Abstracts tagged "OA"

Abstract Number: 1017 • 2014 ACR/ARHP Annual Meeting
BMP9-Induced pSmad1/5/8 Signaling and Chondrocyte Hypertrophy Are Effectively Inhibited By TGFβ1
Arjan van Caam, Esmeralda Blaney Davidson, Ellen W. van Geffen, Wim B. van den Berg and Peter M. van der Kraan, Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose Osteoarthritis is characterized by degradation of articular cartilage. TGFβ-superfamily signaling via Smad phosphorylation (pSmad) plays a crucial role in cartilage maintenance. Two distinct pSmad…
Abstract Number: 1013 • 2014 ACR/ARHP Annual Meeting
Mitochondrial Function Is Impaired in Human Knee Osteoarthritic (OA) Chondrocytes and Improved By Pharmacologic AMPK Activation Via SIRT1 and PGC-1α
Ru Bryan¹, Yun Wang², Xianling Zhao³, Martin Lotz⁴ and Robert Terkeltaub⁵, ¹Medicine-Rheumatology, VA Medical Center/University of California San Diego, San Diego, CA, ²Medicine-Rheumatology, VA Medical Ctr/UCSD, San Diego, CA, ³VAMC, San Diego, CA, ⁴Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ⁵Medicine-Rheumatology, VA Medical Ctr/University of California San Diego, San Diego, CA
Background/Purpose Chondrocyte mitochondrial abnormalities have been identified in OA, and have the potential to mediate disease progression by promoting oxidative stress and inflammation-driven cartilage matrix…
Abstract Number: 1012 • 2014 ACR/ARHP Annual Meeting
Role of High Glucose Environment on Chondrocyte Activation and Characterization of Diabetic Osteoarthritic Cartilage: Toward Pathophysiological Delineation of Diabetes Mellitus-Related Osteoarthritis
Marie-Charlotte Laiguillon¹, Alice Courties^1,2, Xavier Houard¹, Martine Auclair¹, Alain Sautet³, Bruno Fève¹, Jacqueline Capeau¹, Francis Berenbaum² and Jérémie Sellam², ¹Sorbonne Universités, UPMC Univ Paris 06, UMRS 938 and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Paris, France, ²AP-HP, Saint-Antoine Hospital, Rheumatology Department and DHU i2B, Paris, France, ³AP-HP, Saint-Antoine Hospital, Orthopaedic Surgery Department, Paris, France
Background/Purpose: Recent epidemiological studies have suggested an association between type 2 diabetes/hyperglycemia and osteoarthritis (OA) but experimental evidences are lacking (1). We aimed i) to…
Abstract Number: 980 • 2014 ACR/ARHP Annual Meeting
Annual Medical Care Expenditures Among US Adults with Osteoarthritis, 2008 – 2011
Miriam G. Cisternas¹, Louise Murphy², David J. Pasta³, Daniel H. Solomon⁴ and Charles G. Helmick⁵, ¹MGC Data Services, Carlsbad, CA, ²Division of Population Health, Centers for Disease Control and Prevention, Atlanta, GA, ³DMA Corporation, Palo Alto, CA, ⁴Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁵National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA
Background/Purpose: As the US population ages, concerns continue to grow about the cost of medical treatment for osteoarthritis (OA). We estimated all-cause medical care expenditures…
Abstract Number: 923 • 2014 ACR/ARHP Annual Meeting
Phenotypes of Osteoarthritis-Related Knee Pain and Their Transitions over Time: The Osteoarthritis Initiative
Na Lu¹, Tuhina Neogi¹, K. Douglas Gross², Jingbo Niu³, Hyon K. Choi⁴ and Yuqing Zhang¹, ¹Boston University School of Medicine, Boston, MA, ²Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ³Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁴Division of Rheumatology, Allergy, and Immunology Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: The WOMAC questionnaire is one of most commonly used instruments to assess knee pain in persons with or at risk of knee osteoarthritis (OA).…
Abstract Number: 3011 • 2014 ACR/ARHP Annual Meeting
Ambulatory Gait Analysis in Clinical Practice: Single or Dual Task Conditions?
