Abstracts tagged "Osteoarthritis"

Abstract Number: 0029 • ACR Convergence 2022
Characterizing the Anti-fibrotic Effect of Tofacitinib in TGF-β Stimulated Fibroblast-like Synoviocytes from Patients with OA
Sofie Falkenløve Madsen¹, Sarah Madsen², Elle Hollaar³, Thorbjørn Gantzel⁴, Anne-Christine Bay-Jensen³ and Christian Thudium³, ¹University of Copenhagen / Nordic Bioscience, Herlev, Denmark, ²Nordic Bioscience, University of Copenhagen, Herlev, Denmark, ³Nordic Bioscience, Herlev, Denmark, ⁴Gentofte Hospital, Gentofte, Denmark
Background/Purpose: Many osteoarthritis (OA) patients develop fibrosis of the synovial membrane leading to joint swelling, stiffness, and pain. Synovial fibroblasts activated in the synovial membrane…
Abstract Number: 0706 • ACR Convergence 2022
Association Between Metabolic Syndrome and Knee Pain over 10-13 Years in Middle-Aged Adults
Ambrish Singh, Brooklyn Fraser, Alison Venn, Leigh Blizzard, Changhai Ding and Benny Samuel Antony, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
Background/Purpose: Metabolic syndrome (MetS) is characterised by the clustering of central obesity with metabolic abnormalities. MetS has been suggested as having a role in osteoarthritis…
Abstract Number: 1152 • ACR Convergence 2022
A Novel Serological Biomarker Measuring a Fragment of Cartilage Intermediate Layer Protein 1 Is Highly Upregulated in Rheumatic Diseases
Helena Port¹, Walter P Maksymowych², Morten Karsdal³, Anne-Christine Bay-Jensen³ and Signe Holm Nielsen³, ¹University of Copenhagen, Copenhagen, Denmark, ²Department of Medicine, University of Alberta, Edmonton, AB, Canada, ³Nordic Bioscience, Herlev, Denmark
Background/Purpose: A hallmark of rheumatic joint diseases is altered cartilage protein turnover and protein composition. During cartilage erosions, the cartilage intermediate layer protein-1 (CILP-1), is…
Abstract Number: 1759 • ACR Convergence 2022
Factors Affecting Success of Behavioral Interventions to Improve Physical Activity in Patients with Knee Osteoarthritis
Lakshmi Jayaram¹, jing song², Pamela Semanik³, Daniel Pinto⁴, Linda Ehrlich-Jones⁵, Lutfiyya Muhammad⁶, Alison Chang⁶ and Rowland Chang⁷, ¹McGaw Medical Center, Northwestern University, Chicago, IL, ²Northwestern University, Chicago, IL, ³Rush University, Chicago, IL, ⁴Marquette University, Wauwatosa, WI, ⁵Shirley Ryan AbilityLab, Aurora, IL, ⁶Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷Northwestern University Division of Rheumatology, Chicago, IL
Background/Purpose: Knee osteoarthritis (KOA) is a chronic long-term condition that results in pain, disability and reduced quality of life. Over 13 million US adults 45…
Abstract Number: 1898 • ACR Convergence 2022
Radiographic Osteoarthritis Progression Can Be Predicted via Pyrosequencing Analysis of Baseline Peripheral Blood
Chris Dunn¹, Cassandra Velasco², Leoni Schlupp³, Emmaline Prinz³, Vladislav Izda⁴, Liubov Arbeeva⁵, Yvonne Golightly⁶, Amanda Nelson⁶ and Matlock Jeffries³, ¹University of Oklahoma Health Sciences Center, Edmond, OK, ²University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Oklahoma Medical Research Foundation, New York, NY, ⁵University of North Carolina Chapel Hill, Chapel Hill, NC, ⁶UNC School of Medicine, Chapel Hill, NC
Background/Purpose: Knee osteoarthritis (OA) is a heterogeneous disease characterized by a variety of clinical and molecular phenotypes. However, we do not yet have robust biomarkers…
Abstract Number: 1914 • ACR Convergence 2022
Acoustic Classification of Early and Advanced Osteoarthritis of the Knee in Clinical Settings
