Abstracts tagged "MicroRNA"

Abstract Number: 658 • 2016 ACR/ARHP Annual Meeting
Decreased Expression of Ten Micro-RNAs in Plasmacytoid Dendritic Cells of Patients with Primary SS Indicates Dysregulation on Multiple Levels
Maarten R. Hillen^1,2, Sofie L.M. Blokland^1,2, Elena Chouri^1,2, Aike A. Kruize¹, Marzia Rossato^1,2, Joel A.G. van Roon^1,2 and Timothy R.D.J. Radstake^1,2, ¹Department of Rheumatology & Clinical Immunology, UMC Utrecht, Utrecht, Netherlands, ²Laboratory of Translational Immunology, UMC Utrecht, Utrecht, Netherlands
Background/Purpose: Plasmacytoid dendritic cells (pDCs) are indicated to be key players in the pathogenesis of primary Sjögren’s syndrome (pSS) and important producers of type-1 interferon…
Abstract Number: 2099 • 2016 ACR/ARHP Annual Meeting
Micrornas As Potential Modulators of Atherothrombosis in Antiphospholipid Syndrome
Patricia Ruiz-Limon¹, Maria Ángeles Aguirre Zamorano², Nuria Barbarroja², Yolanda Jiménez-Gómez², IVÁN ARIAS DE LA ROSA², Eduardo Collantes-Estévez², Pedro Segui², Francisco Velasco³, Rocio Gonzalez-Conejero⁴, Raul Teruel⁴, Constantino Martinez⁴, Maria Jose Cuadrado⁵, Carlos Perez-Sanchez² and Chary Lopez-Pedrera², ¹Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³Hematology, IMIBIC-Reina Sofia Hospital, Hematology Unit, Cordoba, Spain, ⁴Regional Centre for Blood Donation, University of Murcia, Murcia, Spain, ⁵St Thomas Hospital, Lupus Research Unit, London, United Kingdom
Background/Purpose: 1) To identify and characterize microRNAs linked to thrombosis and atherosclerosis development in APS; 2) To assess the effects of antiphospholipid antibodies in that…
Abstract Number: 808 • 2016 ACR/ARHP Annual Meeting
Down-Regulation of microRNA-126 in Scleroderma Microvascular Endothelial Cells (MVECs) Is Associated with Impaired Responses to Vascular Endothelial Growth Factor (VEGF) and Defective Angiogenesis
bashar kahaleh¹, Nezam Altorok², Yongqing Wang³, Shadia Nada², Mohammed Madkhali³ and John Sun³, ¹Rheumatology, University of Toledo, Toledo, OH, ²Medicine/Rheumatology, University of Toledo, Toledo, OH, ³University of Toledo, Toledo, OH
Background/Purpose: Impaired angiogenesis in SSc is a crucial component of disease pathology that occurs in spite of upregulation of VEGF and other proangiogenic factors. MicroRNA-126…
Abstract Number: 2121 • 2016 ACR/ARHP Annual Meeting
Identification of microRNA-181a-5p and microRNA-4454 As Mediators of Facet Cartilage Degeneration
Akihiro Nakamura^1,2, Y. Raja Rampersaud^3,4, Anirudh Sharma^1,2, Stephen J. Lewis^3,5, Brian Wu^1,2, Poulami Datta^1,2, Kala Sundararajan⁶, Helal Endisha^1,2, Evgeny Rossomacha^1,2, Jason S Rockel^1,2, Igor Jurisica⁷ and Mohit kapoor^1,2,8, ¹Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ²Arthritis Program, University Health Netwok, Toronto, ON, Canada, ³Orthopaedic Surgery and Neurosurgery, Arthritis Program, University Health Network, Toronto, ON, Canada, ⁴Orthopaedics, Toronto Western Hospital, Toronto, ON, Canada, ⁵Spinal Program, Krembil Neuroscience Centre, Toronto Western Hospital, Toronto, ON, Canada, ⁶Orthopaedic Research Department, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, ⁷Medical Biophysics and Computer Science, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada, ⁸Surgery, Laboratory Medicine, and Pathobiology, University of Toronto, Toronto, ON, Canada
Background/Purpose: Osteoarthritis (OA) of spine (facet joints, FJ) is one of the major causes of severe low back pain and disability worldwide. However, specific mechanisms…
Abstract Number: 809 • 2016 ACR/ARHP Annual Meeting
Micrornas Targeting the Wnt Signalling Pathway in Black African Patients with Diffuse Cutaneous Systemic Sclerosis
