Abstracts tagged "osteoarthritis and pain"

Abstract Number: 2859 • 2013 ACR/ARHP Annual Meeting
Pain Pathway Activation In Dorsal Root Ganglia and Dorsal Horn In a Murine Surgical Model Of Osteoarthritis
Rachel E. Miller¹, Phuong Tran², Richard J. Miller³ and Anne-Marie Malfait⁴, ¹Rheumatology/Biochemistry, Rush University Medical Center, Chicago, IL, ²Rheumatology, Rush University Medical Center, Chicago, IL, ³Molecular Biochemistry and Pharmacology, Northwestern University, Chicago, IL, ⁴Internal Medicine/Biochemistry, Rush University Medical Center, Chicago, IL
Background/Purpose: Using a surgical mouse model of osteoarthritis (OA), destabilization of the medial meniscus (DMM), we monitor pain and associated pathways over a period of…
Abstract Number: 1128 • 2012 ACR/ARHP Annual Meeting
Different of Patterns Knee Pain Trajectories: Longitudinal Data From the Osteoarthritis Initiative (OAI)
Joseph Devich Jr.¹, Michael J. Hannon², Zhijie Wang², Robert M. Boudreau³ and C. Kent Kwoh⁴, ¹Imrp, UPMC Shadyside, Pittsburgh, PA, ²Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ³Epidemiology, University of Pittsburgh, Pittsburgh, PA, ⁴School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Knee osteoarthritis (KOA) is one of the most common forms of arthritis and the most common cause of disability among the elderly. Knee pain…
Abstract Number: 1135 • 2012 ACR/ARHP Annual Meeting
Combined Glucosamine and Chondroitin Sulfate, Once of Three Times Daily, Provide Clinically Relevant Analgesia in Knee Osteoarthritis
Jose R. Provenza¹, Samuel K. Shinjo², Joyce M. Silva³, Carla RGS. Peron⁴ and Francisco AC Rocha⁵, ¹Rheumatology, Pontifícia Universidade Católica de Campinas, Campinas, Brazil, ²Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, ³Clinical Research, Sao Paulo, Brazil, ⁴Clinical Research, Laboratórios Aché Ltda, Sao Paulo, Brazil, ⁵Rheumatology, Brazilian Registry of Spondyloarthritis, São Paulo, Brazil
Background/Purpose: The analgesic efficacy of combined glucosamine and chondroitin sulfate (CS) in knee osteoarthritis (OA) remains controversial. Criticism to previous studies includes small sample size,…
Abstract Number: 1115 • 2012 ACR/ARHP Annual Meeting
Relation Between Hip Dysplasia, Pain, and Osteoarthritis in a Cohort of Patients with Hip Symptoms
Johanne Morvan¹, Ronan Bouttier², Bernard Mazieres³, Evelyne Verrouil³, Jacques Pouchot⁴, Anne-Christine Rat⁵, Joel Coste⁶ and Alain Saraux⁷, ¹Rheumatology, CH Quimper, Quimper, France, ²Radiology, CHU Brest, Brest, ³Rhumatologie, Hopital de Rangueil, Toulouse, FRANCE, France, ⁴Medecine Interne, Hopital Louis Mourier, Colombes, FRANCE, France, ⁵Rheumatology, Nancy Teaching Hospital, Nancy, France, ⁶Université de Lorraine, Paris Descartes University, APEMAC, EA 4360, F- 54 000, France, Nancy, France, ⁷Department of rheumatology and unit of immunology (EA 2216), Université Brest Occidentale, Brest, France
Background/Purpose: The relationship between acetabular dysplasia (HD) and hip osteoarthritis remains unclear, especially for mild forms of dysplasia. Our objectives were to estimate the prevalence…
Abstract Number: 734 • 2012 ACR/ARHP Annual Meeting
Chemokine (C-C Motif) Receptor 2 Signaling Mediates Persistent Pain in Experimental Osteoarthritis
Rachel E. Miller¹, Phuong Tran², Rosalina Das², Nayereh Ghoreishi-Haack², Richard J. Miller³ and Anne-Marie Malfait⁴, ¹Rheumatology/Biochemistry, Rush University Medical Center, Chicago, IL, ²Rheumatology, Rush University Medical Center, Chicago, IL, ³Molecular Biochemistry and Pharmacology, Northwestern University, Chicago, IL, ⁴Internal Medicine/Biochemistry, Rush University Medical Center, Chicago, IL
