ACR Meeting Abstracts

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Abstracts tagged "metabolomics"

  • Abstract Number: 1269 • ACR Convergence 2024

    Altered Tryptophan Metabolism in Juvenile Dermatomyositis Is Associated with Muscle Damage and Mental Health

    Yang Wu1, Aviya Lanis2, Jorge Armando Gonzalez-Chapa3, Jia Shi1, qian wang4, Mengtao Li4, Xiaofeng Zeng5, Susan Shenoi6 and Christian Lood3, 1University of Washington, Seattle, 2Seattle Children's Hospital, Seattle, 3University of Washington, Seattle, WA, 4Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China 2National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China, 5Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, 6Seattle Children's Hospital and Research Center, Mercer Island, WA, WA

    Background/Purpose: Children with juvenile dermatomyositis (JDM) and juvenile idiopathic arthritis (JIA) experience impaired quality of life and high rates of anxiety and depression. The underlying…
  • Abstract Number: 1391 • ACR Convergence 2024

    Possible Mechanistic Pathways of the Effective “Plants for Joints” Lifestyle and Dietary Intervention for Rheumatoid Arthritis

    Carlijn Wagenaar1, Márcia Pereira2, Sylvio Redanz3, Arne Gessner4, Wendy Walrabenstein5, Martin Kriegel3, Mario Zaiss6 and Dirkjan van Schaardenburg7, 1Reade Rheumatology Center, Amsterdam, Netherlands, 2University of Münster, Münster, Germany, 3Institute of Musculoskeletal Medicine, University of Münster, Department of Translational Rheumatology and Immunology, Münster, Germany, Münster, Germany, 4Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 5Reade Center for Rheumatology and Rehabilitation, Amsterdam, Netherlands, 6Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universittsklinikum Erlangen, Erlangen, Germany; 2 Deutsches Zentrum für Immuntherapie (DZI), Erlangen, Germany, 7Amsterdam UMC, Amsterdam, Netherlands

    Background/Purpose: The 16-week Plants for Joints (PFJ) intervention, consisting of a whole-food plant-based diet, physical activity, and stress management, significantly reduced 28-joint Disease Activity Score…
  • Abstract Number: 1395 • ACR Convergence 2024

    Effects of Butyrate Supplementation in Modulation of Gut Microbiome and Its Metabolites in New Onset Rheumatoid Arthritis

    Rebecca Blank1, Alba Boix-Amoros2, Erin Reilly3, Kevin Bu4, Ian Cunningham5, Renuka Nayak6, Andrew Patterson7, Jose Clemente4 and Jose Scher8, 1NYU, New York, NY, 2Icahn School of Medicine, New York, NY, 3Penn State, State Park, PA, 4Icahn School of Medicine at Mount Sinai, New York, NY, 5NYU Langone Health, New York, NY, 6University of California, San Francisco (UCSF), San Francisco, CA, 7Penn State University, State College, PA, 8New York University School of Medicine, New York, NY

    Background/Purpose: The gut microbiome and its metabolites are dysregulated in RA and other immune-mediated inflammatory diseases. However, the significance of this observation and its implications…
  • Abstract Number: 1585 • ACR Convergence 2024

    Characterization of the Fecal Metabolome in Early Systemic Sclerosis

    Arissa Young1, Kristofer Andreasson2, Jen Labus3, Nedas Matulianos4, Blake Wilde1, Jonathan Jacobs3, Heather Christofk4 and Elizabeth Volkmann5, 1UCLA, Los Angeles, CA, 2Lund University, Lund, Sweden, 3UCLA, Los Angeles, 4University of California Los Angeles, Los Angeles, CA, 5University of California, Department of Medicine, Los Angeles, CA, USA, Los Angeles

    Background/Purpose: Previous studies have shown that alterations in gut microbiota are present early in systemic sclerosis (SSc) (Andréasson et al. 2022) and are associated with…
  • Abstract Number: 1622 • ACR Convergence 2024

    18F-FDG PET/CT in LVV During Active and Inactive Disease Phases Is Associated with the Metabolic Profile, but Not with Macrophage-related Cytokines: Results of an Integrated Analysis

