Abstracts tagged "Myopathies"

Abstract Number: 1193 • ACR Convergence 2025
Lung Transplant Outcomes in Patients with Myositis- and Systemic Sclerosis-Associated Interstitial Lung Disease Compared to Idiopathic Pulmonary Fibrosis: A Multicentric Retrospective Analysis
Angela Chang¹, Navid Saleh¹, Alec Yu¹, Darya S. Jalaledin², Sabrina Hoa³, Robert Levy⁴, Jennifer Wilson⁵, Charles Poirier⁶, John Yee¹, James Choi¹, Océane Landon-Cardinal⁷, Hyein Kim⁸ and Kun Huang⁹, ¹University of British Columbia, Vancouver, BC, Canada, ²Université de Montréal, Saint-Lambert, QC, Canada, ³University of Montreal, Brossard, QC, Canada, ⁴University of British Columbia, Deerfield, IL, ⁵UBC, Vancouver, BC, Canada, ⁶University of Montreal, Montreal, QC, Canada, ⁷Centre hospitalier de l'Université de Montréal, Montréal, QC, Canada, ⁸The University of British Columbia, Vancouver, BC, Canada, ⁹University of British Columbia, Vancouver, Surrey, BC, Canada
Background/Purpose: Interstitial lung disease (ILD) is a frequent complication of idiopathic inflammatory myositis (IIM) and systemic sclerosis (SSc), ranging from subclinical ILD to rapidly progressive…
Abstract Number: 2066 • ACR Convergence 2025
Psychosocial Factors Strongly Influence Subjective Well-being in Patients with Idiopathic Inflammatory Myopathies
Meera Shah¹, Emilia Naseva², Tsvetelina Velikova³, Tamar Rubinstein⁴, Manali Sarkar⁵, Lavanya Mangla⁶, Oliver Distler⁷, Ingrid de Groot⁸, Lisa Christ⁹, Carlo Vinicio Caballero Uribe¹⁰, Ai Lyn Tan¹¹, Abraham Edgar Gracia Ramos¹², Vincenzo Venerito¹³, Vikas Agarwal¹⁴ and Latika Gupta¹⁵, ¹Indraprastha Apollo Hospital, New Delhi, Mumbai, Maharashtra, India, ²Faculty of Public Health, Medical University of Sofia, ¹⁵ Acad. Ivan Evstratiev Geshov, ¹⁶⁰⁶ Sofia; Medical Faculty, Sofia University St. Kliment Ohridski, Sofia, Bulgaria, ³Medical Faculty, Sofia University St. Kliment Ohridski, Sofia, Bulgaria, ⁴Albert Einstein College of Medicine, White Plains, NY, ⁵Sir H. N. Reliance Foundation Hospital and Research Centre, Mumbai, Maharashtra, India., Mumbai, Maharashtra, India, ⁶Maulana Azad Medical College, ²-Bahadurshah Zafar Marg, New Delhi, New Delhi, India, ⁷Department of Rheumatology, University Hospital Zurich, University of Zurich, Switzerland, Zurich, Switzerland, ⁸The Myositis Association, Rotterdam, Netherlands, ⁹Department of Rheumatology and Immunology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Bern, Switzerland, ¹⁰Department of Medicine, Hospital Universidad del Norte, Barranquilla, Atlantico, Colombi, Barranquilla, Colombia, ¹¹NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, England, United Kingdom, ¹²Department of Internal Medicine, General Hospital, National Medical Center “La Raza”, Instituto Mexicano del Seguro Social, Av. Jacaranda S/N, Col. La Raza, Del. Azcapotzalco, C.P. ⁰²⁹⁹⁰ Mexico City, Mexico., Mexico City, Mexico, ¹³Univeristy of Bari "Aldo Moro", Italy, Bari, Bari, Italy, ¹⁴Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India, ¹⁵School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham; Royal Wolverhampton NHS Trust; Centre for Musculoskeletal Research, School of Biological Sciences, The University of Manchester, Manchester; Francis Crick Institute, London, Birmingham, UK, United Kingdom