Mohammed Tikly¹, Jacqueline Frost², Michèle Ramsay³, Eulalia Marti Puig⁴, Raquel Rabionet⁴, Xavier Estivill⁴ and Marc Friedländer⁵, ¹Division of Rheumatology, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa, ²University of the Witwatersrand, Johannesburg, South Africa, ³Division of Human Genetics, Sydney Brenner Institute for Molecular Biosciences, University of the Witwatersrand, Johannesburg, South Africa, ⁴Center for Genomic Regulation, Barcelona, Spain, ⁵Department of Molecular Biosciences, The Wenner-Gren Institute, Science for Life Laboratory, Stockholm, Sweden
Background/Purpose: Systemic sclerosis (SSc) is a complex autoimmune disease involving the immune system, vasculature and extracellular matrix [1]. Dysregulation of the Wnt pathway has been implicated in…
Abstract Number: 2122 • 2016 ACR/ARHP Annual Meeting
KiSS1 Is a Regulator of ADAMTS4 and ADAMTS5 Expression and Is Post-Transcriptionally Regulated By Micro-RNA N105 in Human OA Chondrocytes
Mohammad Shahidul Makki^1,2 and Tariq Haqqi³, ¹4209 St Rt 44 PO Box 95, Northeast Ohio Medical University, Rootstown, OH, ²Anatomy and Neurobiology, Northeast Ohio Medical University (NEOMED), Rootstown, OH, ³Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Background/Purpose: Osteoarthritis (OA) is a chronic and debilitating disease of the articulating joints in every population. Micro-RNAs are ~22 nucleotides long non-coding single stranded RNAs…
Abstract Number: 810 • 2016 ACR/ARHP Annual Meeting
Microrna-125b As a Potential Anti-Fibrotic and Anti-Apoptotic Regulator in Systemic Sclerosis
Anastasiia Kozlova¹, Elena Pachera¹, Florian Renoux², Michal Rudnik¹, Britta Maurer¹, Astrid Jüngel³, Joerg H.W Distler⁴, Gabriela Kania¹ and Oliver Distler¹, ¹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Depertment of Rheumatology, University Hospital Zurich, Schlieren, Switzerland, ³Ctr Exp Rheum, Univ Hosp Zurich / Zurich Ctr Integr Hum Physiol (ZIHP), Zurich, Switzerland, ⁴Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: MicroRNAs (miRs) are a class of small, noncoding RNAs that regulate many biological processes. Some microRNAs are involved in skin fibrosis. Here, we aimed…
Abstract Number: 2141 • 2016 ACR/ARHP Annual Meeting
Terminal Uridylyl Transferase ZCCHC6-Dependent Generation of miRNA Diversity in Primary Human Chondrocytes
Abdul Haseeb¹, Mohammad Shahidul Makki², Mohammad Ansari³, Helen Piontkivska⁴ and Tariq M. Haqqi¹, ¹Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH, ²4209 St Rt 44 PO Box 95, Northeast Ohio Medical University, Rootstown, OH, ³Anatomy & Neurobiology, Northeast Ohio Medical University, Roostown, OH, ⁴Kent State University, Kent, OH
Terminal Uridylyl Transferase ZCCHC6-dependent Generation Of miRNA Diversity In Primary Human Chondrocytes Background/Purpose: MicroRNAs (miRNAs) are a group of small, noncoding RNAs that post-transcriptionally regulate…
Abstract Number: 817 • 2016 ACR/ARHP Annual Meeting
RNA and Protein Cargo of Exosomes Isolated from Serum of Systemic Sclerosis Patients Induce a Profibrotic Phenotype in Cultured Normal Human Dermal Fibroblasts: A Potential Mechanism for the Initiation and Progression of a Profibrotic Phenotype in SSc
Peter J. Wermuth, Kellan R. Carney, Sonsoles Piera-Velazquez and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Exosomes are lipid bilayer-bound microvesicles that contain various macromolecules including numerous microRNA (miRNA) and proteins. Exosomes mediate intercellular communication by fusing and releasing their…
Abstract Number: 2413 • 2016 ACR/ARHP Annual Meeting
Inflammation Regulating microRNAs, Mir-146b, Mir-155 and Mir-192-5p Are Altered in Plasma and Synovial Fluid of Oligoarticular Juvenile Idiopathic Arthritis
Beata Derfalvi^1,2,3, Sarah Roberts⁴, Breanna Hargreaves⁴ and Sarah McAlpine⁴, ¹Pediatrics, Dalhousie University, Halifax, NS, Canada, ²IWK Health Centre, Halifax, NS, Canada, ³2nd. Dept. of Pediatrics, Semmelweis University, Budapest, Hungary, ⁴Dalhousie University, Halifax, NS, Canada
