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Abstracts tagged "Myositis"

  • Abstract Number: 1057 • ACR Convergence 2020

    Earlier Cancer Diagnosis After Idiopathic Inflammatory Myopathy Onset Is Associated with Improved Long Term Survival – Results from Four European Cohorts

    Alexander Oldroyd1, Paul New2, Janine Lamb1, William Ollier1, Robert Cooper2, Kuberacka Mariampillai3, Olivier Benveniste3, Jiří Vencovský4, Heřman Mann5, Zoltan Griger6, Melinda Nagy-Vincze6, Katalin Dankó6 and Hector Chinoy7, 1University of Manchester, Manchester, United Kingdom, 2University of Liverpool, Liverpool, United Kingdom, 3Sorbonne Université, Paris, France, 4Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 5Institute of Rheumatology, Prague, Czech Republic. Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 6University of Debrecen, Debrecen, Hungary, 7The University of Manchester, Manchester, United Kingdom

    Background/Purpose: The idiopathic inflammatory myopathies (IIMs) are strongly associated with the development of clinically detectable cancer. Cancer screening has therefore been advocated in newly diagnosed…
  • Abstract Number: 1078 • ACR Convergence 2020

    Highly Reactive anti-Jo1 Autoantibodies to Distinct HisRS Variants and Domains Associate with Lung and Joint Involvement in Patients with Myositis

    Antonella Notarnicola1, Charlotta Preger2, Susanna L. Lundström2, Nuria Renard2, Edvard Wigren2, Eveline Van Gompel2, Angeles S. Galindo-Feria2, Helena Persson3, Maryam Fathi4, Johan Grunewald2, Per-Johan Jakobsson2, Susanne Gräslund2, Ingrid Lundberg5 and Cátia Fernandes-Cerqueira2, 1Karolinska Institutet, Stockholm, Stockholms Lan, Sweden, 2Karolinska Institutet, stockholm, Sweden, 3Science for Life Laboratories, KTH, Stockholm, Sweden, 4Karolinska University Hospital, stockholm, Sweden, 5Division of Rheumatology, Department of Medicine, Karolinska Institutet,, Stockholm, Sweden

    Background/Purpose: To address the reactivity and affinity against histidyl-transfer RNA synthetase (HisRS) autoantigen of anti-Jo1 autoantibodies from serum and bronchoalveolar lavage fluid (BALF) and associations…
  • Abstract Number: 1457 • ACR Convergence 2020

    Two Minute Walking Distance and Other Timed Function Tests Are Superior to MMT-8 in Assessing Outcomes in Polymyositis and Dermatomyositis

    Sai kumar Dunga1, Chengappa G Kavadichanda2 and VS Negi2, 1Jawaharlal institute of postgraduate medical education and research, puducherry, India, 2Jawaharlal institute of postgraduate medical education and research, Puducherry, Puducherry, India

    Background/Purpose: Inflammatory myositis are heterogenous group of diseases affecting skeletal muscles and multiple different organs. Assessing improvement in disease activity is done by Manual muscle…
  • Abstract Number: 1059 • ACR Convergence 2020

    Anti-mitochondrial Autoantibodies Are Associated with Cardiomyopathy, Dysphagia, and Features of More Severe Disease in Adult-onset Myositis

    Sara Sabbagh1, Iago Pinal-Fernandez2, Maria Casal-Dominguez3, Jemima Albayda4, Julie Paik4, Frederick W. Miller2, Lisa G. Rider5, Andrew Mammen3 and Lisa Christopher-Stine4, 1Medical College of Wisconsin, Fox Point, WI, 2National Institutes of Health, Bethesda, MD, 3NIH, Bethesda, MD, 4Johns Hopkins University, Baltimore, MD, 5Environmental Autoimmunity Group, Clinical Research Branch, NIEHS, NIH, Garrett Park, MD

    Background/Purpose: We examined the prevalence of anti-mitochondrial autoantibodies (AMA) in adult- and juvenile-onset myositis longitudinal cohorts and investigated phenotypic differences between myositis patients with or…
  • Abstract Number: 1079 • ACR Convergence 2020

    Sex Differences in Antibody Profile, Phenotype, and Treatment Response in a Racially Diverse Population with Idiopathic Inflammatory Myopathies

    Ana Valle1, Jammie Law2, Katherine Mullins3 and Shereen Mahmood4, 1Albert Einstein College of Medicine, New York, NY, 2Montefiore Medical Center, Bronx, NY, 3Montefiore Medical Center, BROOKLYN, NY, 4Albert Einstein College of Medicine / Montefiore Medical Center, Wantagh, NY

