Abstracts tagged "OA"

Abstract Number: 2354 • 2016 ACR/ARHP Annual Meeting
Pharmaceutical Grade Chondroitin Sulfate Improves Knee Osteoarthritis Symptoms More Than Placebo and As Much As Celecoxib: Results of the Chondroitin Vs Celecoxib Vs Placebo Trial (CONCEPT)
J-Y Reginster and CONCEPT Authors' Group, Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium
Background/Purpose: For the assessment of Symptomatic Slow Acting Drugs in Osteoarthritis (SYSADOAs), regulatory Agencies request the assessment of two co-primary endpoints: pain and function. They…
Abstract Number: 2364 • 2016 ACR/ARHP Annual Meeting
Swimming May Associate with Less Osteoarthritis: Data from the Osteoarthritis Initiative
Grace H. Lo¹, Jeffrey B. Driban², Timothy E. McAlindon³, Charles Eaton⁴, C. Kent Kwoh⁵, Andrea Kriska⁶, Richard Souza⁷, Nancy J. Petersen⁸, Kristi Storti⁹, Marc Hochberg¹⁰, Rebecca D. Jackson¹¹, Michael C. Nevitt¹² and Maria Suarez-Almazor¹³, ¹Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, ²Rheumatology, Tufts Medical Center, Boston, MA, ³Division of Rheumatology, Tufts Medical Center, Boston, MA, ⁴Brown University, Providence, RI, ⁵Rheumatology, University of Arizona, College of Medicine, Tucson, AZ, ⁶University of Pittsburgh, Pittsburgh, PA, ⁷University of California, San Francisco, San Francisco, CA, ⁸Medicine, Baylor College of Medicine, Houston, TX, ⁹Department of Kinesiology, Health and Sport Science, Indiana University of Pennsylvania, Indiana, PA, USA, Indiana, PA, ¹⁰Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, ¹¹Ohio State University, Columbus, OH, ¹²Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ¹³Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Houston, TX
Background/Purpose: Swimming is a non-weight-bearing exercise often recommended to people with knee OA because it is viewed as being less harmful to the knee despite…
Abstract Number: 3058 • 2016 ACR/ARHP Annual Meeting
Varus Thrust and Incident and Progressive Knee Osteoarthritis
Leena Sharma¹, Alison H. Chang², Charles Eaton³, Marc Hochberg⁴, Rebecca D. Jackson⁵, C. Kent Kwoh⁶, Michael C. Nevitt⁷, Orit Almagor⁸, Kirsten C. Moisio⁸ and Joan S. Chmiel⁹, ¹Division of Rheumatology, Northwestern University, Chicago, IL, ²PT & Human Movement Sciences, Northwestern University, Chicago, IL, ³Brown University, Providence, RI, ⁴Department of Medicine, University of Maryland, Baltimore, MD, ⁵Ohio State University, Columbus, OH, ⁶Rheumatology, University of Arizona, College of Medicine, Tucson, AZ, ⁷Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁸Northwestern University, Chicago, IL, ⁹Preventive Medicine, Northwestern University, Chicago, IL
Background/Purpose: Varus thrust, bowing-out of the knee during gait, i.e., appearance (or worsening) of varus during stance improving in late stance or swing, was associated…
Abstract Number: 2405 • 2015 ACR/ARHP Annual Meeting
Knee Sounds May Predict Osteoarthritis Severity, Symptoms and Function: Pilot Investigation Toward a Novel Dynamic Imaging System
Victoria Manning¹, Costas Yiallourides², Mads Brevadt¹, Alastair Moore², Edouard Auvinet¹, Patrick Naylor² and Justin Cobb¹, ¹Musculoskeletal Lab, Imperial College London, London, United Kingdom, ²Communications and Signal Processing Group, Imperial College London, London, United Kingdom
Background/Purpose: Knee sounds (KS) may provide a low-cost, risk-free means of identifying presence and severity of knee osteoarthritis (KOA). Unlike static imaging, KS during dynamic…
Abstract Number: 2408 • 2015 ACR/ARHP Annual Meeting
The Quality of Community-Based Osteoarthritis Care Can be Improved. Results from a Systematic Review and Meta-Analysis
Kåre Birger Hagen¹, Geir Smedslund², Nina Østerås² and Gro Jamtvedt³, ¹National Advisory Unit on Rehabilitation in Rheumatology, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²National Advisory Unit on Rehabilitation in Rheumatology, Department of Rheumatology,, Diakonhjemmet Hospital, Oslo, Norway, ³The Norwegian Knowledge Center for the Health Services, Oslo, Norway
