Abstracts tagged "meta-analysis"

Abstract Number: 2367 • 2017 ACR/ARHP Annual Meeting
The Effect of Glucocorticoids on Bone Mineral Density in Patients with Rheumatoid Arthritis: a Systematic Review and Meta-Analysis
Anne-Birgitte Blavnsfeldt^1,2, Malissa Dawn Thomsen³, Simon Tarp⁴, Bente Langdahl^2,5, Ellen-Margrethe Hauge^2,6 and Annette de Thurah^7,8, ¹Rheumatology, Aarhus Universityhospital, Aarhus C, Denmark, ²Department of Clinical Medicine, Aarhus University, Aarhus C, Denmark, ³Diagnostic Centre, Silkeborg Regional Hospital, Silkeborg, Denmark, ⁴The Parker Institute, Bispebjerg & Frederiksberg Hospital, Copenhagen, Denmark, ⁵Endocrinology, Aarhus University Hospital, Aarhus, Denmark, ⁶Aarhus Universityhospital, Aarhus C, Denmark, ⁷Department of Rheumatology, Aarhus University Hospital, Aarhus, DK, Aarhus, Denmark, ⁸Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Background/Purpose: The role of glucocorticoids (GCs) in the treatment of rheumatoid arthritis (RA) is widely debated. GCs stimulate bone resorption and impair bone formation. Inflammatory…
Abstract Number: 2392 • 2017 ACR/ARHP Annual Meeting
Impact of the Pattern of Interstitial Lung Disease on Mortality in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis
Namrata Singh¹, Jimmy Varghese², Bryant R. England³, Joshua J. Solomon⁴, Kaleb Michaud⁵, Ted R. Mikuls⁶ and Marin Schweizer⁷, ¹Internal Medicine, University of Iowa Hospitals and Clinics and Iowa City VA, Iowa City, IA, ²Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, ³Division of Rheumatology & Immunology, Department of Internal Medicine, Nebraska-Western IA VA Health Care System & University of Nebraska Medical Center, Omaha, NE, ⁴Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, CO, ⁵University of Nebraska Medical Center, Omaha, NE, ⁶Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁷Internal Medicine, Iowa City VA, Iowa City, IA
ABSTRACT Impact of the Pattern of Interstitial Lung Disease on Mortality in Rheumatoid Arthritis: A systematic review and meta-analysis Background/Purpose: Interstitial lung disease affects 10-15%…
Abstract Number: 2483 • 2017 ACR/ARHP Annual Meeting
Cycling Versus Swapping in Patients with Rheumatoid Arthritis with an Inadequate Response to at Least One Tumor Necrosis Factor Alpha Inhibitor: A Systematic Review and Meta-Analysis of Observational Studies
Maria A. Lopez-Olivo, Aliza Matusevich and Maria Suarez-Almazor, Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Houston, TX
Background/Purpose: In patients with rheumatoid arthritis (RA) who do not respond or lose response to a tumor necrosis factor inhibitor (TNFi), opinions are divided on…
Abstract Number: 2515 • 2017 ACR/ARHP Annual Meeting
Prevalence and Risk Factors for Osteoporotic Fractures and Low Bone Mineral Density in Axial Spondyloarthritis: A Systematic Review and Meta-Analysis
Julio Ramírez¹, Juan Carlos Nieto², Rafael Curbelo³, Santos Castañeda⁴ and Loreto Carmona⁵, ¹Rheumatology, Hospital Clínic, Barcelona, Spain, ²Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ³Instituto de Salud Musculoesquelética, Madrid, Spain, ⁴Hospital Universitario de La Princesa, Madrid. Spain, Madrid, Spain, ⁵Instituto de Salud Musculoesquelética (InMusc), Madrid, Spain
Background/Purpose: To describe the prevalence of osteoporosis (1), the prevalence and incidence of fractures (2), and the frequency of risk factors for low bone mineral…
Abstract Number: 463 • 2017 ACR/ARHP Annual Meeting
Certolizumab Pegol for Fatigue in Chronic Inflammatory Rheumatic Diseases: A Meta-Analysis
