, and joint damage. There is a large unmet need for safe and…
Abstract Number: 1910 • ACR Convergence 2022
Evaluation of Dynamic Effects of Depressive Symptoms on Functional Outcomes in Knee Osteoarthritis
Rhea Mehta¹, Marc Hochberg², Michelle Shardell¹, Alice Ryan¹, Yu Dong¹, Brock Beamer¹, Jason Peer², Megan Schuler³, Joseph Gallo⁴, Elizabeth Stuart⁴ and Alan Rathbun¹, ¹University of Maryland, School of Medicine, Baltimore, MD, ²University of Maryland School of Medicine, Baltimore, MD, ³Rand Inc., Boston, MA, ⁴Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
Background/Purpose: Knee OA is a leading cause of functional decline, and psychiatric comorbidity is common, particularly major depression. Depressive symptoms decrease physical activity and exacerbate…
Abstract Number: 2261 • ACR Convergence 2022
Pain in Osteoarthritis – Identification of GPR34 and GPR150 as Novel Targets in the Dorsal Root Ganglia
Matthew Wood¹, Terese Geraghty², David Thomas³, Alia Obeidat¹, Jun Li², Richard Miller⁴, Rachel Miller¹ and Anne-Marie Malfait⁵, ¹Rush University Medical Center, Chicago, IL, ²Rush University, Chicago, IL, ³University of Minnesota Internal Medicine Residency, St. Paul, MN, ⁴Northwestern University, Evaston, IL, ⁵Rush University, Oak Park, IL
Background/Purpose: Osteoarthritis (OA) is a leading cause of chronic pain worldwide. Currently available pain-alleviating therapies are often inadequate and associated with serious adverse effects, resulting…
Abstract Number: 0025 • ACR Convergence 2022
Wnt Pathway/Innate Immunity Equilibrium in OA Articular Cells
Eloi Franco-Trepat¹, Ana Alonso Pérez¹, María Guillán-Fresco², Miriam López Fagúndez¹, Andrés Pazos-Pérez³, Antia Crespo Golmar⁴, María Piñeiro-Ramil⁵, Ana Lois Iglesias⁶, Alberto Jorge-Mora¹ and Rodolfo Gomez¹, ¹MSP Group - Institute IDIS - CHUS - SERGAS, Santiago de Compostela, Spain, ²MSP Group - Institute IDIS - CHUS - SERGAS, Catoira, Spain, ³MSP Group - Institute IDIS - CHUS - SERGAS, Pontevedra, Spain, ⁴MSP Group - Institute IDIS - CHUS - SERGAS, León, Spain, ⁵MSP Group - Institute IDIS - CHUAC - SERGA, A Coruña, Spain, ⁶MSP Group - Institute IDIS - CHUAC - SERGAS, A Coruña, Spain
Background/Purpose: The progressive degradation of osteoarthritis (OA) cartilage has been associated with articular innate immune responses (IIR) mediated by the Toll-like receptor 4 (TLR4). Additionally,…
Abstract Number: 0553 • ACR Convergence 2022
Stair Climbing Difficulty and Risk of Functional Limitation in Knee Osteoarthritis: A Simple Functional Vital Sign?
