Abstracts tagged "OA"

Abstract Number: 2196 • 2017 ACR/ARHP Annual Meeting
An Exploratory Analysis of Physical Activity Levels and the Presence of Bone Marrow Lesions in Adults with Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Amanda R. Canavatchel¹, Lori Lyn Price², Jeffrey B. Driban³, Ming Zhang¹, Grace H. Lo⁴ and Timothy E. McAlindon⁵, ¹Tufts Medical Center, Boston, MA, ²Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, ³Rheumatology, Tufts Medical Center, Boston, MA, ⁴Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, ⁵Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Many people with knee OA have bone marrow lesions (BMLs). BMLs are related with structural pathology and pain. Some investigators have found an association…
Abstract Number: 2198 • 2017 ACR/ARHP Annual Meeting
Combinatorial Peripheral Blood Inflammatory and MRI-Based Biomarkers Predict Radiographic Joint Space Narrowing in Knee OA
Svetlana Krasnokutsky Samuels¹, Hua Zhou², Mukundan Attur¹, Jonathan Samuels¹, Gregory Chang³, Jenny Bencardino⁴, Sisi Ma², Leon Rybak³ and Steven B. Abramson⁵, ¹Rheumatology, NYU Langone Medical Center, New York, NY, ²Bioinformatics, New York University, New York, NY, ³Department of Radiology, NYU Langone Medical Center, New York, NY, ⁴Radiology, NYU Langone Medical Center, New York, NY, ⁵Dept of Medicine, NYU Langone Medical Center, New York, NY
Background/Purpose: Inflammation contributes to OA disease pathogenesis. Subsets of knee OA patients with peripheral blood leukocyte (PBL) detected inflammatory gene expression profiles exhibit more rapid…
Abstract Number: 2202 • 2017 ACR/ARHP Annual Meeting
Association between Oxidative Balance Score and Osteoarthritis in Korean Adults: The Korea National Health and Nutrition Examination Survey (2014–2015)
Young Bin Joo¹, Joo-Hyun Lee², Minkyung Han³, Seong-Ryul Kwon⁴, Won Park⁵, Kyung-Su Park⁶, Bo Young Yoon⁷ and Kyong-Hee Jung⁴, ¹Internal Medicine, Department of Rheumatology, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Gyeonggido, Korea, Republic of (South), ²Rheumatology, Inje University Ilsan Paik Hospital, Goyang, Korea, Republic of (South), ³Public health, Yonsei University graduate school, Seoul, Korea, Republic of (South), ⁴Rheumatology, Inha University, Incheon, Korea, Republic of (South), ⁵Medicine/Rheumatology, Inha University Hospital, Incheon, Korea, Republic of (South), ⁶Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea, Republic of (South), ⁷Rheumatology/Internal medicine, Inje Iniversity Ilsan Paik Hospital, Goyang, Korea, Republic of (South)
Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis, caused by a combination of systemic and local factors. Its multi-factorial etiology includes oxidative stress…
Abstract Number: 2212 • 2017 ACR/ARHP Annual Meeting
A Metabolite of C-Reactive Protein, a Marker of Disease Actvity, Is Prognostic of Radiographic Knee OA
Anne C. Bay-Jensen¹, Asger R. Bihlet², Inger Byrjalsen³, Jeppe Andersen⁴, Yi He⁵, Anne Sofie Siebuhr¹, Christian S. Thudium⁶, Bente J. Riis², Claus Christiansen² and Morten Asser Karsdal¹, ¹Rheumatology, Nordic Bioscience, Herlev, Denmark, ²Nordic Bioscience, Clinical Development, Herlev, Denmark, ³Nordic Bioscience, Herlev, Denmark, ⁴Clinical Development, Nordic Bioscience, Herlev, Denmark, ⁵Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ⁶Biomarkers and Research, Nordic Bioscience, Herlev, Denmark
Background/Purpose: There are two major needs in clinical DMOAD development: Identifying a population with an active and progressive disease to demonstrate significant improvements by an…
Abstract Number: 2945 • 2017 ACR/ARHP Annual Meeting
Incident Hand OA Is Strongly Associated with Reduced Peripheral Blood Leukocyte Telomere Length
Timothy E. McAlindon¹, Mary Roberts², Lena Franziska Schaefer³, Jeffrey B. Driban⁴, Jeffrey Duryea³, Francisco J Blanco⁵, Jose-Luis Fernandez-Garcia⁶ and Charles Eaton⁷, ¹Division of Rheumatology, Tufts Medical Center, Boston, MA, ²Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Pawtucket, RI, ³Radiology, Brigham & Women's Hospital/ Harvard Medical School, Boston, MA, ⁴Rheumatology, Tufts Medical Center, Boston, MA, ⁵Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña. España, A Coruña, Spain, ⁶Genetic Department, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ⁷Family Medicine and Epidemiology, Warren Alpert Medical School, School of Public Health, Brown University, Providence, RI