Background/Purpose: To investigate the role of MCP-1/CCR2 in the development of pain in osteoarthritis (OA) using a mouse model, destabilization of the medial meniscus (DMM).…
Abstract Number: 273 • 2012 ACR/ARHP Annual Meeting
The Prevalence of Periarticular Lesions On Magnetic Resonance Imaging and Its Relation to Knee Pain in the Community Residents in Korea
In Je Kim¹, Kyeong Min Son², DH Kim³, Yeong Wook Song⁴, Ali Guermazi⁵ and Hyun Ah Kim⁶, ¹Internal Medicine, Hallym University Kangdong Sacred Heart hospital, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Hallym university Chunchun sacred heart hospital, Chunchun, South Korea, ³Preventive Medicine, Chunchon, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, South Korea, ⁵Boston University, Boston, MA, ⁶Department of internal medicine, Hallym University Sacred Heart Hospital, Kyunggi, South Korea
Background/Purpose: The purpose of this study was to investigate the prevalence of periarticular lesions detected by magnetic resonance imaging (MRI) and its association with…
Abstract Number: 259 • 2012 ACR/ARHP Annual Meeting
Long-Term Tanezumab Treatment for Osteoarthritis: Efficacy and Safety Results
Alfonso E. Bello¹, Evan F. Ekman², David Radin³, Isabelle Davignon⁴, Michael D. Smith⁵, Mark T. Brown⁵, Christine R. West⁶ and Kenneth M. Verburg⁵, ¹Illinois Bone & Joint Institute, Glenview, IL, ²Southern Orthopaedic Sports Medicine, Columbia, SC, ³Stamford Therapeutics Consortium, Stamford, CT, ⁴Pfizer, Groton, CT, ⁵Pfizer, Inc., Groton, CT, ⁶Clinical Sciences, Pfizer, Williamston, MI
Background/Purpose: Nerve growth factor (NGF) levels are associated with increased pain perception and are elevated in joints of arthritis patients. Tanezumab, a humanized monoclonal antibody,…
Abstract Number: 234 • 2012 ACR/ARHP Annual Meeting
Central Sensitization Is Associated with Spontaneous Pain in Knee Osteoarthritis
Anisha B. Dua¹, Tuhina Neogi², Rachel A. Mikolaitis³, Joel A. Block³ and Najia Shakoor⁴, ¹Rheumatology, West Penn Allegheny Health System, Pittsburgh, PA, ²Boston University School of Medicine, Boston, MA, ³Section of Rheumatology, Rush University Medical Center, Chicago, IL, ⁴Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Osteoarthritis (OA) is a chronic, prevalent disease that is a major cause of pain and disability. Pain is the primary symptom of OA, however…
Abstract Number: 235 • 2012 ACR/ARHP Annual Meeting
Peripheral and Central Sensitization in Patients with Different Degree of Knee Osteoarthritis
Lars Arendt-Nielsen¹, Thomas Navndrup Eskehave², Morten Asser Karsdal³, Anne C. Bay-Jensen⁴, Hans Christian Hoeck² and Ole Simonsen⁵, ¹Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Center for Sensory-Motor Interaction, Aalborg, Denmark, ²Center for Clinical and Basic Research and C4Pain, Aalborg, Denmark, ³Nordic Bioscience A/S, Herlev, Denmark, ⁴Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ⁵Frederikshavn Hospital, Frederikshavn, Denmark
Background/Purpose: Though pain is the cardinal symptom of osteoarthritis (OA) the underlying causes are not fully understood. However, peripheral and central sensitization has been suggested…
Abstract Number: 236 • 2012 ACR/ARHP Annual Meeting
The Relationship Between Vibratory Sense and Somatosensory Pain Measures in Knee Osteoarthritis
Anisha B. Dua¹, Rachel A. Mikolaitis², Tuhina Neogi³, Joel A. Block² and Najia Shakoor⁴, ¹Rheumatology, West Penn Allegheny Health System, Pittsburgh, PA, ²Section of Rheumatology, Rush University Medical Center, Chicago, IL, ³Boston University School of Medicine, Boston, MA, ⁴Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Osteoarthritis is the most common form of arthritis, and is a major cause of pain and disability. Continuous nociceptive input can influence somatosensory…
