Abstracts tagged "Myositis"

Abstract Number: 1074 • ACR Convergence 2020
A Novel Autoantibody Recognizing a 65-kDa Protein Is Associated with Scleromyositis with Head Drop and/or Bent Spine
Karel Venne¹, Valérie Leclair², Julie D'Aoust¹, Océane Landon-Cardinal³, Alexandra Albert⁴, Julie Beauchemin⁵, Denis Brunet⁶, Lucie Roy⁷, Benjamin Ellezam⁸, Jason Karamchandani⁹, Rami Massie¹⁰, Erin O'Ferrall¹⁰, Alain Meyer¹¹, Yves Troyanov¹², Minoru Satoh¹³, Marvin Fritzler¹⁴ and Marie Hudson², ¹Division of Rheumatology, Rheumatology Fellow, McGill University,, Montreal, QC, Canada, ²Division of Rheumatology, Jewish General Hospital, Montréal, QC, Canada, ³Division of Rheumatology, Centre hospitalier de l'Université de Montréal, Montréal, QC, Canada, ⁴Division of Rheumatology, Centre Hospitalier de l’Université Laval, Québec, QC, Canada, ⁵Division of Rheumatology, Hôpital Charles-Lemoyne, Longueuil, QC, Canada, ⁶Division of Neurology, Centre Hospitalier de l’Université Laval, Quebec, QC, Canada, ⁷Division of Rheumatology, CIUSSS du Saguenay Lac-Saint-Jean, Saguenay, Canada, ⁸Division of Pathology, CHU Sainte-Justine, Montreal, QC, Canada, ⁹Department of Pathology, Montreal Neurological Institute and Hospital, Montreal, QC, Canada, ¹⁰Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, Montreal, QC, Canada, ¹¹Service de rhumatologie et Centre de références des maladies autoimmunes rares, Hôpitaux universitaires de Strasbourg, Strasbourg, France, ¹²Division of Rheumatology, Hôpital du Sacré-Coeur, Montréal, QC, Canada, ¹³Department of Clinical Nursing, University of Occupational and Environmental Health, Kitakyushu, Japan, ¹⁴Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Background/Purpose: Scleromyositis (SM) is an emerging subgroup of autoimmune myositis associated with features of systemic sclerosis (SSc). There is a paucity of data on scleromyositis…
Abstract Number: 1095 • ACR Convergence 2020
Avascular Necrosis in the Hopkins Myositis Cohort: A Single Center Experience
Khalil Bourji¹, Christopher Mecoli², Julie Paik³, Jemima Albayda³, Eleni Tiniakou³, William Kelly³, Thomas E Lloyd³, Andrew Mammen⁴ and Lisa Christopher-Stine³, ¹Wayne State University/Henry Ford Hospital, Dearborn, MI, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³Johns Hopkins University, Baltimore, MD, ⁴NIH, Bethesda, MD
Background/Purpose: To assess the prevalence of avascular necrosis (AVN) in a large cohort of patients with idiopathic inflammatory myopathies (IIM) and define the major associated…
Abstract Number: 0959 • ACR Convergence 2020
Altered Gut Microbiome in Dermatomyositis
Sangmee Bae¹, Tien Dong², Venu Lagishetty³, William Katzka⁴, Jonathan Jacobs³ and Christina Charles-Schoeman⁵, ¹University of California Los Angeles, Los Angeles, CA, ²University of California Los Angeles, Los Angeles, ³University of California, Los Angeles, Los Angeles, ⁴UCLA, Los Angeles, ⁵University of California, Los Angeles, Los Angeles, CA
Background/Purpose: Dermatomyositis (DM) is an autoimmune myopathy associated with marked microvascular dysfunction and high morbidity and mortality. The gut microbiome has been implicated in the…
Abstract Number: 1075 • ACR Convergence 2020
Diagnostic Utility of Myositis Antibodies in HyperCKemia: A University Affiliated Single Center Retrospective Study
Sandeepkumar Gupta¹, Debendra Pattanaik², Tulio Bertorini² and Amado Afreire³, ¹Medical College Of Georgia at Augusta University Medical Center, Augusta, GA, ²University of Tennessee Health Science Center, Memphis, TN, ³University of Tennessee Health Science Cente, Memphis, TN
Background/Purpose: Myositis specific and associated autoantibodies are now being used more frequently in the diagnosis of idiopathic inflammatory myositis. However there is a no study…
Abstract Number: 1096 • ACR Convergence 2020
Assessing Interstitial Lung Disease in a Racially Diverse Population with Idiopathic Inflammatory Myositis
Jammie Law¹, Ana Valle², Katherine Mullins³ and Shereen Mahmood⁴, ¹Montefiore Medical Center, Bronx, NY, ²Albert Einstein College of Medicine, New York, NY, ³Montefiore Medical Center, BROOKLYN, NY, ⁴Albert Einstein College of Medicine / Montefiore Medical Center, Wantagh, NY
