Abstracts tagged "osteoarthritis and pain"

Abstract Number: 2154 • 2013 ACR/ARHP Annual Meeting
Improvement In Clinical Symptoms After 48 Weeks Of Wearing Flexible Footwear In Osteoarthritis Of Knee: A Randomized Placebo-Controlled Study
Najia Shakoor¹, Roy H. Lidtke², Louis F. Fogg³, Laura E. Thorp⁴, Markus A. Wimmer⁵, Rachel A. Mikolaitis² and Joel A. Block², ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Section of Rheumatology, Rush University Medical Center, Chicago, IL, ³Department of Nursing, Rush University Medical Center, Chicago, IL, ⁴Anatomy and Cell Biology, Rush University Medical Center, Chicago, IL, ⁵Orthopedic Surgery, Rush University Medical Center, Chicago, IL
Background/Purpose: Osteoarthritis (OA), the most common form of arthritis, is a major cause of pain and disability. Biomechanical interventions that reduce dynamic loading are…
Abstract Number: 273 • 2012 ACR/ARHP Annual Meeting
The Prevalence of Periarticular Lesions On Magnetic Resonance Imaging and Its Relation to Knee Pain in the Community Residents in Korea
In Je Kim¹, Kyeong Min Son², DH Kim³, Yeong Wook Song⁴, Ali Guermazi⁵ and Hyun Ah Kim⁶, ¹Internal Medicine, Hallym University Kangdong Sacred Heart hospital, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Hallym university Chunchun sacred heart hospital, Chunchun, South Korea, ³Preventive Medicine, Chunchon, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, South Korea, ⁵Boston University, Boston, MA, ⁶Department of internal medicine, Hallym University Sacred Heart Hospital, Kyunggi, South Korea
Background/Purpose: The purpose of this study was to investigate the prevalence of periarticular lesions detected by magnetic resonance imaging (MRI) and its association with…
Abstract Number: 259 • 2012 ACR/ARHP Annual Meeting
Long-Term Tanezumab Treatment for Osteoarthritis: Efficacy and Safety Results
Alfonso E. Bello¹, Evan F. Ekman², David Radin³, Isabelle Davignon⁴, Michael D. Smith⁵, Mark T. Brown⁵, Christine R. West⁶ and Kenneth M. Verburg⁵, ¹Illinois Bone & Joint Institute, Glenview, IL, ²Southern Orthopaedic Sports Medicine, Columbia, SC, ³Stamford Therapeutics Consortium, Stamford, CT, ⁴Pfizer, Groton, CT, ⁵Pfizer, Inc., Groton, CT, ⁶Clinical Sciences, Pfizer, Williamston, MI
Background/Purpose: Nerve growth factor (NGF) levels are associated with increased pain perception and are elevated in joints of arthritis patients. Tanezumab, a humanized monoclonal antibody,…
Abstract Number: 234 • 2012 ACR/ARHP Annual Meeting
Central Sensitization Is Associated with Spontaneous Pain in Knee Osteoarthritis
Anisha B. Dua¹, Tuhina Neogi², Rachel A. Mikolaitis³, Joel A. Block³ and Najia Shakoor⁴, ¹Rheumatology, West Penn Allegheny Health System, Pittsburgh, PA, ²Boston University School of Medicine, Boston, MA, ³Section of Rheumatology, Rush University Medical Center, Chicago, IL, ⁴Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Osteoarthritis (OA) is a chronic, prevalent disease that is a major cause of pain and disability. Pain is the primary symptom of OA, however…
Abstract Number: 235 • 2012 ACR/ARHP Annual Meeting
Peripheral and Central Sensitization in Patients with Different Degree of Knee Osteoarthritis
Lars Arendt-Nielsen¹, Thomas Navndrup Eskehave², Morten Asser Karsdal³, Anne C. Bay-Jensen⁴, Hans Christian Hoeck² and Ole Simonsen⁵, ¹Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Center for Sensory-Motor Interaction, Aalborg, Denmark, ²Center for Clinical and Basic Research and C4Pain, Aalborg, Denmark, ³Nordic Bioscience A/S, Herlev, Denmark, ⁴Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ⁵Frederikshavn Hospital, Frederikshavn, Denmark
