Abstracts tagged "Monocytes/macrophages"

Abstract Number: 0599 • ACR Convergence 2022
Expansion of HLA-DR+CD45RAhi Non-lymphoid Cells in Patients with Rheumatoid Arthritis
Christian Geier¹, Andras Perl² and Robert Winchester³, ¹SUNY Upstate Medical University, Syracuse, NY, ²SUNY, Syracuse, NY, ³Columbia University, New York, NY
Background/Purpose: In RA, aberrant lymphocytes can damage synovial joints and other organs. Antigen-presenting cells (APC) can activate lymphocytes and are considered critical to initiate immune…
Abstract Number: 0604 • ACR Convergence 2022
Altered Metabolic State in Myeloid Precursors and Mature Cells Within Rheumatoid Arthritis
Patricia Riedlova¹, Luís Almeida², Cecilia Ansalone³, Shatakshi Sood¹, Bart Everts² and Carl Goodyear¹, ¹University of Glasgow, Glasgow, Scotland, United Kingdom, ²Leiden University Medical Center, Leiden, Netherlands, ³UCSD and University of Glasgow, Glasgow, Scotland, United Kingdom
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterised by synovial inflammation and joint destruction. Prior research has revealed perturbation in the myeloid compartment of…
Abstract Number: 0652 • ACR Convergence 2022
Serum from Patients with SLE and Anti-MDA5 Antibody-Positive Dermatomyositis Induce Shared Monocyte Cytokine Signature Through Type 1 Interferon Pathway
Shohei Nakamura, Yuko okamoto, Yasuhiro Katsumata and Masayoshi Harigai, Division of Rheumatology, Department of Internal Medicine, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan
Background/Purpose: Although type 1 interferon (IFN) plays a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE) and polymyositis/dermatomyositis (PM/DM) [1] as typically evidenced…
Abstract Number: 0654 • ACR Convergence 2022
Lymphatic Dysfunction and Immune Activation in Lupus
william ambler¹, Madhavi Somaraju¹, JiHyun Sim¹, Ethan Seltzer¹, Noa Schwartz², Ecem Sevim³, Doruk Erkan¹, Jinyeon Shin⁴, Rahgu Kataru⁴, Babak Mehrara⁵ and theresa Lu¹, ¹Hospital for Special Surgery, New York, NY, ²Albert Einstein College of Medicine, New York, NY, ³Montefiore Medical Center - Wakefield Campus, New York, NY, ⁴Memorial Sloan Kettering, New York, NY, ⁵Department of Surgery, Division of Plastic and Reconstructive Surgery, Memorial Sloan Kettering, New York, NY
Background/Purpose: Systemic lupus erythematosus is a prototypic autoimmune disease in which patients frequently have photosensitivity. Exposure to ultraviolet radiation (UVR) causes the eruption of cutaneous…
Abstract Number: 0663 • ACR Convergence 2022
Anti-Erythrocyte Antibodies in Childhood Onset Systemic Lupus Erythematosus
Lauren Robinson¹, Zurong Wan², Preetha Balasubramanian³, Juan Rodriguez Alcazar³, Lynnette Walters⁴, Jeanine Baisch², karen onel⁵, Tracey Wright⁶, Virginia Pascual³ and Simone Caielli³, ¹Hospital for Special Surgery/New York Presbyterian-Weill Cornell, New York, NY, ²Weill Cornell Medicine, New York, NY, ³Weill Cornell Medical College, New York, NY, ⁴Scottish Rite Hospital for Children, Allen, TX, ⁵Hospital for Special Surgery, New York, NY, ⁶UT Southwestern, Plano, TX
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a disease characterized by the presence of auto-antibodies, immune complex deposition, and a robust type 1 interferon signature. It…
Abstract Number: 1167 • ACR Convergence 2022
Towards an Autologous 3D Skin-like Tissue Harboring Patient-Derived Fibroblasts, Keratinocytes, T-cells and Macrophages
