Abstracts tagged "osteoarthritis and pain"

Abstract Number: 441 • 2018 ACR/ARHP Annual Meeting
The Presence of Neuropathic Pain Does Not Influence the Response to Hyaluronic Acid (HA) in Patients with Knee Osteoarthritis but HA Injections Modify Pain Phenotype
Evariste Tiendrebeogo¹, Thierry Conrozier², Xavier Chevalier³ and Florent Eymard⁴, ¹Rheumatology, APHP Henri Mondor Hospital, Creteil, France, ²Department of Rheumatology,, Nord Franche-Comté Hospital, Belfort, France, ³Rheumatology, APHP Henri Mondor Hospital, Créteil, France, ⁴Department of Rheumatology, APHP Henri Mondor Hospital, Creteil, France
Background/Purpose: Twenty to forty percent of patients with symptomatic knee osteoarthritis (OA) described neuropathic pain (NP). Several studies have shown that hyaluronic acid (HA) is…
Abstract Number: 446 • 2018 ACR/ARHP Annual Meeting
Participation in American Football Is Associated with Increased Risk for Knee Pain and Osteoarthritis: Data from the Osteoarthritis Initiative
Grace H. Lo¹, Timothy E. McAlindon², Andrea Kriska³, Lori Lyn Price⁴, Bonny Rockette-Wagner⁵, Lisa A. Mandl⁶, Charles B. Eaton⁷, Marc C. Hochberg⁸, Rebecca D. Jackson⁹, C. Kent Kwoh¹⁰, Michael C. Nevitt¹¹ and Jeffrey B. Driban¹², ¹Michael E. DeBakey Veterans Affairs Medical Center / Baylor College of Medicine, Houston, TX, ²Division of Rheumatology, Tufts Medical Center, Boston, MA, ³University of Pittsburgh, Pittsburgh, PA, ⁴Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, ⁵University of Pittsburgh Medical Center, Pittsburgh, PA, ⁶Rheumatology, Hospital for Special Surgery, New York, NY, ⁷Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, ⁸University of Maryland School of Medicine, Baltimore, MD, ⁹Ohio State University, Columbus, OH, ¹⁰Medicine, Division of Rheumatology, University of Arizona School of Medicine, University of Arizona Arthritis Center, Tucson, AZ, ¹¹Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ¹²Rheumatology, Tufts Medical Center, BOSTON, MA
Background/Purpose: Male youth commonly participate in American football. Little data inform whether this is associated with knee pain or osteoarthritis (OA) later in life. We…
Abstract Number: 454 • 2018 ACR/ARHP Annual Meeting
Effects of Prolonged Chemogenetic Inhibition of Nociceptors in a Murine Surgical Model of Osteoarthritis
Phuong B. Tran¹, Shingo Ishihara¹, Rachel E. Miller², Richard J. Miller³ and Anne-Marie Malfait⁴, ¹Internal Medicine, Rush University Medical Center, Chicago, IL, ²Rheumatology/Biochemistry, Rush University Medical Center, Chicago, IL, ³Pharmacology/Medical Humanities and Bioethics, Northwestern University, Chicago, IL, ⁴Biochemistry & Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: The aim of this study was to investigate the effects of prolonged chemogenetic inhibition of NaV1.8 nociceptors on pain-related behaviors and cellular changes in…
Abstract Number: 455 • 2018 ACR/ARHP Annual Meeting
Metabolic Syndrome and Trajectories of Pain Severity and Number of Painful Sites in Knee Osteoarthritis: Data from a 10.7-Year Prospective Study
Feng Pan¹, Jing Tian², Flavia Cicuttini³ and Graeme Jones⁴, ¹Musculoskeletal Unit, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ²Public health unit, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ³Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia, ⁴Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
Background/Purpose: Metabolic syndrome (MetS) has been suggested as having a role in osteoarthritis (OA) pathogenesis. No study has assessed whether MetS and its components are…
