ACR Meeting Abstracts

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Abstracts tagged "MicroRNA"

  • Abstract Number: 462 • 2019 ACR/ARP Annual Meeting

    The Endogenous Plasma Small RNAome of Rheumatoid Arthritis

    Michelle Ormseth1, Joseph Solus 2, Quanhu Sheng 2, Fei Ye 2, Haocan Song 2, Qiong Wu 2, Yan Guo 3, Annette Oeser 2, Ryan Allen 2, Kasey Vickers 2 and C. Michael Stein 2, 1Vanderbilt University Medical Center and Veterans Administration: TN Valley Healthcare System, Nashville, 2Vanderbilt University Medical Center, Nashville, 3University of New Mexico, Albuquerque

    Background/Purpose: Small RNA (sRNA) sequencing has revealed new classes of sRNAs beyond microRNAs. These sRNAs can regulate genes and are also useful biomarkers of disease.…
  • Abstract Number: 474 • 2019 ACR/ARP Annual Meeting

    Associations of Plasma Extravesicular (EV) MicroRNA Levels in Seropositive and Seronegative Rheumatoid Arthritis (RA)

    Lissette Delgado-Cruzata 1, Milena Rodriguez Alvarez 2, Nickolas Almodovar3, Toni-Ann Bravo 3 and Shante Hinson 4, 1John Jay College of Criminal Justice, City University of New York, New York, 2SUNY Downstate Medical Center, New York, NY, 3John Jay College of Criminal Justice, City University of New York, New York, NY, 4Lincoln Medical & Mental Mental Health Center, New York

    Background/Purpose: Rheumatoid factor (RF) and anti-citrullinated peptide antibodies (ACPA) are biomarkers that allow early diagnosis of RA in seropositive (ACPA+ or RF+) patients. However, some…
  • Abstract Number: 1067 • 2019 ACR/ARP Annual Meeting

    Identification of miRNAs in Systemic Sclerosis Based on Activity and Network Analysis­­­

    Yiwei Yuan1, Yue Wang 2, Patricia Pioli 3 and Michael Whitfield 4, 1Geisel School of Medicine at Dartmouth, Hanover, 2Geisel School of Medicine at Dartmouth, Hanover, NH, 3Dartmouth College, Hanover, 4Geisel School of Medicine at Dartmouth College, Biomedical Data Science at Dartmouth College, Hanover

    Background/Purpose: Systemic sclerosis (SSc; scleroderma) is a rare, heterogenous autoimmune disease characterized by skin fibrosis, vasculopathy and internal organ involvement. SSc patients can be divided…
  • Abstract Number: 24 • 2018 ACR/ARHP Annual Meeting

    Rituximab Induces an Early Re-Assessment of the Immune and Vascular Systems in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis

    Chary Lopez-Pedrera1, Irene Cecchi2, Nuria Barbarroja3, Alejandra Maria Patiño-Trives1, María Luque Tevar1, Laura Pérez Sánchez4, Alejandro Ibáñez-Costa1, Ivan Arias de la Rosa5, Yolanda Jiménez-Gómez3, Massimo Radin6, Rafaela Ortega-Castro3, M. Carmen Castro-Villegas7, Jerusalem Calvo-Gutierrez3, Alejandro Escudero-Contreras5, Maria Jose Cuadrado8, Savino Sciascia9, Eduardo Collantes Estevez1, Maria Ángeles Aguirre Zamorano1 and Carlos Perez-Sanchez3, 1IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 3Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 4IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, 5Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 6Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 7Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, 8Clinica Universidad de Navarra, Madrid, Spain, 9Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy

    Background/Purpose: While the role of Rituximab (RTX) in controlling the clinical manifestations of Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) has been documented, the…
  • Abstract Number: 2128 • 2018 ACR/ARHP Annual Meeting

    The Effect of miRNA-21 Overexpression on the Aberrant T Follicular Helper Cells Differentiation in Systemic Lupus Erythematosus

    Ming Zhao1, Xiaofei Gao2, Jiali Wu3, Limin Liu1, Haijing Wu2 and Qianjin Lu1, 1Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China, 2The Second Xiangya Hospital of Central South University, Changsha, China, 3Department of Deramtology, The Second Xiangya Hospital of Central South University, Changsha, China

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by a large number of autoantibodies and multiple organs damage. T follicular helper(Tfh)…
  • Abstract Number: 109 • 2018 ACR/ARHP Annual Meeting

    Unique miRNA Signatures Detected in Extracellular Vesicles from Patients with Systemic Lupus Erythematous