Background/Purpose: MicroRNAs (miRNAs) modulate gene expression by inhibiting the translation of targeted mRNAs and causing mRNA degradation in a transcript-specific manner. Several miRNAs have been reported…
Abstract Number: 1034 • 2016 ACR/ARHP Annual Meeting
Microrna-146a Controls Local Bone Destruction By Regulating Fibroblast Induced Osteoclastogenesis in Inflammatory Arthritis
Victoria Saferding¹, Antonia Puchner², Eliana Goncalves-Alves³, Melanie Hofmann³, Julia Brunner⁴, Emine Sahin⁴, Silvia Hayer⁵, Philippe Georgel⁶, Marije M. Koenders⁷, Gernot Schabbauer⁴, Josef S. Smolen⁸, Günter Steiner⁹, Kurt Redlich³ and Stephan Blüml¹⁰, ¹Rheumatology, Medical University of Vienna, Vienna, Austria, ²Department of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Vascular Biology and Thrombosis research, Medical University of Vienna, Vienna, Austria, ⁵Waehringer Guertel 18-20 A-A09, Medical University of Vienna, Vienna, Austria, ⁶Centre de Recherche en Immunologie et Hématologie, Université de Strasbourg, Strasbourg, France, ⁷Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, ⁸Department of Internal Medicine 3, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁹Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ¹⁰Internal Medicine 3; Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: MicroRNA (MiR-) 146a plays an important role in the regulation of the innate immune response and has also been shown to suppress cancer development…
Abstract Number: 2414 • 2016 ACR/ARHP Annual Meeting
Microrna Associated with Active Systemic Juvenile Idiopathic Arthritis Regulate CD163 Expression in Polarized Macrophages through Two Distinct Mechanisms
Thuy Do¹, Rachel Tan², Mark Bennett², Mario Medvedovic², Nan Shen³, Sherry Thornton¹, Alexei Grom¹ and Grant Schulert⁴, ¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²University of Cincinnati, Cincinnati, OH, ³Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: CD163 is a hemoglobin scavenger receptor and innate pattern recognition receptor, and a marker of activated monocytes and macrophages. It is also expressed on…
Abstract Number: 1197 • 2016 ACR/ARHP Annual Meeting
Certain Serum Micro-RNAs Are Associated with Osteoarthritis
Jean-Charles Rousseau¹, Elisabeth Sornay-Rendu¹, Olivier Borel¹ and Roland Chapurlat², ¹INSERM UMR 1033, Lyon, France, ²Service de Rhumatologie et Pathologie Osseuse, Hôpital Edouard Herriot, INSERM UMR 1033 and Université de Lyon and Hospices Civils de Lyon, Lyon, France
Background/Purpose: Sensitive and specific blood biomarkers to detect the initial stages of osteoarthritis (OA) and to predict the future development of the disease are not…
Abstract Number: 2713 • 2016 ACR/ARHP Annual Meeting
Differentially Expressed Microrna As Candidate Biomarker for Disease Activity in Ankylosing Spondylitis
Marina N. Magrey¹, Abdul Haseeb² and Tariq M Haqqi², ¹Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Differentially Expressed MicroRNA as candidate Biomarker for Disease Activity in Ankylosing Spondylitis Background/Purpose: MicroRNAs (miRNAs) have evolved as a novel class of biomarkers We proposed…
Abstract Number: 1568 • 2016 ACR/ARHP Annual Meeting
Microrna-17 Suppresses TNF-α Signaling By Reducing TRAF2 and cIAP2 Association in Rheumatoid Arthritis Synovial Fibroblasts
Nahid Akhtar¹, Anil Singh² and Salahuddin Ahmed¹, ¹Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, ²Washington State University, College of Pharmacy, Spokane, WA
Background/Purpose: TNF-α is a major cytokine implicated in rheumatoid arthritis (RA) and its expression has shown to be regulated at transcriptional and posttranscriptional levels.…

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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