Abstracts tagged "MicroRNA"

Abstract Number: 77 • 2016 ACR/ARHP Annual Meeting
Integrated Analysis of Microrna and mRNA Expression Profiles Related to Cardiovascular Disease in Monocytes from Systemic Lupus Erythematosus and Primary Antiphospholipid Syndrome Patients
Carlos Perez-Sanchez¹, Maria Ángeles Aguirre Zamorano¹, Patricia Ruiz-Limon², Nuria Barbarroja¹, Yolanda Jiménez-Gómez¹, Maria Carmen Abalos-Aguilera², Ivan Arias de la Rosa², María Galindo³, Eduardo Collantes-Estévez¹, Maria Jose Cuadrado⁴ and Chary Lopez-Pedrera¹, ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain, ⁴St Thomas Hospital, Lupus Research Unit, London, United Kingdom
Background/Purpose: The interplay between miRNAs and their mRNA targets might constitute an important mechanism in the regulation of the proatherothrombotic status of SLE and APS…
Abstract Number: 2063 • 2016 ACR/ARHP Annual Meeting
Identification of Microrna Predictive of Outcome in Lupus Nephritis
Mohammad Hadavand¹, Nada Binmadi², Hua Zhou³, Mayank Tandon⁴, Sarfaraz Hasni⁵ and Illias Alevizos⁶, ¹National Institute of Dental and Craniofacial Research, Bethesda, MD, ²Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD, ³Molecular Physiology and Therapeutics Branch,, National Institute of Dental and Craniofacial Research, Bethesda, MD, ⁴Sjogren's Clinic, NIDCR/NIH, Bethesda, MD, ⁵National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁶National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD
Background/Purpose: High dose corticosteroids such as cyclophosphamide are commonly used to treat lupus nephritis (LN). Although effective in preventing end stage renal disease (ESRD)…
Abstract Number: 56 • 2016 ACR/ARHP Annual Meeting
A Systems Biology Approach to Investigating Beneficial Effects of Endurance Exercise in Myositis Patients
Jessica Boehler^1,2, Marshall Hogarth³, Matthew Barberio³, Svetlana Ghimbovschi², Kristy Brown^1,2, Li Alemo Munters⁴, Ingela Loell⁴, Yi-Wen Chen^2,5, Helene Alexanderson⁶, Ingrid E. Lundberg⁷ and Kanneboyina Nagaraju^5,8, ¹Department of Integrative Systems Biology, The George Washington University, Washingtion, DC, ²Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC, ³Research Center for Genetic Medicine, Children's National Medical Center, Washingtion, DC, ⁴Karolinska University Hospital, Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Sweden, Stockholm, Sweden, ⁵Department of Integrative Systems Biology, The George Washington University, Washington, DC, ⁶Department of NVS, Division of Physical Therapy, Karolinska Institutet, Huddinge, Sweden, ⁷Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁸Research Center for Genetic Medicine, Children’s National Medical Center, Washington, DC
Background/Purpose: Polymyositis (PM) and dermatomyositis (DM) are skeletal muscle disorders characterized by proximal muscle weakness and inflammation. Recent studies have suggested that endurance exercise improves…
Abstract Number: 658 • 2016 ACR/ARHP Annual Meeting
Decreased Expression of Ten Micro-RNAs in Plasmacytoid Dendritic Cells of Patients with Primary SS Indicates Dysregulation on Multiple Levels
Maarten R. Hillen^1,2, Sofie L.M. Blokland^1,2, Elena Chouri^1,2, Aike A. Kruize¹, Marzia Rossato^1,2, Joel A.G. van Roon^1,2 and Timothy R.D.J. Radstake^1,2, ¹Department of Rheumatology & Clinical Immunology, UMC Utrecht, Utrecht, Netherlands, ²Laboratory of Translational Immunology, UMC Utrecht, Utrecht, Netherlands
Background/Purpose: Plasmacytoid dendritic cells (pDCs) are indicated to be key players in the pathogenesis of primary Sjögren’s syndrome (pSS) and important producers of type-1 interferon…
Abstract Number: 2099 • 2016 ACR/ARHP Annual Meeting
Micrornas As Potential Modulators of Atherothrombosis in Antiphospholipid Syndrome
Patricia Ruiz-Limon¹, Maria Ángeles Aguirre Zamorano², Nuria Barbarroja², Yolanda Jiménez-Gómez², IVÁN ARIAS DE LA ROSA², Eduardo Collantes-Estévez², Pedro Segui², Francisco Velasco³, Rocio Gonzalez-Conejero⁴, Raul Teruel⁴, Constantino Martinez⁴, Maria Jose Cuadrado⁵, Carlos Perez-Sanchez² and Chary Lopez-Pedrera², ¹Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³Hematology, IMIBIC-Reina Sofia Hospital, Hematology Unit, Cordoba, Spain, ⁴Regional Centre for Blood Donation, University of Murcia, Murcia, Spain, ⁵St Thomas Hospital, Lupus Research Unit, London, United Kingdom
