ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "osteoarthritis and pain"

  • Abstract Number: 2182 • 2019 ACR/ARP Annual Meeting

    Relation of MRI-detected Structural Damage in the Knee to Anterior Knee Pain: The MOST Study

    Joshua Stefanik1, Tuhina Neogi 2, Mohamed Jarraya 3, Ali Guermazi 4, Irina Tolstykh 5, John Lynch 6, James Torner 7, Cora Lewis 8 and Erin Macri 9, 1Northeastern University, Boston, 2Boston University School of Medicine, Boston, MA, 3Mercy Catholic Medical Center, Darby, 4Boston Medical Center, Boston, 5UCSF, San Francisco, 6University of California at San Francisco, San Francisco, CA, 7University of Iowa at Iowa City, Iowa City, 8UAB, Birmingham, 9Erasmus MC, Rotterdam, Netherlands

    Background/Purpose: Discordance between knee osteoarthritis (OA) and knee pain is common yet not well understood. Specifically, anterior knee pain (AKP) is widely held to be…
  • Abstract Number: 2412 • 2019 ACR/ARP Annual Meeting

    Use of Minimal Important Difference (MID) in Randomized Clinical Trials of Pain in Osteoarthritis

    Lavalley Michael1, Matthew Parkes 2, Daniel White 3, Stephan Reichebach 4, Timothy McAlindon 5 and David Felson 6, 1Boston University, Boston, 2University of Manchester, Manchester, England, United Kingdom, 3University of Delaware, Newark, DE, 4University of Bern, Bern, Switzerland, 5Tufts Medical Center, Boston, MA, 6Boston University School of Medicine, Department of Rheumatology, Boston

    Background/Purpose: Minimal important differences (MID), based on within-subject evaluation of attaining  an improvement in a continuous outcome such as a pain scale, are important for…
  • Abstract Number: 2761 • 2019 ACR/ARP Annual Meeting

    Cartilage Thickness Modification with Sprifermin in Knee Osteoarthritis Patients Translates into Symptomatic Improvement over Placebo in Patients at Risk of Further Structural and Symptomatic Progression: Post-Hoc Analysis of a Phase II Trial

    Hans Guehring1, Jeffrey Kraines 2, Flavie Moreau 2, Benjamin Daelken 1, Christoph Ladel 1, Wolfgang Wirth 3, Philip G Conaghan 4, Felix Eckstein 5 and Marc C. Hochberg 6, 1Merck KGaA, Darmstadt, Germany, 2EMD Serono Research and Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, 3Paracelsus Medical University, Salzbury, Austria, 4Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, 5Paracelsus Medical University, Salzburg, Austria, 6University of Maryland School of Medicine, Baltimore, MD

    Background/Purpose: Results from the 5-year Phase II FORWARD study showed significant dose-dependent modification of total femorotibial joint (TFTJ) cartilage thickness change with sprifermin at 2…
  • Abstract Number: 454 • 2018 ACR/ARHP Annual Meeting

    Effects of Prolonged Chemogenetic Inhibition of Nociceptors in a Murine Surgical Model of Osteoarthritis

    Phuong B. Tran1, Shingo Ishihara1, Rachel E. Miller2, Richard J. Miller3 and Anne-Marie Malfait4, 1Internal Medicine, Rush University Medical Center, Chicago, IL, 2Rheumatology/Biochemistry, Rush University Medical Center, Chicago, IL, 3Pharmacology/Medical Humanities and Bioethics, Northwestern University, Chicago, IL, 4Biochemistry & Rheumatology, Rush University Medical Center, Chicago, IL

    Background/Purpose: The aim of this study was to investigate the effects of prolonged chemogenetic inhibition of NaV1.8 nociceptors on pain-related behaviors and cellular changes in…
  • Abstract Number: 455 • 2018 ACR/ARHP Annual Meeting

    Metabolic Syndrome and Trajectories of Pain Severity and Number of Painful Sites in Knee Osteoarthritis: Data from a 10.7-Year Prospective Study

    Feng Pan1, Jing Tian2, Flavia Cicuttini3 and Graeme Jones4, 1Musculoskeletal Unit, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, 2Public health unit, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, 3Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia, 4Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia

    Background/Purpose: Metabolic syndrome (MetS) has been suggested as having a role in osteoarthritis (OA) pathogenesis. No study has assessed whether MetS and its components are…
  • Abstract Number: 456 • 2018 ACR/ARHP Annual Meeting

    Effect of Local and Systemic CCR2 Blockade on Knee Hyperalgesia in a Mouse Model of Osteoarthritis

    Shingo Ishihara1, Rachel E. Miller2, Richard J. Miller3 and Anne-Marie Malfait4, 1Internal Medicine, Rush University Medical Center, Chicago, IL, 2Biochemistry, Rush University Medical Center, Chicago, IL, 3Pharmacology/Medical Humanities and Bioethics, Northwestern University, Chicago, IL, 4Biochemistry & Rheumatology, Rush University Medical Center, Chicago, IL

    Background/Purpose: Surgical destabilization of the medial meniscus (DMM) in the mouse knee results in slowly progressive osteoarthritis (OA), characterized by moderate joint damage by week…
  • Abstract Number: 457 • 2018 ACR/ARHP Annual Meeting

    Neuropathic Pain in Patients with Knee Osteoarthritis (Preliminary Report)

    Pinar Borman1, Ferda Kaygisiz2 and Aysegul Yaman3, 1Department of Physical Medicine and Rehabilitation, University of Hacettepe Faculty of Medicine, Ankara, Turkey, 2Dept of PMR, Ankara Training and Research Hospital, Ankara, Turkey, 3Dept of PMR, University of Hacettepe Faculty of Medicine, Ankara, Turkey

    Background/Purpose: There are limited studies in the literature indicating that neuropathic pain occurs in knee osteoarthritis (OA) (1). The aim of this cross sectional study…
  • Abstract Number: 954 • 2018 ACR/ARHP Annual Meeting

    A New Way to Think about Composite Magnetic Resonance Imaging Scores to Measure Osteoarthritis Severity and Progression

    Lori Lyn Price1,2, Jeffrey B. Driban3, Grace H. Lo4, Ming Zhang5, Michael P. LaValley6 and Timothy E. McAlindon7, 1Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, 2Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, 3Medicine, Division of Rheumatology, Tufts Medical Center, Boston, MA, 4Michael E. DeBakey Veterans Affairs Medical Center / Baylor College of Medicine, Houston, TX, 5Tufts Medical Center, Boston, MA, 6Biostatistics, Boston University School of Public Health, Boston, MA, 7Division of Rheumatology, Tufts Medical Center, Boston, MA

    Background/Purpose: For some rheumatologic diseases (e.g. lupus), separate scores evaluate cumulative damage and disease activity.  No such strategy exists for osteoarthritis (OA).  The prevailing approach…
  • Abstract Number: 1167 • 2018 ACR/ARHP Annual Meeting

    The Role of Fear-Avoidance Model on Pain and Disability in Knee Osteoarthritis Patients

    Leticia Leon1,2, Marta Redondo2, Sara Lopez de Felipe2, Daniel Garriguez3, Lydia A Alcazar4 and Luis Rodriguez-Rodriguez5, 1Rheumatology Department, Hospital Clínical San Carlos, and IdISSC, Madrid, Spain, 2Health Sciences, Universidad Camilo Jose Cela, Madrid, Spain, 3Orthopedics Unit, Hospital Clinico San Carlos, Madrid, Spain, 4Rheumatology Department and Heath Research Institute (IdISSC), Hospital Clinico San Carlos, Madrid, Spain, 5Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain

    Background/Purpose: The model of Fear-Avoidance of pain (anxiety, catastrophization and hypervigilance) appears when the pain has maladaptive interpretations, being associated with greater pain and limitations…
  • Abstract Number: 1169 • 2018 ACR/ARHP Annual Meeting

    Association between Depressive Symptom Subtypes and Disease Severity in Knee Osteoarthritis

    Alan Rathbun1, Megan Schuler2, Elizabeth Stuart3, Michelle Shardell4, Michelle S. Yau5, Joseph Gallo6 and Marc C. Hochberg7, 1Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, 2Rand Coportation, Boston, MA, 3Mental Health, Biostatistics, and Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 4Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, 5Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA, 6Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 7University of Maryland School of Medicine, Baltimore, MD