Background/Purpose: Though pain is the cardinal symptom of osteoarthritis (OA) the underlying causes are not fully understood. However, peripheral and central sensitization has been suggested…
Abstract Number: 236 • 2012 ACR/ARHP Annual Meeting
The Relationship Between Vibratory Sense and Somatosensory Pain Measures in Knee Osteoarthritis
Anisha B. Dua¹, Rachel A. Mikolaitis², Tuhina Neogi³, Joel A. Block² and Najia Shakoor⁴, ¹Rheumatology, West Penn Allegheny Health System, Pittsburgh, PA, ²Section of Rheumatology, Rush University Medical Center, Chicago, IL, ³Boston University School of Medicine, Boston, MA, ⁴Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Osteoarthritis is the most common form of arthritis, and is a major cause of pain and disability. Continuous nociceptive input can influence somatosensory…
Abstract Number: 237 • 2012 ACR/ARHP Annual Meeting
Association Between Pain Threshold, Symptoms and Radiographic Knee and Hip Osteoarthritis: The Johnston County Osteoarthritis Project
Adam P. Goode¹, Xiaoyan A. Shi², Jordan Renner³, Richard Gracely⁴, Mehrnaz Maleki-Fischbach⁵ and Joanne M. Jordan⁶, ¹Community and Family Medicine, Duke University, Durham, NC, ²SAS Institute, Inc, Cary, NC, ³UNC School of Medicine, University of North Carolina, Chapel Hill, NC, ⁴Dentistry, University of North Carolina, Chapel Hill, NC, ⁵Medicine, National Jewish Health, Denver, CO, ⁶Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC
Background/Purpose: Little is known of the association between pain threshold and knee/hip symptoms as well as radiographic knee/hip osteoarthritis (rOA). These analyses: 1) determined the…
Abstract Number: 238 • 2012 ACR/ARHP Annual Meeting
Inevitable Deterioration? Trajectories and Risk Profiles of Pain in Patients with Radiographic, Symptomatic Knee Osteoarthritis
Jamie E. Collins¹, William M. Reichmann², Jeffrey N. Katz³ and Elena Losina¹, ¹Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ²Orthopedics, Brigham and Womens Hospital, Boston, MA, ³Rheumatology and Orthopedics, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Knee pain is the primary reason that patients with OA seek medical care. The goal of this study is to describe pain trajectory over…
Abstract Number: 244 • 2012 ACR/ARHP Annual Meeting
Minimal Clinically Important Difference and Patient Acceptable Symptom State for the Oarsi-Omeract Intermittent and Constant OA Pain (ICOAP) Measure
Z. Anna Liu, Tetyana Kendzerska, Joy Elkayam, Shefali Ram and Gillian A. Hawker, Women's College Research Institute, University of Toronto, Toronto, ON, Canada
Background/Purpose: The Intermittent and Constant Osteoarthritis Pain (ICOAP) measure was developed to evaluate the OA pain experience, independent of the effect of pain on physical…
Abstract Number: 2512 • 2012 ACR/ARHP Annual Meeting
Changes in Bone Marrow Lesion Volume Relate to Changes in Knee Pain. Data From the Osteoarthritis Initiative
Jeffrey B. Driban¹, Lori Lyn Price², Grace H. Lo³, Jincheng Pang⁴, Eric Miller⁴, Charles Eaton⁵, John A. Lynch⁶ and Timothy E. McAlindon⁷, ¹Rheumatology, Tufts Medical Center, Boston, MA, ²Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ³Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, ⁴Department of Electrical and Computer Engineering, Tufts University, Medford, MA, ⁵Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Providence, RI, ⁶Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, ⁷Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Changes in bone marrow lesions (BMLs), common magnetic resonance (MR) imaging findings in osteoarthritis (OA), are predictive of OA progression. However, it is unclear…
