Abstracts tagged "Myositis"

Abstract Number: 1084 • ACR Convergence 2020
Consumer-based Activity Trackers in Evaluation of Physical Function in Myositis Patients
Didem Saygin¹, Bonny Rockette-Wagner², Chester Oddis³, Diane Koontz¹, Siamak Moghadam-Kia¹ and Rohit Aggarwal², ¹University of Pittsburgh Medical Center, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA, ³Department of Medicine, Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Idiopathic inflammatory myopathies are systemic inflammatory conditions characterized by muscle weakness and reduced muscle endurance that limit activities of daily living. Daily step count…
Abstract Number: 1606 • ACR Convergence 2020
Mortality with Idiopathic Inflammatory Myositis in an Academic Hospital Setting: A Five-year Retrospective Study
Jaspreet Kaler¹, Zareen Vaghaiwalla², Gurjit Kaeley³ and Myint Thway⁴, ¹University of Florida - Jacksonville, Jacksonville, FL, ²University of Florida Jacksonville, Jacksonville, FL, ³University of Florida College of Medicine - Jacksonville, Jacksonville, FL, ⁴University of Florida- Jacksonville, ponte vedra, FL
Background/Purpose: Idiopathic inflammatory myositis is a diverse group of muscle diseases characterized by muscle inflammation and dysfunction. Approximately 3-7/100,000 cases are diagnosed per year in…
Abstract Number: 1064 • ACR Convergence 2020
Anti-SMN Autoantibodies Are Associated with Systemic Sclerosis Small Bowel Involvement in anti-U1RNP Positive Autoimmune Myositis
Caroline Vo¹, Océane Landon-Cardinal², Alexandra Albert³, Alain Meyer⁴, Valérie Leclair⁵, Josiane Bourré-Tessier², Sabrina Hoa², Eric Rich¹, Jean-Richard Goulet¹, Benjamin Ellezam⁶, Maude Bouchard-Marmen⁷, Martial Koenig⁸, Geneviève Gyger⁵, Ira N. Targoff⁹, Marie Hudson⁵, Minoru Satoh¹⁰, Marvin Fritzler¹¹, Yves Troyanov¹² and Jean-Luc Senécal², ¹Division of Rheumatology, Centre hospitalier de l'Université de Montréal, Department of Medicine, Université de Montréal, Montréal, QC, Canada, ²Division of Rheumatology, Centre hospitalier de l'Université de Montréal, Montréal, QC, Canada, ³Division of Rheumatology, Centre Hospitalier de l’Université Laval, Québec, QC, Canada, ⁴Service de rhumatologie et Centre de références des maladies autoimmunes rares, Hôpitaux universitaires de Strasbourg, Strasbourg, Alsace, France, ⁵Division of Rheumatology, Jewish General Hospital, Montréal, QC, Canada, ⁶Division of Pathology, Centre hospitalier universitaire Sainte-Justine, Montréal, QC, Canada, ⁷Division of Rheumatology, Centre Hospitalier de l’Université Laval, Department of Medicine, Université Laval, Québec, QC, Canada, ⁸Division of Internal Medicine, Centre hospitalier de l'Université de Montréal, Department of Medicine, Université de Montréal, Montréal, QC, Canada, ⁹University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁰Department of Clinical Nursing, University of Occupational and Environmental Health, Kitakyushu, Japan, ¹¹Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ¹²Division of Rheumatology, Hôpital du Sacré-Coeur, Montréal, QC, Canada
Background/Purpose: The survival of motor neuron (SMN)/gemin proteins are components of a multifunctional protein complex that plays an essential role in RNA metabolism. SMN is…
Abstract Number: 1085 • ACR Convergence 2020
Pain in Myositis Is Associated with the Disease Activity
Anjana Chandrasekhara Pillai¹, Chester Oddis², Siamak Moghadam-Kia³, Dana Ascherman⁴, Nicole Neiman⁵, Diane Koontz⁵, Ren Dianxu⁵ and Rohit Aggarwal⁴, ¹UPMC Mckeesport, Pittsburgh, PA, ²Department of Medicine, Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, ³University of Pittsburgh Medical Center, Pittsburgh, PA, ⁴University of Pittsburgh, Pittsburgh, PA, ⁵UPMC, Pittsburgh, PA