Abstract Number: 237 • 2012 ACR/ARHP Annual Meeting
Association Between Pain Threshold, Symptoms and Radiographic Knee and Hip Osteoarthritis: The Johnston County Osteoarthritis Project
Adam P. Goode¹, Xiaoyan A. Shi², Jordan Renner³, Richard Gracely⁴, Mehrnaz Maleki-Fischbach⁵ and Joanne M. Jordan⁶, ¹Community and Family Medicine, Duke University, Durham, NC, ²SAS Institute, Inc, Cary, NC, ³UNC School of Medicine, University of North Carolina, Chapel Hill, NC, ⁴Dentistry, University of North Carolina, Chapel Hill, NC, ⁵Medicine, National Jewish Health, Denver, CO, ⁶Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC
Background/Purpose: Little is known of the association between pain threshold and knee/hip symptoms as well as radiographic knee/hip osteoarthritis (rOA). These analyses: 1) determined the…
Abstract Number: 238 • 2012 ACR/ARHP Annual Meeting
Inevitable Deterioration? Trajectories and Risk Profiles of Pain in Patients with Radiographic, Symptomatic Knee Osteoarthritis
Jamie E. Collins¹, William M. Reichmann², Jeffrey N. Katz³ and Elena Losina¹, ¹Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ²Orthopedics, Brigham and Womens Hospital, Boston, MA, ³Rheumatology and Orthopedics, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Knee pain is the primary reason that patients with OA seek medical care. The goal of this study is to describe pain trajectory over…
Abstract Number: 244 • 2012 ACR/ARHP Annual Meeting
Minimal Clinically Important Difference and Patient Acceptable Symptom State for the Oarsi-Omeract Intermittent and Constant OA Pain (ICOAP) Measure
Z. Anna Liu, Tetyana Kendzerska, Joy Elkayam, Shefali Ram and Gillian A. Hawker, Women's College Research Institute, University of Toronto, Toronto, ON, Canada
Background/Purpose: The Intermittent and Constant Osteoarthritis Pain (ICOAP) measure was developed to evaluate the OA pain experience, independent of the effect of pain on physical…
Abstract Number: 2512 • 2012 ACR/ARHP Annual Meeting
Changes in Bone Marrow Lesion Volume Relate to Changes in Knee Pain. Data From the Osteoarthritis Initiative
Jeffrey B. Driban¹, Lori Lyn Price², Grace H. Lo³, Jincheng Pang⁴, Eric Miller⁴, Charles Eaton⁵, John A. Lynch⁶ and Timothy E. McAlindon⁷, ¹Rheumatology, Tufts Medical Center, Boston, MA, ²Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ³Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, ⁴Department of Electrical and Computer Engineering, Tufts University, Medford, MA, ⁵Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Providence, RI, ⁶Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, ⁷Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Changes in bone marrow lesions (BMLs), common magnetic resonance (MR) imaging findings in osteoarthritis (OA), are predictive of OA progression. However, it is unclear…
Abstract Number: 34 • 2012 ACR/ARHP Annual Meeting
Rebamipide Attenuates Pain Severity and Cartilage Degeneration in a Rat Model of Osteoarthritis by Downregulating Oxidative Damage and Catabolic Activity in Chondrocytes
Su-Jin Moon¹, Mi-La Cho², Yeon-Sik Hong³, Sung-Hwan Park⁴ and Jun-Ki Min¹, ¹Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul, South Korea, ²Rheumatism Research Center, Catholic Research Institute of Medical Science, Catholic University of Korea, Seoul, South Korea, ³Our Lady of Mercy Hospital, Inchon, South Africa, ⁴Catholic University of Korea, Seoul, South Korea
Background/Purpose: The development and progression of osteoarthritis (OA) are now believed to involve inflammation, even in the early stage of disease. Proinflammatory cytokines and chemokines are…

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