Abstracts tagged "Neutrophil Extracellular Traps"

Abstract Number: 2124 • 2018 ACR/ARHP Annual Meeting
Bacterial Biofilm Product Curli/Edna Induces NETs and Serum Anti-Curli/Edna Levels Correlate with Bacteriuria and Lupus Activity
Ryan Pachucki¹, Chelsea Corradetti², Stefania Gallucci³, Cagla Tukel³, Sarah Tursi³, Laura Nicastro³, Lynne Kohler², Yaj Ghadiali⁴, Laurie Kilpatrick⁵ and Roberto Caricchio¹, ¹Medicine Rheumatology, Lewis Katz School of Medicine, Philadelphia, PA, ²Rheumatology, Lewis Katz School of Medicine, Philadelphia, PA, ³Microbiology and Immunology, Lewis Katz School of Medicine, Philadelphia, PA, ⁴Medicine, Lewis Katz School of Medicine, Philadelphia, PA, ⁵Temple Lung Center, Lewis Katz School of Medicine, Philadelphia, PA
Background/Purpose: Infections are a major contributor to lupus disease. We have previously demonstrated that bacterial amyloid curli, produced by E.coli, can accelerate disease in mouse…
Abstract Number: 11 • 2018 ACR/ARHP Annual Meeting
PAD4-Independent Interaction of ACPA with Nuclear Antigens in Apoptotic Cells and Neutrophil Extracellular Traps (NETs) Defines a Subset of Autoantibodies
Gustaf Wigerblad¹, Katy A. Lloyd¹, Peter Sahlström², Karine Chemin², Johanna Steen², Philip J. Titcombe^2,3, Diana Zhou², Ragnhild Stålesen¹, Bianka Marklein⁴, Elena Ossipova², Johan Rönnelid⁵, Luca Piccoli⁶, Antonio Lanzavecchia⁶, Daniel L. Mueller³, Karl Skriner⁴, Lars Klareskog², Fredrik Wermeling¹, Vivianne Malmström² and Caroline Grönwall⁷, ¹Rheumatology Unit, Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology Unit, Dept. of Medicine, Karolinska Institutet, Stockholm, Sweden, ³The Center for Immunology, Dept. of Medicine, University of Minnesota Medical School, Minneapolis, MN, ⁴Dept. of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany, ⁵Dept. of Immunology Genetics and Pathology, Uppsala University, Uppsala, Sweden, ⁶Università della Svizzera italiana, Institute for Research in Biomedicine, Bellinzona, Switzerland, ⁷Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) bind a wide range of citrullinated proteins with high cross-reactivity. Recent findings suggest that certain, but…
Abstract Number: 77 • 2018 ACR/ARHP Annual Meeting
Single Nucleotide Polymorphism in the Gene Encoding Peptidylarginine Deiminase 4 Correlates with Reduced Neutrophil Extracellular Traps and Anti-Histone Antibodies in Rheumatoid Arthritis
Aisha M. Mergaert¹, Mandar Bawadekar², Thai Q. Nguyen¹, Steven J. Schrodi^3,4 and Miriam A. Shelef^2,5, ¹University of Wisconsin - Madison, Madison, WI, ²Department of Medicine, Division of Rheumatology, University of Wisconsin - Madison, Madison, WI, ³Center for Precision Medicine Research, Marshfield Clinic Research Institute, Marshfield, WI, ⁴Computation and Informatics in Biology and Medicine, University of Wisconsin - Madison, Madison, WI, ⁵William S. Middleton Memorial Veterans Hospital, Madison, WI
Background/Purpose: In neutrophils, peptidylarginine deiminase 4 (PAD4) citrullinates histones allowing chromatin unraveling and neutrophil extracellular trap (NET) formation. NETs are increased and display proteins targeted…
Abstract Number: 106 • 2018 ACR/ARHP Annual Meeting
Highly Elevated Levels of Anti-Mitochondrial Antibodies in Systemic Lupus Erythematosus and Rheumatoid Arthritis
Richard Moore¹ and Christian Lood², ¹Division of Rheumatology, University of Washington, Seattle, WA, ²Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA
Background/Purpose: We recently described the phenomenon in systemic lupus erythematosus (SLE) in which mitochondria are extruded into the extracellular space during formation of neutrophil extracellular…
Abstract Number: 293 • 2017 ACR/ARHP Annual Meeting
Expanded Therapeutic ACPA Utility for Different NET-Driven Human (Autoimmune) Diseases
Renato G.S. Chirivi^1,2, Jos W.G. van Rosmalen¹, Kostantinos Kambas³, Gonny Schmets¹, Hans Kalisvaart¹, Galina S. Bogatkevich⁴, Tim Shaw², Helmuth van Es² and Jos M.H. Raats^1,2, ¹ModiQuest BV, Oss, Netherlands, ²Citryll BV, Nijmegen, Netherlands, ³Laboratory of Molecular Hematology, Democritus University of Thrace, Alexandroupolis, Greece, ⁴Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: Aberrant Neutrophil Extracellular Trap (NET) formation contributes to the induction and propagation of inflammation and plays a key role in causing tissue damage in…