Background/Purpose: Traditional clinical measures are well established in idiopathic inflammatory myopathies (IIM), yet exploration of subjective well-being (SWB) remains limited. SWB assessment facilitates holistic patient…
Abstract Number: 1196 • ACR Convergence 2025
Prevalence of and Factors Associated with Chronic Opioid Use among Individuals with Inflammatory Myopathies
Anuya Natu¹, Haley Zimmerman², Kristin Wipfler³, Kaleb Michaud⁴, Yvonne Lee⁵ and Didem Saygin², ¹John H. Stroger, Jr. Hospital of Cook County, Chicago, IL, ²Rush University Medical Center, Chicago, IL, ³FORWARD, The National Databank for Rheumatic Diseases, Omaha, NE, ⁴University of Nebraska Medical Center, Omaha, NE, ⁵Northwestern University, Chicago, IL
Background/Purpose: Idiopathic inflammatory myopathies (IIM) can be associated with significant pain and functional impairment. While the use of opioids has been documented in other inflammatory…
Abstract Number: 2067 • ACR Convergence 2025
Patterns of Comorbidity in Idiopathic Inflammatory Myopathies: A Cross-sectional Analysis of Disease Burden and Risk Factors
Ilke Coskun Benlidayi¹, Meghna Lama², Oladipo Kunle Afolayan², Meera Shah³, Manali Sarkar⁴, Tamar Rubinstein⁵, Aleksandra Opinc-Rosiak⁶, Rada Miskovic⁷, Marcin Milchert⁸, Dimitri Luz Felipe da Silva⁹, Samuel Katsuyuki Shinjo¹⁰, Elena Nikiphorou¹¹, Ioannis Parodis¹², Vincenzo Venerito¹³, Vikas Agarwal¹⁴ and Latika Gupta¹⁵, ¹Cukurova University, Adana, Turkey, ²The University of Texas Health Science Centre at Houston School of Public Health: Houston, Texas, Houston, ³Indraprastha Apollo Hospital, New Delhi, Mumbai, Maharashtra, India, ⁴Sir H. N. Reliance Foundation Hospital and Research Centre, Mumbai, Maharashtra, India., Mumbai, Maharashtra, India, ⁵Albert Einstein College of Medicine, White Plains, NY, ⁶Medical University of Lodz, Zeromskiego ¹¹³, ⁹⁰-⁵⁴⁹ Lodz, Poland., Lodz, Poland, ⁷University of Belgrade; Clinic of Allergy and Immunology, University Clinical Centre of Serbia, Belgrade, Serbia, ⁸Pomeranian Medical University in Szczecin, Szczecin, Poland, ⁹University Santo Amaro, São Paulo, Brazil, Sao Paulo, Brazil, ¹⁰Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, Sao Paulo, Brazil, ¹¹King's College London, London, United Kingdom, ¹²Karolinska Institutet and Karolinska University Hospital, Department of Medicine Solna, Division of Rheumatology, Stockholm, Sweden, ¹³Univeristy of Bari "Aldo Moro", Italy, Bari, Bari, Italy, ¹⁴Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India, ¹⁵School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham; Royal Wolverhampton NHS Trust; Centre for Musculoskeletal Research, School of Biological Sciences, The University of Manchester, Manchester; Francis Crick Institute, London, Birmingham, UK, United Kingdom
Background/Purpose: Comorbidities contribute to the disease burden in idiopathic inflammatory myopathies (IIMs). Understanding their distribution and predictors across IIM subtypes can guide tailored strategies. This…
Abstract Number: 1199 • ACR Convergence 2025
Interstitial Lung Disease in Systemic Autoimmune Rheumatic Diseases (SARDs): Radiologic and Histologic Correlations