Background/Purpose: Pain in myositis is poorly studied and multifactorial relating to muscle weakness, arthritis, myofasciitis, fibromyalgia or other co-morbidities. We sought to prospectively evaluate patient-reported…
Abstract Number: 1694 • ACR Convergence 2020
Risk Factors Associated with Pneumocystis Jirovecii Pneumonia in Juvenile Myositis in North America
Sara Sabbagh¹, Jessica Neely², Albert Chow³, Marietta DeGuzman⁴, Jamie Lai⁵, Svetlana Lvovich⁶, Tara McGrath⁷, Maria Pereira⁸, Iago Pinal-Fernandez⁹, Jordan Roberts¹⁰, Kelly Rouster-Stevens¹¹, Heinrike Schmeling¹², Anjali Sura¹³, Gabriel Tarshish¹⁴, Lori Tucker¹⁵, Lisa G. Rider¹⁶ and Susan Kim¹⁷, ¹Medical College of Wisconsin, Fox Point, WI, ²UCSF, San Francisco, CA, ³Loma Linda University, San Bernardino, CA, ⁴Baylor College of Medicine, Houston, ⁵University of Colorado, The Woodlands, TX, ⁶St Christopher's Hospital for Children, Philadelphia, PA, ⁷University of British Columbia, Vancouver, BC, Canada, ⁸Baylor College of Medicine, Houston, TX, ⁹National Institutes of Health, Bethesda, MD, ¹⁰Boston Children's Hospital, Boston, MA, ¹¹Emory University/Children's Healthcare of Atlanta, Atlanta, GA, ¹²University of Calgary, Calgary, AB, Canada, ¹³Upstate University Hospital, Syracuse, NY, ¹⁴Children's Hospital at Montefiore, New York, NY, ¹⁵BC Children's Hospital, Vancouver, BC, Canada, ¹⁶Environmental Autoimmunity Group, Clinical Research Branch, NIEHS, NIH, Garrett Park, MD, ¹⁷UCSF Benioff Children's Hospital, San Francisco, CA
Background/Purpose: Pneumocystis jirovecii pneumonia (PJP) is associated with significant morbidity and mortality in adult myositis patients; however, few studies have examined PJP in juvenile myositis…
Abstract Number: 1065 • ACR Convergence 2020
Immunostimulatory Herbal Supplement Use Is More Common Among Patients with Dermatomyositis
Adarsh Ravishankar¹, Daisy Yan², Christina Bax³, Josef Symon Concha², Bridget Shields⁴, Lisa Pappas-Taffer⁴, Rui Feng⁵, Joyce Okawa⁴ and Victoria Werth², ¹University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Philadelphia, ²University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Philadelphia, PA, ³University of Pennsylvania, Department of Dermatology, Philadelphia, ⁴Department of Dermatology, University of Pennsylvania, Philadelphia, PA, ⁵University of Pennsylvania, Philadelphia
Background/Purpose: The use of complementary and alternative medicine (CAM) is prevalent in dermatology. Certain CAMs, including Spirulina, Alfalfa, Chlorella, Echinacea, and Blue-Green Algae have been…
Abstract Number: 1086 • ACR Convergence 2020
The Diagnostic Value and Clinical Significance of Myositis-Specific Antibodies in Patients Suspected to Have Autoimmune Myopathies and/or Autoimmune Rheumatic Diseases
Sarah El Chami¹, Christopher Williams¹, Ghaith Noaiseh¹, Amrita Bath¹ and Duaa Jabari¹, ¹The University of Kansas Health System, Kansas city, KS
Background/Purpose: Myositis-specific antibodies (MSA) are thought to be highly specific in patients with idiopathic inflammatory myopathies.[1] However, in clinical practice these antibodies are frequently found…
Abstract Number: 1916 • ACR Convergence 2020
KZR-616, a First-in-class Selective Inhibitor of the Immunoproteasome, Ameliorates Polymyositis in a Murine Model