Sasha Shenk¹, Jonathan Garlick¹, Lev Brown², Jamie Riesenberg², Christian Evans², Julia Jaffe Zweifach², Andrew Macklin², Tamar Abel³, Noelle Kosarek⁴, Mengqi Huang⁵, Avi Smith¹, Tammara Wood³, Gretel Torres⁶, Patricia pioli⁶ and Michael Whitfield⁷, ¹Tufts University School of Dental Medicine, Boston, MA, ²Tufts University, Boston, MA, ³Dartmouth College, Hanover, NH, ⁴Dartmouth Geisel School of Medicine, Lebanon, NH, ⁵University of Pittsburgh, Pittsburgh, PN, ⁶Geisel School of Medicine at Dartmouth, Lebanon, NH, ⁷Dartmouth Geisel School of Medicine, Department of Biomedical Data Science, Lebanon, NH
Background/Purpose: Scleroderma (Systemic Sclerosis; SSc) is an autoimmune disease of unknown etiology that is characterized by vascular dysfunction, fibrosis, and inflammation. A lack of human…
Abstract Number: 1169 • ACR Convergence 2022
Downregulated Fli1 in Systemic Sclerosis Myeloid Cells Contributes to Enhanced Transendothelial Migration
Pablo Weilg Espejo¹, Taha Dinc², Fatima El Adili³, Maria Trojanowska⁴ and Andreea Bujor⁴, ¹Boston Medical Center, Chelsea, MA, ²Boston University School of Medicine, Boston, MA, ³Boston University School of Medicine, Revere, MA, ⁴Boston University, Boston, MA
Background/Purpose: The mononuclear phagocytic system in Systemic Sclerosis (SSc) is central to fibrogenesis and may contribute to fibrosis via enhanced monocyte migration into injured tissues…
Abstract Number: 1565 • ACR Convergence 2022
Dissection of Ocular and Peripheral Blood Immune Phenotypes Suggests Preferential Transmigration of CD16+ Monocytes to Effector Sites in Behçet’s Disease
Yesim Ozguler¹, Ziyan Lin², Ann Cavers³, gulen Hatemi⁴, Olivier Manches⁵ and Johannes Nowatzky³, ¹Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, New York, NY, ²NYU Grossman School of Medicine, NYU Langone Applied Informatics Laboratories, New York, NY, ³NYU Grossman School of Medicine, New York, NY, ⁴Istanbul University-Cerrahpaşa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, ⁵Recherche et Développement, Immunobiology and Immunotherapy in Chronic Diseases, Institute for Advanced Biosciences, Inserm U 1209, CNRS UMR 5309, Université Grenoble Alpes Etablissement Français du Sang Auvergne-Rhône-Alpes, Grenoble, France
Background/Purpose: Cellular immunity of Behçet's Disease (BD) remains poorly understood. Previous work has provided clues pointing to most innate and adaptive immune cell types in…
Abstract Number: 1699 • ACR Convergence 2022
Arthritis-associated Synovial CD64-Ly6c- myeloid Cells Comprise 2 Subpopulations
Yidan Wang¹, Miranda Gurra¹, Carla Cuda¹, Hadijat Makinde¹, Shangyang Chen¹, Gaurav Gadhvi¹, Salina Dominguez¹, Caroline Shah¹, Deborah Winter² and Harris Perlman¹, ¹Northwestern University, Chicago, IL, ²Northwestern University, Skokie, IL
Background/Purpose: Monocytes are critical for the pathogenesis of rheumatoid arthritis (RA). However, depletion of circulating monocytes – either classical or non-classical monocytes – is not…
Abstract Number: 1710 • ACR Convergence 2022
CCL2 Drives Interferon-enhanced Monocytosis in UV-mediated Skin Injury in Murine Lupus
Mitra Maz¹, Hong Shi², Sonya Wolf-Fortune³, Shannon Estadt³, Alayka Reddy³, Rachael Wasikowski³, Alex Tsoi³, Celine Berthier³ and J. Michelle Kahlenberg³, ¹University of Michigan Medical School, Ann Arbor, MI, ²Department of Internal Medicine/Division of Rheumatology, Vascular Biology Center, Augusta, GA, ³University of Michigan, Ann Arbor, MI