    Dimitrios Anastasios Palamidas1, Georgios Kalykakis2, Dimitra Benaki3, Loukas chatzis1, Ourania Argyropoulou4, Panagiota Palla4, Antonia Kollia5, Pavlos Kafouris5, Marinos Metaxas5, Andreas Goules6, Emmanuel Mikros7, Konstantinos Kambas8, Constantinos Anagnostopoulos5 and Athanasios Tzioufas9, 1Pathophysiology Department, Athens School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, Cholargos Athens, Greece, 2Department of Informatics, Ionian University, Kerkyra, Greece, Athens, Greece, 3Department of Pharmaceutical Chemistry, School of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece, Athens, Greece, 4Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece., Athens, Greece, 5PET-CT Department & Preclinical Imaging Unit, Center for Experimental Surgery, Clinical & Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece., Athens, Greece, 6GENERAL HOSPITAL LAIKO ATHENS, Athens, Greece, 7Department of Pharmaceutical Chemistry, School of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece., Athens, Greece, 8Laboratory of Molecular Genetics, Department of Immunology, Hellenic Pasteur Institute, Athens, Greece., Athens, Greece, 9LAIKO HOSPITAL, Athens, Greece

    Background/Purpose: Giant cell arteritis (GCA) may affect temporal arteries (cranial-GCA) or may present as a systemic disease extended to the large vessels [Large Vessel Vasculitis…
  • Abstract Number: 1651 • ACR Convergence 2024

    Unlocking the Secrets of Breg Dysfunction in Lupus: Glycosylation Patterns as Therapeutic Targets

    Pauline Kerleroux-Trébaol1, Marie Morel1, Sandrine Jousse-Joulin2, Divi Cornec3, Pierre Pochard1 and Anne Bordron1, 1Université de Bretagne Occidentale, brest, France, 2cavale blanche hospital, brest, France, 3Service de Rhumatologie, CHU de Brest, Brest, France

    Background/Purpose: The immune system is a complex network of cells preventing the invasion of the organism from external particles. The break in the homeostasis will…
  • Abstract Number: 1711 • ACR Convergence 2024

    Identification of Psoriatic Arthritis-related Pathways Using Multi-omics Data Integration

    Sreemoyee Ghosh1, Chiara Pastrello2, Omar F. Cruz-Correa3, Darshini Ganatra4, Katerina Oikonomopoulou3, Melanie Anderson5, Igor Jurisica6 and Vinod Chandran7, 1Institute of Medical Science, University of Toronto and Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada, 2Osteoarthritis Research Program, Division of Orthopaedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic diseases, Krembil Research Institute, Toronto, ON, Canada, 3Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada, 4University Health Network, Toronto, ON, Canada, 5The Institute for Education Research, Library and Information Services, University Health Network, Toronto, ON, Canada, 6Departments of Medical Biophysics and Computer Science and Faculty of Dentistry, University of Toronto and Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia, Toronto, ON, Canada, 7University of Toronto, Toronto, ON, Canada

    Background/Purpose: Psoriasis (Pso) is a chronic immune mediated inflammatory skin disease. Up to 24% of Pso patients develop psoriatic arthritis (PsA). Pathophysiology of PsA is…
  • Abstract Number: 1774 • ACR Convergence 2024

    Metabolomics and Lipidomics in Juvenile Localized Scleroderma

    Yuan Zhang1, Angela Aquilani2, Rebecca Nicolai3, Fabrizio De Benedetti4, Emiliano Marasco2 and Cristina Maglio1, 1University of Gothenburg, Gothenburg, Sweden, 2Bambino Gesù Children’s Hospital, Immunology and Rheumatology Unit, Roma, Italy, 3Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, 4IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy

    Background/Purpose: Juvenile localised scleroderma (jLS) is a rare rheumatic disease in children characterized by inflammation and fibrosis in the skin [1, 2]. The cause and…
  • Abstract Number: 0053 • ACR Convergence 2024

    Fasting Reduces an IL-17+/IFNg+ T Helper Cell-inducing Gut Pathobiont in Patients with Rheumatoid Arthritis