    Background/Purpose: It is established that autoimmune diseases are more common in females than males. Large scale idiopathic inflammatory myopathy (IIM) registries have shown a similar…
  • Abstract Number: 1556 • ACR Convergence 2020

    Assessing Calcinosis in Dermatomyositis with Computed Tomography and Calcium Scoring

    Prateek Gowda1, Briana Cervantes2, Lisa G. Rider3, Frederick W. Miller4, Marcus Chen4 and Adam Schiffenbauer4, 1NIBIB, Baltimore, MD, 2NIEHS, Silver Spring, MD, 3Environmental Autoimmunity Group, Clinical Research Branch, NIEHS, NIH, Garrett Park, MD, 4National Institutes of Health, Bethesda, MD

    Background/Purpose: Calcinosis is a condition in which calcium salts are deposited in and around soft tissue and is observed in up to 30% of adult…
  • Abstract Number: 1060 • ACR Convergence 2020

    B-cell-rich Inflammatory Myopathies in Adults: Striking Association with Connective Tissue Diseases

    Pat Korathanakhun1, Océane Landon-Cardinal2, Valérie Leclair3, Benjamin Ellezam4, Alain Meyer5, Josiane Bourré-Tessier2, Anne-Marie Mansour6, Sandrine Larue7, François Grand'Maison7, Rami Massie8, Matthieu Le Page9, Catherine Isabelle7, Nathalie Routhier6, Flavie Roy10, Minoru Satoh11, Marvin Fritzler12, Jean-Luc Senécal2, Yves Troyanov13, Marie Hudson3, Jason Karamchandani14 and Erin O'Ferrall8, 1Montreal Neurological Institute and Hospital, Montreal, QC, Canada, 2Division of Rheumatology, Centre hospitalier de l'Université de Montréal, Montréal, QC, Canada, 3Division of Rheumatology, Jewish General Hospital, Montréal, QC, Canada, 4Division of Pathology, Centre hospitalier universitaire Sainte-Justine, Montréal, QC, Canada, 5Service de rhumatologie et Centre de références des maladies autoimmunes rares, Hôpitaux universitaires de Strasbourg, Strasbourg, France, 6Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada, 7Hôpital Charles-Lemoyne, Longueuil, QC, Canada, 8Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, Montreal, QC, Canada, 9Centre hospitalier de Lanaudière, Saint-Charles-Borromée, QC, Canada, 10Uiversité de Montréal, Montreal, QC, Canada, 11Department of Clinical Nursing, University of Occupational and Environmental Health, Kitakyushu, Japan, 12Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 13Division of Rheumatology, Hôpital du Sacré-Coeur, Montréal, QC, Canada, 14Department of Pathology, Montreal Neurological Institute and Hospital, Montreal, QC, Canada

    Background/Purpose: Myositis with significant B-cell infiltrates on muscle biopsy has scarcely been described in adults. Radke (2018) found B cells in adult dermatomyositis (DM) and…
  • Abstract Number: 1081 • ACR Convergence 2020

    Patient-reported Outcomes in Early Autoimmune Inflammatory Myopathies

    Valérie Leclair1, Brett Thombs2, Mianbo Wang3, Evelyne Vinet4, Alexandra Albert5 and Marie Hudson6, 1Division of Rheumatology, Jewish General Hospital, Montreal, QC, Canada, 2Department of Psychology, McGill University, Montreal, QC, Canada, 3Lady Davis institute for Medical Research, Montreal, QC, Canada, 4McGill University Health Center, Montreal, QC, Canada, 5Division of Rheumatology, Centre Hospitalier de l’Université Laval, Québec, QC, Canada; Department of Medicine, Université Laval, Québec, QC, Canada., Neuville, Canada, 6Division of Rheumatology, Jewish General Hospital, Montréal, QC, Canada

    Background/Purpose: Patient-reported outcomes (PROs) are increasingly used in rheumatology. Such outcomes are under-reported in autoimmune inflammatory myopathies (AIM) especially in incident cohorts. The objective of…
  • Abstract Number: 1559 • ACR Convergence 2020

    Fully Automatic Assessment of Nail Fold Capillaroscopy Software – Early Results

    Olga Brzezińska1, Krzysztof Rychlicki-Kicior2 and Joanna Makowska1, 1Department of Rheumatology, Medical University of Lodz, Poland, Lodz, Lodzkie, Poland, 2University of Economics and Human Sciences in Warsaw, Poland, Lodz, Poland