Jason Jakiela¹, Dana Voinier¹, Yvonne Golightly², Jennifer Horney¹, Thomas Bye¹, Jéssica Bianca Aily¹ and Daniel White¹, ¹University of Delaware, Newark, DE, ²University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Knee osteoarthritis (OA) is a leading cause of functional limitation in older adults, and difficulty with climbing stairs is often the first-reported limitation. As…
Abstract Number: 1116 • ACR Convergence 2022
Peripheral Blood DNA Methylation-based Machine Learning Models for Prediction of Knee Osteoarthritis Progression: Biospecimens and Data from the Osteoarthritis Initiative and Johnston County Osteoarthritis Project
Chris Dunn¹, Cassandra Sturdy², Cassandra Velasco³, Leoni Schlupp², Emmaline Prinz², Vladislav Izda⁴, Liubov Arbeeva⁵, Yvonne Golightly⁶, Amanda Nelson⁷ and Matlock Jeffries², ¹University of Oklahoma Health Sciences Center, Edmond, OK, ²Oklahoma Medical Research Foundation, Oklahoma City, OK, ³University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁴Oklahoma Medical Research Foundation, New York, NY, ⁵University of North Carolina Chapel Hill, Chapel Hill, NC, ⁶University of Nebraska Medical Center, Omaha, NE, ⁷University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Knee osteoarthritis (OA) is a heterogeneous disease characterized by a variety of clinical and molecular phenotypes, for which there exist no widely-available biomarkers. We…
Abstract Number: 1675 • ACR Convergence 2022
Effectiveness of Intensive Diet and Exercise on Knee Pain Among Communities with Knee Osteoarthritis, Overweight, and Obesity: The WE-CAN Pragmatic Randomized Clinical Trial
Stephen Messier¹, Daniel Beavers², Kate Queen³, Shannon Mihalko¹, Gary Miller¹, Elena Losina⁴, Jeffrey Katz⁴, Richard Loeser⁵, Paul DeVita⁶, David Hunter⁷, Jovita Newman¹, Sara Quandt⁸, Mary Lyles², Joanne Jordan⁹ and Leigh Callahan¹⁰, ¹Wake Forest University, Winston-Salem, NC, ²Wake Forest University School of Medicine, Winston-Salem, NC, ³Haywood Regional Medical Center, Waynesville, NC, ⁴Brigham and Women's Hospital, Boston, MA, ⁵University of North Carolina, Chapel Hill, NC, ⁶East Carolina University, Greenville, NC, ⁷University of Sydney, Sydney, Australia, ⁸Wake Forest School of Medicine, Winston-Salem, NC, ⁹University of North Carolina School of Medicine, Chapel Hill, NC, ¹⁰University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC
Background/Purpose: Many health systems that treat people with knee osteoarthritis (OA) have no infrastructure in place to implement weight loss and exercise treatments. The policy…
Abstract Number: 1895 • ACR Convergence 2022
Association Between Synovial Tissue Metabolomic Profile and Pain in Patients with Knee Osteoarthritis
Jessica Murillo Saich¹, Roxana Coras², Robert Meyer³, Nancy Lane⁴ and Monica Guma⁵, ¹University of California San Diego, La Jolla, CA, ²University of California San Diego, San Diego, CA, ³San Diego VA Healthcare Service, San Diego, CA, ⁴University of California Davis, Hillsborough, CA, ⁵UCSD, La Jolla, CA
Background/Purpose: Increasing evidence indicates that osteoarthritis (OA) progression is mediated by low-grade synovial inflammation (synovitis) that contributes to joint pain and stiffness, especially in knee…
Abstract Number: 1911 • ACR Convergence 2022
Baseline Bone Curvature a Biomarker for the Prediction of Knee Osteoarthritis Cartilage Volume Loss at One-Year. Use of Machine Learning
Johanne Martel-Pelletier¹, Hossein Bonakdari¹, Jean-Pierre Pelletier¹ and François Abram², ¹Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montréal, QC, Canada, ²ArthroLab Inc., Montréal, QC, Canada
Background/Purpose: The hallmark of osteoarthritis is the loss of cartilage. At present, we cannot discriminate, early during the osteoarthritis process, patients for whom cartilage will…
Abstract Number: 2262 • ACR Convergence 2022
Albumin-hitchhiking MMP13 siRNA Conjugate (siMMP13< (EG18L)2) for the Treatment of Rheumatic Disease
Juan Colazo¹, Ella Hoogenboezem¹, Fang Yu¹, Veeraj Shah¹, Justin Lo¹, Hongsik Cho², Karen Hasty², Leslie Crofford³ and Craig Duvall¹, ¹Department of Biomedical Engineering, Vanderbilt University, Nashville, Nashville, TN, ²Department of Orthopaedic Surgery and Biomedical Engineering, Memphis VA Medical Center, Memphis, TN, ³Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Osteoarthritis (OA) and rheumatoid arthritis (RA) decrease quality of life due to joint destruction, pain, and decreased function. Multiple joint osteoarthritis (MJOA) can occur…
