Abstracts tagged "Osteoarthritis"

Abstract Number: 1307 • ACR Convergence 2022
Effect of Romosozumab in Postmenopausal Women with Knee Osteoarthritis: Results from the FRAME Clinical Trial
Nancy Lane¹, Donald Betah², Cynthia Deignan², Mary Oates², Zhenxun Wang², Jen Timoshenko³, Aliya Khan⁴ and Neil Binkley⁵, ¹University of California Davis, Hillsborough, CA, ²Amgen, Inc., Thousand Oaks, CA, ³UCB Pharma, Slough, United Kingdom, ⁴McMaster University, Oakville, ON, Canada, ⁵University of Wisconsin, Madison, WI
Background/Purpose: Osteoarthritis (OA) and osteoporosis (OP) often occur concomitantly in the elderly. The relationship between OA and OP is complex, with increased fracture risk reported…
Abstract Number: 1784 • ACR Convergence 2022
Gait Alterations Associated with Worsening Physical Function over 2 Years: A Machine-learning Approach in the Multicenter Osteoarthritis (MOST) Study
Kathryn Bacon¹, David Felson¹, S. Reza Jafarzadeh², Vijaya Kolachalama², Jeffrey Hausdorff³, Eran Gazit⁴, Joshua Stefanik⁵, Patrick Corrigan⁶, Neil Segal⁷, Cora E. Lewis⁸, Michael Nevitt⁹ and Deepak Kumar¹, ¹Boston University, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³Tel Aviv University, Tel Aviv, Israel, ⁴Tel Aviv Suarasky Medical Center, Tel Aviv, Israel, ⁵Northeastern University, Boston, MA, ⁶Saint Louis University, St. Louis, MO, ⁷University of Kansas, Kansas City, KS, ⁸University of Alabama at Birmingham, Birmingham, AL, ⁹University of California at San Francisco, Orinda, CA
Background/Purpose: Altered gait is related to pathogenesis of knee osteoarthritis (OA). For people with knee OA, in addition to pain, declines in physical function are…
Abstract Number: 1902 • ACR Convergence 2022
Structural Severity in Knee Osteoarthritis Impacts Treatment Response: A Post Hoc Pooled Analysis of Lorecivivint Clinical Trials
Yusuf Yazici¹, Christopher Swearingen², Heli Ghandehari³, ismail simsek⁴, Sarah Kennedy⁵, Jeyanesh Tambiah⁶ and Timothy McAlindon⁷, ¹New York University School of Medicine, La Jolla, CA, ²Samumed LLC, San Diego, CA, ³Biosplice Therapeutics, Inc., San Diego, CA, ⁴Alpine Immunesciences, San Diego, CA, ⁵Biosplice Therapeutics, Inc, San Diego, CA, ⁶Biosplice Ther Inc., San Diego, CA, ⁷Tufts Medical Center, Arlington, MA
Background/Purpose: Osteoarthritis (OA) is a leading cause of disability globally, and its disease burden is expected to increase as risk factors such as aging and…
Abstract Number: 1918 • ACR Convergence 2022
Neurobiological Mechanisms of a Remote-Delivered Mind-body Intervention for Knee Osteoarthritis
Jian Kong¹ and Chenchen Wang², ¹Massachusetts General Hospital, Boston, MA, ²Tufts Medical Center, Boston, MA
Background/Purpose: As a recommended intervention for knee Osteoarthritis (OA) according to current guidelines, Tai Chi, a multi-dimensional exercise has exhibited clinically significant improvements in knee…
Abstract Number: 0097 • ACR Convergence 2022
Sex and Race/ethnicity Differences in Knee Symptoms, Function, and Radiographic Features: Preliminary Descriptive Data from the Johnston County Health Study
Luis Palomino¹, Carolina Alvarez², Todd Schwartz³, Yvonne Golightly⁴ and Amanda Nelson², ¹University of North Carolina Chapel hill, Chapel Hill, NC, ²University of North Carolina at Chapel Hill, Chapel Hill, NC, ³University of North Carolina-Chapel Hill, Chapel Hill, NC, ⁴University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Osteoarthritis (OA) is the most common form of joint disorder worldwide. Differences in pain, function, and radiographic features in ethnic groups, specifically Hispanics, are…
Abstract Number: 0839 • ACR Convergence 2022
Association of Tibial Acceleration During Walking to Knee Pain and Loading in Adults with Knee Osteoarthritis