Darya S. Jalaledin¹, Aidan pye², Angela Chang², Navid Saleh², Saud AlHajeri³, Beatrice Daviault⁴, Arusa Shah⁵, Sabrina Hoa⁶, Océane Landon-Cardinal⁷, Alec Yu², Robert Levy⁸, Jennifer Wilson⁹, Charles Poirier⁴, James Choi², John Yee², Hyein Kim² and Kun Huang¹⁰, ¹Université de Montréal, Saint-Lambert, QC, Canada, ²University of British Columbia, VANCOUVER, BC, Canada, ³University of British Columbia, Vancouver, Canada, ⁴University of Montreal, Montreal, QC, Canada, ⁵University of Montreal, Montreal, BC, Canada, ⁶University of Montreal, Brossard, QC, Canada, ⁷Centre hospitalier de l'Université de Montréal, Montréal, QC, Canada, ⁸University of British Columbia, Deerfield, IL, ⁹UBC, Vancouver, BC, Canada, ¹⁰University of British Columbia, Vancouver, Surrey, BC, Canada
Background/Purpose: Systemic autoimmune rheumatic diseases (SARDs) are a major cause of interstitial lung disease (ILD), with high prevalence in inflammatory idiopathic myopathy (IIM), systemic sclerosis…
Abstract Number: 2068 • ACR Convergence 2025
Comparing characteristics, diagnostics, and treatment in people with different idiopathic inflammatory myopathies using a large representative cohort
Michael George¹, Thomas Riley¹, Ellen Romich², Emily Holladay³, Tim Beukelman⁴, Shanette Daigle⁵, Amy Mudano⁵, Fenglong Xie⁶, Xiang Guo⁷, Nicole Kulisek⁸, Arne Yndestad⁹, Ashraf Chaudhary⁸ and Jeffrey Curtis¹⁰, ¹University of Pennsylvania, Philadelphia, PA, ²University of Pennsylvania, Media, PA, ³University of Alabama at Birmingham, Birmingham, AL, ⁴Foundation for Advancing Science Technology Education and Research, Hoover, AL, ⁵Foundation for Advancing Science, Technology, Education and Research (FASTER), Hoover, AL, ⁶The University of Alabama at Birmingham, Birmingham, AL, ⁷Pfizer, Inc, New York, NY, ⁸Pfizer, Inc, Collegeville, PA, ⁹Pfizer Inc, Oslo, Norway, Oslo, Norway, ¹⁰Foundation for Advancing Science, Technology, Education and Research, Birmingham, AL
Background/Purpose: Studies of idiopathic inflammatory myopathies (IIM) are often based on the analysis of single cohorts at academic centers. We aimed to identify potential gaps…
Abstract Number: 0281 • ACR Convergence 2025
Anti-IL-6 Autoantibodies and IL-6 Signalling in Idiopathic Inflammatory Myopathies
Anja Srpcic¹, Manca Ogric¹, Sasa Cucnik¹, Sergej Pirkmajer², Katja Lakota¹ and Katja Perdan Pirkmajer¹, ¹University Medical Centre Ljubljana, Ljubljana, Slovenia, ²Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
Background/Purpose: Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of systemic autoinflammatory diseases that affect muscle tissue, often leading to muscle atrophy, weakness and myalgia.…
Abstract Number: 1201 • ACR Convergence 2025
Prognostic Significance of 1-Year Pulmonary Function Changes in Myositis-Associated Interstitial Lung Disease
