ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "Monocytes/macrophages"

  • Abstract Number: 1169 • ACR Convergence 2022

    Downregulated Fli1 in Systemic Sclerosis Myeloid Cells Contributes to Enhanced Transendothelial Migration

    Pablo Weilg Espejo1, Taha Dinc2, Fatima El Adili3, Maria Trojanowska4 and Andreea Bujor4, 1Boston Medical Center, Chelsea, MA, 2Boston University School of Medicine, Boston, MA, 3Boston University School of Medicine, Revere, MA, 4Boston University, Boston, MA

    Background/Purpose: The mononuclear phagocytic system in Systemic Sclerosis (SSc) is central to fibrogenesis and may contribute to fibrosis via enhanced monocyte migration into injured tissues…
  • Abstract Number: 1565 • ACR Convergence 2022

    Dissection of Ocular and Peripheral Blood Immune Phenotypes Suggests Preferential Transmigration of CD16+ Monocytes to Effector Sites in Behçet’s Disease

    Yesim Ozguler1, Ziyan Lin2, Ann Cavers3, gulen Hatemi4, Olivier Manches5 and Johannes Nowatzky3, 1Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, New York, NY, 2NYU Grossman School of Medicine, NYU Langone Applied Informatics Laboratories, New York, NY, 3NYU Grossman School of Medicine, New York, NY, 4Istanbul University-Cerrahpaşa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 5Recherche et Développement, Immunobiology and Immunotherapy in Chronic Diseases, Institute for Advanced Biosciences, Inserm U 1209, CNRS UMR 5309, Université Grenoble Alpes Etablissement Français du Sang Auvergne-Rhône-Alpes, Grenoble, France

    Background/Purpose: Cellular immunity of Behçet's Disease (BD) remains poorly understood. Previous work has provided clues pointing to most innate and adaptive immune cell types in…
  • Abstract Number: 1699 • ACR Convergence 2022

    Arthritis-associated Synovial CD64-Ly6c- myeloid Cells Comprise 2 Subpopulations

    Yidan Wang1, Miranda Gurra1, Carla Cuda1, Hadijat Makinde1, Shangyang Chen1, Gaurav Gadhvi1, Salina Dominguez1, Caroline Shah1, Deborah Winter2 and Harris Perlman1, 1Northwestern University, Chicago, IL, 2Northwestern University, Skokie, IL

    Background/Purpose: Monocytes are critical for the pathogenesis of rheumatoid arthritis (RA). However, depletion of circulating monocytes – either classical or non-classical monocytes – is not…
  • Abstract Number: 1710 • ACR Convergence 2022

    CCL2 Drives Interferon-enhanced Monocytosis in UV-mediated Skin Injury in Murine Lupus

    Mitra Maz1, Hong Shi2, Sonya Wolf-Fortune3, Shannon Estadt3, Alayka Reddy3, Rachael Wasikowski3, Alex Tsoi3, Celine Berthier3 and J. Michelle Kahlenberg3, 1University of Michigan Medical School, Ann Arbor, MI, 2Department of Internal Medicine/Division of Rheumatology, Vascular Biology Center, Augusta, GA, 3University of Michigan, Ann Arbor, MI

    Background/Purpose: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by overproduction of type I interferons (IFNs) and sensitivity to ultraviolet (UV) light. Though…
  • Abstract Number: 2003 • ACR Convergence 2022

    Anti-rheumatic Treatment Modulates Expression of the Glycolytic Enzyme PFKFB3 in CD14+ Monocytes of Patients with Rheumatoid Arthritis, Which Contributes to Dissimilarities of the IFN Signature

    Malin Erlandsson1, Karin Andersson1, Sofia Töyrä Silfverswärd2, Rille pullerits2 and Maria Bokarewa2, 1Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden, 2Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden

    Background/Purpose: Combination of IFN-stimulated genes known as IFN signature, helps to predict disease activity and treatment response in several autoimmune diseases, including rheumatoid arthritis (RA).…
  • Abstract Number: 0004 • ACR Convergence 2022

    mTORC1 Drives the Spectrum of Pathology in Systemic JIA and Macrophage Activation Syndrome

    zhengping huang1, xiaomeng You2, Liang Chen3, Yan Du3, Kailey Brodeur3, Qiang Wang3, David Sykes4, Margaret Chang5, Julia Charles2, Peter Nigrovic5 and Pui Lee5, 1Guangdong Second Provincial Hospital, Guangzhou, China, 2Brigham and Women's Hospital, Boston, MA, 3Boston Children's Hospital, Boston, MA, 4Massachusetts General Hospital, Boston, MA, 5Division of Immunology, Boston Children's Hospital, Boston, MA

    Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is a severe inflammatory syndrome characterized by fever, skin rash and arthritis. A subset of patients with sJIA develop…
  • Abstract Number: 2144 • ACR Convergence 2022

    JAK Inhibition Re-balances Gene Expression Profile of Circulating Immune Cells in Patients with Psoriatic Arthritis

    Maria Gabriella Raimondo1, Charles Gwellem Anchang1, Hannah Labinsky2, Mina Saad Aziz Saad1, Simon Rauber1, Mario Vogg1, Eleni Kampylafka1, Johannes Knitza1, Alina Soare1, Georg Schett3 and Andreas Ramming1, 1Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054 Erlangen, Germany; Deutsches Zentrum Immuntherapie, Friedrich-Alexander-UniversityErlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, 2Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054 Erlangen, Germany; Deutsches Zentrum Immuntherapie, Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, 3Universitätsklinikum Erlangen, Erlangen, Germany

    Background/Purpose: Janus Kinase (JAK)/Signal Transducers and Activator of Transcription (STAT) is not only involved in IL23- signaling, but rather implemented into a broad range of…
  • Abstract Number: 0152 • ACR Convergence 2022

    Pm/Scl Patients Have an Expanded Population of CD19+CD21lo/negCD11c+CD11b+ Cells Expressing a Monocyte, Not B Cell, Transcriptome

    Erin Wilfong, Leslie Crofford and Rachel Bonami, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: CD19 is considered a canonical B cell lineage marker. Previously, we have reported that CD19+CD21lo/negCD11c+ cells were increased in both systemic sclerosis [PMC8828801] as…
  • Abstract Number: 2181 • ACR Convergence 2022

    Gut Microbe-derived Short-Chain Fatty Acids Regulate Arthritis and Myositis During Chikungunya Virus Infection

    Fang R. Zhao1, Emma Winkler1, Chun-Jun Guo2, Russell B. Williams3, Leran Wang1, Ana Jung1, Lindsay Droit1, Leah Heath1, Ting-ting Li2, Matthias Mack4, Megan T. Baldridge1, Thaddeus S. Stappenbeck5, Larissa B. Thackray1, Scott A. Handley1, Michael A. Fischbach6 and Michael S. Diamond1, 1Washington University in St. Louis, St. Louis, MO, 2Cornell University, New York, NY, 3Donald Danforth Plant Science Center, St. Louis, MO, 4University Hospital Regensburg, Regensburg, Germany, 5Cleveland Clinic, Cleveland, OH, 6Stanford University, Stanford, CA

    Background/Purpose: The intestinal microbiota regulates musculoskeletal inflammation and antibiotic use increases risk for the development or relapse of inflammatory arthritis. However, the basis for this…
  • Abstract Number: 0249 • ACR Convergence 2022

    Identification of Distinct Peripheral Blood Myeloid Cell Subpopulations in Patients with Rheumatoid Arthritis-associated Interstitial Lung Disease

    Jill Poole1, Bryant England1, Kathryn Cole1, James Talmadge1, Amy Nelson1, Rohit Gaurav1, Aaron Schwabb1, Angela Gleason1, Michael Duryee1, Rhonda Walenz1, Bridget Kramer1, Joel VanDeGraaff1, Sara May1, Geoffrey Thiele1 and Ted Mikuls2, 1University of Nebraska Medical Center, Omaha, NE, 2Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Interstitial lung disease (ILD) is associated with significant morbidity and mortality in rheumatoid arthritis (RA). The key cellular players of RA-ILD remain largely unknown.…
  • Abstract Number: 0022 • ACR Convergence 2021