Background/Purpose: The burden of osteoarthritis (OA) is substantial and expected to increase because people are getting older and heavier. Health care providers need to monitor…
Abstract Number: 3249 • 2015 ACR/ARHP Annual Meeting
Pooled Efficacy and Safety from Phase 3 Controlled Studies of Tanezumab in Patients with Osteoarthritis
Leslie Tive¹, David Radin², Alfonso Bello³, Ha Nguyen¹, Mark T. Brown⁴, Christine R. West⁴ and Kenneth M. Verburg⁴, ¹Pfizer, Inc, New York, NY, ²Stamford Therapeutics Consortium, Stamford, CT, ³Illinois Bone & Joint Inst, Glenview, IL, ⁴Pfizer Inc., Groton, CT
Background/Purpose: Tanezumab (TNZ) significantly reduces pain and improves physical function and Patient's Global Assessment (PGA) in patients with chronic pain. From June 2010 to August…
Abstract Number: 321 • 2015 ACR/ARHP Annual Meeting
Effects of Bariatric Surgery on Long-Term Quality of Life Outcomes for Obese Patients with Osteoarthritis
Ankita Satpute¹, Deepak L. Bhatt², Sangeeta Kashyap³, Philip Schauer⁴, Colin O'Rourke⁵, James Bena⁵ and M. Elaine Husni⁶, ¹Case Western Reserve University School of Medicine, Cleveland, OH, ²Brigham and Women’s Hospital Heart & Vascular Center, Boston, MA, ³Endocrinology, Diabetes and Metabolism, Cleveland Clinic Foundation, Cleveland, OH, ⁴General Surgery, Cleveland Clinic Foundation, Cleveland, OH, ⁵Department of Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, OH, ⁶Rheumatology Dept A50, Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: Osteoarthritis (OA) remains a debilitating burden for patients and a challenge to their physicians, as there is no known cure. Obesity has been linked…
Abstract Number: 334 • 2015 ACR/ARHP Annual Meeting
Lifetime Risk of Symptomatic Hand Osteoarthritis: The Johnston County Osteoarthritis Project
Jin Qin¹, Kamil E. Barbour¹, Louise Murphy¹, Charles G. Helmick¹, Nancy A. Baker², Kristina Theis¹, Todd Schwartz^3,4, Jordan B. Renner⁵, Amanda Nelson⁶, Kelli Allen⁷ and Joanne M. Jordan⁸, ¹Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA, ²University of Pittsburgh, Pittsburgh, PA, ³Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁴Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁵UNC School of Medicine, University of North Carolina, Chapel Hill, NC, ⁶Division of Rheumatology, Allergy, and Immunology and Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, ⁷University of North Carolina, Chapel Hill, NC, ⁸Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC
Background/Purpose: Osteoarthritis (OA) affects 27 million adults in the United States. Symptomatic hand osteoarthritis (SHOA) is a common condition that affects hand strength and function.…
Abstract Number: 339 • 2015 ACR/ARHP Annual Meeting
More Inflammatory Signs on Ultrasound, Severe Pain and Stiffness Are Associated with Erosive Than Non-Erosive Hand Osteoarthritis
Olga Sleglova¹, Olga Ruzickova², Karel Pavelka¹ and Ladislav Senolt², ¹Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ²Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Hand osteoarthritis (HOA) causes considerable pain and disability. Radiographic HOA features show only a modest association with symptoms in HOA. Ultrasound is an easy…
Abstract Number: 1136 • 2015 ACR/ARHP Annual Meeting
IL-1β-Induced Stress Granules Sequester COX-2 mRNA and Regulates Its Expression in Human OA Chondrocytes
Mohammad Ansari¹ and Tariq Haqqi², ¹Anatomy & Neurobiology, Northeast Ohio Medical University, Roostown, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Background/Purpose: Stress granules (SGs) are ribonucleoprotein complexes assembled in the cytoplasm of eukaryotic cells to respond adequately to stress (e.g. heat shock, UV irradiation, oxidative…
Abstract Number: 1266 • 2015 ACR/ARHP Annual Meeting
Rheumatologic Diagnoses, Characteristics and Needs of Somali Patients Referred to a Rheumatology Clinic Serving the Somali Population