    Márcia Pereira1, Katja Stuhlträger2, Natalie Scherff3, Anika Rajput Khokhar4, Sylvio Redanz1, Hebah Ebid5, Bérénice Hansen5, Cédric C. Lacny5, Ulrike Löschberger2, Stefan Bletz6, Jochen G. Schneider7, Paul Wilmes7, Christian S. Kessler4, Andreas Michalsen4, Alexander Mellmann3 and Martin Kriegel1, 1Institute of Musculoskeletal Medicine, University of Münster, Department of Translational Rheumatology and Immunology, Münster, Germany, Münster, Germany, 2Institute of Musculoskeletal Medicine, University of Münster, Department of Translational Rheumatology and Immunology, Münster, Germany, Muenster, Germany, 3Institute of Hygiene, University Hospital Münster, Münster, Germany, Muenster, Germany, 4Institute of Social Medicine, Epidemiology and Health Economics, Charité, Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, Berlin, Germany, 54University of Luxembourg, Department of Life Sciences and Medicine (DLSM), 6, Avenue du Swing, L-4367 Belvaux, Luxembourg, Luxemburg, Luxembourg, 6Institute of Hygiene, University Hospital Münster, Germany, Muenster, Germany, 7University of Luxembourg, Department of Life Sciences and Medicine (DLSM), 6, Avenue du Swing, L-4367 Belvaux, Luxembourg, Luxemburg, Luxembourg

    Background/Purpose: The mucosal origins hypothesis suggests rheumatoid arthritis (RA) is triggered at mucosal sites in genetically predisposed hosts1. Animal models support that microbiota‐induced Th17 cells are…
  • Abstract Number: 1785 • ACR Convergence 2024

    Comparative Immuno-Metabolomics Shows Singular Changes in Systemic Lupus Erythematosus Metabolic Phenotype Induced by T-Cell Activation

    Martin Stradner1, Fernanda Monedeiro2, Elmar Zuegner2, Barbara Prietl3, Monika Oberhuber4, Michael Khalil5, Christoph Magnes2, Hans-Peter Brezinsek1, Angela Libiseller3 and Thomas Pieber3, 1Div. of Rheumatology and Immunology, Medical University of Graz, Graz, Austria, 2Joanneum Research, Graz, Austria, 3Div. of Endocrinology, Medical University of Graz, Graz, Austria, 4CBmed, Graz, Austria, 5Dept. of Neurology, Medical University of Graz, Graz, Austria

    Background/Purpose: Metabolic processes have a critical role in regulating immune cell function, therefore being relevant to understanding the pathogenesis and progression of autoimmune diseases.  Here…
  • Abstract Number: 0070 • ACR Convergence 2024

    Shared and Unique Fecal and Plasma Metabolic Signatures and Increased Inflammatory Markers in Ankylosing Spondylitis, Psoriatic Arthritis and Acute Anterior Uveitis

    Sneha Couvillion1, Javier Flores1, Sean Davin2, Kimberly Ogle2, Emma Fale-Olsen2, John Davis2, Gina Many1, Carley Shaut2, Tammy Martin2, Eric Suhler2, Atul Deodhar3, James Rosenbaum4, Ernesto Nakayasu1 and Tejpal Gill2, 1PNNL, Richland, WA, 2OHSU, Portland, OR, 3Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, OR, 4Corvus Pharmaceuticals and Legacy Devers Eye Institute, Portland, OR

    Background/Purpose: Spondyloarthritis (SpA) is a group of immune-mediated inflammatory disorders such as ankylosing spondylitis (AS) and psoriatic arthritis (PsA), along with acute anterior uveitis (AAU)…
  • Abstract Number: 1816 • ACR Convergence 2024

    Paracrine WNT Signaling Drives Pro-fibrotic Metabolic Activation of Systemic Sclerosis Macrophages

    Emily Morris1, Helen Jarnagin2, Heetaek Yang3, Alexandra Turnquist2, Michael Whitfield4 and Patricia Pioli5, 1Dartmouth College, Enfield, NH, 2Dartmouth College, Lebanon, NH, 3Dartmouth College, West Lebanon, NH, 4Geisel School of Medicine at Dartmouth, Hanover, NH, 5Geisel School of Medicine at Dartmouth, Lebanon, NH