    Ifeoma Okafor1, Nicholas A. Young2, Giancarlo R. Valiente3, Emily Schwarz1, Peter Harb1, Caitlin Henry1, William Willis2, Emily Sullivan4, Kyle Jablonski5, Lai-Chu Wu1, Naomi I. Maria6, Anne Davidson7, Elisha D.O. Roberson8 and Wael Jarjour9, 1Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, 2Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, 3Rheumatology & Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, 4The Ohio State Univeristy Wexner Medical Center, Columbus, OH, 5The Ohio State University Wexner Medical Center, Columbus, OH, 6Center for Autoimmunnity, Musculoskeletal & Hematopoietic Diseases, Feinstein Institute for Medical Research, Manhasset, NY, 7Feinstein Institute for Medical Research, Manhasset, NY, 8Depts. of Medicine and Genetics, Division of Rheumatology, Washington University, St. Louis, MO, 9Department of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH

    Background/Purpose: Recent studies have identified distinct changes in cellular miRNA (miR) expression associated with systemic lupus erythematous (SLE). We have previously shown that toll-like receptor…
  • Abstract Number: 2816 • 2018 ACR/ARHP Annual Meeting

    Development of a Microrna Panel for Predicting Coronary Atherosclerosis in Rheumatoid Arthritis

    Michelle J. Ormseth1, Joseph F. Solus1, Quanhu Sheng1, Fei Ye1, Yan Guo1, Qiong Wu1, Annette M. Oeser1, Ryan Allen1, Paolo Raggi2, Kasey Vickers1 and C Michael Stein1, 1Vanderbilt University Medical Center, Nashville, TN, 2University of Alberta, Edmonton, AB, Canada

    Background/Purpose: Small noncoding RNAs (sRNAs), such as microRNAs (miRNAs), regulate gene expression and can be used as biomarkers of disease. Patients with rheumatoid arthritis (RA)…
  • Abstract Number: 127 • 2018 ACR/ARHP Annual Meeting

    MiR-3606-3p Inhibits Systemic Sclerosis through Targeting TGF-β Receptor II

    Xiangguang Shi1, Qingmei Liu2, Wenzhen Tu3, Xueqian Mei1, Li Jin4, Wenyu Wu5 and Jiucun Wang4, 1State Key Laboratory of Genetic Engineering, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai, China, 2State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, Chile, 3Medicine, Shanghai Traditional Chinese Medicine-Integrated Hospital, Shang hai, China, 4State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China, 5Department of Dermatology, Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China, Shanghai, China

    Background/Purpose: Though transforming growth factor-b (TGF-b) plays a fundamental role in the pathogenesis of SSc, the mechanism by which TGF-b signaling acts in SSc remains…
  • Abstract Number: 2840 • 2018 ACR/ARHP Annual Meeting

    MiR-125-b Is a Promising Biomarker for Giant Cell Arteritis in Patients with Negative Temporal Artery Biopsy Examination

    Tadeja Kuret1, Mojca Frank Bertoncelj2, Katja Lakota3,4, Snezna Sodin Semrl3,4, Saša Čučnik3,5, Matija Tomšič3,6 and Alojzija Hočevar1, 1Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 2Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 3University Medical Centre Ljubljana, Department of Rheumatology, Ljubljana, Slovenia, 4University of Primorska, Faculty of Mathematics, Natural Science and Information Technology, Koper, Slovenia, 5University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia, 6Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

    Background/Purpose: Giant cell arteritis (GCA) is a systemic vasculitis of large- and medium-sized arteries, diagnosed either with a temporal artery biopsy (TAB) histology or by…
  • Abstract Number: 172 • 2018 ACR/ARHP Annual Meeting

    Serum Chemokines and miRNA Levels and Its Association with Cumulative Organ Damage in Patients with Antiphospholipid Syndrome: A Bench to Bedside Study

    Laura-Aline Martinez-Martinez1, Fausto Sanchez-Muñoz2, Maya Jazmin Nastia Nicte Chacon-Perez2, Yaneli Juarez-Vicuña2, Nicole Mouneu Ornelas1, Anthony Beltran-Cortez2, Ricardo Alberto Venegas Yañez3, Julio Fonseca Basurto1, Evelyn Aranda Cano1, Mary Carmen Amigo4 and Luis M. Amezcua-Guerra1, 1Rheumatology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, 2Immunology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, 3Reumatologia, Instituto Nacional de Cardiología "Ignacio Chavez", Ciudad de México, Mexico, 4Rheumatology, Centro Medico ABC, Mexico, Mexico

    Background/Purpose: Recent evidence suggests that chemokines and miRNAs are involved in the pathogenesis of antiphospholipid syndrome (APS). However, the specific role of these molecules in…
  • Abstract Number: 1008 • 2018 ACR/ARHP Annual Meeting

