Abstracts tagged "Magnetic resonance imaging (MRI)"

Abstract Number: 2625 • ACR Convergence 2025
Early Detection of Knee Osteoarthritis – The Role of a Composite Disease Activity Metric: Data from the Osteoarthritis Initiative
Julieann Patarini¹, Timothy McAlington², Jonggyu Baek¹, Emily Kirillov³, Nhung Vo³, Michael Richard³, Ming Zhang⁴, Matthew Harkey⁵, Grace Lo⁶, Shao-Hsien Liu¹, Kate Lapane¹, Charles Eaton⁷, James Mackay⁸ and Jeffrey Driban⁹, ¹UMass Chan Medical School, Worcester, MA, ²UMass Chan School of Medicine, Arlington, MA, ³Tufts Medical Center, Boston, MA, ⁴Boston University, Westford, MA, ⁵Michigan State University, East Lansing, MI, ⁶Baylor College of Medicine / MEDVAMC, Houston, TX, ⁷Brown University, Pawtucket, RI, ⁸University of Cambridge; Norwich Medical School, San Diego, CA, ⁹University of Massachusetts Chan Medical School, Marlborough, NH
Background/Purpose: Bone marrow lesions (BMLs) and effusion-synovitis are frequent and dynamic disease processes detected from early- to late-stage knee OA. These processes are associated with…
Abstract Number: 1854 • ACR Convergence 2025
Resting-State Functional Magnetic Resonance Imaging Analysis Revealed Altered Functional Connectivity Associated with Fatigue in Systemic Lupus Erythematosus
Yujie Song¹, Nobuya Abe¹, Yuichiro Fujieda², Kodai Sakiyama¹, Yuta Inoue¹, Kenichi Miyamoto¹, Kazuro Kamada¹, Yotaro Oki¹, Maria Tada¹, Shuhei Takeyama¹, Ryo Hisada², Michihito Kono² and Tatsuya Atsumi², ¹Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, ²Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
Background/Purpose: Fatigue is one of the most frequent constitutional symptoms in systemic lupus erythematosus (SLE), usually accompanied with impaired quality of life. Resting-state functional magnetic…
Abstract Number: 0309 • ACR Convergence 2025
A Composite Cumulative Cartilage Damage Metric Predicts Incident Symptomatic Knee OA: Data from the Osteoarthritis Initiative
Julieann Patarini¹, Timothy McAlington², Jonggyu Baek¹, Emily Kirillov³, Nhung Vo³, Michael Richard³, Ming Zhang⁴, Matthew Harkey⁵, Grace Lo⁶, Shao-Hsien Liu¹, Kate Lapane¹, Charles Eaton⁷, James Mackay⁸ and Jeffrey Driban⁹, ¹UMass Chan Medical School, Worcester, MA, ²UMass Chan School of Medicine, Arlington, MA, ³Tufts Medical Center, Boston, MA, ⁴Boston University, Westford, MA, ⁵Michigan State University, East Lansing, MI, ⁶Baylor College of Medicine / MEDVAMC, Houston, TX, ⁷Brown University, Pawtucket, RI, ⁸University of Cambridge; Norwich Medical School, San Diego, CA, ⁹University of Massachusetts Chan Medical School, Marlborough, NH
Background/Purpose: Cartilage defects are a hallmark of OA progression. We previously developed a composite MRI-based metric that combines cartilage damage from 6 anatomical regions throughout…
Abstract Number: 2623 • ACR Convergence 2025
Disease Activity is a Novel Imaging Biomarker Associated with Knee Pain: Data from the Osteoarthritis Initiative
Jeffrey Driban¹, Jonggyu Baek², Julieann Patarini², Emily Kirillov³, Nhung Vo³, Michael Richard³, Ming Zhang⁴, Matthew Harkey⁵, Grace Lo⁶, Kate Lapane², Shao-Hsien Liu², Charles Eaton⁷, James Mackay⁸, Joshua Harvey² and Timothy McAlington⁹, ¹University of Massachusetts Chan Medical School, Marlborough, NH, ²UMass Chan Medical School, Worcester, MA, ³Tufts Medical Center, Boston, MA, ⁴Boston University, Westford, MA, ⁵Michigan State University, East Lansing, MI, ⁶Baylor College of Medicine / MEDVAMC, Houston, TX, ⁷Brown University, Pawtucket, RI, ⁸University of Cambridge; Norwich Medical School, San Diego, CA, ⁹UMass Chan School of Medicine, Arlington, MA