Background/Purpose: 1) To identify and characterize microRNAs linked to thrombosis and atherosclerosis development in APS; 2) To assess the effects of antiphospholipid antibodies in that…
Abstract Number: 808 • 2016 ACR/ARHP Annual Meeting
Down-Regulation of microRNA-126 in Scleroderma Microvascular Endothelial Cells (MVECs) Is Associated with Impaired Responses to Vascular Endothelial Growth Factor (VEGF) and Defective Angiogenesis
bashar kahaleh¹, Nezam Altorok², Yongqing Wang³, Shadia Nada², Mohammed Madkhali³ and John Sun³, ¹Rheumatology, University of Toledo, Toledo, OH, ²Medicine/Rheumatology, University of Toledo, Toledo, OH, ³University of Toledo, Toledo, OH
Background/Purpose: Impaired angiogenesis in SSc is a crucial component of disease pathology that occurs in spite of upregulation of VEGF and other proangiogenic factors. MicroRNA-126…
Abstract Number: 2121 • 2016 ACR/ARHP Annual Meeting
Identification of microRNA-181a-5p and microRNA-4454 As Mediators of Facet Cartilage Degeneration
Akihiro Nakamura^1,2, Y. Raja Rampersaud^3,4, Anirudh Sharma^1,2, Stephen J. Lewis^3,5, Brian Wu^1,2, Poulami Datta^1,2, Kala Sundararajan⁶, Helal Endisha^1,2, Evgeny Rossomacha^1,2, Jason S Rockel^1,2, Igor Jurisica⁷ and Mohit kapoor^1,2,8, ¹Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ²Arthritis Program, University Health Netwok, Toronto, ON, Canada, ³Orthopaedic Surgery and Neurosurgery, Arthritis Program, University Health Network, Toronto, ON, Canada, ⁴Orthopaedics, Toronto Western Hospital, Toronto, ON, Canada, ⁵Spinal Program, Krembil Neuroscience Centre, Toronto Western Hospital, Toronto, ON, Canada, ⁶Orthopaedic Research Department, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, ⁷Medical Biophysics and Computer Science, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada, ⁸Surgery, Laboratory Medicine, and Pathobiology, University of Toronto, Toronto, ON, Canada
Background/Purpose: Osteoarthritis (OA) of spine (facet joints, FJ) is one of the major causes of severe low back pain and disability worldwide. However, specific mechanisms…
Abstract Number: 809 • 2016 ACR/ARHP Annual Meeting
Micrornas Targeting the Wnt Signalling Pathway in Black African Patients with Diffuse Cutaneous Systemic Sclerosis
Mohammed Tikly¹, Jacqueline Frost², Michèle Ramsay³, Eulalia Marti Puig⁴, Raquel Rabionet⁴, Xavier Estivill⁴ and Marc Friedländer⁵, ¹Division of Rheumatology, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa, ²University of the Witwatersrand, Johannesburg, South Africa, ³Division of Human Genetics, Sydney Brenner Institute for Molecular Biosciences, University of the Witwatersrand, Johannesburg, South Africa, ⁴Center for Genomic Regulation, Barcelona, Spain, ⁵Department of Molecular Biosciences, The Wenner-Gren Institute, Science for Life Laboratory, Stockholm, Sweden
Background/Purpose: Systemic sclerosis (SSc) is a complex autoimmune disease involving the immune system, vasculature and extracellular matrix [1]. Dysregulation of the Wnt pathway has been implicated in…
Abstract Number: 2122 • 2016 ACR/ARHP Annual Meeting
KiSS1 Is a Regulator of ADAMTS4 and ADAMTS5 Expression and Is Post-Transcriptionally Regulated By Micro-RNA N105 in Human OA Chondrocytes
Mohammad Shahidul Makki^1,2 and Tariq Haqqi³, ¹4209 St Rt 44 PO Box 95, Northeast Ohio Medical University, Rootstown, OH, ²Anatomy and Neurobiology, Northeast Ohio Medical University (NEOMED), Rootstown, OH, ³Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Background/Purpose: Osteoarthritis (OA) is a chronic and debilitating disease of the articulating joints in every population. Micro-RNAs are ~22 nucleotides long non-coding single stranded RNAs…
Abstract Number: 810 • 2016 ACR/ARHP Annual Meeting
Microrna-125b As a Potential Anti-Fibrotic and Anti-Apoptotic Regulator in Systemic Sclerosis
Anastasiia Kozlova¹, Elena Pachera¹, Florian Renoux², Michal Rudnik¹, Britta Maurer¹, Astrid Jüngel³, Joerg H.W Distler⁴, Gabriela Kania¹ and Oliver Distler¹, ¹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Depertment of Rheumatology, University Hospital Zurich, Schlieren, Switzerland, ³Ctr Exp Rheum, Univ Hosp Zurich / Zurich Ctr Integr Hum Physiol (ZIHP), Zurich, Switzerland, ⁴Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: MicroRNAs (miRs) are a class of small, noncoding RNAs that regulate many biological processes. Some microRNAs are involved in skin fibrosis. Here, we aimed…