Bernard Auvinet¹, Claude Touzard² and Vincent Goëb³, ¹Rheumatology Unit, Polyclinic, LAVAL, France, ²Gerontology Unit, Hospital of Laval, LAVAL, France, ³Rheumatology, Amiens University Hospital, Amiens, France
Background/Purpose Interest in ambulatory gait analysis is increasing thanks to validated gait analysis apparatus dedicated to clinical practice. Such methodology has to be reproducible, sensitive,…
Abstract Number: 244 • 2014 ACR/ARHP Annual Meeting
Onset, Magnitude, and Durability of Pain Relief in Patients with Knee OA Receiving a Fixed-Dose Combination Tablet of Enteric-Coated (EC) Naproxen Plus Immediate-Release (IR) Esomeprazole Magnesium Versus Celecoxib and Placebo: Pooled Results from Two Randomized Controlled Trials
John Fort¹, Robert Holt², Amy Y. Grahn³, Jana Steinmetz⁴, Ying Zhang⁵ and Jeffery Kent⁶, ¹Pozen, Inc, Chapel Hill, NC, ²College of Pharmacy, University of Illinois-Chicago, Vernon Hill, IL, ³Horizon Pharma, Inc., Deerfield, IL, ⁴Statistics, Premier Research, Naperville, IL, ⁵Biostatistics, Pozen, Inc, Chapel Hill, NC, ⁶Medical Affairs, Horizon Pharma, Inc, Deerfield, IL
Background/Purpose: Over 40% of patients with OA report having significant knee pain every day. (1) Previously published data have demonstrated the overall comparable efficacy of…
Abstract Number: 2965 • 2014 ACR/ARHP Annual Meeting
Effects of Anti-NGF Strategies in Two Animal Models of Osteoarthritis (OA)
Lilian Ngozi Nwosu¹, Paul Mapp¹, Karyn Bouhana², Steven Andrews², Victoria Chapman³ and David Walsh⁴, ¹Academic Rheumatology, Arthritis Research UK Pain Centre, University of Nottingham, Nottingham, United Kingdom, ²Array BioPharma, Boulder, CO, ³Life Sciences, Arthritis Research UK Pain Centre, University of Nottingham, Nottingham, United Kingdom, ⁴Academic Rheum/Clin Sci Bldg, Arthritis Research UK Pain Centre, University of Nottingham, Nottingham, United Kingdom
Background/Purpose Levels of endogenous nerve growth factor (NGF) are increased in osteoarthritic (OA) joints in patients and animal models and may be an important cause…
Abstract Number: 243 • 2014 ACR/ARHP Annual Meeting
Safety of Solumatrix Diclofenac in Adults with Osteoarthritis: Results of a 12-Month, Phase 3 Study
Roy Altman¹, Allan Gibofsky², Marc C. Hochberg³, Byron Cryer⁴, Alan J. Kivitz⁵, Vibeke Strand⁶, Olaolu Imasogie⁷ and Clarence Young⁸, ¹University of California–Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ²Medicine and Public Health, Hospital for Special Surgery, New York, NY, ³Division of Rheumatology & Clinical Immunology, University of Maryland School of Medicine, Baltimore, MD, ⁴University of Texas Southwestern Medical Center, Dallas, TX, ⁵Altoona Center for Clinical Research, Duncansville, PA, ⁶Stanford University, Palo Alto, CA, ⁷Iroko Pharmaceuticals LLC, Philadelphia, PA, ⁸150 Rouse Boulevard, Iroko Pharmaceuticals, LLC, Phila, PA
Background/Purpose: Osteoarthritis (OA) is a frequent cause of disability in adults. NSAIDs such as diclofenac are often prescribed to treat OA pain. However, NSAIDs…
Abstract Number: 2946 • 2014 ACR/ARHP Annual Meeting
The Association Between Accelerometer Monitored Sedentary Behavior and Observed Physical Function Loss
Pamela Semanik¹, Rowland W. Chang², Jing Song³, Jungwha Lee⁴ and Dorothy D. Dunlop³, ¹Nursing, Rush University College of Nursing, Chicago, IL, ²Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Preservation of function in older adults is critical to maintaining independence. Physical activity interventions often focus on increasing activity while giving limited attention to…
Abstract Number: 2949 • 2014 ACR/ARHP Annual Meeting