Yesim Ozguler¹, Sinem Nihal Esatoglu¹, Guzin Karatemiz¹, Ali Ugur Unal², Gul Guzelant¹, Elif Dincses³, Mustafa Erdogan¹, Sema Kaymaz Tahra² and Gulen Hatemi¹, ¹Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, ²Departement of Internal Medicine, Division of Rheumatology, Marmara University, Istanbul, Turkey, ³Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, İstanbul, Turkey
Background/Purpose: Fatigue is an important problem that impairs life quality in patients with rheumatic diseases. Although fatigue is often associated with disease activity, only a…
Abstract Number: 531 • 2017 ACR/ARHP Annual Meeting
Comparative Effectiveness of Tofacitinib Versus Baricitinib in Rheumatoid Arthritis Using a Systematic Review and Network Meta-Analysis of Randomized Trials
Natalia Zamora^1,2,3, Maria A. Lopez-Olivo¹, Jean Tayar¹, Robin Christensen² and Maria Suarez-Almazor¹, ¹Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Houston, TX, ²Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark, Copenhagen, Denmark, ³Reumatologia, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, Buenos Aires, Argentina
Background/Purpose: To explore the comparative effectiveness of tofacitinib or baricitinib in patients with rheumatoid arthritis (RA) following a systematic review of randomized trials, by performing…
Abstract Number: 539 • 2017 ACR/ARHP Annual Meeting
Comparison of Oral Versus Parenteral Methotrexate in Rheumatoid Arthritis: A Meta-Analysis
Sahar Janjua¹, Andreea Bujor¹, Michael P. LaValley², Josefina Duran³, Jürgen Braun⁴ and David T. Felson⁵, ¹Department of Rheumatology, Boston Medical Center, Boston, MA, ²Boston University School of Public Health, Boston, MA, ³Pontificia Universidad Católica de Chile, Santiago, Chile, ⁴Institut für angewandte Statistik Dr. Jörg Schnitker GmbH, Bielefeld, Germany, ⁵Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Methotrexate (MTX) is the mainstay first-line therapy for rheumatoid arthritis (RA), and it can be given orally or parenterally. Bioavailability of oral MTX may…
Abstract Number: 636 • 2017 ACR/ARHP Annual Meeting
Effect of Adding MTX to TNF Inhibitors on Joint Severity Indices and Skin Scores in Psoriatic Arthritis: A Post-Hoc Meta-Analysis of Randomized, Controlled Trials
Rochelle Castillo¹, Khushboo Sheth² and Santhanam Lakshminarayanan³, ¹University of Connecticut, Farmington, CT, ²Rheumatology, Stanford University, Palo Alto, CA, ³Division of Rheumatology, University of Connecticut Health Center, Farmington, CT
Background/Purpose: Co-medication of MTX with TNF inhibitors (TNFi) has proven superior to TNFi monotherapy in improving clinical outcomes in patients with RA. Whether this holds…
Abstract Number: 691 • 2017 ACR/ARHP Annual Meeting
Serum Anti-NR2 Has a Better Specificity Than Sensitivity in Diagnosing Neuropsychiatric Systemic Lupus Erythematosus (NPSLE)
Seyed-Foad Ahmadi¹, Golara Zahmatkesh², Masoud Majed³ and Sheetal Desai⁴, ¹Department of Medicine, University of California Irvine, Orange, CA, ²Department of Psychiatry, Charles Drew University of Medicine and Science/UCLA, Los Angeles, CA, ³Division of Neuroimmunology, Mayo Clinic, Rochester, MN, ⁴Medicine/Rheumatology, Unviersity of California, Irvine, Orange, CA
Background/Purpose: Anti-NR2, a subclass of anti-NMDA receptor antibodies, is reportedly associated with NPSLE syndromes. However, its diagnostic accuracy is inconsistent across prior studies. Hence, we…
Abstract Number: 786 • 2017 ACR/ARHP Annual Meeting
Smoking As a Risk Factor for Giant Cell Arteritis: A Systematic Review and Meta-Analysis
