Abstract Number: 019 • Pediatric Rheumatology Symposium 2020
Characterization of DOCK8 as a Novel Gene Associated with Cytokine Storm Syndrome
Background/Purpose: Cytokine storm syndromes (CSS), such as macrophage activation syndrome (MAS) and secondary hemophagocytic lymphohistiocytosis (HLH), are life threatening conditions that commonly present with unremitting…Abstract Number: 1295 • ACR/ARP Annual Meeting 2019
Otoferlin Is Increased in Muscle and PBMCs from Untreated Children with Juvenile Dermatomyositis: Possible Association with Decreased Circulating Natural Killer Cells
Background/Purpose: Juvenile Dermatomyositis (JDM) is a rare inflammatory myopathy in which the immunoregulatory control is not well understood. Collaboration with A.R. French, MD/PhD, documented the…Abstract Number: 1926 • ACR/ARP Annual Meeting 2019
Characterization of DOCK8 as a Novel Gene Associated with Macrophage Activation Syndrome
Background/Purpose: Macrophage activation syndrome (MAS), also known as secondary hemophagocytic lymphohistiocytosis (HLH), is a life threatening condition that commonly presents with unremitting fever and shock…Abstract Number: 2734 • ACR/ARP Annual Meeting 2019
Signaling Lymphocytic Activation Molecule Family (SLAMF) Receptors Deregulation Is Implicated in the Altered Function of NK Cells in Systemic Lupus Erythematosus
Background/Purpose: Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease characterized by quantitative and qualitative deficiencies of immune cells. Natural killer (NK) cells are innate…Abstract Number: 2805 • ACR/ARP Annual Meeting 2019
Natural Killer Cells Gene Expression Can Differentiate Rheumatoid Arthritis Patients from Healthy Controls
Background/Purpose: Rheumatoid arthritis (RA) is the most prevalent autoimmune diseases (1-3% of the world’s population). RA is a prototypic inflammatory disease, being characterized by an…Abstract Number: 1020 • ACR/ARHP Annual Meeting 2018
Involvement of Toll-like-Receptor-9 Pathway on Natural Killer Cells in Systemic Lupus Erythematosus
Background/Purpose: Natural killer (NK) cells participate in systemic lupus erythematosus (SLE) pathogenesis by promoting dendritic cell (DC) activation and/or interferon (IFN)g over-production. NK c ells…Abstract Number: 1466 • ACR/ARHP Annual Meeting 2018
Altered Count of NK Cells and Non-Classical Monocyte Subpopulation in the Pre-Clinical Phase of Rheumatoid Arthritis
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) are detectable long before the manifestation of rheumatoid arthritis (RA). EULAR provided a clinical definition of individuals with arthralgia suspicious…Abstract Number: 2787 • ACR/ARHP Annual Meeting 2018
−21 HLA-Class I Dimorphism Differentiates Psoriatic Arthritis (PsA) from Psoriasis without Psoriatic Arthritis (PsC)
Background/Purpose: The association between human leukocyte antigen (HLA) class I alleles and psoriatic disease indicates a potential role for the innate immune system in disease…Abstract Number: 2600 • ACR/ARHP Annual Meeting 2016
Tofacitinib Is Associated with an Impaired Function of NK Cells and a Defective Immunosurveillance Against B-Cell Lymphomas
Background/Purpose: Disease activity is the main risk factor for developing lymphoma in patients with rheumatoid arthritis (RA). However, the impact of immunosuppressive drugs remains an…Abstract Number: 2868 • ACR/ARHP Annual Meeting 2016
NK Cell Characterization in Patients with Systemic Lupus Erythematosus: Increased Frequency of Ki67+ NK Cells Associated with Disease Activity and Type I Interferon Signature
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a complex autoimmune disorder whose pathology appears to involve many immune cell types. While it is clear that autoantibody…Abstract Number: 1112 • ACR/ARHP Annual Meeting 2015
Obinutuzumab Outperforms Rituximab at Inducing B-Cell Cytotoxicity in Vitro through Fc-Mediated Effector Mechanisms in Rheumatoid Arthritis and Systemic Lupus Erythematosus
Background/Purpose: Obinutuzumab (OBZ, a Type II anti-CD20 monoclonal antibody [mAb] with afucosylated Fc portion and enhanced affinity for Fcγ receptor III) is more efficient than…Abstract Number: 2831 • ACR/ARHP Annual Meeting 2015
A Subset of Natural Killer Cells Are Expanded in Synovial Fluid of Patients with Reactive Arthritis and Undifferentiated Spondyloarthritis
Background/Purpose: We have previously shown that there is an increase in IL-17 in the synovial fluid of patients with Reactive arthritis(ReA) and undifferentiated spondyloarthropathy(uSpA). Besides…Abstract Number: 2178 • ACR/ARHP Annual Meeting 2014
Extensive Natural Killer Cell Receptor Phenotyping on NK and T Cells Discloses Differences in RA and Psa, Potentially Mirroring Diverse Immunoregulatory Functions
Background/Purpose Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are immune-mediated diseases, which share clinical features, but differ in the mechanisms, leading to aberrant immune responses.…Abstract Number: 1459 • ACR/ARHP Annual Meeting 2014
IL-22 Secreted By NKp44+NK Cells Promote the Proliferation of Synovium in Patients with Rheumatoid Arthritis By Activation of STAT3
Background/Purpose: Although CD3-CD56+NKp44+ natural Killer cells (NKp44+NK cells) have been linked to autoimmune diseases including inflammatory bowel disease, ankylosing spondylitis, and primary Sjogren's syndrome, the…Abstract Number: 508 • ACR/ARHP Annual Meeting 2014
Relationship Between NK Cell Count and Important Safety Events in Rheumatoid Arthritis Patients Treated with Tofacitinib
Background/Purpose: Tofacitinib is an oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA). Cytokines (e.g. interleukin [IL]-2, -4, -7, -15, -21) involved…
ACR Meeting Abstracts