    Background/Purpose: Changes in capillaroscopy nailfold image are a valuable element in the diagnostic procedure and monitoring of systemic sclerosis as well as other systemic diseases.…
  • Abstract Number: 1061 • ACR Convergence 2020

    Daily Myositis Symptom Changes Collected via a Smartphone-Based App Are Associated with Flare Occurrence – Providing Evidence of Potential Digital Biomarkers

    Alexander Oldroyd1, Belay Yimer2, Max Little3, William Dixon2 and Hector Chinoy4, 1University of Manchester, Manchester, United Kingdom, 2Centre for Epidemiology Versus Arthritis, University of Manchester, Manchester, United Kingdom, 3University of Birmingham, Birmingham, United Kingdom, 4The University of Manchester, Manchester, United Kingdom

    Background/Purpose: The concept of idiopathic inflammatory myopathy (IIM) flare is widely used, although no consensus definition exists. Studies have demonstrated the feasibility and utility of…
  • Abstract Number: 1082 • ACR Convergence 2020

    The Presence of Anti-Jo1, anti-PL7, And/or anti-MDA5 Antibodies in Idiopathic Inflammatory Myopathy Confers an Increased Risk of a Significant Restrictive Pulmonary Defect

    Dmitriy Cherny1 and Carrie Richardson1, 1Rush University Medical Center, Chicago, IL

    Background/Purpose: A subset of patients with idiopathic inflammatory myopathy develop significant restrictive lung disease, although risk factors for this are poorly defined. Autoantibodies may be…
  • Abstract Number: 1574 • ACR Convergence 2020

    Over Half of Patients with Immune Checkpoint Inhibitor-related Myositis, Myasthenia Gravis and/or Myocarditis Have Autoantibodies: Results from a Systematic Literature Review

    Nilasha Ghosh1, Karmela Kim Chan2, Bridget Jivanelli3 and Anne Bass1, 1Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, 2Hospital For Special Surgery, New York, NY, 3Hospital for Special Surgery, New York

    Background/Purpose: Although immune checkpoint inhibitor (ICI) cancer treatments are known to activate cytotoxic T-cells, autoantibodies may also contribute to the development of immune-related adverse events…
  • Abstract Number: 1062 • ACR Convergence 2020

    Dermatomyositis: A Dermatology-Rheumatology Clinic Retrospective Analysis

    Burak Elkiran1, Mahroo Tajalli2, Terrence M. Vance3, Abrar A. Qureshi4 and Anthony M. Reginato5, 1Department of Medicine, Division of Rheumatology; Warren Alpert Medical School of Brown University, BOSTON, 2Department of Dermatology, Warren Alpert Medical School of Brown University, PROVIDENCE, 3Department of Epidemiology, Warren Alpert Medical School of Brown University, PROVIDENCE, 4Department of Dermatology, Warren Alpert Medical School of Brown University, BOSTON, 5Department of Medicine, Division of Rheumatology, Warren Alpert Medical School of Brown University, Boston, MA

    Background/Purpose: Dermatomyositis (DM) can be categorized into two major subtypes: clinically amyopathic dermatomyositis (CADM) and classic dermatomyositis (CDM). In this study, we aimed to identify characteristics…
  • Abstract Number: 1084 • ACR Convergence 2020

    Consumer-based Activity Trackers in Evaluation of Physical Function in Myositis Patients

    Didem Saygin1, Bonny Rockette-Wagner2, Chester Oddis3, Diane Koontz1, Siamak Moghadam-Kia1 and Rohit Aggarwal2, 1University of Pittsburgh Medical Center, Pittsburgh, PA, 2University of Pittsburgh, Pittsburgh, PA, 3Department of Medicine, Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Idiopathic inflammatory myopathies are systemic inflammatory conditions characterized by muscle weakness and reduced muscle endurance that limit activities of daily living. Daily step count…
  • Abstract Number: 1606 • ACR Convergence 2020

    Mortality with Idiopathic Inflammatory Myositis in an Academic Hospital Setting: A Five-year Retrospective Study

    Jaspreet Kaler1, Zareen Vaghaiwalla2, Gurjit Kaeley3 and Myint Thway4, 1University of Florida - Jacksonville, Jacksonville, FL, 2University of Florida Jacksonville, Jacksonville, FL, 3University of Florida College of Medicine - Jacksonville, Jacksonville, FL, 4University of Florida- Jacksonville, ponte vedra, FL

    Background/Purpose: Idiopathic inflammatory myositis is a diverse group of muscle diseases characterized by muscle inflammation and dysfunction. Approximately 3-7/100,000 cases are diagnosed per year in…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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