Abstract Number: 2141 • 2016 ACR/ARHP Annual Meeting
Terminal Uridylyl Transferase ZCCHC6-Dependent Generation of miRNA Diversity in Primary Human Chondrocytes
Abdul Haseeb¹, Mohammad Shahidul Makki², Mohammad Ansari³, Helen Piontkivska⁴ and Tariq M. Haqqi¹, ¹Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH, ²4209 St Rt 44 PO Box 95, Northeast Ohio Medical University, Rootstown, OH, ³Anatomy & Neurobiology, Northeast Ohio Medical University, Roostown, OH, ⁴Kent State University, Kent, OH
Terminal Uridylyl Transferase ZCCHC6-dependent Generation Of miRNA Diversity In Primary Human Chondrocytes Background/Purpose: MicroRNAs (miRNAs) are a group of small, noncoding RNAs that post-transcriptionally regulate…
Abstract Number: 817 • 2016 ACR/ARHP Annual Meeting
RNA and Protein Cargo of Exosomes Isolated from Serum of Systemic Sclerosis Patients Induce a Profibrotic Phenotype in Cultured Normal Human Dermal Fibroblasts: A Potential Mechanism for the Initiation and Progression of a Profibrotic Phenotype in SSc
Peter J. Wermuth, Kellan R. Carney, Sonsoles Piera-Velazquez and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Exosomes are lipid bilayer-bound microvesicles that contain various macromolecules including numerous microRNA (miRNA) and proteins. Exosomes mediate intercellular communication by fusing and releasing their…
Abstract Number: 2413 • 2016 ACR/ARHP Annual Meeting
Inflammation Regulating microRNAs, Mir-146b, Mir-155 and Mir-192-5p Are Altered in Plasma and Synovial Fluid of Oligoarticular Juvenile Idiopathic Arthritis
Beata Derfalvi^1,2,3, Sarah Roberts⁴, Breanna Hargreaves⁴ and Sarah McAlpine⁴, ¹Pediatrics, Dalhousie University, Halifax, NS, Canada, ²IWK Health Centre, Halifax, NS, Canada, ³2nd. Dept. of Pediatrics, Semmelweis University, Budapest, Hungary, ⁴Dalhousie University, Halifax, NS, Canada
Background/Purpose: MicroRNAs (miRNAs) modulate gene expression by inhibiting the translation of targeted mRNAs and causing mRNA degradation in a transcript-specific manner. Several miRNAs have been reported…
Abstract Number: 1034 • 2016 ACR/ARHP Annual Meeting
Microrna-146a Controls Local Bone Destruction By Regulating Fibroblast Induced Osteoclastogenesis in Inflammatory Arthritis
Victoria Saferding¹, Antonia Puchner², Eliana Goncalves-Alves³, Melanie Hofmann³, Julia Brunner⁴, Emine Sahin⁴, Silvia Hayer⁵, Philippe Georgel⁶, Marije M. Koenders⁷, Gernot Schabbauer⁴, Josef S. Smolen⁸, Günter Steiner⁹, Kurt Redlich³ and Stephan Blüml¹⁰, ¹Rheumatology, Medical University of Vienna, Vienna, Austria, ²Department of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Vascular Biology and Thrombosis research, Medical University of Vienna, Vienna, Austria, ⁵Waehringer Guertel 18-20 A-A09, Medical University of Vienna, Vienna, Austria, ⁶Centre de Recherche en Immunologie et Hématologie, Université de Strasbourg, Strasbourg, France, ⁷Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, ⁸Department of Internal Medicine 3, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁹Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ¹⁰Internal Medicine 3; Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: MicroRNA (MiR-) 146a plays an important role in the regulation of the innate immune response and has also been shown to suppress cancer development…
Abstract Number: 2414 • 2016 ACR/ARHP Annual Meeting
Microrna Associated with Active Systemic Juvenile Idiopathic Arthritis Regulate CD163 Expression in Polarized Macrophages through Two Distinct Mechanisms
Thuy Do¹, Rachel Tan², Mark Bennett², Mario Medvedovic², Nan Shen³, Sherry Thornton¹, Alexei Grom¹ and Grant Schulert⁴, ¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²University of Cincinnati, Cincinnati, OH, ³Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: CD163 is a hemoglobin scavenger receptor and innate pattern recognition receptor, and a marker of activated monocytes and macrophages. It is also expressed on…

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