Background/Purpose: Barriers to developing effective osteoarthritis (OA) therapies include the lack of standardized definitions for disease progression and structural endpoints that reliably predict changes in…
Abstract Number: 1496 • ACR Convergence 2025
Demyelinating Syndromes in Systemic Lupus Erythematosus: A 23-Year Retrospective Analysis of Clinical Features and Treatment Outcomes from a Tertiary Care Center
Manikandan Gopal¹, Ashish Jacob Mathew² and john mathew³, ¹christian medical college, Vellore, India, ²Christian Medical College, Vellore, Tamil Nadu, India, ³Christian Medical college , Vellore , India, Vellore, Tamil Nadu, India
Background/Purpose: Systemic Lupus Erythematosus (SLE) with acute myelitis or optic neuritis is rare and causes significant morbidity. Data on these conditions remain limited. This study…
Abstract Number: 0242 • ACR Convergence 2025
Contemporary Recurrent Pericarditis Management – Real-world Evidence of Limited Cardiac Magnetic Resonance Imaging Prior to Initiating Rilonacept
Brittany Weber¹, Paul Cremer², Michael Garshick³, Sushil Allen Luis⁴, Ajit Raisinghani⁵, Vidhya Parameswaran⁶, Allison Curtis⁶, Allan Klein⁷ and John Paolini⁶, ¹Brigham and Women's Hospital, DEDHAM, MA, ²Cleveland Clinic, Shaker Heights, OH, ³NYU Langone Health, Tenafly, NJ, ⁴Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, ⁵Division of Cardiology, Department of Medicine, Sulpizio Cardiovascular Center, University of California San Diego, San Diego, CA, ⁶Kiniksa Pharmaceuticals, LEXINGTON, MA, ⁷Cleveland Clinic, Cleveland, OH
Background/Purpose: Recurrent pericarditis (RP) is a chronic autoinflammatory disease (mediated by IL-1) that requires long-term treatment, and selection of therapy is guided by multiple factors.…
Abstract Number: 2614 • ACR Convergence 2025
Impact of Vagus Nerve-Mediated Neuroimmune Modulation on structural joint damage using Gd-MRI RAMRIS imaging in Biologic-Experienced Patients with Rheumatoid Arthritis
Charles Peterfy, MD, PhD¹, John Tesser², Yaakov Levine³, Melissa Evangelista⁴, Vibeke Strand⁵, Michael Weinblatt⁶ and David Chernoff⁷, ¹Spire Sciences, Inc., Boca Raton, FL, ²Arizona Arthritis & Rheumatology Associates, Phoenix, AZ, ³SetPoint Medical, Valencia, CA, ⁴SetPoint Medical Corporation, Valencia, CA, ⁵Stanford University School of Medicine, Palo Alto CA, Portola Valley, CA, ⁶Brigham and Women's Hospital/ Harvard Medical School, Waban, MA, ⁷SetPoint Medical, Sausalito, CA
Background/Purpose: Previously reported results from RESET-RA (ClinicalTrials.gov, NCT04539964) showed neuroimmune modulation via electrical stimulation of the left vagus nerve using an implantable device to treat…
Abstract Number: 1466 • ACR Convergence 2025
Impact of Bimekizumab on Spinal MRI Inflammation and Structural Lesions in Patients with Radiographic Axial Spondyloarthritis: 2-Year CANDEN Scoring Results from a Phase 3 Study and Its Open-Label Extension