Dave Ewart¹, Ashley Draisey², Omer Inan³, Chris Nichols³ and Goktug Ozmen³, ¹Minneapolis Veterans Affairs Medical Center, Minneapolis, MN, ²Allina Health, Minneapolis, MN, ³Georgia Institute of Technology, Atlanta, GA
Background/Purpose: Knee osteoarthritis (OA) is a prevalent and debilitating disease. Diagnosis of early knee OA is difficult and insensitive with current technologies. The human knee…
Abstract Number: 0030 • ACR Convergence 2022
Fluidic Shear Stress Reduces TNFα-mediated Cartilage Damage in a 3D Model of Degenerative Joint Disease
Alexandra Damerau¹, Duc Ha Do Nguyen¹, Christina Lubahn¹, Thomas Leeuw², Timo Gaber³ and Frank Buttgereit³, ¹Charité-Universitätsmedizin Berlin, Berlin, Germany, ²Sanofi-Aventis Deutschland GmbH, Frankfurt, Germany, ³Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin / DRFZ Berlin, Berlin, Germany
Background/Purpose: Degenerative joint diseases such as osteoarthritis (OA) ultimately result in the breakdown of cartilage. The exact underlying mechanisms of cause and progression of OA…
Abstract Number: 0756 • ACR Convergence 2022
Rheumatic Toxicities of Immune Checkpoint Inhibitors in Patients with Advanced Melanoma and the Effect of Pre-existing Autoimmune and Non-immune Mediated Rheumatic Conditions
Alana Bruce¹, Georgina V Long², Alexander M Menzies², Brian Fernandes³ and Fredrick Joshua⁴, ¹Macquarie University, Balaclava, Victoria, Australia, ²Melanoma Institute Australia, The University of Sydney, Royal North Shore and Mater Hospitals, Sydney, Australia, ³Royal Prince Alfred Hospital, Sydney, Australia, ⁴Macquarie University, Integrated Specialist Medical Care, Sydney, Australia
Background/Purpose: To estimate the frequency of rheumatic toxicities of immune checkpoint inhibitors (ICI) presenting as de novo or exacerbations of pre-existing rheumatic disease in patients…
Abstract Number: 1228 • ACR Convergence 2022
Distinctive Alterations in the Functional Anatomy of the Cerebral Cortex in Pain-sensitized Osteoarthritis and Fibromyalgia Patients
Jesús Pujol¹, Fabiola Ojeda¹, Laura Blanco-Hinojo¹, Andrea Doreste¹, Gerard Martinez-Vilavella¹, Víctor Pérez-Solá¹, Joan Deus² and Jordi Monfort¹, ¹Hospital del Mar, Barcelona, Spain, ²Autonomous University of Barcelona, Barcelona, Spain
Background/Purpose: Fibromyalgia is a primary pain sensitization disorder showing augmented pain sensitivity with no apparent origin. In contrast, secondary sensitization often occurs in knee osteoarthritis…
Abstract Number: 1775 • ACR Convergence 2022
More Than Half of Patients with Osteoarthritis Have Positive Screening for Fibromyalgia And/or Depression, Feasibly Assessed in Routine Care on Indices Within a Single MDHAQ (multidimensional Health Assessment Questionnaire)
Theodore Pincus¹, Kathryn Gibson², Juan Schmukler¹, Tengfei Li³ and Joel Block¹, ¹Rush University Medical Center, Chicago, IL, ²Liverpool Hospital, Sydney, Australia, ³Georgetown University, Washington, DC
Background/Purpose: Osteoarthritis (OA) patients may have widely divergent scores for pain severity vs X-ray joint damage, indicating that elevated OA pain 0-10 visual numeric scale…
Abstract Number: 1899 • ACR Convergence 2022
A Phase 3, 28-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial (OA-10) to Evaluate the Efficacy and Safety of a Single Injection of Lorecivivint Injected in the Target Knee Joint of Moderately to Severely Symptomatic Osteoarthritis Subjects
