ACR Meeting Abstracts

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Abstracts tagged "Monocytes/macrophages"

  • Abstract Number: 0946 • ACR Convergence 2024

    Tissue Resident Monocyte-lineage Cells (TR-MC) Exist as Two Different Subpopulations

    Yidan Wang1, Jessica Maciuch2, Tyler Therron3, Carla Cuda2, Deborah Winter4 and Harris Perlman2, 1Northwestern University, Hanover Park, IL, 2Northwestern University, Chicago, IL, 3Northwestern University, Chicago, 4Northwestern University, Skokie, IL

    Background/Purpose: Monocytes are critical for the pathogenesis of rheumatoid arthritis (RA). However, depletion of peripheral monocytes (PM) is not sufficient to rescue disease in RA…
  • Abstract Number: 0962 • ACR Convergence 2024

    Characterizing the Contribution of Myeloid Cells to Limited and Diffuse Cutaneous Systemic Sclerosis

    Parker Jones1, Salina Dominguez2, Miranda Gurra3, Gaurav Gadhvi4, Tyler Therron2, Kathleen Aren5, Carla Cuda3, Monique Hinchcliff6, Harris Perlman3, Hadijat Makinde3 and Deborah Winter7, 1Northwestern University Feinberg School of Medicine, Chicago, IL, 2Northwestern University, Chicago, 3Northwestern University, Chicago, IL, 4University of Michigan, Ann Arbor, MI, 5Northwestern University Division of Rheumatology, Chicago, IL, 6Yale School of Medicine, Westport, CT, 7Northwestern University, Skokie, IL

    Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by multiorgan fibrosis. The two main subtypes are diffuse cutaneous SSc (dcSSc) and limited cutaneous SSc…
  • Abstract Number: 0970 • ACR Convergence 2024

    Deubiquitylase (DUB) BRCC36 Isopeptidase Complex (BRISC) Inhibitors Prevent IFNAR1 Deubiquitination to Restore Natural Type I IFN Response in Autoimmunity

    Rebecca Ross1, Poli Adi Narayanna Reddy2, Joseph Salvino2, Elton Zeqiraj3 and Francesco Del Galdo3, 1Medicine and Health, University of Leeds, Leeds, United Kingdom, 2The Wistar Institute, Philadelphia, PA, 3University of Leeds, Leeds, United Kingdom

    Background/Purpose: Increased Type I IFN activation plays a key role in Scleroderma (SSc), Systemic Lupus Erythematosus and Inflammatory Myositis. Deubiquitylase (DUB) BRCC36 isopeptidase complex (BRISC)…
  • Abstract Number: 1139 • ACR Convergence 2024

    Comprehensive Single-cell Profiling of Diverse Circulating Immune Cells in Idiopathic Inflammatory Myopathies Identifies a Novel Pathogenic Subset of Monocytes

    Shinji Izuka1, Toshihiko Komai2, Hayato Yuuki2, Ikuko Ueda3, Manabu Fujimoto4, Hiroyuki Fukui5, Masaru Takeshita6, Natsuka Umezawa7, Shinsuke Yasuda7, Mitsutaka Yasuda8, Yuichiro Fujieda9, Tatsuya Atsumi9, Takeshi Iwasaki10, Akio Morinobu10, Yuya Kondo11, Isao Matsumoto11, Toshio Kawamoto12, Masakazu Matsushita12, Naoto Tamura13, Taro Iwamoto14, Hiroshi Nakajima14, Ken Yoshida15, Takeo Isozaki16, Nobuyuki Yajima16, Keiichi Sakurai17, Kimito Kawahata17, Yasuyuki Kamata18, Kojiro Sato18, Yoshiya Tanaka19, Akari Suzuki20, Kazuhiko Yamamoto21, Tomohisa Okamura22 and Keishi Fujio2, 1Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Tokyo, Japan, 2Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Bunkyo, Tokyo, Japan, 3Department of Dermatology, Osaka University Graduate School of Medicine, Suita, Japan., Suita, Japan, 4Department of Dermatology, Osaka University Graduate School of Medicine, Suita, Japan., Suita, Osaka, Japan, 5Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan., Tokyo, Japan, 6Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan, 7Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan., Tokyo, Japan, 8Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan., Sapporo, Japan, 9Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, Sapporo, Japan, 10Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Kyoto, Japan, 11Department of Rheumatology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan., Tsukuba, Japan, 12Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan., Tokyo, Japan, 13Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, 14Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan., Chiba, Japan, 15Division of Rheumatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan., Tokyo, Japan, 16Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan., Tokyo, Japan, 17Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan., Kawasaki, Japan, 18Division of Rheumatology and Clinical Immunology, Department of Medicine, Jichi Medical University, Tochigi, Japan., Tochigi, Japan, 19Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan, 20Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan., Kanagawa, Japan, 21Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan., Kawasaki, Japan, 22Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Department of Functional Genomics and Immunological Diseases, Graduate School of Medicine, The University of Tokyo, Japan., Bunkyo, Tokyo, Japan