Abstract Number: 456 • 2018 ACR/ARHP Annual Meeting
Effect of Local and Systemic CCR2 Blockade on Knee Hyperalgesia in a Mouse Model of Osteoarthritis
Shingo Ishihara¹, Rachel E. Miller², Richard J. Miller³ and Anne-Marie Malfait⁴, ¹Internal Medicine, Rush University Medical Center, Chicago, IL, ²Biochemistry, Rush University Medical Center, Chicago, IL, ³Pharmacology/Medical Humanities and Bioethics, Northwestern University, Chicago, IL, ⁴Biochemistry & Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Surgical destabilization of the medial meniscus (DMM) in the mouse knee results in slowly progressive osteoarthritis (OA), characterized by moderate joint damage by week…
Abstract Number: 457 • 2018 ACR/ARHP Annual Meeting
Neuropathic Pain in Patients with Knee Osteoarthritis (Preliminary Report)
Pinar Borman¹, Ferda Kaygisiz² and Aysegul Yaman³, ¹Department of Physical Medicine and Rehabilitation, University of Hacettepe Faculty of Medicine, Ankara, Turkey, ²Dept of PMR, Ankara Training and Research Hospital, Ankara, Turkey, ³Dept of PMR, University of Hacettepe Faculty of Medicine, Ankara, Turkey
Background/Purpose: There are limited studies in the literature indicating that neuropathic pain occurs in knee osteoarthritis (OA) (1). The aim of this cross sectional study…
Abstract Number: 2183 • 2017 ACR/ARHP Annual Meeting
Two-Year Changes in Knee Osteoarthritis Symptoms: Comparing Clinical Relevance of Patient-Reported Outcomes By Anchoring to Knee Replacement
C. Kent Kwoh¹, Hans Guehring², Erin Ashbeck³, Michael J Hannon⁴ and Aida Aydemir⁵, ¹University of Arizona Arthritis Center, Tuscan, AZ, ²Merck KGaA, Darmstadt, Germany, ³The University of Arizona Arthritis Center, Tucson, AZ, ⁴Medicine, University of Pittsburgh, Pittsburgh, PA, ⁵EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA
Background/Purpose: Randomized controlled trials (RCTs) of interventions for knee OA (KOA) may include a patient-reported outcome (PRO) measure as a primary endpoint. Several measures of…
Abstract Number: 2186 • 2017 ACR/ARHP Annual Meeting
The Role of Hip Injury in Pain Exacerbation in Hip Osteoarthritis: an Internet-Based Case-Crossover Study
Kai Fu¹, Joanna Makovey², Ben Metcalf³, Kim Bennell³, Yuqing Zhang⁴, Rebecca Asher⁵, Sarah Meneses², Leticia Deveza² and David Hunter², ¹Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Syndey, Australia, ²Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ³Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne, Melbourne, Australia, ⁴School Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁵NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia
Background/Purpose: Pain is the main symptom in hip osteoarthritis (OA) and many patients experience recurrent pain exacerbations. The purpose of this study is to evaluate…
Abstract Number: 2204 • 2017 ACR/ARHP Annual Meeting
Neuropathic Pain in Patients with Knee Osteoarthritis and Related Factors: A Multicenter Longitudinal Study-Preliminary Report