Background/Purpose: Hand OA (HOA) is a painful, destructive and deforming polyarticular disorder that impairs an individual’s ability to perform manipulative activities of daily life and…
Abstract Number: 2348 • 2016 ACR/ARHP Annual Meeting
Does Arthritis in Other Joints and Spine Influence the 1-Year Outcome of Total Hip Replacement? a Prospective European Multicenter Cohort Study Measuring the Influence of Musculoskeletal Morbidity
Joerg Huber¹, Paul Dieppe², Karsten Dreinhoefer³, Klaus-Peter Günther⁴, Georg Ruflin⁵ and Andrew Judge⁶, ¹Orthopedics, Triemli Spital, Zurich, Switzerland, ²Exeter Medical School, University of Exeter, Exeter, United Kingdom, ³Centre of Musculosceletal Surgery, Charité, Charite, Berlin, Berlin, Germany, ⁴University Center of Orthopedics and Traumatology, Technische Universität, Dresden, Germany, ⁵Orthopedics, Kantonsspital Aarau, Aarau, Switzerland, ⁶Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom
Background/Purpose: Whilst arthritis in other affected joints and back pain is known to lead to worse outcomes following total hip replacement surgery, these risk factors…
Abstract Number: 2354 • 2016 ACR/ARHP Annual Meeting
Pharmaceutical Grade Chondroitin Sulfate Improves Knee Osteoarthritis Symptoms More Than Placebo and As Much As Celecoxib: Results of the Chondroitin Vs Celecoxib Vs Placebo Trial (CONCEPT)
J-Y Reginster and CONCEPT Authors' Group, Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium
Background/Purpose: For the assessment of Symptomatic Slow Acting Drugs in Osteoarthritis (SYSADOAs), regulatory Agencies request the assessment of two co-primary endpoints: pain and function. They…
Abstract Number: 2364 • 2016 ACR/ARHP Annual Meeting
Swimming May Associate with Less Osteoarthritis: Data from the Osteoarthritis Initiative
Grace H. Lo¹, Jeffrey B. Driban², Timothy E. McAlindon³, Charles Eaton⁴, C. Kent Kwoh⁵, Andrea Kriska⁶, Richard Souza⁷, Nancy J. Petersen⁸, Kristi Storti⁹, Marc Hochberg¹⁰, Rebecca D. Jackson¹¹, Michael C. Nevitt¹² and Maria Suarez-Almazor¹³, ¹Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, ²Rheumatology, Tufts Medical Center, Boston, MA, ³Division of Rheumatology, Tufts Medical Center, Boston, MA, ⁴Brown University, Providence, RI, ⁵Rheumatology, University of Arizona, College of Medicine, Tucson, AZ, ⁶University of Pittsburgh, Pittsburgh, PA, ⁷University of California, San Francisco, San Francisco, CA, ⁸Medicine, Baylor College of Medicine, Houston, TX, ⁹Department of Kinesiology, Health and Sport Science, Indiana University of Pennsylvania, Indiana, PA, USA, Indiana, PA, ¹⁰Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, ¹¹Ohio State University, Columbus, OH, ¹²Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ¹³Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Houston, TX
Background/Purpose: Swimming is a non-weight-bearing exercise often recommended to people with knee OA because it is viewed as being less harmful to the knee despite…
Abstract Number: 3058 • 2016 ACR/ARHP Annual Meeting
Varus Thrust and Incident and Progressive Knee Osteoarthritis
Leena Sharma¹, Alison H. Chang², Charles Eaton³, Marc Hochberg⁴, Rebecca D. Jackson⁵, C. Kent Kwoh⁶, Michael C. Nevitt⁷, Orit Almagor⁸, Kirsten C. Moisio⁸ and Joan S. Chmiel⁹, ¹Division of Rheumatology, Northwestern University, Chicago, IL, ²PT & Human Movement Sciences, Northwestern University, Chicago, IL, ³Brown University, Providence, RI, ⁴Department of Medicine, University of Maryland, Baltimore, MD, ⁵Ohio State University, Columbus, OH, ⁶Rheumatology, University of Arizona, College of Medicine, Tucson, AZ, ⁷Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁸Northwestern University, Chicago, IL, ⁹Preventive Medicine, Northwestern University, Chicago, IL
Background/Purpose: Varus thrust, bowing-out of the knee during gait, i.e., appearance (or worsening) of varus during stance improving in late stance or swing, was associated…
Abstract Number: 155 • 2016 ACR/ARHP Annual Meeting
Evaluation of Ultrasonography As Modality for Identification of Calcium Crystal Deposits in Patients of Primary Osteoarthritis of Knee Joint