Walter P. Maksymowych¹, Robert G. W. Lambert², Victoria Navarro-Compan³, Xenofon Baraliakos⁴, Jason Coarse⁵, Natasha de Peyrecave⁶ and Mikkel Ostergaard⁷, ¹Department of Medicine, University of Alberta, ⁵⁶⁸ Heritage Building, Edmonton, AB, Canada, ²University of Alberta, Department of Radiology & Diagnostic Imaging, Edmonton, AB, Canada, ³Department of Rheumatology, La Paz University Hospital, IdiPaz, Madrid, Spain, ⁴Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, ⁵UCB, Morrisville, NC, ⁶UCB, Brussels, Belgium, ⁷Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, and Copenhagen Center for Arthritis Research, Center for Rheumatology, Rigshospitalet, Glostrup, Denmark
Background/Purpose: Spinal inflammation and structural progression are key features of radiographic axial spondyloarthritis (r-axSpA).1 Canada-Denmark (CANDEN) scoring enables anatomical-based assessments of MRI inflammatory and structural…
Abstract Number: 0116 • ACR Convergence 2025
Cerebral small vessel disease in antiphospholipid syndrome: subtypes and total burden of cSVD on MRI
Chun Li¹, Jianping Guo², Yangyi Fan¹, Yu Kang¹ and Xiaodan Hu¹, ¹Peking University People's Hospital, Beijing, China (People's Republic), ²Peking University People's Hospital, Beijing, Beijing, China
Background/Purpose: Cerebrovascular diseases are common and severe neurological complications in antiphospholipid syndrome (APS). However, few studies focused on cerebral small vessel disease (cSVD) in APS.…
Abstract Number: 2541 • ACR Convergence 2025
Development of Severity Classification Criteria for Introduction of Infliximab for Chronic Pogressive Neuro-Behçet’s Disease
Shunsei Hirohata¹, Hirotoshi Kikuchi², Tetsuji Sawada³, Toshihiro Tono⁴, Mitsuhiro Takeno⁵ and Izumi Kawachi⁶, ¹Nobuhara Clinic, Tokyo, Japan, ²Teikyo University School of Medicine, ³-¹²-¹ ????????????¹³⁰⁸, Japan, ³Tokyo Medical University, Tokyo, Japan, ⁴Kitasato University School of Medicine, Kanagawa, Japan, ⁵Nippon Medical School Musashi Kosugi Hospital, Kawasaki, Japan, ⁶Niigata University Graduate School of Medicine and Dental Sciences and Niigata University Brain Institute, Niigata, Japan
Background/Purpose: Chronic progressive neuro-Behçet’s disease (CPNB) is characterized by progressive deterioration leading to disability and death. It has been appreciated that methotrexate (MTX) has beneficial…
Abstract Number: 1414 • ACR Convergence 2025
Multidimensional Assessment to Differentiate Early Psoriatic Arthritis from Cutaneous Psoriasis
Eugeniu Russu¹, Victor Cazac², Mircea Betiu³, Alesea Nistor³ and Liliana Groppa⁴, ¹"Nicolae Testemitanu" State Medical and Pharmaceutical University; ”Timofei Moșneaga” Republican Clinical Hospital, Chisinau, Moldova, ²Norwalk Hospital, Nuvance Health, Connecticut, ³State Medical and Pharmaceutical University ”Nicolae Testemițanu”, Chisinau, Chisinau, Moldova, ⁴State Medical and Pharmaceutical University ”Nicolae Testemițanu”, Chisinau, Moldova
Background/Purpose: Psoriatic arthritis (PsA) develops in ~20-30% of psoriasis patients. However, early PsA diagnosis is challenging due to heterogeneous, subtle symptoms and overlap with psoriasis…
Abstract Number: 2154 • ACR Convergence 2025
Whole-Body MRI Findings in a Cohort of Children with Chronic Nonbacterial Osteomyelitis