    Background/Purpose: Latent and modifiable factors, such as depressive symptoms, may affect the course of knee OA. Depression is clinically heterogeneous, and effects on pain and…
  • Abstract Number: 1170 • 2018 ACR/ARHP Annual Meeting

    Sex-Specific Associations between Systemic Inflammatory Cytokines and Osteoarthritis Knee Pain

    Anthony V. Perruccio1, J. Denise Power1, Mayilee Canizares1, Elizabeth M. Badley1,2, Mohit Kapoor1, Rajiv Gandhi1 and Y. Raja Rampersaud1, 1Arthritis Program, Krembil Research Institute, University Health Network, Toronto, ON, Canada, 2Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Significant challenges remain in mitigating OA pain and despite growing evidence of sex differences, including in pain and in response to NSAIDs, sex has…
  • Abstract Number: 1364 • 2018 ACR/ARHP Annual Meeting

    Treatment of Knee Osteoarthritis with SM04690 Improved WOMAC A1 “Pain on Walking” – Results from a 52-Week, Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of a Novel, Intra-Articular, Wnt Pathway Inhibitor

    Jeyanesh Tambiah1, Sarah Kennedy1, Heli Ghandehari1, Christopher Swearingen1 and Marc C. Hochberg2, 1Samumed, LLC, San Diego, CA, 2University of Maryland School of Medicine, Baltimore, MD

    Background/Purpose: Knee osteoarthritis (OA) is characterized by pain, functional limitation, and physical disability due to articular cartilage degradation and bone remodeling. Wnt signaling is involved…
  • Abstract Number: 1377 • 2018 ACR/ARHP Annual Meeting

    Knee Osteoarthritis Symptom Duration Is Associated with Conditioned Pain Modulation and Vibration Perception Threshold Impairment

    Kharma C. Foucher1, Samuel Chmell2 and Carol Courtney3, 1Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, 2Orthopedic Surgery, University of Illinois at Chicago, Chicago, IL, 3Physical Therapy, University of Illinois at Chicago, Chicago, IL

    Background/Purpose: Impaired descending pain inhibition has been observed in people with knee OA and may be associated with development of chronic pain as well as…
  • Abstract Number: 425 • 2018 ACR/ARHP Annual Meeting

    Efficacy, Safety, and Tolerability of ONO-4474, an Orally Available Pan-Tropomyosin Receptor Kinase Inhibitor, in Japanese Patients with Moderate-to-Severe Osteoarthritis of the Knee: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Comparative Study

    Naoki Ishiguro1, Shusuke Oyama2, Ryunosuke Higashi3 and Kunio Yanagida4, 1Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan, 2Data Science, Ono Pharmaceutical Co., Ltd., Osaka, Japan, 3Translational Science, Translational Medicine Center, Ono Pharmaceutical Co., Ltd., Osaka, Japan, 4Translational Science, Translational Medicine Center, Ono Pharmaceutical Co., Ltd, Osaka, Japan

    Background/Purpose: ONO-4474 is an orally available, peripheral-specific, pan-tropomyosin receptor kinase (pan-Trk) inhibitor currently under development for treatment of musculoskeletal pain in OA patients. This study…
  • Abstract Number: 1920 • 2018 ACR/ARHP Annual Meeting

    Is There Objective Evidence of Neuropathy in Knee Osteoarthritis Based on Clinical Evaluation?

    Priyanka Ballal1, Joachim Scholz2, Laura Frey-Law3, Na Wang1, Michael C. Nevitt4, Cora E. Lewis5 and Tuhina Neogi6, 1Boston University School of Medicine, Boston, MA, 2Departments of Anesthesiology and Pharmacology, Columbia University Medical Center, New York, NY, 3University of Iowa, Iowa City, IA, 4Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, 5University of Alabama Birmingham, Birmingham, AL, 6Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA

    Background/Purpose: Self-reported descriptors of pain in knee osteoarthritis (OA) such as burning and stabbing pain are suggestive of a neuropathic component of pain beyond that…
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