David Brennan¹, Patompong Ungprasert², Kenneth J. Warrington² and Matthew J. Koster², ¹Internal Medicine, Mayo Clinic, Rochester, MN, ²Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: Tobacco smoking is a well-established risk factor for the development of several autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. A similar…
Abstract Number: 896 • 2017 ACR/ARHP Annual Meeting
The Steroid Tapering in ANCA Vasculitis Evaluation Study (STAVE) 2: A Systematic Review and Meta-Analysis
Jennifer Rodrigues¹, David Collister¹, Amy Archer², Kim Cheema³, Paul Alexander⁴, Christian Pagnoux⁵, Lehana Thabane⁴, Peter A. Merkel⁶, David Jayne⁷ and Michael Walsh¹, ¹Nephrology, McMaster University, Hamilton, ON, Canada, ²Rheumatology, Northwestern University, Chicago, IL, ³Nephrology, University of Calgary, Calgary, AB, Canada, ⁴Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada, ⁵Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁶Division of Rheumatology, University of Pennsylvania; Perelman School of Medicine, Philadelphia, PA, ⁷Vasculitis and Lupus Clinic, Department of Medicine, University of Cambridge, Cambridge, United Kingdom
Background/Purpose: Relapses of ANCA-associated vasculitis (AAV) are associated with death, decreased renal function, and end-stage renal disease. Whether longer-term treatment with glucocorticoids (GC) reduces the…
Abstract Number: 617 • 2016 ACR/ARHP Annual Meeting
Therapy in Patients with Rheumatoid Arthritis (RA) with Inadequate Response to Tumor Necrosis Factor Alpha Inhibitors (TNFi): A Systematic Review and Meta-Analysis of Randomized Controlled Trials (RCTs
Maria A. Lopez-Olivo¹, Aliza Matusevich^2,3 and Maria Suarez-Almazor⁴, ¹Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine,The University of Texas MD Anderson Cancer Center, Houston, Texas, USA,, Houston, TX, ²General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, ³The University of Texas, School of Public Health, Houston, TX, ⁴Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Houston, TX
Background/Purpose: Up to one-third of the patients who receive TNFi lose responsiveness over time. Options available to these patients include treatment with an alternative TNFi…
Abstract Number: 1155 • 2016 ACR/ARHP Annual Meeting
The Effect of Nurse-Led Follow-up in Rheumatoid Arthritis. a Systematic Review and Meta-Analysis of Randomized Controlled Trails
Annette de Thurah^1,2, Bente Appel Esbensen^3,4, Ida K Roelsgaard⁴, Tove F Frandsen⁵ and Jette Primdahl^6,7, ¹Department of Rheumatology, Aarhus University Hospital, Aarhus, DK, Aarhus, Denmark, ²Department of Clinical Medicine, Aarhus University, Aarhus, DK, Aarhus N, Denmark, ³Copenhagen Center for Arthritis Research (Copecare), Rigshospitalet, Copenhagen, DK, Copenhagen, Denmark, ⁴Department of Clinical Medicine, University of Copenhagen, Copenhagen, DK, Copenhagen, Denmark, ⁵The knowledge Center of Odense University Hospital, Odense University Hospital, Odense, DK, Odense, Denmark, ⁶King Christian X’s Hospital for Rheumatic Diseases, Graasten, Hospital of Southern Jutland, DK, Graasten, Denmark, ⁷Institute for Regional health Research, University of Southern Denmark, Odense, DK, Odence, Denmark
Background/Purpose: Due to a longer life expectancy in general, the treatment burden of RA is growing, and although treatment is generally becoming more effective and…
Abstract Number: 1206 • 2016 ACR/ARHP Annual Meeting
A Replication Study and Meta-Analysis Demonstrate the Influence of the mtDNA Haplogroups in the Rate of Incident Knee Osteoarthritis. Functional Explanation of This Association Using Transmitochondrial Cybrids