Ece Kaptanoglu¹, Ozlem Şahin², Tiraje Tuncer³, Sami Hizmetli¹, Lale Altan⁴, Figen Ayhan⁵, Ajda Bal⁶, Meral Bilgilisoy⁷, Gulnur Bozbas⁸, Lale Cerrahoglu⁹, Remzi Cevik¹⁰, Tuncay Duruoz¹¹, Deniz Dulgeroglu⁶, Gulcan Gurer¹², Savas Gursoy¹³, Simin Hepguler¹⁴, Cahit Kacar¹⁵, Taciser Kaya¹⁶, Meltem Melikoglu¹⁷, Kemal Nas¹⁸, Suheda Ozcakir¹⁹, Senay Ozdolap²⁰, merih Saridogan²¹, Selda Sarikaya²⁰, Dilsad Sindel²², Omer F Şendur⁸, Canan Tikiz²³ and Hatice Ugurlu²⁴, ¹Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Cumhuriyet University School of Medicine, Sivas, Turkey, ²Department of Physical Medicine and Rehabilitation, Cumhuriyet University School of Medicine, Sivas, Turkey, ³Department of Physical Medicine and Rehabilitation, Akdeniz University School of Medicine, Antalya, Turkey, ⁴Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Uludag University School of Medicine, Bursa, Turkey, ⁵Department of Physical Medicine and Rehabilitation, University of Health Ankara Training and Research Hospital, Ankara, Turkey, ⁶Department of Physical Medicine and Rehabilitation, University of Health Sciences Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey, ⁷Department of Physical Medicine and Rehabilitation, University of Health Sciences Antalya Training and Research Hospital, Antalya, Turkey, ⁸Department of Physical Medicine and Rehabilitation, Adnan Menderes University School of Medicine, Aydin, Turkey, ⁹Department of Physical Medicine and Rehabilitation, Celal Bayar University School of Medicine, Manisa, Turkey, ¹⁰Department of Physical Medicine and Rehabilitation, Dicle University School of Medicine, Diyarbakir, Turkey, ¹¹Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Marmara University School of Medicine, Istanbul, Turkey, ¹²Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Adnan Menderes University School of Medicine, Aydin, Turkey, ¹³Department of Physical Medicine and Rehabilitation, Gaziantep University School of Medicine, Gaziantep, Turkey, ¹⁴Department of Physical Medicine and Rehabilitation, Ege University School of Medicine, Izmir, Turkey, ¹⁵Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Akdeniz University School of Medicine, Antalya, Turkey, ¹⁶Department of Physical Medicine and Rehabilitation, University of Health Sciences İzmir Bozyaka Training and Research Hospital, Izmir, Turkey, ¹⁷Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Ataturk University School of Medicine, Erzurum, Turkey, ¹⁸Department of Physical Medicine and Rehabilitation, Sakarya University School of Medicine, Sakarya, Turkey, ¹⁹Department of Physical Medicine and Rehabilitation, Uludag University School of Medicine, Bursa, Turkey, ²⁰Department of Physical Medicine and Rehabilitation, Bulent Ecevit University School of Medicine, Zonguldak, Turkey, ²¹Department of Physical Medicine and Rehabilitation, Istanbul University Cerrahpasa School of Medicine, Istanbul, Turkey, ²²Department of Physical Medicine and Rehabilitation, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey, ²³Celal Bayar University School of Medicine, Manisa, Turkey, ²⁴Department of Physical Medicine and Rehabilitation, Necmettin Erbakan University Meram School of Medicine, Konya, Turkey
Background/Purpose: Neuropathic pain (NP) was accused for increased pain and reduced functional capacity in knee osteoarthritis (KO). Here we aimed to find out the prevalence…
Abstract Number: 2232 • 2017 ACR/ARHP Annual Meeting
A Role for CCR2 in Chronic Behavioral and Neuroimmune Changes in the DMM Model of Osteoarthritis
Phuong Tran¹, Shingo Ishihara², Rachel E. Miller³, Richard J. Miller⁴ and Anne-Marie Malfait¹, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Internal Medicine, Rush University Medical Center, Chicago, IL, ³Biochemistry, Rush University Medical Center, Chicago, IL, ⁴Pharmacology/Medical Humanities and Bioethics, Northwestern University, Chicago, IL
Background/Purpose: The aim of this study was to explore pain-related behaviors and associated cellular changes in the pain pathway in experimental osteoarthritis (OA) induced by…