Shiri Keret¹, Silvia Martinez Laverde², Irada Choudhuri², Raisa Lomanto Silva³, Eugenia Gkiaouraki², Tanya Chandra², Nantakarn Pongtarakulpanit⁴, Shreya Sriram², Niladri Bhowmick², Vaidehi Kothari², Kaushik Sreerama Reddy², Eaman Alhassan⁵, Anushka Aggarwal⁶, Maha Almackenzie⁷, Daniel Sullivan², Sara Faghihi-Kashani⁸, Koichi Yamaguchi², Daniel Kass², Kevin Gibson², Dana Ascherman⁹, Siamak Moghadam-Kia⁵, Chester V. Oddis⁹ and Rohit Aggarwal¹⁰, ¹Bnai Zion Medical Center, Atlit, Israel, ²University of Pittsburgh Medical Center, Pittsburgh, ³Massachusetts General Hospital, Boston, MA, ⁴Mahidol University, University of Pittsburgh, Bangkok, Thailand, ⁵University of Pittsburgh Medical Center, Pittsburgh, PA, ⁶Indraprastha Apollo Hospital, New Delhi, India, ⁷Medical Cities of the Ministry of the Interior, Riyadh, Saudi Arabia, ⁸UCSF, Mountain View, CA, ⁹University of Pittsburgh, Pittsburgh, PA, ¹⁰University of Pittsburgh, Rheumatology and Clinical Immunology, Pittsburgh, United States of America, Pittsburgh, PA
Background/Purpose: Lung involvement is the most frequent and severe extramuscular complication of Idiopathic Inflammatory Myopathy (IIM). The utility of pulmonary function test (PFT) monitoring for…
Abstract Number: 2071 • ACR Convergence 2025
Impact of Diagnostic Delay on Disease Activity and Cumulative Damage in Patients with Idiopathic Inflammatory Myopathies in a Third-level Hospital in Mexico
valeria cantu¹, Rebeca L. Polina-Lugo¹, Emmanuel Dominguez-Chapa², Ana Cecilia Bardan Inchaustegui³, Fernanda M. Garcia-Carrillo⁴, Daniela A. Mejia-Rodriguez⁴, Ericka S. Reyna-Hernandez⁴, Rosa Arvizu-Rivera⁵, Jesus Alberto Cardenas-de la Garza⁶ and Miguel Villarreal-Alarcón⁷, ¹Division of Rheumatology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo León, Mexico, ²Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo León, Mexico, ³Universidad Autónoma de Nuevo Leon, Monterrey, Nuevo León, Mexico, ⁴Rheumatology Service, Hospital Universitario “Dr. Jose Eleuterio Gonzalez”, Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon, Mexico, ⁵Hospital Universitario "Dr. José Eleuterio Gonzalez", Escobedo, Nuevo León, Mexico, ⁶Rheumatology Service, University Hospital “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, México, Monterrey, Mexico, ⁷Hospital Universitario UANL, Monterrey, Nuevo León, Mexico
Background/Purpose: Idiopathic inflammatory myopathies (IIM) are a rare and heterogeneous group of autoimmune diseases marked by inflammation of muscle tissue and extramuscular manifestations. Their atypical…
Abstract Number: 1140 • ACR Convergence 2024
Pulmonary Hypertension in Hospitalized Patients with Dermatomyositis & Polymyositis: A Nationwide Cohort Analysis
Saman Tanveer¹, Daksh Ahluwalia¹, Fatima Tanveer², Abdullah Saeed³, Almurtada Razok⁴ and Faria Sami⁵, ¹John H. Stroger Jr. Hospital of Cook County, Chicago, IL, ²CMH Lahore Medical and Dental College, Lahore, Pakistan, ³CMH Lahore Medical and Dental College, Lahore, Punjab, Pakistan, ⁴John H Stroger Jr Hospital of Cook County, Chicago, IL, ⁵University of Alabama, Chicago, IL
Background/Purpose: Dermatomyositis (DM) and polymyositis (PM) are idiopathic inflammatory myopathies characterized by muscles inflammation, proximal muscle weakness and extramuscular manifestations. A particularly challenging extramuscular manifestation…
Abstract Number: 2052 • ACR Convergence 2024
Role of Scleroderma/myositis-related Autoantibodies Detected by Immunoblot to the Diagnosis of Systemic Autoimmune Rheumatic Diseases in 410 Patients from a Single Referral Center