    Background/Purpose: Idiopathic inflammatory myopathies (IIMs) are heterogeneous diseases, making it crucial to identify distinct pathological processes to improve a treatment strategy. Transcriptomic analyses have revealed…
  • Abstract Number: 1421 • ACR Convergence 2024

    Differential Impact of B-cell Targeted Monotherapy and Combination Regimen on the Peripheral Blood Transcriptome of Adults with Active Sjögren Disease

    Coziana Ciurtin1, Lucia Martin-Gutierrez1, John Casement2, Kyle Thompson3, Fai Ng4, Andre van Maurik5 and Elizabeth Jury1, 1University College London, London, United Kingdom, 2Newcastle University, Newcastle, United Kingdom, 3Newcastle University, Newcastle, England, United Kingdom, 4Newcastle University, Newcastle upon Tyne, England, United Kingdom, 5Precision Medicine, GlaxoSmithKline, Stevenage, United Kingdom

    Background/Purpose: Sjögren disease (SD) is characterised by B-cell hyperactivity associated with increased levels of B-lymphocyte stimulator (BlyS), but there are no effective biologic treatments for…
  • Abstract Number: 1656 • ACR Convergence 2024

    Loss of Nr4a1 Expression Protects Cartilage During Post-traumatic Osteoarthritis

    Katherine Escalera-Rivera, Jennifer Jonason and Jennifer Anolik, University of Rochester Medical Center, Rochester, NY

    Background/Purpose: Osteoarthritis (OA) is a complex disease involving pathological processes in joint tissues such as the cartilage and synovium. Cartilage is degraded by matrix metalloproteinases…
  • Abstract Number: 1712 • ACR Convergence 2024

    Transcriptome Analysis Characterizes the Role of Monocytes in Ankylosing Spondylitis with TNF-blocker Treatment

    Yulong Tang1, Jiangnan Xie2, Dachun Zhuo1, Qi ZHU3, Jiucun Wang1 and Jing Liu2, 1Fudan University, Shanghai, China (People's Republic), 2Fudan University, Shanghai, Shanghai, China (People's Republic), 3Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, China (People's Republic)

    Background/Purpose: Ankylosing spondylitis (AS) is an autoimmune and auto-inflammatory disease characterized by chronic inflammation of the spine, sacroiliac joint, and occasionally peripheral joints. TNF-α inhibitor…
  • Abstract Number: 2363 • ACR Convergence 2023

    Increase in Macrophage Infiltration in Scleroderma Esophageal Mucosa Is Associated with Motility and Mucosal Complications

    Tai-Ju Lee1, Ting-Yuan Lan1, Ko-Jen Li2, Song-Chou Hsieh2 and Ping-Huei Tseng3, 1National Taiwan University Hospital Hsinchu Branch, Hsinchu City, Taiwan, 2National Taiwan University Hospital, Taipei, Taiwan, 3National Taiwan University Hospital, Taipei City, Taiwan