    Background/Purpose: While we have shown that systemic sclerosis (SSc) dermal fibroblasts and macrophages (MØs) engage in reciprocal activation mediated by exosomes via paracrine signaling, the…
  • Abstract Number: 0101 • ACR Convergence 2024

    Metabolomic Profiling Reveals a Role for Citric Acid Cycle Dysfunction in Antiphospholipid Syndrome Neutrophils

    Ajay Tambralli1, Megan Radyk1, Kaitlyn Sabb1, Li Zhang1, Harrison Wong1, Emily Becker1, Srilakshmi Yalavarthi1, Claire Hoy1, Cyrus Sarosh2, Jacqueline Madison1, Yu Zuo1, Jason Knight1 and Costas Lyssiotis1, 1University of Michigan, Ann Arbor, MI, 2University of Michigan, Temperance, MI

    Background/Purpose: As early effectors of the immune response, neutrophils must access energy rapidly. Neutrophils rely on glycolysis for antimicrobial functions such as phagocytosis and reactive…
  • Abstract Number: 2085 • ACR Convergence 2024

    The Effects of Pioglitazone on Metabolic Dysregulation in Inclusion Body Myositis: An Open-Label Pilot Study

    Brittany Adler1, Michael Bene1, Cissy Zhang2, Julie Paik1, Christopher Mecoli1, Thomas Lloyd3, Eleni Tiniakou4, Erika Darrah1, Lisa Christopher-Stine1, Albert Mears1, Megan McGowan1, Ruben Pagkatipunan1, Anne Le2 and Jemima Albayda5, 1Johns Hopkins University, Baltimore, MD, 2Gigantest, Baltimore, MD, 3Baylor College of Medicine, Houston, TX, 4Johns Hopkins University, Lutherville Timonium, MD, 5Johns Hopkins School of Medicine, Baltimore, MD

    Background/Purpose: Inclusion body myositis (IBM) is a progressive muscle disease for which there is no effective treatment. Mitochondrial dysregulation is a pathologic hallmark of IBM.…
  • Abstract Number: 0485 • ACR Convergence 2024

    Biomarkers for Disease Activity and Response to Treatment in Early Rheumatoid Arthritis: Metabolomics and Machine Learning Analyses in NORD-STAR Cohort

    Tahzeeb Fatima1, Yuan Zhang2, Georgios Vasileiadis2, Araz Rawshani2, Ronald Van Vollenhoven3, Jon Lampa4, Bjorn Gudbjornsson5, Espen Haavardsholm6, Dan Nordstrom7, Gerdur Gröndal5, Kim Hørslev-Petersen8, Kristina Lend9, Marte Heiberg10, Merete Hetland11, Michael Nurmohamed12, Mikkel Ostergaard13, Tillmann Uhlig6, Tuulikki Sokka-Isler14, Anna Rudin15 and Cristina Maglio2, 1University of Gothenburg, Göteborg, Sweden, 2University of Gothenburg, Gothenburg, Sweden, 3Department of Rheumatology and Clinical Immunology, Amsterdam University Medical Centers, Amsterdam, Netherlands, 4Karolinska University Hospital, Hässelby, Sweden, 5Landspitali University Hospital and University of Iceland, Reykjavik, Iceland, 6Diakonhjemmet Hospital, Oslo, Norway, 7Helsinki University Hospital, Helsinki, Finland, 8University Hospital of Southern Denmark, Sønderborg, Denmark, 9Amsterdam UMC, Karolinska Institute, Stockholm, Sweden, 10Diakonhjemmet Hospital, Oslo, Oslo, Norway, 11Rigshospitalet Glostrup and University of Copenhagen, Glostrup, Denmark, 12Amsterdam University Medical Centers, Amsterdam, Netherlands, 13Department of Clinical Medicine, University of Copenhagen and Center for Rheumatology, Copenhagen Center for Arthritis Research, Glostrup, Denmark, 14Jyväskylä Central Hospital, Jyväskylä, Finland, 15Institute of Medicine, University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: The variability in treatment response in people with rheumatoid arthritis (RA) warrants the prediction of patients at high risk of treatment failure. Identification of…
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