Siddharth K. Das¹, Durgesh Srivastava², Urmila Dhakad³, Manju Singh², Ragini Srivastava⁴ and Archana Wakhlu², ¹Rheumatology, Prof. and Head, Rheumatology, K.G. Medical University, Lucknow, Lucknow, India, ²Rheumatology, King Georges Medical Univesity, Lucknow, India, ³Rheumatology, Asst Professor, K.G. Medical University, Lucknow, India, Lucknow, India, ⁴Rheumatology, Senior Research Officer, Rheumatology, K.G. Medical University, Lucknow, India, Lucknow, India
Background/Purpose: Calcium deposition diseases, the disordered calcification of cartilage and/or periarticular soft tissue, are associated with aging, degenerative joint disease, and genetic and metabolic disorders.…
Abstract Number: 307 • 2016 ACR/ARHP Annual Meeting
Visualizing Different Patterns of Cartilage Change: A Two-Year Study of Data from the Osteoarthritis Initiative
Amanda R. Canavatchel¹, Grace H. Lo², Michael P. LaValley³, Ming Zhang¹, Jeffrey B. Driban⁴, Lori Lyn Price⁵, Eric Miller⁶, Charles Eaton⁷ and Timothy E. McAlindon⁸, ¹Tufts Medical Center, Boston, MA, ²Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, ³Biostatistics, Boston University School of Public Health, Boston, MA, ⁴Rheumatology, Tufts Medical Center, Boston, MA, ⁵Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁶Department of Electrical and Computer Engineering, Tufts University, Medford, MA, ⁷Brown University, Providence, RI, ⁸Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Traditionally, regions of the knee that are assessed in clinical trials are selected based on anatomy or responsiveness to change. However, it is unclear…
Abstract Number: 314 • 2016 ACR/ARHP Annual Meeting
The Clinical Efficacy and Safety of the Gumiganhwal-Tang in Knee Osteoarthritis: A Phase II Randomized Double Blind Placebo Controlled Study
Sung Hae Chang¹, Mi-Il Kang² and Seong-Su Nah³, ¹Internal Medicine, Rheumatology, Soonchunhyang University, College of Medicine, Cheonan, South Korea, ²Dankuk University Hospital, Cheonan, Korea, The Republic of, ³Soonchunhyang University, College of Medicine, Cheonan, South Korea
Background/Purpose: Gumiganghwal-tang (GMGHT) is a traditional herbal medicine consisted of nine different herbs. GMGHT inhibit the production and mRNA expression of inflammatory cytokine production TNF…
Abstract Number: 683 • 2016 ACR/ARHP Annual Meeting
Risk Factors of Uveitis in Ankylosing Spondylitis
Feng Wang¹, Qin Xue², Li Sun³ and Niansong Wang⁴, ¹Nephrology and Rheumatology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China, ²Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China, ³Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing, China, ⁴Shanghai Jiao Tong University Affiliated Sixth People's Hospital, shanghai, China
Background/Purpose: Uveitis is the most common extra-articular manifestation in patients with ankylosing spondylitis (AS).The prevalence and characteristics of uveitis in AS have been studied in previous literatures while…
Abstract Number: 1018 • 2016 ACR/ARHP Annual Meeting
Dietary Intake of Fiber and Risk of Knee Osteoarthritis
Zhaoli (Joy) Dai¹, Jingbo Niu¹, Yuqing Zhang², Paul Jacques³ and David T. Felson⁴, ¹Clinical epidemiology research and training unit, Boston University School of Medicine, Boston, MA, ²Clinical Epidemiology and Training Unit, Boston University School of Medicine, Boston, MA, ³Jean Mayer USDA Human Nutrition Research Center on Aging and Friedman School of Nutrition Science and Policy, Tufts University, Boston, Boston, MA, ⁴Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Dietary fiber reduced risks of metabolic diseases in part by reducing systemic inflammation and body weight. These factors are both likely to contribute to…
Abstract Number: 1124 • 2016 ACR/ARHP Annual Meeting
IL37 Rescues Human OA Cartilage Explants from GAG Release
Ellen van Geffen¹, Arjan van Caam², Henk van Beuningen², Elly Vitters², Esmeralda Blaney Davidson² and Peter M. van der Kraan², ¹Experimential Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: In healthy cartilage, there is a balance between anabolic and catabolic activities of chondrocytes that maintains the functional integrity of the extracellular matrix. However,…

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