Background/Purpose: Interstitial lung disease (ILD) is a common extra-muscular manifestation of Idiopathic Inflammatory Myositis (IIM) and increases risk of mortality. Prior studies and registries have focused on either smaller cohorts or predominantly Caucasian/European populations. Our aim was to better characterize the…
Abstract Number: 1055 • ACR Convergence 2020
Myositis and Systemic Sclerosis Spectrum IPAF Patients Are More Likely to Respond Favorably to Immunosuppression
Erin Wilfong¹, Gabriel Schroeder¹, April Barnado¹, Steven Lord¹, Narender Annapureddy¹, Rosemarie Dudenhofer¹ and Leslie J. Crofford¹, ¹Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Classification criteria for interstitial pneumonia with autoimmune features (IPAF) were introduced in 2015 to identify interstitial lung disease (ILD) patients who might benefit from…
Abstract Number: 1076 • ACR Convergence 2020
Anti-Jo1 Antibody Quantification Serve as a Prognostic Factor in Anti-synthetase Syndrom
Lois Bolko¹, Kevin Didier², Jean-Hugues Salmon¹, Makoto Miyara³, Segolene Toquet², Amelie Servettaz², Yves Allenbach³, Olivier Benveniste⁴ and Baptiste Hervier⁵, ¹Maison Blanche Hospital, Reims, Champagne-Ardenne, France, ²Robert Debre Hospital, Reims, Champagne-Ardenne, France, ³Sorbonne Université, Paris, Ile-de-France, France, ⁴Sorbonne Université, paris, France, ⁵Saint-Louis Hospital, Paris, Ile-de-France, France
Background/Purpose: Anti-Synthetase Syndrome (ASyS) is a rare systemic autoimmune disease defined by a combination of pulmonary, muscle, joint, and skin manifestations and the presence of…
Abstract Number: 1098 • ACR Convergence 2020
Anti-cortactin Autoantibodies Are Associated with Key Clinical Features in Adult Myositis but Are Rarely Present in Juvenile Myositis
Iago Pinal-Fernandez¹, Katherine Pak², Albert Gil-Vila³, Andres Baucells⁴, Benjamin Plotz⁵, Maria Casal-Dominguez⁶, Assia Derfoul⁷, Maria Angeles Martinez⁴, Albert Selva-O'Callaghan³, Sara Sabbagh⁸, Frederick W. Miller¹, Lisa G. Rider⁹, Lisa Christopher-Stine¹⁰ and Andrew Mammen⁶, ¹National Institutes of Health, Bethesda, MD, ²NIAMS, NIH, Bethesda, MD, ³Vall d’Hebron Hospital, Barcelona, Spain, ⁴Sant Pau Hospital, Barcelona, Spain, ⁵Division of Rheumatology, New York University Langone Health, New York, NY, ⁶NIH, Bethesda, MD, ⁷NIAMS, NIH, Bethesda, ⁸Division of Rheumatology, Department of Pediatrics, Medical College of Wisconsin, Washington, DC, ⁹Environmental Autoimmunity Group, Clinical Research Branch, NIEHS, NIH, Garrett Park, MD, ¹⁰Johns Hopkins University, Baltimore, MD
Background/Purpose: To define the prevalence and clinical phenotype of anti-cortactin autoantibodies in adult and juvenile myositis.Methods: In this longitudinal cohort study, anti-cortactin autoantibody tiers were…
Abstract Number: 1056 • ACR Convergence 2020
Descriptive Data Analysis of Patients with Anti Jo1 Syndrome (AJS) and Lung Involvement
Mohamed Alalwani¹, Bassam Alhaddad², Basem Zraik³, Christopher O'Rourke³, Ruchi Yadav³, Ali Askari¹, Charles Malemud¹ and Soumya Chatterjee⁴, ¹Case Western Reserve University / University Hospitals Cleveland Medical Center, Cleveland, OH, ²MetroHealth Medical Center, Westlake, OH, ³Cleveland Clinic, Cleveland, OH, ⁴Cleveland Clinic, Richmond Heights, OH
Background/Purpose: To evaluate the patterns, severity and, prognostic parameters of interstitial lung disease (ILD) in Anti Jo1 Syndrome (AJS).Methods: We identified 51 anti-Jo-1 patients with…
Abstract Number: 1077 • ACR Convergence 2020
Glucagon-like Peptide-1 Receptor Agonist Suppresses Muscle Inflammation and Muscle Fiber Death, and Ameliorates Muscle Weakness in Experimental Polymyositis
Mari Kamiya¹, Seon Uk Kim², Jeong Yeon Kim³, Shinsuke Yasuda⁴, Eun Young Lee⁵ and Fumitaka Mizoguchi¹, ¹Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, ²Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Jongno-gu, Seoul, Republic of Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, ⁴Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Tokyo, Japan, ⁵Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
Background/Purpose: Glucocorticoids (GC) are the cornerstone of the treatment for polymyositis (PM). However, the treatment with GC causes GC-induced myopathy, which further deteriorates the muscle…