Khara James¹, Patrick Corrigan², Corey Lanois³, Chun-Hao Huang⁴, Irene Davis⁵ and Joshua Stefanik⁴, ¹Northeastern Unviersity, Boston, MA, ²Saint Louis University, St. Louis, MO, ³Northeastern University, Providence, RI, ⁴Northeastern University, Boston, MA, ⁵University of South Florida, Tampa, FL
Background/Purpose: Pain and abnormal loading are known to be associated with the progression of knee osteoarthritis (OA). Individuals with knee OA have increased vertical loading…
Abstract Number: 1350 • ACR Convergence 2022
A Prospective Study on Pain Associated with Injection of Needles: PAIN Study
Chay Bae¹, Eugenia Chen¹ and Maida Wong², ¹Rheumatology, University of California, Irvine School of Medicine, Irvine, CA, ²Rheumatology, VA Long Beach Healthcare System, Long Beach, CA
Background/Purpose: Joint pain is a common issue amongst patients. In the appropriate clinical setting, joint injections or aspirations may benefit the patient. Pain, however, is…
Abstract Number: 1786 • ACR Convergence 2022
Anterior Knee Pain Is Associated with 2-year Compartment Specific Patellofemoral Cartilage Worsening: The MOST Study
Corey Lanois¹, Natalie Collins², Tuhina Neogi³, Ali Guermazi⁴, Frank Roemer⁵, Michael LaValley⁶, Michael Nevitt⁷, James Torner⁸, Cora E. Lewis⁹ and Joshua Stefanik¹⁰, ¹Northeastern University, Providence, RI, ²University of Queensland, Brisbane, Australia, ³Boston University School of Medicine, Boston, MA, ⁴Boston University, Boston, MA, ⁵Friedrich-Alexander University Erlangen Nürnberg, Erlangen, Germany, ⁶Boston University School of Public Health, Arlington, MA, ⁷University of California at San Francisco, Orinda, CA, ⁸University of Iowa, Iowa City, IA, ⁹University of Alabama at Birmingham, Birmingham, AL, ¹⁰Northeastern University, Boston, MA
Background/Purpose: Anterior knee pain (AKP) may be a precursor to patellofemoral osteoarthritis (PFOA). Cross-sectionally, frequent AKP has been associated with MRI features of PFOA; however,…
Abstract Number: 1903 • ACR Convergence 2022
Does Pain Sensitization by Pressure Pain Thresholds and Temporal Summation Predict Persistent Pain in Persons with Hand OA?
Pernille Steen Pettersen¹, Tuhina Neogi², Elisabeth Mulrooney¹, Marthe Gløersen¹, Hilde Berner Hammer³ and Ida K. Haugen¹, ¹Center for treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway, Oslo, Norway, ²Boston University School of Medicine, Boston, MA, ³Diakonhjemmet hospital, Jar, Norway
Background/Purpose: Pain sensitization is part of the complexity of osteoarthritis (OA) pain. We aimed to examine whether pain sensitization by pressure pain thresholds (PPT) and…
Abstract Number: 1919 • ACR Convergence 2022
Underdiagnosis and Undertreatment of Knee Osteoarthritis in Persons with Type 2 Diabetes: A Cross-sectional Study
Lauren King¹, Esther Waugh¹, Ian Stanaitis², Alanna Weisman¹, Baiju Shah¹, Lorraine Lipscombe¹ and Gillian Hawker¹, ¹University of Toronto, Toronto, ON, Canada, ²Women's College Hospital, Toronto, ON, Canada
Background/Purpose: Knee osteoarthritis (OA) and type 2 diabetes commonly co-occur due to shared risk factors. Concomitant knee OA makes type 2 diabetes management, particularly engaging…
Abstract Number: 0101 • ACR Convergence 2022
Twenty-five Years of Mortality Data in Those with Lower Extremity Osteoarthritis: The Role of Socioeconomic Status
Cara Murphy¹, Rebecca Cleveland¹, Amanda Nelson², Yvonne Golightly³ and Leigh Callahan⁴, ¹University of North Carolina, Chapel Hill, NC, ²University of North Carolina at Chapel Hill, Chapel Hill, NC, ³University of Nebraska Medical Center, Omaha, NE, ⁴University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC
Background/Purpose: The purpose of this study is to explore the relationship between socioeconomic status (SES) measures (income, professional employment, block group poverty level, education level,…
Abstract Number: 0841 • ACR Convergence 2022