Carmen Secada Gómez¹, Diana Prieto-Peña², Mónica Renuncio-García³, Juan Irure-Ventura⁴, Marcos Lopez-Hoyos⁵ and Ricardo Blanco-Alonso⁶, ¹Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, ²Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Cantabria, Spain, ³Division of Immunology, Hospital Universitario Marqués de Valdecilla, Immunopathology Group, IDIVAL, Santander, Spain, ⁴Division of Immunology, Hospital Universitario Marqués de Valdecilla. Immunopathology group, IDIVAL, Santander, Cantabria, Spain, ⁵Division of Immunology, Hospital Universitario Marqués de Valdecilla. Immunopathology group, IDIVAL, Santander, Spain, ⁶Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain
Background/Purpose: In clinical practice, immunoblot assays are being used more frequently as a diagnostic tool for systemic autoimmune rheumatic diseases (SARDs).Our aim was to evaluate the…
Abstract Number: 1141 • ACR Convergence 2024
Defining a Novel Type of Myositis: Immune Mediated Megaconial Myopathy (IMMM)
Teerin Liewluck¹, Ashley Santilli², Oliver Ni³, Margherita Milone², Duygu Selcen², Anahit Mehrabyan⁴, Arjun Seth⁵, Christine Hsieh⁵, Wasim Raslan⁶, Moayd Alkhalifah⁶, Raed Alenezi⁶, Stefan Nicolau⁷ and Pannathat Soontrapa⁸, ¹Mayo Clinic, Rochester, MN, ²Mayo Clinic-Rochester, Rochester, MN, ³Hennepin Healthcare, Minneapolis, MN, ⁴University of North Carolina, Chapel Hill, NC, ⁵Northwestern University, Chicago, IL, ⁶Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia, ⁷Nationwide Children’s Hospital, Columbus, OH, ⁸Siriraj Hospital, Mahidol University, Bangkok, Thailand
Background/Purpose: To describe a novel type of myositis, immune mediated megaconial myopathy (IMMM), pathologically characterized by giant mitochondria (megaconia).Methods: We reviewed the Mayo Clinic Muscle…
Abstract Number: 2058 • ACR Convergence 2024
Association of Anti-Synthetase Antibody Subtypes with Radiographic Progression of Interstitial Lung Disease in Anti-Synthetase Syndrome: An Analysis of the CLASS Project Database
Daphne Rivero Gallegos¹, Francisca Bozan², Sangmee Bae³, Giovanni Zanframundo⁴, Sara Faghihi-Kashani⁵, Iazsmin Bauer Ventura⁶, Eduardo Dourado⁷, Gianluca sambataro⁸, Akira Yoshida⁹, Tamera J Corte¹⁰, Francesco Bonella¹¹, Tracy J Doyle¹², david fiorentino¹³, Miguel Angel Gonzalez-Gay¹⁴, marie Hudson¹⁵, Masataka Kuwana¹⁶, Antonella Notarnicola¹⁷, Andrew Mammen¹⁸, Neil McHugh¹⁹, Frederick Miller²⁰, Carlomaurizio Montecucco²¹, Chester Oddis²², Jorge Rojas-Serrano²³, Jens Schmidt²⁴, Carlo A. Scire²⁵, Albert Selva-O’Callaghan²⁶, Victoria Werth²⁷, Rohit Aggarwal²⁸ and Lorenzo Cavagna²⁹, and CLASS project participating investigators, ¹INER, Ciudad de México, Mexico State, Mexico, ²Hospital Clinico Universidad de Chile, Santiago, Chile, ³UCLA, Los Angeles, CA, ⁴Università di Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, Milano, Italy, ⁵Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, San Francisco, CA, ⁶University of Chicago, Chicago, IL, ⁷Unidade Local de Saúde da Região de Aveiro, Aveiro, Portugal, ⁸University of Catania, Catania, Italy, ⁹Nippon Medical School Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan, ¹⁰Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia, ¹¹Center for interstitial and rare lung diseases, Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany, ¹²Brigham