Abstract Number: 2236 • 2017 ACR/ARHP Annual Meeting
Neuropathic Pain in End-Stage Hip and Knee Osteoarthritis: Differences between Men and Women and Differential Associations with Pain at Rest and Pain on Activity
J. Denise Power¹, Anthony V. Perruccio¹, Rajiv Gandhi¹, Christian Veillette¹, J. Roderick Davey¹, Khalid Syed¹, Nizar Mahomed¹ and Y. Raja Rampersaud², ¹Arthritis Program, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ²Arthritis Program, Krembil Research Institute, University Health Network, Torotno, ON, Canada
Background/Purpose: There is increasing support in the literature for a neuropathic component to OA pain. Our primary objective was to determine whether pain at rest…
Abstract Number: 2852 • 2017 ACR/ARHP Annual Meeting
Widespread Pain Prior to Total Knee Replacement (TKR) Is Associated with Increased Risk of No Clinical Improvement in Pain Among Women
Ernest Vina¹, Di Ran², Erin L. Ashbeck² and C. Kent Kwoh³, ¹Rheumatology, University of Arizona, Tucson, AZ, ²The University of Arizona Arthritis Center, Tucson, AZ, ³University of Arizona, Tucson, AZ
Background/Purpose: Up to 47% of individuals may not have clinically significant improvement following joint replacement surgery. Evidence also suggests that women are less likely to…
Abstract Number: 62 • 2017 ACR/ARHP Annual Meeting
Convergence of Joint Repair and Pain Pathways Via Nerve Growth Factor and p75 Expressing Mesenchymal Stem Cells in Established Osteoarthritis
Thomas Baboolal¹, Sumaiya Al Hinai², Elena Jones², Jill Reckless³, Martyn Foster⁴, Rachel Doyle⁵, Kerry af Forselles⁴, Simon Westbrook⁴ and Dennis McGonagle², ¹PhD, Leeds, United Kingdom, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ³Rxcelerate Ltd, Cambridge, United Kingdom, ⁴Levicept Ltd, Ramsgate, United Kingdom, ⁵Tetrad Discovery Ltd, Ramsgate, United Kingdom
Background/Purpose: Nerve growth factor (NGF) is a key regulator of pain and anti-NGF therapy reduces osteoarthritis (OA) associated pain. However, anti-NGF therapy is associated with…
Abstract Number: 1193 • 2017 ACR/ARHP Annual Meeting
A Randomized, Placebo-Controlled, Double-Blind, Phase II Clinical Trial of the First-in-Class Imidazoline-2 Receptor Ligand CR4056 in Pain from Knee Osteoarthritis and Disease Phenotypes
Lucio C. Rovati¹, Nadia Brambilla¹, Tomasz Blicharski², Nicholas J Probert³, Cristina Vitalini¹, Giampaolo Giacovelli¹, Federica Girolami¹ and Massimo D'Amato¹, ¹Clinical Research Department, Rottapharm Biotech, Monza, Italy, ²Lubelskie Centrum Diagnostyczne, Świdnik, Poland, ³MAC Clinical Research, Manchester, United Kingdom
Background/Purpose: CR4056 is a novel imidazoline-2 receptor (I2R) ligand endowed with potent analgesic activities in several and diverse animal models of nociceptive and neuropathic pain,…
Abstract Number: 1195 • 2017 ACR/ARHP Annual Meeting
Efficacy and Safety of Subcutaneous Tanezumab in Patients with Knee or Hip Osteoarthritis (NCT01089725)
Charles A. Birbara¹, Eugene J. Dabezies², Aimee M. Burr³, Robert J. Fountaine⁴, Michael D. Smith³, Mark T. Brown³, Christine R. West³, Rosalinda H. Arends³ and Kenneth M. Verburg³, ¹University of Massachusetts Medical School, Worcester, MA, ²Pensacola Research Consultants, Pensacola, FL, ³Pfizer, Inc., Groton, CT, ⁴Pfizer, Inc., Grotoon, CT
Background/Purpose : Tanezumab (TNZ) is a monoclonal antibody that inhibits nerve growth factor and reduces hip or knee osteoarthritis (OA) pain. A placebo-controlled phase 3…

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