    Presence of a Specific Defect in M2 Polarization of Blood Monocytes from Patients with Rheumatoid Arthritis, Associated with Increased microRNA-155

    Audrey Paoletti1, Julien Rohmer2, Juliette Pascaud3, Bineta Oumouly1, Elodie Rivière3, Samuel Bitoun4, Gaetane Nocturne5 and Xavier Mariette6, 1U1184 IMVA, INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, le kremlin bicetre, France, 2National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Internal medicine, France, Paris, France, 3Immunology of viral Infections and Autoimmune Diseases, IDMIT, CEA - Université Paris Sud - INSERM U1184, Le Kremlin Bicêtre & Fontenay aux Roses, France, 4INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, le kremlin bicetre, France, 5INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, Le Kremlin Bicêtre, France, 6Rheumatology department, Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique- Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, Paris, France

    Background/Purpose: Macrophages contribute in situ to the RA pathogenesis. Two distinct states of polarization for macrophages have been recognized: the classically activated macrophage phenotype (M1),…
  • Abstract Number: 1025 • 2018 ACR/ARHP Annual Meeting

    MiR-146a a Key Player in Bone Metabolism

    Victoria Saferding1, Melanie Hofmann1, Julia S. Brunner2, Mihaela Militaru1, Antonia Puchner1, Silvia Hayer3, Gernot Schabbauer4, Melanie Timmen5, Richard Stange5, Josef S. Smolen6 and Stephan Blüml7, 1Medical University of Vienna, Austria, Vienna, Austria, 2Vascular Biology and Thrombosis research, Medical University of Vienna, Austria, Vienna, Austria, 3Waehringer Guertel 18-20 A-A09, Medical University of Vienna, Austria, Vienna, Austria, 4Vascular Biology and Thrombosis research, Medical University of Vienna, Vienna, Austria, 5Institute for Experimental Muskuloskeletal Medicine, University Hospital Muenster, Muenster, Germany, 6Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria, 7Division of Rheumatology, Department of Internal Medicine III, Medical University Vienna, Vienna, Austria

    Background/Purpose: Micro RNAs (miRNAs) play a crucial role in the regulation of bone metabolism. MiR-146a, an important anti-inflammatory miRNA, was found to negatively impact osteogenesis…
  • Abstract Number: 1460 • 2018 ACR/ARHP Annual Meeting

    Plasma Mir-146a-5p Associates with Beneficial Body Composition and Plasma Metabolic Profiles in Rheumatoid Arthritis

    Brian J. Andonian1, Ching-Heng Chou2, Virginia B. Kraus2, William E. Kraus3 and Kim M. Huffman4, 1Department of Medicine, Division of Rheumatology and Immunology, Duke University, Durham, NC, 2Duke Molecular Physiology Institute, Duke University, Durham, NC, 3Medicine, Duke University, Durham, NC, 4School of Medicine, Division of Rheumatology, Immunology and Molecular Physiology and Durham VA Medical Center, Duke University, Durham, NC

    Background/Purpose: In rheumatoid arthritis (RA), sarcopenic obesity is associated with significant cardiometabolic disease and mortality. Biomarkers of disease activity in RA and obesity are complicated…
  • Abstract Number: 1474 • 2018 ACR/ARHP Annual Meeting

    Circulating Transfer RNA-Derived Small RNAs Are Altered in Patients with Rheumatoid Arthritis

    Qiong Wu, Quanhu Sheng, Joseph F. Solus, Kasey Vickers, Ryan Allen, Shilin Zhao, Yan Guo, Fei Ye, C Michael Stein and Michelle J. Ormseth, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Small RNAs (sRNAs) are important gene regulators and markers of disease. Transfer RNA (tRNA)-derived sRNAs (tDRs), including tRNA fragments (tRFs) and halves (tRHs), are…
  • Abstract Number: 1817 • 2018 ACR/ARHP Annual Meeting

    MicroRNA-128 Impairs Cartilage Integrity and Deteriorates Osteoarthritis Pathogenesis through Deregulating Chondrocyte Autophagy

    Feng-Sheng Wang1, Wei-Shiung Lian2, Yi-Chih Sun1, Jih-Yang Ko3 and Yu-Shan Chen1, 1Core Facility for Phenomics & Diagnostics, Department of Medical Research, Core Facility for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan, 2Core Facility for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan, 3Department of Orthopedic Surgery, Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan

    Background/Purpose: Autophagy gets rids of unwanted proteins or organelle keeping cells to stay functional upon encountering adverse stresses. While non-coding microRNAs interfere with mRNA targets…
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