Background/Purpose: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by overproduction of type I interferons (IFNs) and sensitivity to ultraviolet (UV) light. Though…
Abstract Number: 1890 • ACR Convergence 2021
Cellular Origin and Functions of Osteoclasts in Inflammatory Arthritis
Hannah Nelson¹, Ellen Gravallese², Julia Charles¹ and Christian Jacome-Galarza¹, ¹Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA
Background/Purpose: Inflammatory arthritis (IA) is an autoimmune disease targeting multiple joints and characterized by joint destruction caused by osteoclasts (OC), leading to physical disability. However,…
Abstract Number: 0022 • ACR Convergence 2021
The Effects of MAA-Modified and/or Citrullinated Proteins on Calcium Influx and Peptidyl Arginine Deiminase (PAD) Expression in Macrophage
Andrew Gerber, Michael Duryee, Nozima Aripova, Bryant England, James O'Dell, Ted Mikuls and Geoffrey Thiele, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Expressed in synovial fluid mononuclear and other inflammatory cells, peptidyl arginine deiminase (PAD) catalyzes post-translational citrullination of synovial proteins in a calcium (Ca2+)-dependent manner.…
Abstract Number: 0040 • ACR Convergence 2021
M1-M2 Polarization by CTLA4-Ig (Abatacept) on Cultured Circulating Monocytes from Rheumatoid Arthritis Patients and Healthy Subjects
Samuele tardito¹, Stefano Soldano², Emanuele Gotelli², Paola Montagna¹, Rosanna Campitiello², Sabrina Paolino², Carmen Pizzorni¹, Alberto Sulli², Vanessa Smith³ and Maurizio Cutolo², ¹Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Dept. Internal Medicine, University of Genova, IRCCS Polyclinic San Martino Hospital, Genoa, Italy, ²Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Polyclinic San Martino Hospital, Genoa, Italy, ³Department of Rheumatology and Internal Medicine, Ghent University Hospital, Ghent, Belgium
Background/Purpose: Rheumatoid Arthritis (RA) is a chronic autoimmune disorder affecting 1% of the population worldwide [1]. Monocytes/macrophages are known to play a crucial role in…
Abstract Number: 0041 • ACR Convergence 2021
Vascularized ‘Synovium-on-a-Chip’ – A Novel and Adaptable Model for Dissecting Inflammatory Biology Underlying Rheumatoid Arthritis
Theresa Wampler Muskardin¹, Chao Ma², Benteng Ma², Kayla Van Buren³, Timothy Niewold⁴ and Weiqiang Chen², ¹Colton Center for Autoimmunity, NYU School of Medicine, New York, NY, ²New York University, New York, NY, ³Mnemo Therapeutics, New York, NY, ⁴Colton Center for Autoimmunity NYU School of Medicine, New York, NY
Background/Purpose: Rheumatoid arthritis (RA) is a common multisystem inflammatory condition, affecting approximately 1% of the world population. The mechanisms underlying RA are still incompletely defined…
Abstract Number: 0508 • ACR Convergence 2021
The Impact of Macrophages Stimulated with Malondialdehyde-Acetaldehyde And/or Citrulline Modified Proteins on Fibroblasts Activation
Nozima Aripova, Michael Duryee, Evan Ryan, Peter Maloley, Bryant England, James O'Dell, Ted Mikuls and Geoffrey Thiele, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: In rheumatoid arthritis (RA), chronic synovial inflammation is accompanied by fibrotic responses that together lead to pannus formation and progressive joint damage. Exposure to…

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