Ignacio Rego-Pérez¹, Mercedes Fernandez Moreno¹, Angel Soto-Hermida¹, Maria Eugenia Vazquez Mosquera¹, Estefanía Cortés-Pereira¹, Sara Relaño-Fernandez², Tamara Hermida-Gómez³, Sonia Pertega⁴, Rafael Garesse⁵, Natividad Oreiro³, Carlos Fernandez-Lopez¹ and Francisco J. Blanco^1,6, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo HospitalarioUniversitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ²Plataforma de Genómica. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ³Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ⁴Unidad de Epidemiología Clínica y Bioestadística. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ⁵Departamento de Bioquímica, Instituto de Investigaciones Biomédicas "Alberto Sols" UAM-CSIC y Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Universidad Autónoma de Madrid 28029, Madrid, Spain, Madrid, Spain, ⁶Rheumatology Division, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), La Coruña, Spain
Background/Purpose: The study of the mitochondria in the context of osteoarthritis (OA) attracted much attention. In this study we aimed to evaluate the influence of…
Abstract Number: 1212 • 2016 ACR/ARHP Annual Meeting
A Combined Large Scale Meta-Analysis Identifies COG6 As a Novel Shared Risk Locus for Rheumatoid Arthritis and Systemic Lupus Erythematosus
Ana Márquez¹, Laura Vidal-Bralo², Luis Rodriguez-Rodriguez³, Miguel Angel González-Gay⁴, Alejandro Balsa⁵, Isidoro Gonzalez-Alvaro⁶, Patricia Carreira⁷, Norberto Ortego Centeno⁸, Maria del Mar Ayala Gutierrez⁹, Francisco José García-Hernández¹⁰, Francisca González Escribano¹¹, José Mario Sabio¹², Carles Tolosa¹³, Ana Suárez¹⁴, Antonio Gonzalez¹⁵, Leonid Padyukov¹⁶, Jane Worthington¹⁷, Timothy J. Vyse^18,19, Marta E. Alarcon Riquelme^20,21 and Javier Martín¹, ¹Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS-Granada, Granada, Spain, ²Instituto Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, ³Rheumatology Department and Heath Research Institute (IdISSC), Hospital Clinico San Carlos, Madrid, Spain, ⁴Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain, ⁵Department of Rheumatology and Institute for Health Research (IdiPAZ), University Hospital La Paz, Madrid, Spain, ⁶Rheumatology, Rheumatology Service, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain, ⁷Department of Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ⁸Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, ⁹Department of Internal Medicine, Hospital Carlos Haya, Málaga, Spain, ¹⁰Department of Internal Medicine, Hospital Universitario Virgen del Rocío, Sevilla, Spain, ¹¹Department of Immunology, Hospital Universitario Virgen del Rocío (IBiS, CSIC, US), Sevilla, Spain, ¹²Department of Internal Medicine, Hospital Virgen de las Nieves, Granada, Spain, ¹³Department of Internal Medicine, Hospital Parc Taulí, Sabadell, Spain, ¹⁴Department of Functional Biology, Immunology Area, Faculty of Medicine, University of Oviedo, Oviedo, Spain, ¹⁵Laboratorio de Investigación 10 and Rheumatology Unit, Instituto de Investigación Sanitaria - Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, ¹⁶Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ¹⁷Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ¹⁸Department of Medical and Molecular Genetics, King's College London, London, United Kingdom, ¹⁹Division of Immunology, Infection and Inflammatory Disease, King’s College London, London, United Kingdom, ²⁰Centro de Genómica e Investigación Oncológica (GENYO), Pfizer-Universidad de Granada-Junta de Andalucía, Granada, Spain, ²¹Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: One of the main limitations of the association studies in autoimmunity is the difficulty in identifying genetic risk variants with modest effects, given the…

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