Marta Del Rio Oliva¹, Michael Basler¹, Darrin Bomba², Diana Lam², Jennifer Brandl², Christopher Kirk² and Marcus Groettrup¹, ¹University of Konstanz, Konstanz, Germany, ²Kezar Life Sciences, Inc, San Francisco, CA
Background/Purpose: Polymyositis (PM) is a chronic autoimmune inflammatory myopathy affecting striated muscles and resulting in muscle weakness. PM is a rare disease, and there are…
Abstract Number: 1066 • ACR Convergence 2020
Prevalence of Cervical Dysplasia in Women with Antisynthetase Syndrome
Alexis Katz¹, Yuxuan Jin¹ and Soumya Chatterjee², ¹Cleveland Clinic, Cleveland, OH, ²Cleveland Clinic, Richmond Heights, OH
Background/Purpose: Increased risk of cervical dysplasia and cervical cancer have been reported in patients with systemic lupus erythematosus (SLE). However, the reason for this increased…
Abstract Number: 1088 • ACR Convergence 2020
Recruitment Rates of Virtual Remote Research (Tele-Research) in Myositis
Siamak Moghadam-Kia¹, Chester Oddis², Swamy Venturupalli³, Shalini Mahajan⁴, Daphne Scaramangas Plumley⁵, Dana Ascherman⁶, Nicole Neiman⁷, Faith Onelangsy⁷, Diane Koontz¹, Kim Goldby-Reffner⁷, Sedin Dzanco⁷, Lei Zhu⁶ and Rohit Aggarwal⁶, ¹University of Pittsburgh Medical Center, Pittsburgh, PA, ²Department of Medicine, Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, ³Cedars Sinai Medical Center, Los Angeles, ⁴Attune Health, Los Angeles, ⁵Attune Health, Los Angeles, CA, ⁶University of Pittsburgh, Pittsburgh, PA, ⁷UPMC, Pittsburgh
Background/Purpose: There is a paucity of randomized, controlled clinical trials in myositis. Subject enrollment and retention in clinical trials for this rare, heterogeneous disease has…
Abstract Number: 1917 • ACR Convergence 2020
In Myositis Patients, Sjögren’s Syndrome Is Associated with Inclusion Body Myositis and with anti-cN1A Antibody Independently of the Myositis Subgroups
Dan Lévy¹, Benoit Nespola², Margherita Giannini³, Renaud Felten⁴, Francois Severac³, Coralie Varoquier³, Marina Rinagel³, Anne-Sophie Korganow⁵, Vincent Poindron⁵, Thierry Martin⁵, Julien Campagne⁶, Hassam Chereih⁷, Bastien Bouldoires⁸, Baptiste Hervier⁹, Cédric Lenormand³, Emmanuel Chatelus³, Laurent Arnaud¹⁰, Bernard Gény³, Jean Sibilia⁴, Jacques-Eric Gottenberg¹¹ and Alain Meyer¹², ¹CHU Strasbourg, CH, ²Department of Immunobiology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, ³CHU Strasbourg, Strasbourg, ⁴Department of rheumatology, University Hospitals of Strasbourg and French National Reference Center for Rare Auto-immune diseases, Strasbourg, France, ⁵Department of Clinical Immunology and Internal Medicine, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, ⁶Department of Internal Medicine, Hôpitaux Privés de Metz, Metz, France, ⁷CH Pontarlier, Pontarlier, ⁸HP Colmar, Colmar, ⁹APHP Paris, Paris, ¹⁰Department of rheumatology, University Hospitals of Strasbourg and French National Reference Center for Rare Auto-immune diseases, Strasbourg, Alsace, France, ¹¹Strasbourg University Hospital, Strasbourg, France, ¹²Service de rhumatologie et Centre de références des maladies autoimmunes rares, Hôpitaux universitaires de Strasbourg, Strasbourg, Alsace, France
Background/Purpose: Myositis are characterized by weakness and muscle inflammation. They encompass heterogeneous conditions, which include dermatomyositis (DM), inclusion body myositis (IBM) and polymyositis (PM) according…
Abstract Number: 1068 • ACR Convergence 2020
Efficacy of Early Initiation of Plasma Exchange Therapy for a Patient with Anti-MDA5 Autoantibody-Positive Dermatomyositis Developing Refractory Rapidly Progressive Interstitial Lung Disease