and Women's Hospital, West Roxbury, MA, ¹³Department of Dermatology, Stanford University School of Medicine, Stanford, CA, Palo Alto, CA, ¹⁴University of Cantabria, Fundación Jimenez Díaz, Madrid, Madrid, Spain, ¹⁵McGill University, Montreal, QC, Canada, ¹⁶Department of Allergy and Rheumatology, Nippon Medical School, Tokyo, Japan, Tokyo, Japan, ¹⁷Karolinska University Hospital and Karolinska Institutet, Stockholm, Stockholms Lan, Sweden, ¹⁸NIH, Bethesda, MD, ¹⁹University of Bath, Bath, United Kingdom, ²⁰NIH, NIEHS, Chapel Hill, NC, ²¹IRCCS policlinico S. Matteo foundation, University of Pavia, Pavia, Italy, ²²Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ²³National Institute of Respiratory Diseases, Ismael Cosío Villegas, Mexico City, Mexico, ²⁴University Medical Center Goettingen, Göttingen, Germany, ²⁵University of Milano Bicocca, Milan, Italy, ²⁶Systemic Autoimmune Disease Unit, Vall d’Hebron Institute of Research, Barcelona, Spain, ²⁷University of Pennsylvania, Wynnewood, PA, ²⁸Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA, Pittsburgh, PA, ²⁹University of Pavia and Fondazione IRCCS Policlinico San Matteo Hospital of Pavia, Pavia, Pavia, Italy
Background/Purpose: In anti-synthetase syndrome (ASSD), clinical presentations vary from isolated interstitial lung disease (ILD) to systemic multi-organ manifestations. Several studies emphasize the crucial role of…
Abstract Number: 1144 • ACR Convergence 2024
Autoantibody and Radiological Profiles as Prognostic Indicators in Idiopathic Inflammatory Myopathies: Insights into Mortality and Interstitial Lung Disease Development
cristiana sieiro santos¹, Miriam Retuerto², Laura Sierra², Jose Ordas Martínez³, Paula Pérez García², Pedro Baenas², Clara Moriano Morales² and Elvira Díez Álvarez⁴, ¹Rheumatology Department, Complejo Asistencial Universitario de León, León, Spain, Leon, Spain, ²Complejo Asistencial Universitario de León, León, Spain, ³Complejo Asistencial Universitario de Leon, Leon, ⁴Complejo Asistencial Universitario de León, Leon, Spain
Background/Purpose: The idiopathic inflammatory myopathies (IIMs) constitute a diverse group of acquired muscle disorders, often involving multiple organs such as the skin, heart, and lungs.…
Abstract Number: 2059 • ACR Convergence 2024
The Rs35705950 Promoter Variant of Muc5b Is Associated with Usual Interstitial Pneumonia in Antisynthetase Syndrome
Daphne Rivero Gallegos¹, Mayra Mejía², Karol J. Nava-Quiroz², Heidegger N. Mateos-Toledo³, Héctor I. Rocha-González⁴, Juan C. Huerta-Cruz³, Espiridion Ramos-Martínez⁵, Gloria Pérez-Rubio³, Ingrid Fricke-Galindo³, Jorge Rojas-Serrano⁶ and Ramcés Falfán-Valencia³, ¹INER, Ciudad de México, Mexico State, Mexico, ²INER, Mexico, Distrito Federal, Mexico, ³INER, Mexico City, Distrito Federal, Mexico, ⁴Instituto Politècnico Nacional, Mexico City, Distrito Federal, Mexico, ⁵UNAM, Ciudad de Mexico, Distrito Federal, Mexico, ⁶National Institute of Respiratory Diseases, Ismael Cosío Villegas, Mexico City, Mexico
Background/Purpose: Rs35705950 variant in the MUC5B gene promoter is a critical genetic risk factor in idiopathic pulmonary fibrosis (IPF). It has been associated with usual…

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