Abstract Number: 294 • 2017 ACR/ARHP Annual Meeting
DNA Area and Netosis Analysis (DANA): A High-Throughput Method to Quantify Neutrophil Extracellular Traps in Fluorescent Microscope Images
Ryan Rebernick¹, Lauren Fahmy², Christopher Glover², Nicole Rademacher², Hemanth Potluri², Mandar Bawadekar¹, Christie M. Bartels³ and Miriam A. Shelef^1,4, ¹Department of Medicine, Division of Rheumatology, University of Wisconsin - Madison, Madison, WI, ²University of Wisconsin - Madison, Madison, WI, ³Rheumatology/Medicine, University of Wisconsin - Madison, Madison, WI, ⁴William S. Middleton Memorial Veterans Hospital, Madison, WI
Background/Purpose: Neutrophil extracellular traps (NETs), extracellular structures composed of decondensed chromatin, are released in a process called NETosis. NETs, which are part of normal host…
Abstract Number: 479 • 2017 ACR/ARHP Annual Meeting
Protein Carbamylation Is Induced By Activated Neutrophil: Ex Vivo Analysis
Shuichiro Nakabo¹, Koichiro Ohmura¹, Shuji Akizuki¹, Nobuo Kuramoto¹, Kosaku Murakami², Ran Nakashima², Motomu Hashimoto³, Hajime Yoshifuji¹, Masao Tanaka³ and Tsuneyo Mimori¹, ¹Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ²Clinical Immunology and Rheumatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ³Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Protein carbamylation is induced by activated neutrophil: ex vivo analysisBackground/Purpose: Anti-carbamylated protein (anti-CarP) antibodies were reported to be detected in 45% of rheumatoid arthritis (RA)…
Abstract Number: 484 • 2017 ACR/ARHP Annual Meeting
Sputum Neutrophils Demonstrate Increased Neutrophil Extracellular Trap Formation in RA-Free Subjects at-Risk of Future RA
Yuko Okamoto¹, Michael P. Mohning², Stacey M. Thomas², Ashley Visser¹, Lindsay B. Kelmenson³, Jill M. Norris⁴, Mariana J. Kaplan⁵, William J. Janssen², V. Michael Holers¹, Kevin D. Deane¹ and M. Kristen Demoruelle¹, ¹Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²Division of Pulmonary Disease and Critical Care Medicine, National Jewish Health, Denver, CO, ³Division of Rheumatoloty, University of Colorado School of Medicine, Aurora, CO, ⁴Department of Epidemiology, Colorado School of Public Health, Aurora, CO, ⁵Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, MD
Background/Purpose: Data support that ACPAs are generated in the lung in RA-free subjects At-Risk of future RA. Our group previously demonstrated a significant positive correlation…
Abstract Number: 890 • 2017 ACR/ARHP Annual Meeting
Synergetic B-Cell Immunomodulation with Rituximab and Belimumab Combination Treatment in Severe, Refractory SLE
Tineke Kraaij¹, Sylvia W.A. Kamerling¹, Esther N.M. de Rooij¹, Paul L. van Daele², O.W. Bredewold¹, Jaap A. Bakker³, Ingeborg Bajema⁴, Hans U. Scherer⁵, Rene E.M. Toes⁵, Tom W.J. Huizinga⁵, Ton Rabelink¹, Cees van Kooten¹ and Y.K. Onno Teng¹, ¹Nephrology, Leiden University Medical Center, Leiden, Netherlands, ²Immunology, Erasmus Medical Center, Rotterdam, Netherlands, ³Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, Netherlands, ⁴Pathology, Leiden University Medical Center, Leiden, Netherlands, ⁵Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Neutrophil extracellular traps (NETs) are auto-antigenic DNA strands and potentially give rise to SLE-specific autoantibodies that can deposit in glomeruli. It has been shown…
Abstract Number: 2564 • 2017 ACR/ARHP Annual Meeting
Inhibition of Neutrophil Elastase Protects Against Glomerulonephritis and Thrombosis in a Mouse Model of Lupus
Gautam Sule¹, Levi F. Mazza¹, Nayef M. Kazzaz¹, Srilakshmi Yalavarthi¹, He Meng¹ and Jason S. Knight², ¹University of Michigan, Ann Arbor, MI, ²., University of Michigan, Ann Arbor, MI
Background/Purpose: Neutrophils are potential instigators of autoimmunity and effectors of organ damage in lupus. However, there is presently no consensus as to whether inhibition of…
Abstract Number: 2579 • 2017 ACR/ARHP Annual Meeting