Abstract Number: 0026 • ACR Convergence 2022
Silencing of WISP-2 Induces Inflammatory Mediators and Catabolic Factors in Cartilage
Clara Ruiz-Fernández¹, María González-Rodríguez², Vera Francisco³, Djedjiga Ait Eldjoudi², Alfonso Cordero-Barreal², Yousof Farrag², Jesús Pino⁴, Miguel Ángel González-Gay⁵, Antonio Mera⁶, Francisca Lago² and Oreste Gualillo⁷, ¹Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Galicia, Spain, ²Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain, ³Institute of Health Research-INCLIVA, València, Spain, ⁴Santiago Clinic Hospital CHUS-Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain, ⁵Department of Medicine and Psychiatry, Universidad de Cantabria; Rheumatology Division, Hospital Universitario Marqués de Valdecilla; Research group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVAL, Santander, Spain. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa, ⁶Santiago University Clinical Hospital CHUS, Santiago de Compostela, Spain, ⁷Hospital Clínico Universitario de Santiago, SERGAS (Servizo Galego de Saude) and IDIS (Instituto de Investigación Sanitaria de Santiago), NEIRID Lab (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Research Laboratory 9, Santiago de Compostela, Spain
Background/Purpose: Wnt-1 inducible signaling pathway protein 2 (WISP-2/CCN5) is an adipokine that has been described as an important mediator of canonical Wnt activation in adipogenic…
Abstract Number: 0590 • ACR Convergence 2022
Molecular Profiling of Normal Human Synovium Reveals Striking Impact of Adipocytes and Homeostatic Cortisol Signaling
Heather Faust¹, Tan-Yun Cheng¹, Ilya Korsunsky¹, Gerald FM Watts¹, David Moody¹ and Michael Brenner², ¹Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: The synovium encapsulates joints and contains fibroblasts which proliferate, become invasive, and drive disease progression in rheumatoid arthritis (RA) and osteoarthritis (OA). There is…
Abstract Number: 1143 • ACR Convergence 2022
Epigenome-wide Analysis of Osteoarthritis in the Multicenter Osteoarthritis Study
Michelle S. Yau¹, Paul C. Okoro², Ida K. Haugen³, John A. Lynch⁴, Michael Nevitt⁵, Cora E. Lewis⁶, James Torner⁷ and David Felson⁸, ¹Hebrew SeniorLife, Harvard Medical School, Boston, MA, ²Hebrew SeniorLife, Boston, MA, ³Center for treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway, Oslo, Norway, ⁴UCSF, San Francisco, CA, ⁵University of California at San Francisco, Orinda, CA, ⁶University of Alabama at Birmingham, Birmingham, AL, ⁷University of Iowa, Iowa City, IA, ⁸Boston University, Boston, MA
Background/Purpose: Epigenetic mechanisms like DNA methylation may play a role in OA. For example, expression of GDF5, a well-known OA gene, is modulated by demethylation…
Abstract Number: 1754 • ACR Convergence 2022
Association of Cognitive Impairment and Symptomatic Lower Extremity Osteoarthritis by Level of Physical Activity: Preliminary Data from the Johnston County Health Study
Kharma Foucher¹, Amanda Nelson², Leigh Callahan³ and Yvonne Golightly⁴, ¹University of Illinois at Chicago, Chicago, IL, ²University of North Carolina at Chapel Hill, Chapel Hill, NC, ³University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC, ⁴University of Nebraska Medical Center, Omaha, NE
Background/Purpose: While osteoarthritis (OA) is associated with an increased risk of dementia,1 the frequency of milder cognitive impairment is unknown. Mild to moderate cognitive impairment…
Abstract Number: 1896 • ACR Convergence 2022
Alkylresorcinol, a Biomarker for Whole Grain Intake, and Its Association with Osteoarthritis: The MOST Study
Juan-Pablo Zertuche¹, Gabriela Rabasa¹, Alice H. Lichtenstein², Nirupa R. Matthan², Michael Nevitt³, James Torner⁴, Cora E. Lewis⁵, Devyani Misra⁶ and David Felson¹, ¹Boston University, Boston, MA, ²Tufts University, Boston, MA, ³University of California at San Francisco, Orinda, CA, ⁴University of Iowa, Iowa City, IA, ⁵University of Alabama at Birmingham, Birmingham, AL, ⁶Beth Israel Deconess Medical Center, Boston, MA
Background/Purpose: Whole grains, particularly wheat, are an important source of dietary fiber in the US. By providing a fermentable source, whole grains can modify the…

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