Abstract Number: 1099 • ACR Convergence 2020
High Burden of Infections in Indian Patients with Idiopathic Inflammatory Myopathy: Validation of Observations from the MyoCite Dataset
Rudrarpan Chatterjee¹, Pankti Mehta², Vikas Agarwal¹ and Latika Gupta², ¹Sanjay Gandhi Post Graduate Institute of Medical Sciences, lucknow, Lucknow, Uttar Pradesh, India, ²Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
Background/Purpose: Infections are a major cause of morbidity and mortality in idiopathic inflammatory myopathy (IIM), more so in India.[1-3] The objective of this study was…
Abstract Number: 1057 • ACR Convergence 2020
Earlier Cancer Diagnosis After Idiopathic Inflammatory Myopathy Onset Is Associated with Improved Long Term Survival – Results from Four European Cohorts
Alexander Oldroyd¹, Paul New², Janine Lamb¹, William Ollier¹, Robert Cooper², Kuberacka Mariampillai³, Olivier Benveniste³, Jiří Vencovský⁴, Heřman Mann⁵, Zoltan Griger⁶, Melinda Nagy-Vincze⁶, Katalin Dankó⁶ and Hector Chinoy⁷, ¹University of Manchester, Manchester, United Kingdom, ²University of Liverpool, Liverpool, United Kingdom, ³Sorbonne Université, Paris, France, ⁴Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ⁵Institute of Rheumatology, Prague, Czech Republic. Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ⁶University of Debrecen, Debrecen, Hungary, ⁷The University of Manchester, Manchester, United Kingdom
Background/Purpose: The idiopathic inflammatory myopathies (IIMs) are strongly associated with the development of clinically detectable cancer. Cancer screening has therefore been advocated in newly diagnosed…
Abstract Number: 1078 • ACR Convergence 2020
Highly Reactive anti-Jo1 Autoantibodies to Distinct HisRS Variants and Domains Associate with Lung and Joint Involvement in Patients with Myositis
Antonella Notarnicola¹, Charlotta Preger², Susanna L. Lundström², Nuria Renard², Edvard Wigren², Eveline Van Gompel², Angeles S. Galindo-Feria², Helena Persson³, Maryam Fathi⁴, Johan Grunewald², Per-Johan Jakobsson², Susanne Gräslund², Ingrid Lundberg⁵ and Cátia Fernandes-Cerqueira², ¹Karolinska Institutet, Stockholm, Stockholms Lan, Sweden, ²Karolinska Institutet, stockholm, Sweden, ³Science for Life Laboratories, KTH, Stockholm, Sweden, ⁴Karolinska University Hospital, stockholm, Sweden, ⁵Division of Rheumatology, Department of Medicine, Karolinska Institutet,, Stockholm, Sweden
Background/Purpose: To address the reactivity and affinity against histidyl-transfer RNA synthetase (HisRS) autoantigen of anti-Jo1 autoantibodies from serum and bronchoalveolar lavage fluid (BALF) and associations…
Abstract Number: 1457 • ACR Convergence 2020
Two Minute Walking Distance and Other Timed Function Tests Are Superior to MMT-8 in Assessing Outcomes in Polymyositis and Dermatomyositis
Sai kumar Dunga¹, Chengappa G Kavadichanda² and VS Negi², ¹Jawaharlal institute of postgraduate medical education and research, puducherry, India, ²Jawaharlal institute of postgraduate medical education and research, Puducherry, Puducherry, India
Background/Purpose: Inflammatory myositis are heterogenous group of diseases affecting skeletal muscles and multiple different organs. Assessing improvement in disease activity is done by Manual muscle…
Abstract Number: 1059 • ACR Convergence 2020
Anti-mitochondrial Autoantibodies Are Associated with Cardiomyopathy, Dysphagia, and Features of More Severe Disease in Adult-onset Myositis
Sara Sabbagh¹, Iago Pinal-Fernandez², Maria Casal-Dominguez³, Jemima Albayda⁴, Julie Paik⁴, Frederick W. Miller², Lisa G. Rider⁵, Andrew Mammen³ and Lisa Christopher-Stine⁴, ¹Medical College of Wisconsin, Fox Point, WI, ²National Institutes of Health, Bethesda, MD, ³NIH, Bethesda, MD, ⁴Johns Hopkins University, Baltimore, MD, ⁵Environmental Autoimmunity Group, Clinical Research Branch, NIEHS, NIH, Garrett Park, MD
Background/Purpose: We examined the prevalence of anti-mitochondrial autoantibodies (AMA) in adult- and juvenile-onset myositis longitudinal cohorts and investigated phenotypic differences between myositis patients with or…

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