Noriko Sasaki¹, Akira Ishii¹, Keigo Shimura¹, Azusa Kojima¹, Mai Sugiyama², Yuto Izumi¹, Kazuki Hirano¹, Sho Sasaki², Takayoshi Kurabayashi¹, Yuji Hosono², Chiho Yamada² and Shinji Sato², ¹Tokai University School of Medicine, Isehara, Kanagawa, Japan, ²Tokai University School of Medicine, Isehara, Japan
Background/Purpose: Dermatomyositis (DM), and particularly the subtype clinically amyopathic DM (CADM), is often associated with fatal rapidly progressive interstitial lung disease (RP-ILD) when anti-melanoma differentiation-associated…
Abstract Number: 1090 • ACR Convergence 2020
Abnormal HDL Antioxidant Function Is Associated with Longitudinal Change in Lung Physiology in Dermatomyositis/Polymyositis Associated Lung Disease
Sangmee Bae¹, Jennifer Wang¹, Ani Shahbazian² and Christina Charles-Schoeman², ¹University of California Los Angeles, Los Angeles, CA, ²University of California, Los Angeles, Los Angeles, CA
Background/Purpose: Interstitial lung disease (ILD) is a leading cause of death in patients with dermatomyositis (DM) and polymyositis (PM). We previously reported abnormal anti-oxidant function…
Abstract Number: 1989 • ACR Convergence 2020
NXP2 Autoantibodies Link to Interferon Signature in Juvenile Myositis Lesional Skin
Jessica Turnier¹, Lauren Pachman², Lori Lowe³, Alex Tsoi³, Sultan Elhaj¹, Rajasree Menon¹, Maria Amoruso², Gabrielle Morgan⁴, Johann Gudjonsson⁵, Celine Berthier³ and J Michelle Kahlenberg¹, ¹University of Michigan, Ann Arbor, MI, ²Northwestern University Feinberg School of Medicine, Chicago, IL, ³University of Michigan, Ann Arbor, ⁴Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵University of Michigan, Ann ArborUniversity of Michigan
Background/Purpose: Skin inflammation can herald systemic disease in juvenile myositis (JM), yet we lack an understanding of pathogenic mechanisms driving skin inflammation in JM. The…
Abstract Number: 1069 • ACR Convergence 2020
Scleromyositis Is Associated with Nailfold Capillary Abnormalities Compared to Immune-Mediated Necrotizing Myopathy
Océane Landon-Cardinal¹, Valérie Leclair², Yves Troyanov³, Martial Koenig⁴, Alain Meyer⁵, Sabrina Hoa¹, Josiane Bourré-Tessier¹, Isabelle Ferdinand⁶, Jason Karamchandani⁷, Erin O'Ferrall⁸, Minoru Satoh⁹, Marvin Fritzler¹⁰, Benjamin Ellezam¹¹, Jean-Luc Senécal¹, Marie Hudson² and Geneviève Gyger², ¹Division of Rheumatology, Centre hospitalier de l'Université de Montréal, Montréal, QC, Canada, ²Division of Rheumatology, Jewish General Hospital, Montréal, QC, Canada, ³Division of Rheumatology, Hôpital du Sacré-Coeur, Montréal, QC, Canada, ⁴Division of Internal Medicine, Centre hospitalier de l'Université de Montréal, Montréal, QC, Canada, ⁵Service de rhumatologie et Centre de références des maladies autoimmunes rares, Hôpitaux universitaires de Strasbourg, Strasbourg, Alsace, France, ⁶Institut de Rhumatologie de Montréal, Montréal, QC, Canada, ⁷Department of Pathology, Montreal Neurological Institute and Hospital, Montreal, QC, Canada, ⁸Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, Montreal, QC, Canada, ⁹Department of Clinical Nursing, University of Occupational and Environmental Health, Kitakyushu, Japan, ¹⁰Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ¹¹Division of Pathology, Centre hospitalier universitaire Sainte-Justine, Montréal, QC, Canada
Background/Purpose: Scleromyositis (SM) is an emerging subgroup of autoimmune myositis associated with features of systemic sclerosis (SSc) and characterized by prominent vasculopathic features on ultrastructural…

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