    The Effects of MAA-Modified and/or Citrullinated Proteins on Calcium Influx and Peptidyl Arginine Deiminase (PAD) Expression in Macrophage

    Andrew Gerber, Michael Duryee, Nozima Aripova, Bryant England, James O'Dell, Ted Mikuls and Geoffrey Thiele, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Expressed in synovial fluid mononuclear and other inflammatory cells, peptidyl arginine deiminase (PAD) catalyzes post-translational citrullination of synovial proteins in a calcium (Ca2+)-dependent manner.…
  • Abstract Number: 0040 • ACR Convergence 2021

    M1-M2 Polarization by CTLA4-Ig (Abatacept) on Cultured Circulating Monocytes from Rheumatoid Arthritis Patients and Healthy Subjects

    Samuele tardito1, Stefano Soldano2, Emanuele Gotelli2, Paola Montagna1, Rosanna Campitiello2, Sabrina Paolino2, Carmen Pizzorni1, Alberto Sulli2, Vanessa Smith3 and Maurizio Cutolo2, 1Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Dept. Internal Medicine, University of Genova, IRCCS Polyclinic San Martino Hospital, Genoa, Italy, 2Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Polyclinic San Martino Hospital, Genoa, Italy, 3Department of Rheumatology and Internal Medicine, Ghent University Hospital, Ghent, Belgium

    Background/Purpose: Rheumatoid Arthritis (RA) is a chronic autoimmune disorder affecting 1% of the population worldwide [1]. Monocytes/macrophages are known to play a crucial role in…
  • Abstract Number: 0041 • ACR Convergence 2021

    Vascularized ‘Synovium-on-a-Chip’ – A Novel and Adaptable Model for Dissecting Inflammatory Biology Underlying Rheumatoid Arthritis

    Theresa Wampler Muskardin1, Chao Ma2, Benteng Ma2, Kayla Van Buren3, Timothy Niewold4 and Weiqiang Chen2, 1Colton Center for Autoimmunity, NYU School of Medicine, New York, NY, 2New York University, New York, NY, 3Mnemo Therapeutics, New York, NY, 4Colton Center for Autoimmunity NYU School of Medicine, New York, NY

    Background/Purpose: Rheumatoid arthritis (RA) is a common multisystem inflammatory condition, affecting approximately 1% of the world population. The mechanisms underlying RA are still incompletely defined…
  • Abstract Number: 0508 • ACR Convergence 2021

    The Impact of Macrophages Stimulated with Malondialdehyde-Acetaldehyde And/or Citrulline Modified Proteins on Fibroblasts Activation

    Nozima Aripova, Michael Duryee, Evan Ryan, Peter Maloley, Bryant England, James O'Dell, Ted Mikuls and Geoffrey Thiele, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: In rheumatoid arthritis (RA), chronic synovial inflammation is accompanied by fibrotic responses that together lead to pannus formation and progressive joint damage. Exposure to…
  • Abstract Number: 0513 • ACR Convergence 2021

    Spirulina Activates IFNγ via TLR4 in Dermatomyositis Skin and Peripheral Blood

    DeAnna Diaz1, Thomas Vazquez2, Christina Bax3, Jay Patel4, Madison Grinnell5, Emily Keyes6, Yubin Li5 and Victoria Werth7, 1Philadelphia College of Medicine, Philadelphia, PA, 2FIU Wertheim College of Medicine, Virginia Beach, VA, 3Corporal Michael J. Crescenz VAMC/ Department of Dermatology, U Penn, Philadelphia, PA, 4Corporal Michael J. Crescenz VAMC, Department of Dermatology, U Penn, Philadelphia, NJ, 5Corporal Michael J. Crescenz VAMC, Department of Dermatology, U Penn, Philadelphia, PA, 6Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania and Philadelphia VAMC, Philadelphia, PA, 7University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Our group has previously shown that Spirulina, a popular herbal supplement with purported immune boosting effects, is temporally associated with dermatomyositis (DM) onset and…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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