    Background/Purpose: The macrophage activation is elevated in systemic sclerosis (SSc) patients, and is implicated in pathogenesis of tissue inflammation, fibrosis, and the development of skin…
  • Abstract Number: 2440 • ACR Convergence 2023

    Synovial Shaping of Skin-derived Migrating Immune Cells Determines Initiation of Inflammation in Psoriatic Arthritis

    Maria Gabriella Raimondo1, Simon Rauber2, Hashem Mohammadian3, Mario Angeli1, Cong Xu1, Aleix Rius Rigau4, Markus Luber1, Hannah Labinsky5, Alina Ramming1, Stefano Alivernini6, Jörg Distler1, Ursula Fearon7, Douglas Veale8, Michael Sticherling9, Juan D Canete10, Georg Schett11 and Andreas Ramming1, 1Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany; Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, 23 Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany. 4 Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany, 3Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany. Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, 4Department of Internal Medicine 3, Rheumatology and Clinical Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany; Deutsches Zentrum Immuntherapie (DZI), FAU Erlangen-Nürnberg and University Hospital Erlangen, Erlangen, Germany, 5Medical Department II, Rheumatology, University Hospital Würzburg, Würzburg, Germany, 6Immunology Research Core Facility, Gemelli Science and Technology Park, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Division of Rheumatology - Fondazione Policlinico Universitario A. Gemelli IRCCS - Università Cattolica del Sacro Cuore, Rome, Italy, 7Trinity College Dublin, Dublin, Ireland, 8St.Vincent's University Hosp, Dublin, Ireland, 9Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg & Universitätsklinikum Erlangen, Department of Dermatology, Erlangen, Germany, 10Hospital Clinic an IDIBAPS, Barcelona, Spain, 11Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

    Background/Purpose: Around 30% of the patients with psoriasis (PsO) develop psoriatic arthritis (PsA) overtime, suggesting the existence of a disease mediated skin-joint crosstalk. To date,…
  • Abstract Number: 0035 • ACR Convergence 2023

    Using Genotyping and Functional Data from Monocytes to Identify Risk-Driving SNPs on JIA Risk Haplotypes

    Emma Haley1, gilad Barshad2, Adam He2, Edward J Rice3, Elizabeth Crinzi1, Marc Sudman4, Susan Thompson5, Charles G Danko3 and James N Jarvis6, 1Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, 2Cornell University, Ithaca, NY, 3Baker Institute of Animal Health Cornell University, Ithaca, NY, 4Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 5Cincinnati Children's Hospital Medical Center/University of Cincinnati College of Medicine, Blue Ash, OH, 6University at Buffalo Jacobs School of Medicine, Buffalo, NY

    Background/Purpose: GWAS have identified multiple genetic regions that confer risk for juvenile idiopathic arthritis (JIA).However, identifying the single nucleotide polymorphisms (SNPs) that drive disease risk…
  • Abstract Number: 0041 • ACR Convergence 2023

    Interactions Between Synovial Fibroblasts and Macrophages: Implications for Tissue Remodeling in Chronic Inflammatory Diseases and Macrophage Differentiation in Response to the Immune Microenvironment

    Jia Li, Yanrong Cai, Xin Guan, Meike Ewald, Lars-Oliver Tykocinski, Hanns-Martin Lorenz and Theresa Tretter, Department of Internal Medicine V, Div. of Rheumatology, University Hospital Heidelberg, Heidelberg, Germany

    Background/Purpose: Activated macrophages (Mph) can be subdivided in at least 2 major subgroups according to their polarization into classical pro-(M1-Mph) or anti-inflammatory (M2-Mph) subtypes. Together…
  • Abstract Number: 0054 • ACR Convergence 2023

    RA Monocytes and Monocyte-Derived Macrophages Display Heightened Inflammatory Responses, Reduced Endocytic Capacity and Distinct TET Expression Compared to PsA Monocytes