Mara Rodriguez¹, Maurice Davenport Munoz², Kiery Braithwaite³, Lori Ponder⁴, Kelly Rouster-Stevens⁵, Solveig Argeseanu Cunningham⁶ and Sampath Prahalad⁷, ¹Emory University School of Medicine / Children's Healthcare of Atlanta, Atlanta, GA, ²Emory University School of Medicine, Pediatrics, Atlanta, ³Children's Healthcare of Atlanta, Atlanta, GA, ⁴Emory University, Atlanta, GA, ⁵Emory University/Children's Healthcare of Atlanta, Peachtree Corners, GA, ⁶Emory Rollins School of Public Health Department of Global Health, Atlanta, GA, ⁷Emory + Children's Pediatric Institute, Atlanta, GA
Background/Purpose: Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disorder characterized by multifocal, sterile bone inflammation in childhood. Whole-body magnetic resonance imaging (WB-MRI) allows for…
Abstract Number: 1239 • ACR Convergence 2025
JAK inhibition appears to alter clinical and neurobiological markers of nociplastic pain in rheumatoid arthritis: a 7T MRI Brain study
Kristian Stefanov¹, Andrew McGucken¹, Maxine Arnott¹, Tyrone Lau¹, Norah Aldehmi¹, Vinod Kumar², Neil McKay³, James Dale⁴, Lindsay Robertson⁵, James Brock¹, Flavia Sunzini⁶ and Neil Basu⁷, ¹University of Glasgow, Glasgow, United Kingdom, ²NHS Tayside, Dundee, United Kingdom, ³NHS Lothian, Edinburgh, United Kingdom, ⁴NHS Lanarkshire, Wishaw, United Kingdom, ⁵NHS Grampian, Aberdeen, United Kingdom, ⁶Glasgow University, Glasgow, United Kingdom, ⁷Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: Pain remains a prevalent and highly impactful issue for people with rheumatoid arthritis (RA). Among modern day targeted therapies, the janus kinase (JAK) inhibitors…
Abstract Number: 2148 • ACR Convergence 2025
Initial MRI Findings as Predictors of Disease Phenotype in Juvenile Dermatomyositis: A Comparative Study of Myositis Specific Antibodies NXP2-Positive and Myositis Specific Antibody-Negative Patients in a Large Tertiary Hospital
Juan Torres Sanchez¹, Pritish Bawa², Andrea Ramirez¹, MaiLan Nguyen³, Amit Thakral⁴, Xiaofan Huang¹, J Herman Kan² and Marietta De Guzman¹, ¹Baylor College of Medicine, Houston, TX, ²Texas Childrens Hospital, Houston, TX, ³Baylor College of Medicine, Austin, TX, ⁴Texas Children’s Hospital, Houston, TX
Background/Purpose: Juvenile dermatomyositis (JDM) is the most common idiopathic inflammatory myopathy of childhood, characterized by proximal muscle weakness and distinctive cutaneous findings. Magnetic resonance imaging…
Abstract Number: 1205 • ACR Convergence 2025
Real-time MRI for assessment of swallowing impairment in inclusion body myositis and oculopharyngeal muscular dystrophy.
Rachel Zeng¹, Anke Rietveld², Omar Al-Bourini¹, Rosemarie HMJM Kroon², Arno Olthoff¹, Matthias Weidenmüller¹, Per-Ole Carstens¹, Isabel Kommerell¹, Saskia G Schütz¹, Corinne GC Horlings³, Johanna G Kalf³, Bert JM de Swart³, Baziel GM van Engelen², Tim Friede¹, Sabine Hofer¹, Jens Frahm⁴, Ali Seif Amir Hosseini¹, Jens Schmidt⁵ and Christiaan GJ Saris², ¹University Medical Center Göttingen, Göttingen, Germany, ²Radboudumc Research Institute for Medical Innovation, Nijmegen, Netherlands, ³Radboudumc Research Institute for Medical Innovation, Nijmegen, Germany, ⁴Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany, ⁵Immanuel University Hospital Rüdersdorf, Brandenburg Medical School, Rüdersdorf bei Berlin, Germany
Background/Purpose: Swallowing dysfunction -dysphagia- is a frequent and debilitating symptom in neuromuscular disorders, leading to malnutrition, cachexia, aspiration pneumonia and death. Identification of the underlying…

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