Rock-Mediated Pkca Nuclear Translocation Is Important in Neutrophil Netosis and UVB Induced-Skin Inflammation
Ming-Lin Liu¹, Yubin Li², Meena Sharma³ and Victoria P. Werth⁴, ¹Department of Dermatology,, Philadelphia V.A. Medical Center, Philadelphia, PA, ²Dermatology, University of pennsylvania, Philadelphia, PA, ³Department of Dermatology, Philadelphia V.A. Medical Center, Philadelphia, PA, ⁴Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
Background/Purpose: Neutrophils are the most abundant circulating leukocytes and the earliest inflammatory cells to be recruited to the site of photodamage after ultraviolet B (UVB)…
Abstract Number: 2641 • 2017 ACR/ARHP Annual Meeting
Immune Complex-Driven Neutrophil Activation in Systemic Lupus Erythematosus – Novel Biomarkers of Disease Activity and Severity
Hsin-Hsuan Juo¹, Edward Chiou², Keith B. Elkon³ and Christian Lood⁴, ¹Rheumatology, University of Washington, Seattle, WA, ²University of Washington, Seattle, WA, ³Department of Medicine & Immunology, University of Washington, Seattle, WA, ⁴Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Neutrophil activation is linked to inflammation and autoimmune diseases, including systemic lupus erythematosus (SLE) where nucleic acid-containing immune complexes (ICs) drive inflammation through engagement…
Abstract Number: 2761 • 2017 ACR/ARHP Annual Meeting
Adenosine Receptor Agonism Protects Against Antiphospholipid Antibody-Mediated Netosis and Venous Thrombosis
Ramadan A. Ali¹, He Meng¹, Srilakshmi Yalavarthi¹, Yogendra Kanthi¹ and Jason S. Knight², ¹University of Michigan, Ann Arbor, MI, ²., University of Michigan, Ann Arbor, MI
Background/Purpose: We have previously reported that antiphospholipid antibodies (aPL) activate neutrophils and thereby exaggerate neutrophil extracellular trap release (NETosis), which potentially contributes to the thrombotic…
Abstract Number: 2775 • 2017 ACR/ARHP Annual Meeting
Critical Role of Neutrophil Extracellular Traps (NETs) in Patients with Behcet’s Disease
Alexandre LE JONCOUR^1,2, Stephane Loyau³, Nicolas Lelay⁴, Marie-Christine Bouton⁵, Antoine Dossier⁶, Anne-Claire Desbois⁷, Fanny Domont⁸, Thomas Papo⁹, Martine Jandrot-Perrus⁵, Patrice Cacoub¹⁰, Nadine Ajzenberg⁵, David saadoun⁷ and Yacine Boulaftali², ¹Département Hospitalo-Universitaire Inflammation-Immunopathologie-Biotherapie (DHU i2B), F-75005, Paris, France., National center for Autoimmune and Systemic rare diseases and for Autoinflammatory diseases, Paris, France, ²INSERM 1148, CHU Xavier Bichat, paris, France, ³Unité INSERM 1148, CHU Xavier Bichat, Faris, France, ⁴2. Unité INSERM 1148, CHU Xavier Bichat, paris, France, ⁵Unité INSERM 1148, CHU Xavier Bichat, paris, France, ⁶3. Service de Médecine Interne, CHU Xavier Bichat, paris, France, ⁷Département Hospitalo-Universitaire Inflammation-Immunopathologie-Biotherapie, National center for Autoimmune and Systemic rare diseases and for Autoinflammatory diseases, Paris, France, ⁸Département Hospitalo-Universitaire Inflammation-Immunopathologie-Biotherapie, National center for Autoimmune and Systemic rare diseases and for Autoinflammatory diseases, paris, France, ⁹Service de Médecine Interne, CHU Xavier Bichat, Paris, France, ¹⁰Département de Médecine Interne et Immunologie Clinique, National center for Autoimmune and Systemic rare diseases and for Autoinflammatory diseases, Paris, France
Background/Purpose: Behçet's disease (BD) is a chronic systemic vasculitis characterised by muco-cutaneous, ocular, gastrointestinal, cerebral recurrent lesions. Venous thrombosis, is a frequent and life-threatening complication.…
Abstract Number: 2917 • 2017 ACR/ARHP Annual Meeting
Neutrophil Activation in Rheumatoid Arthritis – Potential Biomarkers of Disease Activity and Severity
Mary Bach¹, Daniel Moon², Marcel Bach², Marcus Bach² and Christian Lood³, ¹VA Puget Sound Health Care System, Seattle, WA, ²University of Washington, Seattle, WA, ³Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Neutrophil activation is associated with inflammation and autoimmunity, including rheumatoid arthritis (RA), where neutrophil infiltration to joints participates in tissue destruction and development of…

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