    Success Amaechi1, Megan Hanlon2, Alyssa Gilmore2, Dumitru Anton2, Mary Canavan3, Sonia Sundanum4, Carl Orr5, Douglas Veale6, Viviana Marzaioli7 and Ursula Fearon8, 1Trinity College Dublin, Mullingar, Ireland, 2Molecular Rheumatology Department, Trinity Biomedical Sciences Institute, Trinity College Dublin, EULAR Centre for Arthritis and Rheumatic Diseases, St Vincent University Hospital, University College Dublin, Dublin, Ireland, 3Molecular Rheumatology Department, Trinity Biomedical Sciences Institute, Trinity College Dublin, EULAR Centre for Arthritis and Rheumatic Diseases, St Vincent University Hospital, University College Dublin, School of Biochemistry & Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, 4EULAR Centre for Arthritis and Rheumatic Diseases, St Vincent University Hospital, University College Dublin, Dublin, Ireland, 5Saint Vincent's University Hospital, Dublin, Ireland, 6St.Vincent's University Hosp, Dublin, Ireland, 7Trinity College Dublin and University College Dublin, Dublin, Ireland, 8Trinity College Dublin, Dublin, Ireland

    Background/Purpose: RA and PsA share various pathogenic features, while also displaying significant differences at the clinical, cellular and molecular levels. In this study, we investigate…
  • Abstract Number: 0061 • ACR Convergence 2023

    Discovery of a RIPK2 Scaffolding Inhibitor for the Treatment of Joint Autoimmune Diseases

    Marta Wlodarska1, Chad Van Huis2, Florian Hoss3, Rosana Meyer1, Xiaokang Lu2, Dominik Koelmel2, Brian Sanchez2, Chuck Lesch2, Alissa Telling2, Martin Minns1, Nneka Mbah2, Isabelle Lacan1, Robert Aversa1, Charles Lesburg1, Carmen Yu2, Stephen Soisson1, Natalie Dales1, Darryl Patrick1, Anthony Opipari2, Shifeng Pan4 and Luigi Franchi2, 1Odyssey Therapeutics, Boston, MA, 2Odyssey Therapeutics, Ann Arbor, MI, 3Odyssey Therapeutics, Frankfurt, Germany, 4Odyssey Therapeutics, San Diego, CA

    Background/Purpose: Receptor interacting protein kinase 2 (RIPK2) is a key signaling node for inflammation caused by peptidoglycan (PGN). In the intestine, RIPK2 integrates signaling originating…
  • Abstract Number: 0062 • ACR Convergence 2023

    Differential Metabolic Profiles, Activation and Circadian Dynamics in Rheumatoid Arthritis and Psoriatic Arthritis Circulatory Monocytes

    Alyssa Gilmore1, Success Amaechi2, Megan Hanlon3, Dumitru Anton4, Carl Orr5, Viviana Marzaioli6, Douglas Veale7 and Ursula Fearon1, 1Trinity College Dublin, Dublin, Ireland, 2Trinity College Dublin, Mullingar, Ireland, 3Molecular Rheumatology, Dublin, Ireland, 4Molecular Rheumatology Department, Trinity Biomedical Sciences Institute, Trinity College Dublin, EULAR Centre for Arthritis and Rheumatic Diseases, St Vincent University Hospital, University College Dublin, Dublin, Ireland, 5Saint Vincent's University Hospital, Dublin, Ireland, 6Trinity College Dublin and University College Dublin, Dublin, Ireland, 7St.Vincent's University Hosp, Dublin, Ireland

    Background/Purpose: While Rheumatoid Arthritis (RA) and Psoriatic Arthritis (PsA) share many features, they are distinct in clinical presentation and molecular profile. As monocytes are crucial…
  • Abstract Number: 0916 • ACR Convergence 2023

    Upregulation of the M-CSF Receptor on Non-Classical Monocytes from SLE Patients as an Indicator for Premature Monocyte Aging

    Markus Zeisbrich1, Stephanie Finzel2, Nils Venhoff1 and Reinhard Voll1, 1University Medical Center Freiburg, Freiburg, Germany, 2Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany

    Background/Purpose: Circulating monocytes are divided into three subsets: classical, intermediate, and non-classical monocytes. Monocytes egress from the bone marrow as classical monocytes and develop into…
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