Elizabeth Miller¹, Elie Gertner², Rosemary Quirk¹ and Maribet McCarty¹, ¹Hennepin County Medical Center, Minneapolis, MN, ²Section of Rheumatology, Regions Hospital and University of Minnesota, St. Paul, MN
Background/Purpose: With the growing immigrant and refugee population in the United States, the landscape of medicine is constantly changing. In order to provide quality healthcare,…
Abstract Number: 2169 • 2015 ACR/ARHP Annual Meeting
Low Education Is Associated with Mortality Among Individuals with Knee and/or Hip OA: The Johnston County Osteoarthritis Project
Rebecca J. Cleveland¹, Todd A. Schwartz², Jordan B. Renner³, Joanne M. Jordan⁴ and Leigh F. Callahan⁴, ¹University of North Carolina at Chapel Hill, Chapel Hill, NC, ²School of Nursing, University of North Carolina, Chapel Hill, NC, ³Radiology, University of North Carolina, Chapel Hill, NC, ⁴Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC
Background/Purpose: Low socioeconomic status (SES) is associated with an increased risk of death as well as knee and/or hip osteoarthritis (OA). SES and mortality has…
Abstract Number: 2172 • 2015 ACR/ARHP Annual Meeting
Distribution of Clinical Osteoarthritis and Associations to Health-Related Quality of Life in a Population-Based Osteoarthritis Cohort
Guro Økelsrud Lombnæs¹, Karin Magnusson² and Kåre Birger Hagen¹, ¹National Advisory Unit on Rehabilitation in Rheumatology, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Department of Rheumatology, National Advisory Unit on Rehabilitation in Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: Osteoarthritis (OA) is a major cause of musculoskeletal pain and disability, and is commonly reported to impair health-related quality of life (HRQoL). We aimed…
Abstract Number: 1293 • 2014 ACR/ARHP Annual Meeting
Identification of an Inflammation-Driven Phenotype of Osteoarthritis By Quantification of Synovial Inflammation Ex Vivo and in Serum from Patients
Cecilie F. Kjelgaard-Petersen¹, Anne Sofie Siebuhr², Kristian Kjaer Petersen³, Lars Arendt-Nielsen⁴, Thomas Eskehave⁵, Hans Christian Hoeck⁵, Ole Simonsen⁶, Thorbjørn Christiansen⁷, Line Lindhardt Egsgaard⁸, Morten A. Karsdal⁹ and Anne C. Bay-Jensen¹, ¹Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ²Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ³Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Denmark, Center for Sensory-Motor Interaction, Aalborg, Denmark, ⁴Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Center for Sensory-Motor Interaction, Aalborg, Denmark, ⁵Center for Clinical and Basic Research (CCBR), Aalborg, Denmark, ⁶Frederikshavn Hospital, Frederikshavn, Denmark, ⁷Orthopaedic Surgery Unit, Gentofte University Hospital, Gentofte, Denmark, ⁸Center for Sensory-Motor Interaction (SMI), Aalborg University, Aalborg, Denmark, ⁹Research & Development, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark
Background/Purpose Osteoarthritis (OA) is a multifaceted degenerative joint disease, where inflammation of the synovial membrane leads to accelerated joint destruction, resulting in elevated release of…
Abstract Number: 1125 • 2014 ACR/ARHP Annual Meeting
The Mitochondrial Genome Influences the Risk of Incident Knee OA. DATA from the Osteoarthritis Initiative
Angel Soto-Hermida¹, Ignacio Rego-Pérez¹, Juan Fernández-Tajes¹, Mercedes Fernandez Moreno¹, María Eugenia Vázquez-Mosquera¹, Estefanía Cortés-Pereira¹, Sonia Pértega-Díaz², Natividad Oreiro-Villar¹, Carlos Fernandez-Lopez¹ and Francisco J. Blanco Garcia¹, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ²Unidad de Epidemiología Clínica y Bioestadística. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain
Background/Purpose Previous studies by our group showed a significant influence of the mtDNA haplogroups on both radiographic progression and cartilage integrity of knee OA patients…

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