Activation of AMP-Activated Protein Kinase (AMPK) By Berberine Limits Both Surgical Knee Instability-Induced and Aging-Related Osteoarthritis in Mice
Ru Bryan¹, Xianling Zhao², Yun Wang³, Han Sol Lee², Hyunje Kim⁴, Alifah Akasdi² and Robert Terkeltaub⁵, ¹Medicine-Rheumatology, VA Medical Center/University of California San Diego, San Diego, CA, ²VAMC, San Diego, CA, ³Medicine-Rheumatology, VA Medical Ctr/UCSD, San Diego, CA, ⁴Internal medicine, School of medicine, Yeungnam University, Daegu, South Korea, ⁵Medicine-Rheumatology, VA Medical Ctr/University of California San Diego, San Diego, CA
Background/Purpose Human knee OA articular cartilage chondrocytes and aged mouse knee cartilage chondrocytes demonstrate decreased activation of master cellular energy bio-sensor AMPK. Moreover, inflammatory stimuli…
Abstract Number: 2858 • 2014 ACR/ARHP Annual Meeting
Education Effects on Outcome Expectations for Exercise in Adults with Knee Osteoarthritis
Tressa Gamache¹, Lori Lyn Price², Jeffrey B. Driban¹, William F. Harvey¹ and Chenchen Wang¹, ¹Rheumatology, Tufts Medical Center, Boston, MA, ²Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA
Background/Purpose Outside of a clinical trial setting, higher outcome expectations for exercise, more education, and greater physical activity are inter-related, and outcome expectations may partly…
Abstract Number: 2236 • 2014 ACR/ARHP Annual Meeting
Plant–Derived Products Are Effective for Treatment of OA Pain and Safer Than Other Active Therapies
Laura Laslett, Xingzhong Jin and Graeme Jones, Menzies Research Institute Tasmania, University of Tasmania, HOBART, Australia
Background/Purpose: Osteoarthritis (OA) is a leading cause of chronic disability. There are no approved treatments for modifying the disease course, therefore disease management consists of…
Abstract Number: 1885 • 2014 ACR/ARHP Annual Meeting
Integrative Omics Profiling Reveals Dysregulated Novel Pathways Mediated By microRNAs and DNA Methylation in Osteoarthritis
Kathleen M. Fisch¹, Ryuichiro Akagi², Oscar Alvarez-Garcia¹, Takeshi Teramura¹, Yuta Muramatsu¹, Masahiko Saito³, Stuart Duffy¹, Shawn Grogan⁴, Takahisa Sasho⁵, Darryl D'Lima⁶, Andrew I. Su¹ and Martin K. Lotz¹, ¹Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ²The Scripps Research Institute, San Diego, CA, ³Orthopaedic Surgery, Toho University Sakura Medical Center, Sakura, Japan, ⁴The Scripps Research Institute, La Jolla, CA, ⁵Orthopaedic Surgery, Chiba University School of Medicine, Chiba, Japan, ⁶SCORE, The Scripps Research Institute, La Jolla, CA
Background/Purpose: Osteoarthritis (OA) is a prevalent joint disease, with several identified clinical risk factors. However, the search for genetic risk factors by candidate gene and…
Abstract Number: 1823 • 2014 ACR/ARHP Annual Meeting
Inflammation Is Associated with Erosive Progression in Patients with Hand Osteoarthritis: A Prospective Ultrasonography Study
Marion C. Kortekaas^1,2, Wing Yee Kwok³, Monique Reijnierse⁴, Theo Stijnen⁵ and Margreet Kloppenburg⁶, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Department of Rheumatology, Flevoziekenhuis, Almere-Stad, Netherlands, ³Leiden University Medical Center, Leiden, Netherlands, ⁴Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁵Medical Statistics, Leiden University Medical Center, Leiden, Netherlands, ⁶Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose Erosive hand osteoarthritis (OA) is a subset that shows inflammatory features with ultrasound or MRI much more frequent than non-erosive hand OA, and can…

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