Abstract Number: 34 • 2012 ACR/ARHP Annual Meeting
Rebamipide Attenuates Pain Severity and Cartilage Degeneration in a Rat Model of Osteoarthritis by Downregulating Oxidative Damage and Catabolic Activity in Chondrocytes
Su-Jin Moon¹, Mi-La Cho², Yeon-Sik Hong³, Sung-Hwan Park⁴ and Jun-Ki Min¹, ¹Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul, South Korea, ²Rheumatism Research Center, Catholic Research Institute of Medical Science, Catholic University of Korea, Seoul, South Korea, ³Our Lady of Mercy Hospital, Inchon, South Africa, ⁴Catholic University of Korea, Seoul, South Korea
Background/Purpose: The development and progression of osteoarthritis (OA) are now believed to involve inflammation, even in the early stage of disease. Proinflammatory cytokines and chemokines are…
Abstract Number: 1581 • 2012 ACR/ARHP Annual Meeting
The Association Between Symptoms, Pain Coping Strategies, and Physical Activity Among People with Symptomatic Knee and Hip Osteoarthritis
Susan L. Murphy¹, Anna Kratz², David A. Williams³ and Michael E. Geisser², ¹Physical Medicine & Rehabilitation, University of Michigan, Ann Arbor, MI, ²Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, ³Chronic Pain & Fatigue Rsch Ctr, Univ of MI Hlth System-Lobby M, Ann Arbor, MI
Background/Purpose: Effective use of coping strategies by people with chronic pain conditions is associated with better functioning and adjustment to chronic disease. Although the effects…
Abstract Number: L1 • 2012 ACR/ARHP Annual Meeting
A Randomized, Placebo-Controlled Phase 2 Study of ARRY-797 in Patients with Osteoarthritis Pain Refractory to NSAID Treatment Showed Statistically Significant Improvements in WOMAC Pain and in Biomarkers of Bone and Cartilage Degradation
Alan J. Kivitz¹, Shane G. Christensen², John Agaiby³, Egilius Spierings⁴, Julie Daves⁵, Roger Aitchison⁶, Stephen G. Miller⁷, Karsten Witt⁸ and Joseph Gimbel⁹, ¹Altoona Center for Clinical Research, Duncansville, PA, ²J. Lewis Research, Inc., Salt Lake City, UT, ³Clinical Investigation Specialists, Gurnee, IL, ⁴MedVadis Research Corporation, Watertown, MA, ⁵Clinical Operations, Array Biopharma, Inc., Boulder, CO, ⁶Biostatistics & Data Management, Array Biopharma, Inc., Boulder, CO, ⁷Translational Medicine, Array Biopharma, Inc., Boulder, CO, ⁸Clinical Sciences, Array Biopharma, Inc., Boulder, CO, ⁹Arizona Research Center, Phoenix, AZ
Background/Purpose: Osteoarthritis (OA) is the most common chronic joint disease and OA pain is a leading cause of work disability. p38 inhibition suppresses the production…
Abstract Number: 1556 • 2012 ACR/ARHP Annual Meeting
The Effect of Ginger Therapy On Symptoms of Osteoarthritis: An Open Pilot Study
Tessa Therkleson, Nursing, Edith Cowan University, Perth, Australia
Background/Purpose: Osteoarthritis (OA) is a painful, progressive disease of synovial joints characterised by deterioration of cartilage and bone and inflammation. Osteoarthritis of the knee and…
Abstract Number: 2631 • 2012 ACR/ARHP Annual Meeting
Radiographic Osteoarthritis Severity Is Associated with an Increased Risk of Developing Knee Pain: Findings From the Osteoarthritis Initiative
Jingbo Niu¹, David T. Felson², Tuhina Neogi³ and Yuqing Zhang⁴, ¹Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ²Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ³Clinical Epidemiology, Boston Univ School of Medicine, Boston, MA, ⁴School of Medicine, Boston Univ School of Medicine, Boston, MA
Background/Purpose : While knee pain is a major complaint from subjects with knee osteoarthritis (OA), most epidemiologic studies have found only weak to moderate associations…

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