Yusuf Yazici¹, Christopher Swearingen², Heli Ghandehari³, Victor Lopez⁴, ismail simsek⁵, Mark Fineman⁶, Sarah Kennedy⁷, Jeyanesh Tambiah⁸ and Timothy McAlindon⁹, ¹New York University School of Medicine, La Jolla, CA, ²Samumed LLC, San Diego, CA, ³Biosplice Therapeutics, Inc., San Diego, CA, ⁴Biosplice Therapeutics, Santa Clarita, CA, ⁵Alpine Immunesciences, San Diego, CA, ⁶Biosplice Therapeutics, San Diego, CA, ⁷Biosplice Therapeutics, Inc, San Diego, CA, ⁸Biosplice Ther Inc., San Diego, CA, ⁹Tufts Medical Center, Arlington, MA
Background/Purpose: Knee osteoarthritis (OA) is a common joint disorder associated with pain, disability, and joint damage. There remains a large unmet need for treatments that…
Abstract Number: 1915 • ACR Convergence 2022
Development of an MRI-based Definition of Knee Osteoarthritis: Data from the Multicenter Osteoarthritis Study
Jean Liew¹, Gabriela Rabasa², Michael LaValley³, Jamie collins⁴, Joshua Stefanik⁵, Ali Guermazi², Cora E. Lewis⁶, Michael Nevitt⁷, James Torner⁸ and David Felson², ¹Boston University School of Medicine, Boston, MA, ²Boston University, Boston, MA, ³Boston University School of Public Health, Arlington, MA, ⁴Brigham and Women's Hospital, Boston, MA, ⁵Northeastern University, Boston, MA, ⁶University of Alabama at Birmingham, Birmingham, AL, ⁷University of California at San Francisco, Orinda, CA, ⁸University of Iowa, Iowa City, IA
Background/Purpose: MRI is becoming the OA imaging modality of choice. It allows quantification of cartilage damage, the signature pathologic feature of disease. Proposed MRI-based definitions…
Abstract Number: 0032 • ACR Convergence 2022
Defective Chaperone-mediated Autophagy Is a Hallmark of Joint Disease in Patients with Knee Osteoarthritis
Irene Lorenzo-Gomez¹, uxia Nogueira-recalde¹, Christian garcía-Domínguez¹, Natividad Oreiro², Martin Lotz³, JA Pinto-Tasende², FJ Blanco² and beatriz caranes¹, ¹Instituto de Investigación Biomédica de A Coruña (INIBIC), Unidad de Biología del Cartílago, A Coruña, Spain, ²Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ³Scripps Research, La Jolla
Background/Purpose: Defects in autophagy contribute to joint aging and Osteoarthritis (OA). Identifying specific autophagy types could be useful for developing novel treatments for OA.Methods: A…
Abstract Number: 0836 • ACR Convergence 2022
Bone Turnover and Physical Activity Before and After Anterior Cruciate Ligament Reconstruction
Elizabeth Wellsandt¹, David Werner¹, Mikayla McKee², Matthew Tao², Kaleb Michaud¹ and Yvonne Golightly¹, ¹University of Nebraska Medical Center, Omaha, NE, ²University of Nebraska Medical Center, Omaha
Background/Purpose: Individuals after anterior cruciate ligament reconstruction (ACLR) have 8 times higher odds of developing knee osteoarthritis (OA) within 10 years compared to those with…
Abstract Number: 1232 • ACR Convergence 2022
Reliability and Validity of Single Axial Slice vs. Multiple Slice Quantitative Measurement of the Volume of Effusion-Synovitis on 3T Knee MRI in Knees with Osteoarthritis
Greg Gilles¹, Arjun Vohra¹, Chelsea Caruso¹, Dagoberto Robles¹, Mihra Taljanovic¹, Jeffrey Duryea², Erin Ashbeck¹, Edward Bedrick³ and Kent Kwoh⁴, ¹University of Arizona Arthritis Center, Tucson, AZ, ²Brigham and Women's Hospital, Boston, MA, ³Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, ⁴University of Arizona, Tucson, AZ
Background/Purpose: Effusion-synovitis (ES) on knee MRI has been identified as an important biomarker of OA. Semi-automated software methods offer objective measurements of ES volume on…

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