Relation of PainDETECT to Unpredictable Pain in People with or at Risk of Knee Osteoarthritis
Kosaku Aoyagi¹, Laura Frey-Law², Gabriela Rabasa³, Cora E. Lewis⁴, Michael Nevitt⁵ and Tuhina Neogi⁶, ¹Boston University, Quincy, MA, ²University of Iowa, Iowa City, IA, ³Boston University, Boston, MA, ⁴University of Alabama at Birmingham, Birmingham, AL, ⁵University of California at San Francisco, Orinda, CA, ⁶Boston University School of Medicine, Boston, MA
Background/Purpose: PainDETECT has been used in studies of knee OA to identify "neuropathic-like pain", though neuropathic lesions have not been identified in clinical knee OA.…
Abstract Number: 1353 • ACR Convergence 2022
Dietary Practices and Beliefs of Patients with Rheumatic Diseases and Relationship with Symptoms: Results of a Multicenter Cross-sectional Study
Domitille RENARD¹, Sophie Tuffet², Philippe Dieude³, Pascal Claudepierre⁴, Laure Gossec⁵, Bruno Fautrel⁶, Anna Molto⁷, Corinne MIceli⁸, Pascal Richette⁹, Emmanuel Maheu¹⁰, Claire Carette¹¹, Sebastien Czernichow¹¹, Chloe JAMAKORZYAN¹², alexandra Rousseau², Francis Berenbaum¹³, Catherine Beauvais¹⁴ and Jérémie SELLAM¹⁵, ¹Sorbonne University Paris- Sant Antoine Hospital, Paris, France, ²Saint Antoine hospital, Paris, Ile-de-France, France, ³Université Paris Cité, Paris, France, ⁴Paris Est Creteil University, Creteil, France, ⁵Sorbonne Université, Paris, France, ⁶Sorbonne University Paris, France and Pierre Louis Institute of Epidemiology and Public Health, Paris, France, Paris, France, ⁷Rheumatology Department, Cochin Hospital, APHP, Paris, France, ⁸APHP, Paris, France, ⁹Department of Rheumatology, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France, ¹⁰Hôpital Paris Saint Antoine, Moirans, Auvergne-Rhône-Alpes, France, ¹¹Hôpital Européen Georges Pompidou, Paris, France, ¹²Hopital Begin, Saint-Mandé, France, ¹³Sorbonne University - Saint-Antoine hospital, Paris, France, ¹⁴Saint Antoine hospital, Paris, France, ¹⁵Sorbonne Universite, AP-HP, Saint-Antoine hospital, Paris, France
Background/Purpose: Diet is a subject of questioning and beliefs among patients with rheumatic diseases. They are inclined to change their eating habits and sometimes follow…
Abstract Number: 1888 • ACR Convergence 2022
Novel Small Molecule Modulator of the gp130 Receptor Shows Dose-dependent Therapeutic Efficacy in a Canine Model of Osteoarthritis
Ben Van Handel¹, Candace Flynn², Emma Lamoure², Nancy Liu³, Jinxiu Lu³, Nancy Lane⁴, Mark Hurtig² and Denis Evseenko³, ¹CarthroniX, Inc., Los Angeles, CA, ²University of Guelph, Guelph, ON, Canada, ³University of Southern California, Los Angeles, CA, ⁴University of California Davis, Hillsborough, CA
Background/Purpose: The pathogenesis of OA often begins from an injury to articular cartilage, which establishes chronic, low-grade inflammation principally mediated by IL-6 family cytokines that…
Abstract Number: 1904 • ACR Convergence 2022
Is Treating Painful Hand Osteoarthritis with Hormone Replacement Therapy Feasible? Primary Results from a Randomised Controlled Trial in Post-menopausal Women
Jennifer Williams¹, Mae Chester-Jones¹, Megan Goff², Anne Francis¹, Gretchen Brewer¹, Ioana Marian¹, Malvika Gulati¹, Charles Mackworth-Young³, Victoria Glover⁴, Sarah Lamb¹, Tonia Vincent⁵, Katy Vincent¹, Susan Dutton¹ and Fiona Watt⁶, ¹University of Oxford, Oxford, United Kingdom, ²University of Oxford, London, United Kingdom, ³Imperial College Healthcare NHS Trust, London, United Kingdom, ⁴White Horse Medical Practice, Faringdon, United Kingdom, ⁵Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, ⁶Imperial College London, London, United Kingdom
Background/Purpose: Hand osteoarthritis (OA) is more common in females and relative risk increases further around the age of menopause, potentially implicating sex hormone deficiency. There…

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